Heterocyclic Building Blocks-piperazine

196811-66-2, tert-Butyl 4-carbamothioylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of tert-butyl 4-carbamothioylpiperazine-1-carboxylate (0.5 g, 2.08 mmol) in dioxane (10 mL), triethyl amine (0.22 mL, 2.6 mmol) and 2-bromo-1- phenylethan-1-one (0.52 g, 2.6 mmol) were added at rt. The resulting mixture was stirred at 90 C for 20 h. The completion of the reaction was monitored by TLC. It was diluted with water and extracted with EtOAc. The organic layer was separated, driedover anhydrous Na2SO4 concentrated under vacuum. The resulting crude product was taken as such for the next step. Yield: 86% (0.5 g, colorless liquid).

196811-66-2, 196811-66-2 tert-Butyl 4-carbamothioylpiperazine-1-carboxylate 12093220, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; TORONTO, Dawn, V.; CROWE, David, Malcolm; (150 pag.)WO2017/144637; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

74879-18-8, Example 41 GENERAL PROCEDURE: PALLADIUM CATALYZED COUPLING TO HETEROARYL CHLORIDE; 2-Chloro-nicotinonitrile (1.0 mmol), (S) -2-methyl piperazine (1.5 mmol), sodium tert- butoxide (1.5 mmol) and tris (dibenzylideneacetone)-dipalladium (0) (0.04 mmol) were added to a screw cap vial. 2, 8, 9-Triisobutyl-2,5, 8, 9-tetraaza-1-phospha-bicyclo [3.3. 3] undecane (0. 08 mmol) was dissolved in toluene (5 mL) and this solution was added to the other reagents. The reaction mixture was stirred at 100 C overnight. The solution was diluted with dichloromethane and washed with water. The organic phase was dried, filtered and concentrated, then purified by flash chromatography in 10% (2M ammonia in methanol) in dichloromethane to yield the desired product.

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2005/80356; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129779-30-2,(3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Adding ZTH-1 (10.7g, 50mmol, 1eq) into 250ml flask; adding 100ml tetrahydrofuran, kalium carbonicum (10.35g,75mmol, 1.5eq) and methyl iodide (8.52g, 60mmol, 1.2eq) in turn; reacting under room temperature overnight; filteringand condensing, adding 100ml water and 100ml dichloromethane into the residue; and rinsing with dichloromethane(50ml x twice), merging organic layer, rinsing with saturated brine, drying with anhydrous sodium sulfate, condensing,and column chromatography of the residue (methanol : dichloromethane = 1:20), 5.7g orange-colored oily substance ZTH-2 is obtained, wherein the yield is 50%.

129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Suzhou Maidixian Pharmaceutical Inc.; Zhang, Nan; Zhong, Rong; ZHANG, Nan; ZHONG, Rong; EP2589601; (2013); A1;,
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39539-66-7, 4-Methylpiperazine-1-carbonyl chloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 8; 2-(2-difluoromethylbenzimidazoH-yI)-4-[4-(4-methylpiperaziii-l-ylcarbonyl)piperazin- 1 -y 1] -6-morpholinopy rimidine; Diisopropylethylamine (0.261 ml) was added to a stirred mixture of2-(2-difluoromethylbenzimidazol- 1 -yl)-6-morpholino-4-piperazin- 1 -ylpyrimidine (0.208 g), 4-methylpiperazin-l-ylcarbonyl chloride (0.122 g) and methylene chloride (20 ml) and the resultant mixture was stirred at ambient temperature for 1 hour. The reaction mixture was evaporated and the reaction product was purified using a Waters ‘Sunfre’ preparative reversed-phase column (5 microns silica, 19 mm diameter, 100 mm length) and decreasingly polar mixtures of a 0.1% solution of trifluoroacetic acid in water and a 0.1% solution of trifluoroacetic acid in acetonitrile as eluent. There was thus obtained the title compound (0.085 g); NMR Spectrum: (CDCl3) 2.85 (s, 3H), 3.35-3.43 (m, 2H), 3.45-3.5 (m, 4H), 3.5-3.62 (m, 4H), 3.63-3.73 (m, 8H), 3.75-3.88 (m, 6H), 5.53 (s, IH), 7.35-7.5 (m, 3H), 7.9-7.94 (d, IH), 8.18-8.22 (d, IH); Mass Spectrum: MH-H+ 542., 39539-66-7

As the paragraph descriping shows that 39539-66-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/32064; (2008); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-35-9,tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A solution of the product of EXAMPLE 18A (70 mg, 0.21 mmol), tert-butyl 4-(4- amino-2-fiuorophenyl)piperazine- l -carboxy late (61 mg, 0.21 mmol) and catalytic p- toluenesulfonic acid (5 mg) in n-butanol (3 mL) was heated at 100C for 18 hours. After cooling to ambient temperature, the mixture was poured into saturated aqueous sodium bicarbonate (50 mL). The resulting solution was extracted with ethyl acetate (3 x 30 mL), and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by preparative thin layer chromatography using 20: 1 dichloromethane/methanol to afford the crude title compound which was used in the next step without further purification. MS: 598 (M+H4).

154590-35-9, As the paragraph descriping shows that 154590-35-9 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas, Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97479; (2012); A1;,
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5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5308-25-8

Add to the reaction flask5-bromo-2-nitropyridine (4.0 g, 19.7 mmol), 1-ethylpiperazine (3.4 g, 29.8 mmol)K2CO3 (4.1 g, 29.6 mmol), TBAI (0.42 g, 1.2 mmol) and dimethylsulfoxide (40 mL) were added and the mixture was heated with stirring at 80 C for 16 hours.The mixture was cooled to room temperature and the reaction solution was poured into ice water and extracted with dichloromethane (20 mL x 3).The combined organic layers were washed with saturated brine (20 mL), dried over anhydrous sodium sulfate,The filtrate was concentrated in vacuo. The residue was purified by column chromatography (DCM / MeOH = 10: 1)The resulting residue was purified to give the title compound (3.59 g, brown solid) in 77% yield.

The synthetic route of 5308-25-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
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103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 9 (13.0 g, 100 mmol) was weighed in 100 mL of anhydrous tetrahydrofuran (THF)Adding di-tert-butyl dicarbonate(Boc) 20) (21.8g, lOOmmol), room temperature stirring lh; TLC detection, iodine cylinder color; raw materials disappeared after the solvent was recovered l0 (23g)., 103-76-4

As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Yang Chunhao; Miao Zehong; Yue Zhizhou; Liang Yukun; Feng Jianming; Li Jiaxin; He Qian; (30 pag.)CN104250246; (2017); B;,
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13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 2-chloroalkyl/aryl substitutedwith or without N-substitution as well as with or without 5 and/or 6-substituted benzimidazole derivative (1.75g,0.01051mol) and 1-[(4-phenyl)carbonyl]piperazine (3g,0.0105mol) in N, N dimethylformamide was taken in a RBF.K2CO3(2gm,) was added to the reaction mixture. The reaction mixture was stirred for 8h at 80C on a magnetic stirrer (heat + stirring). The progress of the reaction was monitored by thin layer chromatography (TLC).Upon completion of the reaction, water was added to the reaction mixture and the product extracted by shaking the reaction mixture with dichloromethane in a separating funnel.The dichloromethane layer was washed successively with water and brine, dried over anhydrous sodium sulfate. Evaporation of the solvent gave theproduct. 11a-l Recrystallized with various solvent like chloroform, ethanol, methanol., 13754-38-6

The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kankate, Rani S.; Gide, Parag S.; Belsare, Deepak P.; Oriental Journal of Chemistry; vol. 30; 4; (2014); p. 1855 – 1863;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

120737-78-2, General Procedure: To a round bottom flask equipped with a stir bar were added l-bromo-2- chloro-4-fluoro benzene (0.314 g, 1.5 mmol), 2-methyl-piperazine-l-carboxylic acid tert-butyl ester (0.451 g, 2.25 mmol), sodium tert-butoxide (0.216 g, 2.25 mmol) and toluene (15 mL). The reaction mixture was heated to 80 C and then a mixture of tris(dibenzylidine acetone)dipalladium (31.1 mg, 0.015 mmol) and racemic 2,2′-bis(diphenylphosphino)-l,l’- binaphthyl (13.7 mg, 0.05 mmol) in toluene (2 mL) was slowly added to the reaction mixture. The reaction mixture was stirred at 110 C overnight and then concentrated in vacuo. The residue was dissolved in ethyl acetate (100 mL) and washed with water (3 x 50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified on silica gel using hexanes:diethyl ether = 100:0 to 80:20 in a gradient fashion, to give the desired product (147.9 mg, 28 %). 1H NMR (300 MHz5 CDCl3): delta 7.15 (m, IH)5 6.96 (m, 2H), 4.33 (m5lH), 3.95 (d, IH), 3.29 (m5 IH), 3.13 (m5 2H), 2.74 (m, 2H)5 1.49 (s, 9H)5 1.40 (d, 3H).

120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Step 2: To a solution of compound 2 (5.8 g, 20 mmol) in dichloro methane (DCM) (100 ml) was added N-bromosuccinimide (NBS) (3.74 g, 21 mmol). The mixture was stirred for -30 min at 0 C. After completion of the reaction, the mixture was directly purified by column chromatography with a mixture of petroleum ether and ethyl acetate (PE/EA) in a 5 : 1 ratio to afford the product (2.56 g, 35%).

197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference£º
Patent; ACETYLON PHARMACEUTICALS, INC.; SHEARSTONE, Jeffrey, R.; JARPE, Matthew, B.; (152 pag.)WO2016/57779; (2016); A2;,
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Piperazines – an overview | ScienceDirect Topics