Heterocyclic Building Blocks-piperazine

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 98 Preparation of 2-(4-((4-Isopropylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one To a mixture of 4-(bromoethyl)benzaldehyde (0.200 g, 1.0 mmol) and K2CO3 (0.277 g, 2.0 mmol) in DMF (5 mL) was added N-isopropylpiperazine (0.129 g, 1.0 mmol) and the reaction was stirred at room temperature for 5 hours, then concentrated in vacuo. The resulting mixture was diluted with H2O and extracted with EtOAc. The organics were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford 4-((4-Isopropylpiperazin-1-yl)methyl)benzaldehyde (0.240 g, 97percent).

4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Resverlogix Corp.; Hansen, Henrik C.; (96 pag.)US9238640; (2016); B2;,
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112257-24-6, 1-Boc-3-Carbamoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-acryloyl-3-carbamoylpiperazine-1-carboxylate To a solution of tert-butyl 3-carbamoylpiperazine-1-carboxylate (300 mg, 1.31 mmol) and Et3N (396 mg, 3.93 mmol) in DCM (5 mL) at 0 C., acryloyl chloride (130 mg, 1.44 mmol) in DCM (1 mL) was added and the resulting mixture was stirred at room temperature for 1.5 h. The mixture was partitioned between DCM and saturated NaHCO3 aqueous solution. The organic layer was washed with saturated NaHCO3 and brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (DCM/MeOH=30:1) to afford the desired product (200 mg, 53.9% yield) as an off-white solid.

112257-24-6, 112257-24-6 1-Boc-3-Carbamoylpiperazine 11042527, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao; US2014/288045; (2014); A1;,
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84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 49 4-Benzyloxycarbonyl-1-(4-methyl-5-isoquinolinesulfonyl)-2-methylpiperazine To a solution of 1-benzyloxycarbonyl-3-methylpiperazine (5.09 g) in chloroform (150 ml), a solution of triethylamine (3.0 ml) and 4-methyl-5-isoquinolinesulfonyl chloride (6.05 g) in chloroform (50 ml) was gradually added dropwise. After completion of the dropwise addition, the resultant mixture was continuously stirred at 60C for 20 hours.The reaction mixture was washed first with water (100 ml x 2) and then with a saturate aqueous solution of sodium chloride (100 ml), and was then dried over anhydrous magnesium sulfate. The solvent was then distilled off under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (chloroform), whereby 3.95 g of the target compound were obtained. 1H-NMR (270 MHz, CDCl3) delta: 9.15(1H,s), 8.54(1H,s), 8.37(1H,dd,J=7.92,1.32Hz), 8.17(1H,dd,J=7.92,1.32Hz), 7.61(1H,t,J=7.59Hz), 7.36(5H,m), 5.17(2H,dd,J=14.85,12.21Hz), 4.05-4.18(3H,m), 3.33-3.55(3H,m), 3.04(3H,s), 1.34(3H,d,J=6.60Hz)., 84477-85-0

As the paragraph descriping shows that 84477-85-0 is playing an increasingly important role.

Reference£º
Patent; Hidaka, Hiroyoshi; EP1074545; (2001); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

To a mixture of 2-(3-bromo-phenyl)-6-chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester (410 mg, 1 mmol), palladium acetate (6.73 mg, 0.03 mmol), cesium carbonate (0.65 g, 2 mmol), xantphos (23 mg, 0.04 mmol) and N-acetylpiperazine (192 mg, 1.5 mmol) in toluene (10 mL) was stirred at 120 C. for 12 hours. Then the reaction mixture was concentrated in vacuo and the residue was extracted with ethyl acetate (2¡Á100 mL), washed with saturated aqueous sodium chloride (2¡Á50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo. Purification on flash silica gel chromatography (silica gel from QingDao, 200-300 mesh, glass column from Shanghai SD company) (20% ethyl acetate/hexanes) to afford 2-[3-(4-acetyl-piperazin-1-yl)-phenyl]-6-chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester (0.25 g, 54%) as a white solid: LC/MS m/e calcd for C25H30ClN3O3 M+: 455.99, observed: 456.1, 13889-98-0

The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chen, Li; Feng, Lichun; Huang, Mengwei; Liu, Yongfu; Wu, Guolong; Wu, Jim Zhen; Zhou, Mingwei; US2011/257151; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A suspension of IX-214 (30 mg; 0.065 mmol; Example 1), potassium carbonate (9 mg; 0.065 mmol) and potassium iodide (2 mg; 0.012 mmol) in ethanol (1 mL) was stirred 5 min at room temperature, was supplemented with /-butyl 4-(2-chloroethyl)piperazine-l-carboxylate (24.3 mg; 0.098 mmol; Acros Organics), and was stirred 6 h at 80C. The reaction mixture was evaporated, re-dissolved in 10 mL water, and extracted with dichloromethane (3 x 10 mL). The pooled extracts were dried over anhydrous sodium sulfate, filtered, and evaporated, and the product was purified by silica chromatography (methanol/di chloromethane gradient).Yield: 34.4 mg; 79%., 208167-83-3

The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; EBRIGHT, Richard H.; EBRIGHT, Yon W.; LIN, Chih-Tsung; (85 pag.)WO2019/226915; (2019); A1;,
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169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 ,1-dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate (1.5g, 7.5 mmol) in anhydrous DCM (3OmL) was added triethylamine (2.59ml_, 19 mmol) and 2,4-difluoro-1-isocyanatobenzene (0.88ml_, 7.5 mmol) the sample was stirred under an argon atmosphere at room temperature for 2hours. The reaction was evaporated and the residue was suspended DCM (3OmL) which was washed with 0.5M aqueous HCI (10OmL), and then water (10OmL). The collected organic layer was dried (MgSO4), filtered and evaporated, the residue was dried in a vac-oven at 400C overnight (approx 18hours) to yield the title compound as a white solid (2.41 g, 91%).1H NMR (CDCI3) 51.22 (3H, d, J=6.58Hz), 1.48 (9H, s), 3.11 (1 H, m), 3.22 (1 H, m), 3.34 (1 H, dd, J=13.37, 3.95Hz), 3.71 (1 H, m), 3.92 (1 H, m), 4.31 (1 H, br m), 6.39 (1 H, NH, br m), 6.85 (2H, m), 7.99 (1 H, m)., 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BESWICK, Paul, John; CAMPBELL, Alister; CRIDLAND, Andrew; GLEAVE, Robert, James; PAGE, Lee, William; WO2010/102663; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

694499-26-8, j00607j A solution of 3-Iodo4-rnethylbenzoyl chloride (6.98 g, 20.0 rnrnol), prepared from the reaction of 3.-iodoAme(hylbenzoic acid and oxalyl chloride, was charged to a solution of 4-((4-niethylpiperazin- I -yl) rnethyl)-3 -(trifluoromethyl) aniline (6.80 g, 20.0 mmol), N, N-diisopropylettyiamine (3.86 g, 29,0 rnmol), and a catalytic amount of DMAP in THF (75 rnL).The reaction mixture was stirred at room temperature for 4 h, then diluted with water (20 rnL) and extracted with EtOAc (3 X 50 rnL). The combined organic layers were dried over anhydrous Na2504, filtered and concentrated in vacuo resulting in a crude compound which purified by chromatography on silica gel, eluting with 5% methanol in DCM and niethano] presaturated with ammonia gas to give 9.6 g, 74% yield of the title compound as an offwhite solid. ?H NMR (400 MHz, CDC13): oe = 8.28 (d, J= 1.9 Hz, 1H), 7.70 – 7.89 (m, 5H), 7.34 (d, J= 7.9 Hz, 1H), 3.63 (d, J= 1.8 Hz, 2H), 2.49 (s, 3H), 2.41(m, 8H) 2.29 (s, 3H). MS (ES): m/z= 518.22 [M+H] LCMS: tR = 2.33 mm.

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 10-(benzyloxy)-4-bromo-2-(4-fluorobenzyl)-8-methyl-7,8- dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione (0.10 g, 0.19 mmol; Example 160, Step 1) and 1-methylpiperazin-2-one (2 mL) was heated in a sealed tube in an oil bath at 100 ¡ãC overnight. The benzyl protecting group was also cleaved in the process. The reaction mixture was subjected to reverse phase preparative HPLC purification. Collection and lyophilization of appropriate fractions provided the title compound. 1H NMR (400 MHz, DMSO-d6) No. 7.33 (dd, J = 8.6,5.7 Hz, 2H), 7.14 (t, J = 9.0 Hz, 2H), 5.08 (s, 2H), 4.49 (br s, 2H), 3.68 (m, 2H), 3.30 (m, 2H), 2.99 (s, 3H), 2.83 (s, 3H). ES MS M+l = 455, 59702-07-7

As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2005/110414; (2005); A2;,
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Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-2-fluoropyridine (0.100 mL, 0.972 mmol) in N,N-dimethylformamide (4.0 mL) was added triethylamine (0.284 mL, 2.04 mmol) and 1-methylpiperazin-2-one hydrochloride (0.161 g, 1.07 mmol). The resulting mixture was heated at 100 C. for 12 h then cooled to room temperature, diluted with DCM, washed with water and brine. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on a silica gel column eluting with 0 to 100% EtoAc/Hexanes to give the desired product. LC-MS calculated for C10H13BrN3O (M+H)+: m/z=270.0. found 270.0., 109384-27-2

As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.

Reference£º
Patent; Incyte Corporation; Wu, Liangxing; Courter, Joel R.; He, Chunhong; Li, Jingwei; Lu, Liang; Sun, Yaping; Wang, Xiaozhao; Yao, Wenqing; Zhang, Colin; Zhuo, Jincong; (87 pag.)US2016/9720; (2016); A1;,
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Piperazines – an overview | ScienceDirect Topics

120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12A tert-butyl (2R)-2-methyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate The product from Example 1D (200 mg, 0.56 mmol) was subjected to the conditions described in Example 11, substituting (R)-tert-butyl 2-methylpiperazine-1-carboxylate for 4-(piperidin-4-yl)morpholine to give the titled compound (242 mg, 74%)., 120737-78-2

The synthetic route of 120737-78-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; Bogdan, Andrew; Cowart, Marlon D.; DeGoey, David A.; Jinkerson, Tammie K.; Koenig, John R.; Kort, Michael E.; Liu, Bo; Matulenko, Mark A.; Nelson, Derek W.; Patel, Meena V.; Peltier, Hillary; Scanio, Marc J.; Wakefield, Brian D.; US2015/218102; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics