Heterocyclic Building Blocks-piperazine

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182181-38-0,3-Fluoro-4-(piperazin-1-yl)benzonitrile,as a common compound, the synthetic route is as follows.

Combine 1-(4-cyano-2-fluorophenyl)piperazine (1.57 g, 7.6 mmol) and Et3N (1.28 ml, 9.2 mmol) in CH2Cl2 (10 ml) and add Boc2O (1.67 g, 7.6 mmol). Stir 1 h wash with satd. NaHCO3. Dry (MgSO4) and concentrate to obtain the crude carbamate as a yellow solid.

182181-38-0, As the paragraph descriping shows that 182181-38-0 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation; US2005/239795; (2005); A1;,
Piperazine – Wikipedia
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208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate (1.00 g, 4.02 mmol, 1.00 eq), 4-benzyloxyphenol (965 mg, 4.82 mmol, 1.20 eq) in N,N-dimethylformamide (20 mL) was added cesium carbonate (1.57 g, 4.82 mmol, 1.20 eq) and potassium iodide (66 mg, 0.4 mmol, 0.10 eq) under nitrogen. The reaction was stirred at 80 C. for 10 hours. TLC (Petroleum ether/Ethyl acetate=3/1) and LCMS showed most of the starting material was consumed. Water (100 mL) was added to the mixture, the resulting mixture was extracted with Ethyl acetate (50 mL*3). The combined organic phase was washed with brine (80 mL), dried over sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel chromatography (Petroleum ether/Ethyl acetate=50/1 to 3/1). tert-butyl 4-[2-(4-benzyloxyphenoxy)ethyl]piperazine-1-carboxylate (1.4 g, 3.39 mmol, 84% yield) was obtained as a colorless oil. Chemical Formula: C24H32N2O4, Molecular Weight: 412.5 Total H count from HNMR data: 32. ?H NMR: (400 MHz, CHEOROFORM-d)oe: 7.46-7.29 (m, 5H), 6.95-6.88 (m, 2H), 6.88-6.812H), 5.02 (s, 2H), 4.07 (t, J=5.8 Hz, 2H), 3.5 1-3.42 (m, 4H), 2.80 (t, J=5.8 Hz, 2H), 2.56-2.48 (m, 4H), 1.47 (s, 9H)

208167-83-3, The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Arvinas, Inc.; Crew, Andrew P.; Berlin, Michael; Dong, Hanqing; Homberger, Keith R.; Qian, Yimin; Snyder, Lawrence B.; Wang, Jing; Zimmermann, Kurt; (504 pag.)US2018/215731; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Yellow solid; IR (KBr, cm-1): v 3284 (-NH), 3069-3078 (-CH str.), 2223 (CN), 1255 (C-O-C), 836 (s-triazine C-N str.), 749 (C-F). 1H NMR (400 MHz, Me2SO-d6): delta 9.22 (s, 1H, -NH, s-triazine to amino-benzonitrile linkage), 8.10 (dd, J = 1.7, 1.1 Hz, 1H, C5 proton of coumarin), 7.61-7.64 (m, 1H, coumarin), 7.45 (t, J = 8.5 Hz, 1H, C6 proton of coumarin), 7.33-36 (m, 1H, coumarin), 7.29-6.90 (9H, m, Ar-H), 3.87 (4H, br s, piperazine), 3.48 (4H, br s, piperazine). 13C NMR (100 MHz, Me2SO-d6): delta 175.4 (1C, C-6, s-triazine, C-N at piperazine linkage), 167.2 (1C, C-4, s-triazine, C-O-C at quinoline linkage), 165.9, 163.8 (2C, 1C at C-2, s-triazine, C-NH at benzonitrile moiety and 1C of CO), 152.9 (1C of C-9, coumarin), 148.3-119.6 (19C, Ar. C including C-CF3 at 129.7 and CF3 at 126.1), 106.1 (1C, CN), 97.4 (1C, -C-CN), 48.6, 46.2 (4C, piperazine ring carbon atoms). 19F NMR (400 MHz, CDCl3): delta -65.33 (3F, s, 4-CF3)., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Patel, Rahul V.; Kumari, Premlata; Rajani, Dhanji. P.; Chikhalia, Kishor H.; Journal of Fluorine Chemistry; vol. 132; 9; (2011); p. 617 – 627;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

Preparation 8:1-[3-((3R,5S)-3,4,5-TrimethyI-pperazin-1-yI)-phenyl]-ethanone; STEP A; An oven-dried MW tube was charged with Pd2(dba)3 (592 mg, 0.65 mmol), K3PO4 (1.92 g, 9.06 mmol) and (2′-dicyclohexylphosphanyl-biphenyl-2-yl)-dimethyl-amine (127 mg, 0.32 mmol). The tube was purged and backfilled with N2 and then 1-(3- chloro-phenyl)-ethanone (1 g, 6.47 mmol), (2R,6S)-2,6-dimethyl-piperazine (886 mg, 7.76 mmol) and DME (10 ml) were added. The mixture was heated in a MW apparatus for 4 h at 1000C and then further Pd2(dba)3 (592 mg, 0.65 mmol) and (2′-dicyclohexylphosphanyl-biphenyl-2-yl)-dimethyl-amine (127 mg, 0.32 mmol) were added. The reaction mixture was heated to 1000C for additional 10 h and then the solid was filtered off over a Celite pad. The filtrate was diluted with AcOEt and extracted with 1 M HCI. The aqueous phase was brought to basic conditions with NH4OH and extracted with AcOEt. The organic phase was dried over Na2SO4 and evaporated in vacuo. The crude reaction mixture was purified by column chromatography (eluent: AcOEt/MeOH 8:2) to give 226 mg of 1-[3-((3R,5S)-3,5- dimethyl-piperazin-1-yl)-phenyl]-ethanone. Y= 15percent

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAC S.R.L.; WO2007/113249; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

To a suspension of Intermediate 10A (50 mg, 0.17 mmol) and Pd2(dba)3 (15 mg, 0.017 mmol) in toluene (2 mL) was added Xantphos (29 mg, 0.050 mmol), benzyl piperazine-l-carboxylate (37 mg, 0.17 mmol), followed by sodium tert-butoxide (48 mg, 0.50 mmol). The reaction mixture was stirred at 70 ¡ãC for 16 h, and then filtered. The filtrate was concentrated and purified by flash chromatography using a 15 min gradient from 0 to 100percent EtOAc in hexanes to give Intermediate 10B (70 mg, 0.16 mmol, 96percent yield). LC-MS (ESI) m/z 440.1 (M+H), RT = 2.27 min (Method B).

31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; HU, Carol Hui; QIAO, Jennifer X.; WANG, Tammy C.; WO2013/151923; (2013); A1;,
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Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a sealed tube, 7-fluoro-9-methyl-2-(2-methyl-[l,2,4]triazolo[l,5-b]pyridazin-6-yl)-4H- pyrido[l,2-a]pyrimidin-4-one (Intermediate (VT3), 30 mg, 0.097 mmol), TEA (48.9 mg, 67.4 mu, 0.483 mmol, 5 eq.) and (2S,6R)-2,6-dimethylpiperazine (33.1 mg, 0.290 mmol, 3 eq.) were stirred in DMSO (1.5 ml) at 120¡ãC for 24 hours. The crude was purified by column (0428) chromatography (Si02, DCM/MeOH=90/10) to afford the title product (30 mg, 76percent) as a brown solid. MS m/z 405.3 [M+H]+.

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GILLESPIE, Robert Jack; HASANE, Ratni; SARIE, Jerome Charles; (89 pag.)WO2016/184832; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5747-48-8, 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5747-48-8, ll-Piperazin-l-yldibenzo[b,f][l,4]thiazepine was screened for potential salt formation with 30 acids listed below in Table 1. Stock solutions (0.05 M) of each of the acids were prepared in methanol. A stock solution (0.05 M) of amorphous 11-piperazin-l- yldibenzo[b,f][l,4]thiazepine (free base) was also prepared. A 150 muL aliquot of free base solution was mixed with a 150 muL aliquot of each of the acid solutions in individual wells of a glass 96-well plate. Each combination was prepared in duplicate. The methanol was allowed to evaporate either at room temperature (rt) or at 50 0C. Each well was then viewed microscopically at a magnification of 4Ox initially, under crossed-polars, to determine the nature (crystalline or non-crystalline) of any solid material that was formed.A 300 muL aliquot of another solvent (either acetone, acetonitrile or ethyl acetate) was added to each well. The plate was then sonicated to re-dissolve the solid material, followed by storage at room temperature or 50 C, allowing evaporation of solvent. Each well was then viewed microscopically at a magnification of 4Ox initially, under crossed-polars, to determine the nature (crystalline or non-crystalline) of any solid material that was formed. Results are shown in Table 1. The symbol “A” indicates formation of solid amorphous particles/film. The symbol “B” indicates formation of amorphous cake. The symbol “C” indicates formation of ciystalline particles. The symbol “P” indicates precipitation after mixing and formation of crystalline particles.Table 1

As the paragraph descriping shows that 5747-48-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2007/62336; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

Under nitrogen protection, 4-fluorobenzoic acid methyl ester (3.0 mL, 20.69 mmol) was dissolved in 20 mL DMSO,K2CO3 (5.718 g, 41.38 mmol) was added sequentially,N-ethylpiperazine (1.93 mL, 24.83 mmol). 120 C overnight,The reaction was cooled to room temperature, and the mixture was partitioned between ethyl acetate and saturated brine (50 mL). The aqueous layer was extracted with ethyl acetate (50 mL ¡Á 3), and the combined organic layers were washed with saturated sodium chloride,Dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure, and the residue was subjected to silica gel column chromatography (dichloromethane / methanol = 10/1) to obtain 4.405 g of a white solid, yield 85.8%.

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Fudan University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Li, Yingxia; Geng, Meiyu; Liu, Jing; Ding, Jian; Zhang, Wei; Ai, Jing; (20 pag.)CN106032359; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, 4-(4-(4-methyl piperazine-1-carbonyl) phenyl) amino-6- […] (intermediate 1-c) weighing 4-chloro-6- […] (1-a, 0 . 16g, 0.58mmol) in isopropanol (5 ml), add 4-(4-methyl piperazine-1-carbonyl) aniline (0.14g, 0 . 64mmol), to reflux temperature under nitrogen for 5h, cooling to room temperature, filter, the white solid obtained 1-c (0.18g, 73%).

As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.

Reference£º
Patent; Xi’an Jiaotong University; Xin, Minghang; Zhang, Sanqi; Zhang, Hao; Xie, Xiaoxiao; Hei, Yuanyuan; Zuo, Saijie; Mao, Shuai; (40 pag.)CN105237484; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118753-66-5,tert-Butyl 4-aminopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,118753-66-5

The compound 4-chloro-5-nitro-1-p-toluenesulfonyl-1H-pyrrolo [2,3-b] pyridine (1.18 g, 5.87 mmol), N, N-diisopropylethylamine (7.10 g, 55mmol)And 1-Boc-4-aminopiperazine (1.18 g, 5.87 mmol) were added to 60 mL of isopropanol (suspension), and the temperature was raised to 100 C. with stirring under nitrogen for 16 hours.After the reaction was completed, the mixture was cooled to room temperature, ether was added, and a large amount of a yellow solid precipitated.Filtration, collection of solids and drying1-Boc-4-((5-nitro-1-p-toluenesulfonyl-1H-pyrrolo [2,3-b] pyridin-4-yl) amino) piperazine (2.16 g, yield 76%) .

As the paragraph descriping shows that 118753-66-5 is playing an increasingly important role.

Reference£º
Patent; Weimou Bio-technology (Shanghai) Co., Ltd.; Shen Wang; Liu Pengfei; Bai Rujun; Liu Yufei; Luo Qiuping; Ke Pingbo; Gong Yanchuan; (71 pag.)CN110483514; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics