Heterocyclic Building Blocks-piperazine

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5308-25-8, To a stirred solution of Ethyl piperazine (11.06 g, 96.8 mmol, 2.0 eq) and triethylamine (24.46 g, 242 mmol, 5.0 eq) in CH2Cl2 (150 ml) at 0C was added a solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(chlorocarbonyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl acetate (25 g, 48.4 mmol, 1.0 eq) in CH2Cl2 (150 ml). The reaction mixture was allowed to stir at room temperature for overnight. TLC indicated starting material was consumed and the desired product was observed. The reaction mixture was quenched with water and extracted with CH2Cl2 (3×200 ml). The combined organic layers were dried over Na2S04, filtered and evaporated under reduced pressure. The crude residue was purified by silicagel column chromatography by using 2% methanol: dichloromethane as an eluent to obtain the desired product (26 g, 90% yield) as a white solid. 1H NMR (300 MHz, CDCl3): delta ppm 4.72 (s, 1H), 4.57 (s, 1H), 4.50-4.42 (m, 1H), 3.68-3.56 (m, 4H), 3.03-2.82 (m, 2H), 2.48-2.32 (m, 6H), 2.04 (s, 3H), 1.68 (s, 3H), 1.10 (t, J= 7.2 Hz, 3H), 0.95 (s, 3H), 0.94 (s, 3H), 0.84 (s, 3H), 0.836 (s, 3H), 0.83 (s, 3H), 2.15-0.75 (m, 23H); ES MS: [M+H]+ 595.4 (100%).

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi; WO2013/160810; (2013); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115761-79-0,1-(2,4-Difluorophenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of compounds 21a, b (0.5mmol) in anhydrous DCM (20mL) was added BOP-Cl (0.6mmol), Et3N (1.5mmol) and the amino parts (3, 4, 8a-l, 9a-d, 13a,b, 14a,b, 16a-i, 18, 22a,b and 23) at room temperature. The mixture was stirred overnight at the same temperature, and washed by H3PO4 solution (1%), saturated NaHCO3 solution and brine, dried over anhydrous MgSO4, filtered, and concentrated. The residue was purified by Flash column chromatography (DCM/MeOH, 0-10%) to afford the crude target compounds as yellow solids. The solid was further purified by treating with EtOAc and hexane (11mL, 1: 10) to yield the target compounds (24, 25, 26a-l, 27a-g, 28a,b, 29a,b, 30a-i, 31, 32a,b, 33).

115761-79-0, As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.

Reference£º
Article; Lv, Kai; Li, Linhu; Wang, Bo; Liu, Mingliang; Wang, Bin; Shen, Weiyi; Guo, Huiyuan; Lu, Yu; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 117 – 125;,
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197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-(2,7-diazaspiro[4.4]non-2-yl)-6-(2,2,2-trifluoroethyl)pyrrolo[2, 1 -f][1 ,2,4]triazine hydrochloride (intermediate 122), 72.0 mg (0.166 mmol), and tert-butyl 4-(4- formylphenyl)piperazine-1-carboxylate (CAS 197638-83-8), 40.1 mg (0.138 mmol), in dichloromethane, 1.40 ml, and triethylamine, 63.0 pL (0.455 mmol), was stirred at room temperature for 30 minutes. Sodium triacetoxyborohydride, 87.8 mg (0.4 14 mmol), was added in portions. The reaction mixture was stirred at room temperature for 18 hours. The reaction was quenched with water and stirred at room temperature for 30 minutes. The product wasextracted into dichioromethane and the organics were dried over magnesium sulfate and concentrated under vacuum. The residue was by flash chromatography on silica gel 60 (eluent: ethyl acetate-5% ammonia/methanol 1:0, 9:1) to give the desired product, 84.0 mg (85%).LC-MS (method 13): Rt = 1.00 mm., 96%. MS (ESIpos): m/z = 600 [M+H].1H NMR (400 MHz, CDCI3): 6 [ppm] = 1.47 (s, 9H), 1.82-2.12 (m, 4H), 2.38-2.78 (m, 4H),3.07-3.14 (m, 4H), 3.36-3.42 (m, 2H), 3.54-3.57 (m, 6H), 3.62-4.00 (m, 4H), 6.66 (s, 1H), 6.85 (d, 2H), 7.20 (d, 2H), 7.50 (s, 1H), 7.81 (s, 1H)., 197638-83-8

As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference£º
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; SIEGEL, Stephan; HAENDLER, Bernard; STRESEMANN, Carlo; FERNANDEZ-MONTALVAN, Amaury, Ernesto; TER LAAK, Antonius; STOeCKIGT, Detlef; HARB, Hassan, Youssef; KOSEMUND, Dirk; EHEIM, Ashley; MOeNNING, Ursula; (234 pag.)WO2018/24602; (2018); A1;,
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109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (3-bromophenyl)methanol (570 mg, 3.05 mmol) in THF (5 mL) was added LHMDS (7.43 mL, 7.43 mmol) and the mixture was stirred at RT for 30 minutes. Ru-phos precatalyst (97 mg, 0.133 mmol), dicyclohexyl(2′,6′-diisopropoxy-[l,l’- biphenyl]-2-yl)phosphine (61.9 mg, 0.133 mmol), and 1-methylpiperazine (0.441 mL, 3.98 mmol) were added, the mixture was degassed with a stream of nitrogen and heated to 75 C for 1 h. The mixture was then diluted with DCM and washed with water. The organic layer was concentrated under reduced pressure and the residue was purified by Si02gel chromatography (0-20% MeOH in DCM) to give the title compound (506 mg, 80%). MS(ES+) C12H18N20 requires: 206, found: 207 [M+H]+.

109-01-3, 109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JONES, Philip; DIFRANCESCO, Maria, Emilia; PETROCCHI, Alessia; MARSZALEK, Joe; LIU, Gang; KANG, Zhijun; CARROLL, Christopher, L.; MCAFOOS, Timothy; CZAKO, Barbara; WO2014/31928; (2014); A2;,
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Piperazines – an overview | ScienceDirect Topics

122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(methylsulfonyl)-4-(3-nitrophenoxy)pyrazolo[l ,5-a][ l ,3,5]triazine (7, 0.25 g, 0.74 mmol), 2-methoxy-4-(4-methylpiperazin- l -yl)aniline (8, 0.164 g, 0.74 mmol), Cul (14 mg, 0.074 mmol), L- proline (17 mg, 0.14 mmol) and K3P04 (0.474 g, 2.2 mmol) in DMF (5 mL) was stirred at 80 C for overnight. Reaction was monitored by TLC and LCMS. After completion of the reaction, water was added and extracted with ethyl acetate. Organic layer was washed with brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure. Crude product was purified by column chromatography using 3% MeOH-DCM to afford N-(2-methoxy-4-(4-methyIpiperazin- l -yl)phenyl)- 4-(3-nitrophenoxy) pyrazolo[ l ,5-a][ l ,3,5]triazin-2-amine (9, 0.15 g, 42%). NMR (400 MHz, CDjOD): delta 8.20-8.18 (m, 2H), 8.10 (s, 1 H), 7.70-7.45 (m, 3H), 6.65 (s, 1 H), 6.40-6.30 (d, 1 H), 6.25 (s, 1 H), 3.95 (s, 3H), 3.30-3.20 (t, 4H), 2.70-2.60 (t, 4H), 2.32 (s, 3H).

122833-04-9, 122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GATEKEEPER PHARMACEUTICAL, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun; WO2011/79231; (2011); A1;,
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314741-39-4, (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Example 1(c) in dry tetrahydrofuran (40ml) at 0C was treated with lithium aluminium hydride (0.50g) and the mixture was stirred at 0C for 1.5 hours.. The cooled solution was treated dropwise with a solution of 2M sodium hydroxide until a white precipitate had formed.. Dichloromethane and anhydrous sodium sulfate were added and the solution was filtered and evaporated to give a pale yellow oil (3.0g). MS (+ve ion electrospray) m/z 217 (MH+).

314741-39-4, 314741-39-4 (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 1501855, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SmithKline Beecham plc; EP1187828; (2004); B1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 1: Ninety grams of L-CYCLOPROPYL-6, 7-DIFLUORO-1, 4-DIHYDRO-8-METHOXY-4-OXO-3- quinoline carboxylic acid and 64g (2.1 eq) of 2-methyl piperazine were put in suspension in 1.8 liter of DMSO under nitrogen atmosphere. The mixture was heated to 55 C during 24 hours. Subsequently, the mixture was heated to 70 C and half of the amount of DMSO was distilled-off at reduced pressure (1-5 mm Hg). At the end of the distillation, the reaction mixture was cooled to 20 C and left at this temperature overnight. The solution was then filtered under vacuum and the wet cake washed twice with n-butanol (300 ml). The collected solid was then dried under vacuum to obtain 94 g. The calculated yield, after assay, was 84%.

109-07-9, The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2004/69825; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 0C was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4) and concentrated to give (R)-3-methyl-piperazine-l- carboxylic acid tert-butyl ester as a white solid (669 mg, 84%).

As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.

Reference£º
Patent; PIRAMED LIMITED; GENENTECH, INC.; BAYLISS, Tracy; CHUCKOWREE, Irina; FOLKES, Adrian; OXENFORD, Sally; WAN, Nan, Chi; CASTANEDO, Georgette; GOLDSMITH, Richard; GUNZNER, Janet; HEFFRON, Tim; MATHIEU, Simon; OLIVERO, Alan; STABEN, Steven; SUTHERLIN, Daniel, P.; ZHU, Bing-Yan; WO2008/70740; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.259808-67-8,1-Boc-3,3-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of the product from the previous step (1.0 g, 4.7 mmol) in CH2Cl2 (20 mL) at 0 C were added TEA (2.0 ml, 14 mmol) and methanesulfonyl chloride (0.641 g, 5.60 mmol) and the resulting mixture was stirred RT for 3 h. The mixture was concentrated under reduced pressure. The residue was purified via silica gel chromatography (5 – 100 % EtOAc in hexanes) to afford a colorless liquid. The residue was taken up in CH2CI2 (20 mL), 4 N HCl in dioxane (3.5 mL, 14 mmol) was added and the mixture was stirred at RT for 14 h. A white ppt was collected by vacuum filtration to afford the title compound (716 mg, 80 % yield).

259808-67-8, As the paragraph descriping shows that 259808-67-8 is playing an increasingly important role.

Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; CHEMPARTNER CORPORATION; DI FRANCESCO, Maria, Emilia; JONES, Philip; CARROLL, Christopher, Lawrence; CROSS, Jason, Bryant; JOHNSON, Michael, Garrett; LIVELY, Sarah; (187 pag.)WO2018/218197; (2018); A2;,
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694499-26-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%).

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics