Heterocyclic Building Blocks-piperazine

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 7, 8 or 9 (0.74-0.91 mmol) in 3 mL of n-BuOH kept in a PV with stirring, cyclic amines (1.12 mmol) was added. The sealed PV was placed in an oil bath at 145-150 C and stirred for 30-40 min. n-BuOH was evaporated in vacuo and the residue was re-dissolved in 3:1 EtOAc/DCM and washed successively with saturated NaHCO3 and NaCl solution (1 ¡Á 15 mL), respectively. The aqueous layer was washed with EtOAc (3 ¡Á 5 mL) and the organic layer was dried over anhydrous MgSO4 then filtered. The solution was evaporated in vacuo to afford either solid or semisolid product. Some physical and spectroscopy data are provided below for 7a-r, 8a-f, 9a-e.

13484-40-7, As the paragraph descriping shows that 13484-40-7 is playing an increasingly important role.

Reference£º
Article; Mohamed, Tarek; Zhao, Xiaobei; Habib, Lila K.; Yang, Jerry; Rao, Praveen P.N.; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2269 – 2281;,
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20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20327-23-5, A mixture of the chloropyrimidine (200 mg, 0.38 mmol), the piperazine (238 mg, 1.88 mmol) and N,N-diisopropylethylamine (0.26 mL, 1.51 mmol) in DMSO (1.5 mL) was heated in a sealed tube at 110 C for 2 h. The reaction was cooled to room temperature and diluted with water. The layer was then extracted with EtOAc (x2). The combined organic layers were washed with water and brine, dried over MgS04, filtered and concentrated to leave a residue which was used purified by column chromatography (Si02; elution with 2:1 hexane:EtOAc) to yield the desired adduct. LCMS 621 [M+H]+.

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; BASU, Kallol; DEMONG, Duane; SCOTT, Jack; LI, Wei; HARRIS, Joel; STAMFORD, Andrew; POIRIER, Marc; TEMPEST, Paul; WO2014/137719; (2014); A1;,
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149057-19-2, 4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 587a (25 g, 69 mmol) in EtOH (50 mL) was added HCl.EtOH (35%, 50 mL). The mixture was stirred at 25 C. for 4 hours. The mixture was evaporated to afford product as white solid (18 g, 100%). MS (ESI): mass calcd. for C13H16N2O4 264.11, m/z found 265.1 [M+H]+., 149057-19-2

The synthetic route of 149057-19-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VenatoRx Pharmaceuticals, Inc.; BURNS, Christopher J.; COBURN, Glen; LIU, Bin; YAO, Jiangchao; BENETATOS, Christopher; BOYD, Steven A.; CONDON, Stephen M.; HAIMOWITZ, Thomas; US2019/375708; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.,70261-82-4

General procedure: To a solution of 2 (0.3 g, 0.68 mmol), HATU (0.26 g, 0.68 mmol)and DIPEA (0.24 mL, 1.36 mmol) in dry CH2Cl2 (10 mL) were stirred for20 min at room temperature, the substituted anilines or benzylamines (0.68 mmol) was added slowly. The reaction mixture was stirred for 5 hat room temperature. The resulting mixture was diluted by H2O(10 mL), and extracted by EtOAc (3¡Á10 mL). The combined organiclayers were washed with brine and dried over anhydrous MgSO4, filtered,and concentrated under reduced pressure. The residue was recrystallized from the solution of MeOH-H2O (1:1) to give the amides3a-n in good yields of 80.2-88.5%.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Article; Qiu, Yinda; Xiao, Zhongxiang; Wang, Yanyan; Zhang, Dingfang; Zhang, Wenxin; Wang, Guangbao; Chen, Wenbin; Liang, Guang; Li, Xiaokun; Zhang, Yali; Liu, Zhiguo; Bioorganic and Medicinal Chemistry; vol. 27; 20; (2019);,
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162046-66-4, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4- (4-t-butoxycarbonylpiperazin-1-yl) benzoic acid (1.0 g, 3.3 mmol) and 1- (t-butoxycarbonylamino)-2-aminobenzene (Method 17,0. 68 g, 3.3 mmol) in DMF (10 ml) was added 4- (4, 6-dimethoxy-1, 3, 5-triazinyl-2-yl)-4-methylmorpholinium chloride (1. 1 g, 4.0 mmol) (Method 18). The mixture was stirred at ambient temperature for 20 hours. The mixture was concentrated itt vacuo and the residue partitioned between water and ethyl acetate. The organic phase was separated and the aqueous reextracted with ethyl acetate. The combined organic extracts were dried over magnesium sulfate and evaporated. The residue was purified by flash chromatography (eluting with 4: 1-1: 1 isohexane/ethyl acetate). The product was dissolved in 1,4-dioxane (2.5 ml) and treated with a 4M solution of hydrogen chloride in 1,4-dioxane (2.5 ml). The mixture was stirred at ambient temperature for 4 hours. The resulting solid was collected by filtration, trated with a 2M aqueous solution of sodium hydroxide and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate to afford the title compound as a colourless solid (176 mg, 92%); NMR Spectrum : (DMSO-d6) 2.89 (t, 4H), 3.25 (t, 4H), 4.90 (s, 2H), 6.66 (t, 1H), 6.84 (d, 1H), 7.01 (m, 3H), 7.21 (d, 1H), 7.92 (d, 2H), 9.48 (s, 1H) ; Mass Spectrum : M+H 297., 162046-66-4

The synthetic route of 162046-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/87057; (2003); A1;,
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692058-21-2,692058-21-2, 1-Boc-4-(2,2,2-trifluoroethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(lH-Indazol-4-yl)-4-mophiholin-4-yl-6-[4-(2,2,2-trifluoro-ethyl’)-piperazin-l- ylmethyl]-thieno[3,2-dlpyrimidine (90).Prepared via 2-Chloro-4-morpholin-4-yl-6-[4-(2,2,2-trifluoro-ethyl)- piperazin-l-ylmethyl]-thieno[3,2-d]pyrimidine, prepared from l-(2,2,2-trifluoro- ethyl)-piperazine.Amine preparation: to BOC-piperazine (4g) in DCM (4OmL) was added trifluoroacetic anhydride (6.06mL) and triethylamine (3.29mL). After stirring overnight the reaction mixture was diluted with diluted with DCM, washed with sodium bicarbonate solution, dried (MgSO4) and the solvent removed in vacuo to yield 4-(2,2,2-trifluoro-acetyl)-piperazine-l-carboxylic acid tert-butyl ester (6.06g).To 4-(2,2,2-trifluoro-acetyl)-piperazine-l-carboxylic acid tert-butyl ester (6.06g) in dry THF (6OmL) was added borane dimethyl sulfide complex (4.5ml) and EPO the reaction mixture was heated to reflux. After 2 h the reaction mixture was cooled to O0C and MeOH was carefully added, followed by water. The organics were extracted into ethyl acetate, dried (MgSO4) and the solvent removed in vacuo to yield 4-(2,2,2-trifluoro-ethyl)-piperazine-l-carboxylic acid tert-butyl ester (4.46g). Treatment with HCl in DCM/MeOH yielded the desired compound, which was isolated as the hydrochloride salt.1H NMR (400MHz, CDCl3): 2.56 (4H, m), 2.69 (4H, m), 2.93 (2H, q), 3.79 (2H, s), 3.85 (4H, m), 4.02 (4H, m), 7.23 (IH, s), 7.44 (IH, d), 7.52 (IH, d), 8.21 (IH, d), 8.94 (IH, s).

As the paragraph descriping shows that 692058-21-2 is playing an increasingly important role.

Reference£º
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
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Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-82-4, General procedure: 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoic acid (8.95g, 31mmol) was stirred in a solvent of 58 dimethyl formamide (25mL).The reaction solution was added with 59 HATU (12.98g, 34.1mmol), 72 DIPEA (10.26mL, 62.0mmol) and 104 3-(trifluoromethyl)aniline (5g, 31mmol), followed by stirring for about 8h at room temperature. The reaction mixture was diluted with ethyl acetate and washed with a saturated aqueous sodium bicarbonate solution and saline. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting mixture was concentrated to give the crude 132 product, which was purified by silica gel column chromatography.

The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Qi; Dai, Yang; Ji, Yinchun; Shi, Huanyu; Guo, Zuhao; Chen, Danqi; Chen, Yuelei; Peng, Xia; Gao, Yinglei; Wang, Xin; Chen, Lin; Jiang, Yuchen; Geng, Meiyu; Shen, Jingkang; Ai, Jing; Xiong, Bing; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 671 – 689;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8

INTERMEDIATE 46(S)-N-(I – (2- r4-(Cyclopropanecarbony?piperazin- 1 -yl] -8-methylquinolin-3 -yl) ethvD- 2,2,2-trifluoroacetamideIntermediate 45 (100 mg, 0.32 mmol), cyclopropyl(piperazin-l-yl)methanone (0.09 mL, 0.63 mmol), NMP (2 mL) and DIPEA (0.10 mL, 0.80 mmol) were combined in a sealed tube and heated to 1400C for 4 days. After cooling, Et2O (50 mL) was added to the reaction mixture. The organic layer was washed with water (5 x 50 mL) and brine. The organic layer was dried (MgSO4), filtered and the solvent was removed in vacuo. Purification by column chromatography on silica, eluting with 0-30% EtOAc in isohexane, gave the title compound (82 mg, 60%) as a pale yellow gum. delta? (CDCl3) 8.01 (IH, s), 7.75-7.65 (IH, m), 7.59 (IH, d, J 8.1 Hz), 7.55-7.48 (IH, m), 7.40-7.31 (IH, m), 5.58-5.47 (IH, m), 4.00-3.86 (3H, s), 3.85-3.72 (IH, s), 3.54-3.30 (2H, m), 3.18 (2H, m), 2.71 (3H, s), 1.84-1.76 (IH, m), 1.64 (3H, d, J6.8 Hz), 1.09-0.97 (2H, m), 0.84-0.75 (2H, m).

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-38-0,2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.

5521-38-0, General procedure: The substituted nitro compound 11 (1 equiv in a mixture of EtOH-H2O, 95:5, 20mL) was treated with 10% Pd-carbon (5% w/w). The reaction was subjected to hydrogenation under hydrogen gas at room temperature and the reaction was monitored by TLC. After completion of the reaction, the mixture was filtered through a Celite bed and concentrated in a vacuum to afford product 12.

5521-38-0 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol 2763936, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53788-49-1,tert-Butyl 4-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

53788-49-1, Example 2 Preparation of Intermediate 4-(4-chloro-pyrimidin-2-yl)-piperazine-1-carboxylic Acid Tert-Butyl Ester (I-2a): To a suspension of 2,4-dichloropyrimidine (1.00 g, 6.71 mmol) in 13.4 mL of toluene was added 4-methyl-piperazine-1-carboxylic acid tert-butyl ester (1.34 g, 6.71 mmol). The reaction was heated to reflux overnight, then cooled to room temperature and concentrated in vacuo. The residue was taken up in 20 mL of water and extracted with ethyl acetate (2*40 mL). The combined organic layers were washed with brine (25 mL), then dried over sodium sulfate, filtered, and concentrated in vacuo to an off-white solid. Flash column chromatography (silica gel, gradient elution from 5% ethyl acetate-hexanes to 20% ethyl acetate-hexanes) yielded 1.14 g of the title compound (I-2a). 1H NMR (400 MHz, CDCl3) delta 8.15 (d, 1H); 6.52 (d, 1H); 3.80 (m, 4H); 3.48 (m, 4H); 1.47 (s, 9H). MS (APCI+) Calc: 298, Found: 299.1 (M+1).

The synthetic route of 53788-49-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chiang, Phoebe; Novomisle, William A.; Welch JR., Willard M.; US2003/105106; (2003); A1;,
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Piperazines – an overview | ScienceDirect Topics