Heterocyclic Building Blocks-piperazine

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 5 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-5-methyl-7-[3-methyl-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid A suspension of 0.80 g (2.69 mmol) of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid, 1.08 g (10.8 mmol) of 2-methylpiperazine, and 20 ml of acetonitrile was refluxed for three hours, then cooled in an ice bath. The precipitate was filtered, washed with water and acetonitrile, and dried to give 0.76 g of the title compound, mp 187-188 C., 109-07-9

As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference£º
Patent; Warner-Lambert Company; US4920120; (1990); A;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

A mixture of starting material (28 mg, 0.1 mmol), 2-methoxy-4-(4-methylpiperazin-1-yl)benzenamine (22 mg, 0.1 mmol), X-Phos (4.3 mg), Pd2(dba)3 (5.5 mg) and K2CO3 (41.5 mg, 0.3 mmol) in t-BuOH (1.5 mL) was heated at 100 C. in a seal tube for 4 h. The reaction was then filtered through celite, eluted with dichloromethane, and concentrated in vacuo. The residue was then purified by reverse-phase prep-HPLC to afford the title compound as the TFA salt (7.2 mg, 15%)., 122833-04-9

As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; Gray, Nathanael S.; Waller, David; Choi, Hwan Guen; Wang, Jinhua; Deng, Xianming; (104 pag.)US2016/24115; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288251-85-4,tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Crude 4-(4-amino-2-cyano-phenyl)-piperazine-l-carboxylic acid tert-butyl ester from above was dissolved in methylene chloride (10 mL) and to the resulting solution was added 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid (454 mg), triethylamine(247 muL) and l-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDCI,337 mg). The reaction mixture was stirred at room temperature for 3 hr. Another portion of l-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.5 eq) was added. The reaction mixture was stirred at 500C for 3 hr and at room temperature for 3.5 days.The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over sodium sulfate, filtered and evaporated. Purification by flash chromatography afforded 4- {2-cyano-4-[(2-phenyl-5-trifluoromethyl-oxazole-4- carbonyl)-amino]-phenyl}-piperazine-l-carboxylic acid tert-butyl ester (240 mg, 25 % yield) as a yellow solid. LCMS calcd for C27H26F3N5O4 (m/e) 541, obsd 542 (M+H)., 288251-85-4

288251-85-4 tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate 22227872, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/141976; (2008); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

The 100 mg compound II, 75 mg compound III by adding 5 ml dichloromethane (DCM) in, stirring, 40 C reaction 2 hours, TLC monitoring, after the reaction, the solvent turns on lathe does, the reactant putting into the 100 ml water, ethyl acetate (20 ml ¡Á 3) extraction, standing liquid, organic phase are respectively 5% of NaHCO3 (20 Ml ¡Á 3), saturated salt water (20 ml ¡Á 3) washing, then drying water-free magnesium sulfate, filtered, reduced pressure to remove the ethyl acetate to get the yellow oily compound IV 83 mg.

20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Southern Medical University; Chen Jianjun; Cheng Binbin; (22 pag.)CN109456284; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1214196-85-6,1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a mixture of l-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (200 mg, 0.86 mmol) and DIPEA (333 mg, 2.58 mmol) in THF (8 mL) and DMF (0.5 mL) was dropped a solution of Compound 7B (216 mg, 0.86 mmol) in THF (8 mL) at 0 C. The reaction mixture was stirred at room temperature under nitrogen overnight and concentrated under reduced pressure. The residue was purified with reverse phase chromatography eluting with 25%-50% methanol in water (0.1% MLOH) to give Compound 7C: LC-MS (ESI) m/z: 445 [M+H]+., 1214196-85-6

1214196-85-6 1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid 22507584, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; (270 pag.)WO2019/104011; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1238951-37-5,(2S,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of 2,4,6-trichloro-8-fluoro-7-(2-fluoro-6- methoxyphenyl)quinazoline (2 g, 5.34 mmol) in DCM (2OmL) at 0 ¡ãC, TEA (1.08 g, 10.7 mmol) was added and then (2R,5S)-tert-butyl 2,5-dimethylpiperazine-1- carboxylatet (1.15 g, 5.34 mmol) in DCM (20 mL) was added slowly. The mixture was stirred at RT overnight. The mixture was partitioned between water (5OmL) and DCM(lOOmL X 2).The organic layer was concentrated in vacuo and the residue was purified by flash column chromatography on silica gel to afford the desired product 3-2 (2.1 g). ESI-MS m/z: 553 [M+H]., 1238951-37-5

The synthetic route of 1238951-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARAXES PHARMA LLC; LI, Liansheng; FENG, Jun; WU, Tao; LIU, Yuan; WANG, Yi; REN, Pingda; LIU, Yi; (110 pag.)WO2018/218069; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

A solution of 2-methyl-5-fluoroquinazoline (100 mg; 0.616 MMOL ; 1EQ), 2- methylpiperazine (310 mg; 3.083 MMOL ; 5eq) and triethylamine (0.17 mL; 1.23 MMOL ; 2 eq) in dry DMF (2.5 mL) was heated at 120C for 5 h. The yellow solution was cooled and the solvent was evaporated in vacuo. The crude material was purified on SPE cartridge (Si; 2 g) eluting with a gradient from 100% dichloromethane to 85% DICHLOROMETHANE : 1% NH40H 2M sol in methanol to afford the title compound (D15) (85 mg; yield 57%). MS; (ES) m/z: 243.3 [MH+]. CAHSN4 requires 242.32. ‘H NMR (300MHZ, CDCI3) 8 : 9.48 (s, 1H), 7.81 (t, 1H), 7.48 (d, 1H), 7.10 (d, 1H), 3.03 (m, 1H), 3.23-2. 98-2.76-2. 41 (m, 6H), 2.72 (s, 3H) 1.01 (d, 3H).

109-07-9, The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/46124; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1001180-21-7,(R)-tert-Butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 13aTert-butyl 4- [(5R,7R)-7-hydroxy-5-methyl-6,7-dihydrocyclopentaldl pyrimidin-4- yllpiperazine-1-carboxylate mM Potassium dihydrogen phosphate pH 7.2), 78 g 2-Propanol and 50 mg NAD (75iimol) was formed under vigorous stirring. The reduction started by the addition of 500 mg KRED-X1.1- P1 FO 1. The reaction mixture is sparged with nitrogen and heated to 40C for 22 hours. After reaction completion 174 g isopropylacetate are added, agitated, phases were split and the5 aqueous phase removed. The aqueous phase was extracted again with 174 g isopropylacetate. The aqueous phase was removed and the organic phases were combined and concentrated at 35C in vacuo to a final volume of 115 mL. At the same temperature 212 g Heptane are added within 1 hour, the suspension is aged for 1 hour and cooled to 10C within 6 hours. The suspension is filtered and washed with 68g heptane. After drying of the filter cake for 4 hours at10 50C and 41.1 g (82% yield, purity 100% area) white crystals are obtained.

1001180-21-7, 1001180-21-7 (R)-tert-Butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate 59580350, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; IDING, Hans; REENTS, Reinhard; SCALONE, Michelangelo; GOSSELIN, Francis; WO2015/73739; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-70-5,(S)-tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A 100 niL round-bottom flask was charged with 2-fluoro-4-(morpholin-4- yl)benzaldehyde (0.800 g, 3.82 mmol, 1.00 equiv), tert-butyl (2S)-2-methylpiperazine-l- carboxylate (0.840 g, 4.20 mmol, 1.10 equiv), 1,2-dichloroethane (20 mL). The mixture was stirred for 30 min at room temperature. Sodium triacetoxyborohydride (2.40 g, 11.3 mmol, 3.00 equiv) was added. The resulting solution was stirred overnight at room temperature, diluted with ]0 (10 mL), extracted with dichloromethane (3 x 10 mL). The organic layers were combined and washed with brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was chromatographed on a silica gel column with ethyl acetate/petroleum ether (25/75) to provide 1.40 g (93% yield) of tert-butyl (2S)-4- [[2-fluoro-4-(morpholin-4-yl)phenyl]methyl]-2-methylpiperazine-l-carboxylate as a white solid. LCMS (ESI, m/z): 394 [M+H]+.

169447-70-5, As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.

Reference£º
Patent; ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Chery, A.; JONES, Todd, K.; NIPHAKIS, Micah, J.; CHANG, Jae, Won; LUM, Kenneth, M.; CRAVATT, Benjamin, F.; WO2013/103973; (2013); A1;,
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1030377-21-9, (S)-1-Boc-2-(Hydroxymethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: (S)-tert-butyl 4-(5-(1-(2-cyanophenyl)piperidin-4-ylamino)-2,4-dimethylbenzoyl)-2-(hydroxymethyl)piperazine-1-carboxylate The procedure for (S)-tert-butyl 4-(5-(1-(2-cyanophenyl)piperidin-4-ylamino)-2,4-dimethylbenzoyl)-2-(hydroxymethyl)piperazine-1-carboxylate was HATU generic method A. ESI-MS (EI+, m/z): 548.0 [M+H]+. 1H NMR (500 MHz, CD3OD-d4) delta: 7.55-7.62 (m, 2H), 7.20 (d, J=8.5 Hz, 1H), 7.06-7.09 (t, J=7.5 Hz, 1H), 6.96 (s, 1H), 6.49-6.58 (m, 2H), 3.47-4.32 (m, 9H), 2.97-3.21 (m, 5H), 2.10-2.22 (m, 8H), 1.77 (d, J=10.0 Hz, 2H), 1.48 (s, 9H)., 1030377-21-9

As the paragraph descriping shows that 1030377-21-9 is playing an increasingly important role.

Reference£º
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics