Heterocyclic Building Blocks-piperazine

1228780-72-0, 1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Into a 250-mL round-bottom flask, was placed a solution of Example 1-i, i.e, 1- [[2-(4-chlorophenyl)-4,4-dimethylcyclohex- i-en-i -ylj methyljpiperazine (15.09 g, 47.32 mmol, 1.00 equiv) in DMA (150 mL), DIEA (12.9 g, 99.81 mmol, 2.00 equiv), methyl 2-bromo-4-fluorobenzoate (11.6 g, 49.78 mmol, 1.00 equiv). The resulting solution was stirred for 12 h at 100 degree. The reaction mixture was cooled to room temperature. The reaction was then quenched by the addition of 50 mL of water. The resulting solution was extracted with 3xiOO mL of ethyl acetate and the organic layers combined. The resulting mixture was washed with 3xiOO mL of brine. The mixture was dried over anhydrous sodium sulfate, then filtered and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (0:1-1:5). This resulted in 7 g (crude) of methyl 2-bromo-4-(4-[[2- (4-chlorophenyl)-4,4-dimethylcyclohex- i-en-i -ylj methyljpiperazin- 1 -yl)benzoate as yellow oil. LC-MS: (ES, m/z): M+i=533, 531., 1228780-72-0

As the paragraph descriping shows that 1228780-72-0 is playing an increasingly important role.

Reference£º
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; LOU, Yan; (108 pag.)WO2019/40550; (2019); A1;,
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170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 32 (500 mg, 1.66 mmol) in s-butanol (5 mL) were added tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (498 mg, 1.82 mmol) and TFA (760 mg, 6.64 mmol) at room temperature. The resulting reaction mixture was stirred at 100 C for 12 h. It was then diluted with 10% MeOH in CH2Cl2 (100 mL) and washed with saturated sodium bicarbonate solution. The organic layer was dried over Na2SO4 and concentrated in vacuo. Column chromatography (3% MeOH in CHCl3) to afford 33 (400 mg, 44%) as a pale yellow solid.1H NMR (400 MHz, DMSO-d6) delta ppm 9.56 (s, 1H), 9.40 (s, 1H), 8.45 (d, J = 5.2 Hz, 1H), 7.58 (d, J = 9.2 Hz, 2H), 7.44 (s, 1H), 7.24 (d, J = 5.2, Hz, 1H), 6.95 – 6.88 (m, 3H), 5.45 (s, 1H), 4.58 (d, J = 3.2 Hz, 2H), 3.48 – 3.45 (m, 4H), 3.04 – 3.02 (m, 4H), 2.37 – 2.33 (m, 1H), 1.42 (s, 9H), 1.06 – 1.04 (m, 4H).LC-MS (MeCN, pH 3): [M+H]+ = 542, rt = 1.62 mins, purity = > 95%.

170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Large, Jonathan M.; Birchall, Kristian; Bouloc, Nathalie S.; Merritt, Andy T.; Smiljanic-Hurley, Ela; Tsagris, Denise J.; Wheldon, Mary C.; Ansell, Keith H.; Coombs, Peter J.; Kettleborough, Catherine A.; Whalley, David; Stewart, Lindsay B.; Bowyer, Paul W.; Baker, David A.; Osborne, Simon A.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 19; (2019);,
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21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-(chloromethyl)-l-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl} pyrrolidin-2-one a56 (0.26 g, 0.74 mmol, 1 eq), potassium carbonate (0.4 g, 2.96 mmol, 4 eq), 1-cyclopentylpiperazine a58 (0.34 g, 2.22 mmol, 3 eq) and a catalytic amount of sodium iodide in acetonitrile (20 ml) is stirred at reflux for 4 days. Potassium carbonate is filtered and the mixture is concentrated under vacuum, then the residue is dissolved in ethyl acetate, and washed twice with a saturated solution of aqueous sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate and concentrated under vacuum to give 0.17 g of crude material. This product is purified by chromatography over silicagel (dicloromethane/methanol/ammonia 94/6/0.6) to afford 0.052 g of 4-[(4-cyclopentylpiperazin-l-yl)methyl]-l-{4-[3-(2- methylpyrrolidin-l-yl)propoxy]phenyl} pyrrolidin-2-one 44 as an orange oil. Yield : 15 %. LC-MS (MH+): 469

21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UCB PHARMA, S.A.; WO2007/48595; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196811-66-2,tert-Butyl 4-carbamothioylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

a) 4-(Dimethylaminomethylene-thiocarbamoyl)-piperazine-l-carboxylic acid tert-butyl ester; A mixture of 122 mmol N,N-dirnethylformamide dimethyl acetal and 6.11 mmol 4- thiocarbamoyl-piperazine-1-carboxylic acid tert-butyl ester (prepared from tert-butyl 1- piperazinecarboxylate, lj’-thiocarbonyldiimidazole and ammonia according to the procedure of J. Med. Chem. 1998, 41, 5037-5054) was heated at 110 0C for 3 h. The reaction mixture was then concentrated in vacuo and the residue was resuspended in ethyl acetate/ tetrahydrofuran ( 1:1) and washed with brine. The organic phase was dried over sodium sulphate and concentrated in vacuo to afford the title compound as a light yellow crystalline solid (yield 95%). MS (m/e): 301.4 (M+H+, 100%)., 196811-66-2

The synthetic route of 196811-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2006/72436; (2006); A1;,
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4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 46-4 (8E,12E,14E)-6-(1-ethoxyethoxy)-6,10,12,16,20-pentamethyl-7-(4-nitrophenoxy)carboxy-3,16,21-tris(triethylsiloxy)-18,19-epoxytricosa-8,12,14-trien-11-olide (1.27 g, 1.16 mmol) obtained in the fourth step of Example 46 in tetrahydrofuran (25 mL) were added triethylamine (470 mg, 4.64 mmol) and isopropylpiperazine (298 mg, 2.32 mmol) at room temperature, and the reaction mixture was stirred at the same temperature for 1.5 hours. The reaction mixture was diluted with ethyl acetate and then washed with a saturated aqueous solution of sodium bicarbonate and brine. The organic layer was dried over anhydrous magnesium sulfate, filtrated and concentrated. The resulting residue was purified by silica gel column chromatography (Kanto silica gel 60N, 40 to 100 mum; hexane:ethyl acetate=1:1 to ethyl acetate to ethyl acetate_methanol=97:3) to give the title compound (1.12 g, 89percent) as a colorless oil.1H-NMR Spectrum (CD3OD,400MHz) delta(ppm): 0.58-0.70 (27H,m), 0.80-1.72(53H,m),1.76(3H,s),1.88-1.98(1H,m),2.33-2.64(8H,m), 2.64-2.76(1H,m),2.80-2.90(1H,m),3.38-3.66(6H,m),3.68-3.78 (1H,m),3.85-3.98(1H,m),4.88-4.99(2H,m),5.05(0.4H,q,J=5.2Hz), 5.13(0.6H,q,J=5.2Hz),5.57(1H,dd,J=10.0,15.2Hz),5.72-5.80 (1H,m),5.82(1H,d,J=14.8Hz),6.13(1H,d,J=10.8Hz),6.50(1H,dd, J=10.8,15.2Hz)., 4318-42-7

As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference£º
Patent; MERCIAN CORPORATION; Eisai Co., Ltd.; EP1508570; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.

A) 3-Oxo-piperazine-l-carboxylic acid tert-butyl ester: Piperazinone (20 g, 0.20 mol) was dissolved in 120 mL iV,iV-dimethylformamide. Di-tert- butyldicarbonate (47.9g, 0.20 mmol) was added in portions. After 5 minutes the product precipitated. The solids formed were filtered and dried and used further in step B.1HNMR (400 MHz, chloroform-das solvent and internal reference) delta(ppm) 1.46 (s, 9H), 3.37 (m, 2H), 3.62 (t, 2H, J = 5.1 Hz), 4.08 (s, 2H)., 5625-67-2

The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2007/8144; (2007); A1;,
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67455-41-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

EXAMPLE 1 4-[4-(3,3,3-Triphenylpropanoylamino)phenyl]piperazine To an ice cooled and stirred solution of 4-(4-aminophenyl)piperazine (4.29 g, 24.2 mmol) in dichloromethane (100 mL) containing Et3 N (7.42 mL, 52.5 mmol) was added trifluoroacetic anhydride (7.52 mL, 53.2 mmol) in dichloromethane (25 mL) over a 5 minute period. The mixture was allowed to warm to room temperature and stirred two days, then stirred with ice water. The pink solid that separated was isolated by filtration, washed with dichloromethane, aqueous sodium bicarbonate, and water, and dried to obtain 1-(4-(trifluoroacetamido)phenyl)-4-trifluoroacetylpiperazine (4.09 g, 46%, mp 193-194 C.).

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference£º
Patent; Demers; James P.; Johnson; Sigmond; Weidner-Wells; Michele Ann; Kanojia; Ramesh M.; Fraga; Stephanie A.; Klaubert; Dieter; US5874436; (1999); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a mixture of 61 (131 mg, 0.303 mmol, 1.0 equiv), Pd2dba3 (27 mg, 0.0303 mmol, 0.10 equiv), 2-Dicyclohexylphosphino-2′, 4′, 6′-tri-1-propyl-1,1′-biphenyl (17 mg, 0.036 mmol, 0.12 equiv), and NaOtBu (58 mg, 0.606 mmol, 2.0 equiv) was added toluene (5 mL) which was first purged with argon. After 1 min of vigorous stirring, tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (63 muL, 0.606 mmol, 2.0 equiv) was added and the mixture was heated to 90¡ã C. After starting material was consumed as indicated by TLC, the solvent was removed in vacuo. The resulting residue was taken up in EtOAc (50 mL) and washed with water and brine. After drying with MgSO4 and concentration in vacuo, the crude mixture was purified by silica gel chromatography (10percent MeOH:CH2Cl2) to afford amine 10v [MS (MH+) 625; Calculated 624.3 for C36H44N6O4] and amine 15 [MS (MH+) 398; Calculated 397.2 for C25H23N3O2]., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; Nunes, Joseph J.; Martin, Matthew W.; White, Ryan; McGowan, David; Bemis, Jean E.; Kayser, Frank; Fu, Jiasheng; Liu, Jinqian; Jiao, Xian Yun; US2006/46977; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7365-45-9,2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid,as a common compound, the synthetic route is as follows.

General procedure: In a typical procedure, 10 mL zinc acetate solution (200 mM) was mixed with 20 mL HEPES solution (200 mM pH 7.4). A microwave and ultrasonic wave combined reactor (XH-300A, Beijing Xianghu Technology Co., Ltd.) provided continuous and homogeneous ultrasonic wave and microwave irradiation for the mixed solutions. Firstly, the mixture was continuously sonicated for 5 min by ultrasonic processor with a power of 1000 W. Then the mixed solution was heated to 110 C within 3 min and kept at this temperature for 17 min under microwave heating combined with discontinuous ultrasonic irradiation (1 s sonication and 2 s interruption) with a power of 500 W. After cooling down to room temperature naturally, the product was collected by centrifugation and washed with deionized water and absolute alcohol for 5 times, then dried in a desiccator for further characterization (S1). Other ZnO samples (S2-S15) were also prepared under identical conditions by varying Zn/HEPES moral ratio, pH value of HEPES solution and Zn precursor. The detailed procedure is same as described above and all the experimental parameters are listed in Table 1., 7365-45-9

The synthetic route of 7365-45-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Qin; Li, Hui; Wang, Runming; Li, Guangfang; Yang, Hao; Chen, Rong; Journal of Alloys and Compounds; vol. 567; (2013); p. 1 – 9;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.,74879-18-8

In a sealed tube, 2-(2,8-dimethylimidazo[l,2-b]pyridazin-6-yl)-7-fluoro-9-methyl- pyrido[l,2-a]pyrimidin-4-one (Intermediate 4; 50 mg, 0.155 mmol) and (S)-2-methylpiperazine (62 mg, 0.619 mmol, 4.0 eq.) were stirred in DMSO (2 mL) at 125C overnight. The solvent was removed under high vacuum. The residue was taken up in CH2CI2and washed with an aqueous saturated solution of NaHC03. The organic layer was separated and dried over Na2S04and concentrated in vacuo. The crude was purified by column chromatography (S1O2,CH2Cl2/MeOH=95/5 to 90/10) to afford the title product (45 mg, 72%) as a light yellow solid. MS m/z 404.3 [M+H+].

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; MCCARTHY, Kathleen Dorothy; METZGER, Friedrich; RATNI, Hasane; (76 pag.)WO2017/81111; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics