Heterocyclic Building Blocks-piperazine

75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

75336-86-6, 15g of compound 6,150 ml of dichloromethane was added to the reaction flask.Cool down to 0 C,Dissolve in 100 mL of dichloromethane16.5g of Boc-anhydride was added to the reaction flask and stirred for 1 hour.Point plate monitoring, after the reaction, filtering,The filtrate was spun dry, added with 100 mL of water, stirred, filtered, and the filtrate was added with saturated 10 g of potassium carbonate and stirred with methyl tert-butyl ether ether.Extract, dry over sodium sulfate, spin dry,Adding petroleum ether, stirring and crystallizing under cooling to obtain 25 g of compound 7;

75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Tonghua Normal College; Geng Xiaoyu; Xue Mingxing; Zang Hao; Liu Xuekun; Sun Renshuang; Xue Changsong; Zhang Haifeng; (13 pag.)CN109438423; (2019); A;,
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2815-34-1, trans-2,5-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

An NMP solution of fluoro-4-nitrobenzene and (+/-)-trans-2,5-dimethylpiperazine was stirred at an oil bath temperature of 120C for 3 hours to obtain (+/-)-trans-2,5-dimethyl-1-(4-nitrophenyl)piperazine, which was further treated in a similar manner to Example 4 to obtain an objective compound., 2815-34-1

As the paragraph descriping shows that 2815-34-1 is playing an increasingly important role.

Reference£º
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1396487; (2004); A1;,
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132710-90-8, 1-Boc-4-(3-hydroxypropyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Triphenylphosphine (1.86 g, 7.08 mmol) was charged to a round bottom flask under nitrogen atmosphere and dissolved in dry tetrahydrofuran (40 mL). The solution was cooled to -40 C via an acetonitrile/dry ice bath. After 30 minutes of cooling, DIAD (1.14 g, 7.08 mmol, 1.11 mL) was added dropwise over the course of about 30 minutes. The solution became a slurry of white precipitate and was allowed to stir for 10 minutes at -40 C before 27B (500 mg, 1.42 mmol) and tert-butyl 4-(3- hydroxypropyl)piperazine-l-carboxylate (1.04 g, 4.25 mmol) were added. The reaction continued to stir for 1 hour before the the reaction was pulled from the cooling bath and allowed to warm to room temperature and stir for 3 days. The boc- protected product was precipitated from the reaction with water (150 mL) and isolated by vacuum filtration. The solid was resuspended in TFA (7.45 g, 65.34 mmol, 5 mL) and dichlormethane (5 mL) and stirred overnight. The product was precipitated with MTBE (100 mL) and isolated by filtration to yield 211 mg of Compound 27A (42%) as an off-white solid (2.23m, M+H = 480), 132710-90-8

132710-90-8 1-Boc-4-(3-hydroxypropyl)piperazine 16217800, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TARVEDA THERAPEUTICS, INC.; CIPRIANI, Tyler; MOREAU, Benoit; BILODEAU, Mark T.; QUINN, James M.; WOOSTER, Richard; CIRELLO, Amanda L.; PERINO, Samantha; WHALEN, Kerry; KADIYALA, Sudhakar; WHITE, Brian H.; (172 pag.)WO2019/118830; (2019); A1;,
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5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5317-33-9, Step b:4.775 g (30 mmol) of 3-(4-methylpiperazin-1-yl)propan-1-ol are dissolved in 20 ml of dioxane, 20 ml of 4 N HCl in dioxane are added, and the mixture is evaporated to dryness. This residue is triturated in MTBE, filtered off with suction and dried. This solid (6.7 g) is suspended in 50 ml of acetonitrile, and 6 g (30 mmol) of trichloromethy choroformate, dissolved in 10 ml of acetonitrile, are added at 0. The mixture is stirred at room temperature for a further 48 h. The reaction mixture is filtered off with suction, washed with acetonitrile and dried, giving a white solid, m.p. 248-250 (decomposition).

The synthetic route of 5317-33-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; US2011/269756; (2011); A1;,
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109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

109384-27-2, 6-Chloro-3-[(S)-1-(6-fluoro-1-methyl-1 H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine(Intermediate E, SO.Omg, 0.152 mmol), KF (26.4mg, 0.455 mmol) and 1-methylperazine-2- one hydrochloride (51.9mg, 0.455 mmol) were suspended in NMP (1 ml_). The RM was stirred at 180 0C for 5 h. The mixture was diluted with EtOAc and washed with NaHCO3 10% (2 x) and water (4 x). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography and afforded the title compound as a light brown foam (tR 3.66 min (conditions 5), (tR 12.22 min (conditions 2), MH+ = 408.2, 1H-NMR in DMSO-d6: 7.92 (s, 1 H); 7.83 (d, 1 H); 7.49 (m, 3H); 7.11 (d, 1 H); 4.78 (m, 1H); 4.00 (d, 1H); 3.95 (S1 3H); 3.86 (d, 1 H); 3.67 (m, 2H); 3.30 (m, 2H); 2.80 (s, 3H); 1.71 (d, 3H)).

109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; FURET, Pascal; McCARTHY, Clive; SCHOEPFER, Joseph; STUTZ, Stefan; WO2011/15652; (2011); A1;,
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278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 32(R)-4-(2-ChIoro-acetyl)-3-hydroxymethyl-piperazine-l-carboxylic acid tert-butyl esterTo a solution of (i?)-3-hydroxymethyl-piperazine-l-carboxylic acid tert-butyl ester (795 mg, 3.68 mmol) in DCM (20 mL) was added triethylamine (1.53 mL, 11.04 mmol). The resulting mixture was cooled to 0 0C before the dropwise addition of chloroacetyl chloride (325 muL, 4.05 mmol). The mixture was warmed to RT and stirred for 5 h. The reaction mixture was partitioned between a saturated aqueous solution OfNaHCO3 and DCM and the aqueous layer extracted with further DCM. The combined organic fractions were dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by column chromatography to give the title compound as a colourless oil which was a mixture of rotamers (710 mg, 66%).1H NMR (400 MHz, CDCl3): delta 1.48 (s, 9H), 2.80-2.92 (m, IH), 2.95-3.10 (m, 2H), 3.34-3.44 (m, 1AH), 3.60-3.74 (m, 21Z2H), 3.96-4.16 (m, 31AH), 4.22-4.30 (m, ‘/2H)5 4.32-4.40 (m, Y2H) and 4.63 (bs, VzYi)., 278788-66-2

The synthetic route of 278788-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F.HOFFMANN-LA ROCHE AG; WO2009/53716; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.509073-62-5,tert-Butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,509073-62-5

tert-Bupsilontyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate (12.9 g, 38.5 mmol) was dissolved in methanol (150 ml) and transferred into a 500-ml PARR flask. The flask was flushed with nitrogen, 10% Pd/C (0.38 g, 0.357 mmol) was added, flushed again with nitrogen, then hydrogen, then hydrogenate for 17 hours while shaking. (H2 pressure 50 psi). The reaction mixture was filtered through CELITE, the CELITE washed with MeOH and the collected liquids concentrated in vacuum. 11.67 g of tert- butyl 4-(4-amino-benzoyl)piperazine-1-carboxylate were isolated as a beige solid. MS (ESI) m/z 306 (M+H). 1H NMR (CDCl3) delta ppm 7.25 (d, 2 H, J= 7.7), 6.64 (d, 2 H, J= 7.7), 3.89 (bs, 2 H), 3.58 (bs, 4 H), 4.43 (bs, 4H), 1.46 (s, 9H).

As the paragraph descriping shows that 509073-62-5 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; PURANDARE, Ashok, Vinayak; BATT, Douglas, G.; LIU, Qingjie; JOHNSON, Walter, L.; MASTALERZ, Harold; ZHANG, Guifen; ZIMMERMANN, Kurt; WO2010/80474; (2010); A1;,
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148546-99-0, 3-(4-Methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of intermediate 6 (prepared according to A2. c-1) (0.0005 mol) and 3-(4-methyl-1-piperazinyl)-benzenamine (0.0005 mol) in 2-methoxyethanol (4 ml) was stirred for 1 hour at 100C and the solvent was evaporated. The residue was stirred in DIPE and then the DIPE was decanted off. The residue was dissolved in CH3OH, warmed and acidified with HCl/2-propanol. The resulting precipitate was filtered off and dried. Yield: 0.123 g of final compound 36 (51.5 %; M. p.: > 250C).

148546-99-0, 148546-99-0 3-(4-Methylpiperazin-1-yl)aniline 11564613, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/12304; (2005); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3022-15-9,Piperazine-2-carboxylic acid dihydrochloride,as a common compound, the synthetic route is as follows.,3022-15-9

Piperazine-2-carboxylic acid dihydrochloride (10.0 g, 49.2 mmol) was dissolved in H2O (125 mL) and 1,4-dioxane (200 mL), and the solution was brought to pH 11 with 50% NaOH in H2O. Benzyl chloroformate (14 mL, 98 mmol) was added while maintaining the pH at 11 with 50% NaOH in H2O. After 1 h, an additional portion of benzyl chloroformate (2 mL, 14 mmol) was added. After 30 min, the solution was extracted with Et2O (3 x 100 mL). The aqueous layer was brought to pH 2 with concentrated HCl and extracted with EtOAc (3 x 200 mL). The combined EtOAc extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure to give 18.9 g (96%) of the desired product as a thick oil. The material was used without further purification. LC-MS: RT = 9.250 min; [M+H]+ = 421.1.

As the paragraph descriping shows that 3022-15-9 is playing an increasingly important role.

Reference£º
Patent; CRITICAL THERAPEUTICS, INC.; WO2007/146066; (2007); A2;,
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Piperazines – an overview | ScienceDirect Topics

50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50606-32-1, 56.2. 4-[2-Benzyloxycarbonylamino-2-(dimethoxy-phosphoryl)-acetyl]-piperazine-l- carboxylic acid butyl ester: To a solution of intermediate 56.1 (1.5 g) in DCM (5 mL) was added DIPEA (3.4 mL) and HATU (2.2 g). After stirring at RT for 10 min, intermediate 2.2 (1.1 g) was added. The reaction mixture was stirred overnight at RT and H2O was added. The phases were separated, the org. phase was washed with sat NaCl solution, dried (MgStheta4) and evaporated off. The crude was purified by CC (Hept/EA 2/8) to afford the desired compound (1.1 g). LC-MS (A): tR = 0.95 min; [M+H]+: 486.01.

The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/69100; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics