Heterocyclic Building Blocks-piperazine

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-07-7, A solution of 5 – ((2,4-dioxo-3,4-dihydroquinazolin-1 (211) -yl) methyl) -2-fluorobenzoic acid, EDC (123 mg, 0.64 mmol ), H0Bt (86 mg, 0.64 mmol) and DIEA (125 mg, 0.96 mmol)In a flask, about 3 mL of anhydrous DMF was added, stirred at room temperature for 15 min, followed by the dropwise addition of 1-methyl-niazin-2-one (225 mg,1.97 mmol) in DMF was added to the reaction solution, stirred overnight at r.t. The reaction was poured into 100 mL of water and treated with 100 mL of DCMThe organic layer was washed successively with water (100 mL), saturated NaCl (100 mL) and water (100 mL), concentrated under reduced pressure and subjected to column chromatography to give the title compound.

59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Zhou Jie; Ji Ming; Yao Haiping; Zhou Qin; (57 pag.)CN107098886; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-cyclopentylpiperazine (1.27 mL, 10 mmole) was added to 10 mL DMF containing 0.3 g of 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one (TC-XCl-1)(1 mmol). The mixture was heated while stirring at 150 C. for 4 hours and added pyridine (0.5 mL, 6.21 mmole) as the catalyst. Pour the mixture into ice water after the reaction is completed and filter to get the crude product. Recrystallized from hot EtOH to get compound SJ-14 (0.16 g). [0141] Mol. Wt.: 417.9306 (C25H24ClN3O); Rf: 0.46 (Dichloromethane:Hexane:Methanol=2:1:0.5); Yield: 37.3%; Mp.: 183-184 C. (EtOH); IR (KBr) cm-1: 1716 (C?O); HRMS (ESI) m/z calcd for C25H24ClN3O+[M]+: 417.1608. Found: [M+H]+=418.1689 (error1H-NMR (300 MHz, CDCl3) delta (ppm): 1.19 (t, 3H, J=7.2 Hz, -CH3), 2.57 (q, 2H, J=7.4 Hz, N-CH2-), 3.03 (br, 4H, -CH2-), 3.46 (br, 4H, -CH2-), 7.43-7.48 (m, 2H, Ar-H8,10), 7.57-7.63 (m, 3H, Ar-H2,3,4), 7.85 (d, J=8.7 Hz, 1H, Ar-H7), 8.69 (d, J=8.1 Hz, 1H, Ar-H1); 13C-NMR (300 MHz, CDCl3) delta (ppm): 24.32, 30.67, 50.12, 52.36, 67.87, 120.99, 124.28, 124.61, 125.05, 127.31, 128.50, 130.40, 131.56, 134.36, 135.19, 135.32, 136.58, 141.94, 149.85, 157.48, 194.40 (CO).

21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; National Defense Medical Center; Huang, Hsu-Shan; Chen, Tsung-Chih; Chen, Shiang-Jiun; Chen, Chun-Liang; Lee, Chia-Chung; US2015/197492; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

A solution of 4S-(3,5-bis-trifluoromethyl-benzloxy)-3R-2-tolyl-piperidine (Example 1) 100 mg (0.220 mmol) was dissolved in CH2Cl2 under nitrogen. 4-methyl-piperazine carbonyl chloride (purchased from Aldrich Chemical Company or Aztec Chemical Company) 46 mg (0.231 mmol), and diisopropylethylamine 0.4 mL (2.20 mmol) were added, and the reaction mixture was stirred at room temperature under nitrogen. The reaction mixture was diluted with EtOAc (100 ml) and washed with water three times. The organic layer was dried with MgSO4. Evaporation of most of the solvent gave 120 mg of oil. This oil was dissolved in about 10 mL of ether and a solution of HCl gas in ether was added drop by drop. The HCl salt was dried under nitrogen on high vacuum for one hour to give 125 mg of [4S-(3,5-bis-trifluoromethyl-benzyloxy)-3R-2-tolyl-piperidine-1-yl]-(4-methyl-piperazine-1-yl)-methanone. Fab/MS m/e 544 (M+1)

39539-66-7, The synthetic route of 39539-66-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2005/256164; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

934-98-5, The mixture of 4-(4-chloro-1,6-naphthyridin-2-yl)-N,N-diethylbenzamide (150 mg, 0.44 mmol), 2-(4-methylpiperazin-1-yl)ethanamine (94 mg, 0.66 mmol) and K2C03 (121 mg, 0.88 mmol) in DMF (1 mL) was heated at 100¡ãC for l8hrs. The reaction mixture was poured into water (20 mL), extracted with EA (10 mL x 3). The combined organic layers were washed by water (10 mL x 3) and brine (10 mL), dried over Na2SO4. The drying agent was filtered off and the filtrate was concentrated under the reduced pressure to give the residue which was purified prep-TLC to afford N,N-diethyl-4-(4- (2-(4-methylpiperazin- 1 -yl)ethylamino)- 1 ,6-naphthyridin-2-yl)benzamide. (8 mg, 4percent). HPLC/UV purity:100percent; LC-MS (ESI): 447.2 (M + 1). ?H NMR (METHANOL-d4) oe: 9.76 (s, 1H), 8.90 (d, J = 6.2 Hz, 1H), 8.08 – 8.17 (d, J = 8.3 Hz, 2H), 7.93 (d, J = 6.2 Hz, 1H), 7.64 – 7.74 (d, J = 8.3 Hz, 2H), 7.30 (s, 1H),3.95 (t, J = 6.2 Hz, 2H), 3.63 (q, J = 6.8 Hz, 2H), 3.32 – 3.47 (m, 10H), 3.06 (t, J = 6.2 Hz, 2H), 2.92 (s,3H), 1.32 (t, J = 7.0 Hz, 3H), 1.18 (t, J = 7.0 Hz, 3H).

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; PINKERTON, Anthony B.; ARDECKY, Robert J.; ZOU, Jiwen; (256 pag.)WO2018/204176; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: A solution of 5-bromo-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione (1.0 mmol) in methanol (5 ml) was treated with the substituted piperazines or homopiperazines (2 mmol) and stirred for 24 h at ambient temperature. Compounds 8a, 8b, 8c, 8f, and 8g precipitated. The precipitates were collected by filtration and dried in vacuo to afford the solids. In the case of compounds 8d, 8e, 8h, 8i and 9a-d, the solvents of reactions were removed and the residues purified by flash column chromatography and dried to yield the pure solids.

59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Jun; Medina, Carlos; Radomski, Marek W.; Gilmer, John F.; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4985 – 4999;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of cis-2,6-dimethyl-piperazine (600 mg) and triethylamine (0.80 mL) in dichloromethane (10 mL) at 0¡ã C. was added dropwise methanesulfonyl chloride (0.43 mL). The reaction mixture was stirred at room temperature for 16 h and then quenched with water (10 mL) and extracted into dichloromethane (2*20 mL). The combined organic layers were washed with saturated aqueous brine solution (2*20 mL), dried (MgSO4) and concentrated to afford (3S,5R)-1-methanesulfonyl-3,5-dimethyl-piperazine as a white solid (817 mg, 81percent). Reaction between 6-(bromomethyl)-2-chloro-4-morpholinothieno[3,2-d]pyrimidine and (3S,5R)-1-methanesulfonyl-3,5-dimethyl-piperazine using potassium carbonate and acetonitrile yielded 2-chloro-6-((2S,6R)-4-methanesulfonyl-2,6-dimethyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine. This compound was subjected to procedure A to yield the desired final compound which was purified using flash chromatography. [M+H]+ 542.24 NMR: (400 MHz, CDCl3): 1.18 (6H, d, J 6.90, Me), 2.48-2.52 (2H, m, CH2), 2.72 (3H, s, SO2Me), 2.78-2.88 (2H, m, CH2), 3.51-3.56 (2H, m, CH2), 3.81-3.88 (4H, m, CH2), 3.96-4.02 (4H, m, CH2), 4.12 (2H, s, CH2), 7.28 (1H, s, Ar), 7.42 (1H, t, J 8.22, Ar), 7.49 (1H, d, J 8.31, Ar), 8.20 (1H, d, J 7.26, Ar) 8.94 (1H, s, Ar) and 10.08 (1H, s, NH).

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Piramed Limited; Genentech, Inc.; US2008/76758; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373608-48-1,tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,373608-48-1

JQ-acid (176.6 mg, 0.441 mmol, 1 eq) was dissolved in DMF (4.4 mL) at room temperature. HATU (176 mg, 0.463 mmol, 1.05 eq) was added, followed by DIPEA (0.23 mL), 1.32 mmol, 3 eq). After 10 minutes, fert-butyl 4-(3-aminopropyl)piperazine-l- SUBSTITUTE SHEET (RULE 26) carboxylate (118 mg, 0.485 mmol, 1.1 eq) was added as a solution in DMF (0.44 mL). After 24 hours, the mixture was diluted with half saturated sodium bicarbonate and extracted twice with DCM and once with EtOAc. The combined organic layer was dried over sodium sulfate, filtered and condensed. Purification by column chromatography (IS CO, 24 g silica column, 0-15% MeOH/DCM, 23 minute gradient) gave a yellow oil (325.5 mg, quant yield) NMR (400 MHz, Chloroform-i ) delta 7.67 (t, J= 5.3 Hz, 1H), 7.41 – 7.28 (m, 4H), 4.58 (dd, J= 7.5, 5.9 Hz, 1H), 3.52 – 3.23 (m, 8H), 2.63 (s, 9H), 2.37 (s, 3H), 1.80 – 1.69 (m, 2H), 1.64 (s, 3H), 1.42 (s, 9H). 13C NMR (100 MHz, cdch) delta 171.41, 164.35, 155.62, 154.45, 150.20, 136.92, 136.64, 132.19, 131.14, 130.98, 130.42, 129.98, 128.80, 80.24, 56.11, 54.32, 52.70, 38.96, 37.85, 28.42, 25.17, 14.43, 13.16, 11.82. LCMS 626.36 (M+H).

The synthetic route of 373608-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; BUCKLEY, Dennis; WINTER, Georg; (418 pag.)WO2017/24317; (2017); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215309-01-6,3-(4-Methylpiperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.

General procedure: A solution of 2-(2-methyl-1H-indol-1-yl)ethanamine (4a) (65 mg, 0.373 mmol) and 4-(piperidin-1-yl)benzoic acid (5) (76 mg, 1 eq.), and dimethylaminopyridine (catalytic, ?5 mg) in dichloromethane (6 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide.hydrochloride (EDCI) (92 mg, 1.3 eq.) at room temperature. The resulting reaction mixture was stirred for 6h. At the conclusion of the reaction (TLC), water (15 mL) was added to quench the reaction. The product was extracted with ethyl acetate (20mL¡Á3). Organics were washed with dilute HCl (10 mL), saturated NaHCO3 solution (10 mL), water (10 mL) and brine solution (10 mL) and dried over Na2SO4 and concentrated. The resulting crude product was subjected to silica gel chromatography eluting with 0-40% ethyl acetate in hexane to furnish 7k (TG7-152) (100mg, 74% yield). 1H NMR (CDCl3): delta 7.52 (d, J=5.6Hz, 1H), 7.49 (d, J=8.8Hz, 2H), 7.30 (d, J=8Hz, 1H), 7.07 (m, 2H), 6.80 (d, J=8.2Hz, 2H), 6.23 (s, 1H), 5.98 (t, J=5.4Hz, 1H), 4.33 (t, J=6Hz, 2H), 3.76 (q, J=6Hz, 2H), 3.25 (t, J=4.8Hz, 4H), 2.37 (s, 3H), 1.6 (m, 6H). LCMS (ESI): >97% purity at lambda 254, MS; m/z, 362 [M+H]+. Anal. Calcd. for C23H27N3O: C, 76.42; H, 7.53; N, 11.62; found; C, 76.48; H, 7.55; N, 11.59.

215309-01-6, As the paragraph descriping shows that 215309-01-6 is playing an increasingly important role.

Reference£º
Article; Ganesh, Thota; Jiang, Jianxiong; Dingledine, Ray; European Journal of Medicinal Chemistry; vol. 82; (2014); p. 521 – 535;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution containing 2.7 g (18.9 mmol) of 1-[2-(methyloxy)ethyl]piperazine and 20 ml. of THF at O0C was added 0.9 g (23 mmol) of a 60% suspension of NaH in mineral oil. The reaction mixture was allowed to stir for 15 min and 3.0 g (18.9 mmol) of 2- chloro-5-nitropyridine was added. The reaction mixture was heated at 6O0C overnight and then quenched by the addition of water and extracted with EtOAc. The combined organic layers were dried over MgSO4 and the solvents were removed under reduced pressure. The residue was subjected to silica gel chromatography to give 2.7 g (54%) of 1-[2-(methyloxy)ethyl]-4-(5-nitro-2-pyridinyl)piperazine as a yellow solid: 1H NMR (400 MHz, DMSO-d6) delta 2.50-2.53 (m, 6H), 3.24 (s, 3 H), 3.46 (t, J = 5.7 Hz, 2 H), 3.71 – 3.78 (m, 4 H), 6.94 (d, J = 9.7 Hz, 2 H), 8.21 (dd, J = 9.6 and 2.8 Hz, 1 H), and 8.95 (d, J = 2.75 Hz, 1 H)., 13484-40-7

As the paragraph descriping shows that 13484-40-7 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/32667; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

Will 97 (0.30g, 0.88mmol),EDC.HCl (0.25 g, 1.32 mmol),HOBt (0.14 g, 1.06 mmol),A mixture of NMM (0.23 ml, 2.11 mmol) and DMF (2.5 ml) was stirred for a while, then 2-(4-methylhexahydropyrazin-1-yl)ethanamine (0.16 ml, 1.06) was added thereto at room temperature. Mmol) and stir overnight.The residue was purified by flash column on silica gel (dichloromethane:methanol=9:1, Rf=0.19) to give 49 (0.08 g, 19.47percent) as a red solid.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY (TW); YEN, YUN (US); LIOU, JING PING (TW); PAN, SHIOW LIN (TW); (56 pag.)TW2018/5267; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics