Heterocyclic Building Blocks-piperazine

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: 8-Fluoro-1,3,4,5-tetrahydro-2- (4-carboxyphenyl) -6H- pyrrolo [4,3,2-EF] [2] benzazepin-6 (100 mg, 0.31 mmol), benzotriazole-N, N, N ‘, N’- tetramethyluronium hexafluorophosphate (HBTU, 129 mg, 0.34 mmol), 1-(cyclopropanecarbonyl)piperazine (52 mg, 0.34 mmol), N, N-diisopropylethylamine (DIPEA, 80 mg, 0.62 mmol) and DMF (3 mL) were added to the reaction flask and stirred at room temperature for 2 h. H20 (5 mL) was added dropwise and the mixture was stirred to precipitate a solid which was filtered to give a gray solid which was recrystallized from methanol (10 mL) to give 8-fluoro-1,3,4,5-tetrahydro-2-(4-(4-(cyclopropanoyl)piperazine-1-carbonyl)phenyl)-6H-pyrrolo[4,3,2-EF][2]benzazepin-6-one (I-1) as a white solid (70 mg, yield 49.3%)., 59878-57-8

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Xunhe Pharmaceutical Technology Co., Ltd.; Zheng Yongyong; Jin Hua; Zhou Feng; Huang Meihua; Meng Xin; (23 pag.)CN107286166; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE 66(S)-tert-RvLty 1 – |”2-(4-acetylpiperazin- 1 -yl)-8-methylquinolin-3 -yl] ethylcarbatnateIntermediate 4 (150 mg, 0.47 mmol), 1-acetylpiperazine (300 nig, 2.34 mmol), DIPEA (0.42 niL, 2.34 mmol) and NMP (3 mL) were combined in a sealed tube and heated to 14O0C for 48 h. After cooling, the reaction mixture was dissolved in a 1 :1 mixture of EtOAc and Et2O (100 mL) and washed with saturated brine (3 x 25 mL). The organic layer was dried (MgSO4) and concentrated in vacuo. Purification by column chromatography on silica, eluting with 0-100% EtOAc in isohexane, afforded the title compound (151 mg, 78%) as a white solid. LCMS (ES+) 413 (M+H)+.

13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

EXAMPLE 30B 7-chloro-5-(2-methoxy-4-(4-methy lpiperazin- l-yl)pheny lamino)py rido[3.4-i/]py ridazin- 4(3H)-one To a solution of EXAMPLE 7K (120 mg, 0.56 mmol) in dioxane (10 mL) was added EXAMPLE 30A (136 mg, 0.6 ] mmol) and NN-diisopropy lethylamine (724 mg, 5.6 mmol) and the mixture was stirred at 120C in a sealed tube for 16 hours. The mixture was cooled to ambient temperature, poured into water (50 mL) and extracted with ethy l acetate (3 * 50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash chromatography on si lica gel (200-300 mesh) eluting with 50/1 dichlomethane/methanol to give the title compound. MS : 401 (M + IT)., 122833-04-9

The synthetic route of 122833-04-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140447-78-5,1-(2-N-Boc-Aminoethyl)piperazine,as a common compound, the synthetic route is as follows.

Compound 10 10- { 3 -[4-(N-Boc-2 -amino)ethylpiperazinyl] propyl } -2- dimethylsulfamidolphenothiazineTo a stirred solution of the phenothiazine chloro derivative 9 (382 mg, 1.0 mmol), potassium carbonate (500 mg,3.62 mmol), and l-(2-N-Boc- aminoethyl)piperazine (229 mg, 1.0 mmol) in methyl ethyl ketone (20 mL) was added sodium iodide (150 mg, 1 mmol). The reaction mixture was stirred for 24 h at reflux under an atmosphere of argon. The reaction mixture was filtered, and the filtrate was concentrated under vacuum. The residue was partitioned between ethyl acetate (20 mL) and brine (10 mL). The organic layer was dried over anhydrous sodium sulphate, filtered, and evaporated. The resulting residue was purified by silica gel chromatography (9:1 CH2Cl2:MeOH) to give 10 (410 mg, 71%) as a foam. MS(ESI): m/z 576 (M+H)., 140447-78-5

140447-78-5 1-(2-N-Boc-Aminoethyl)piperazine 1514401, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; IMMUNE CONTROL, INC.; WO2008/27521; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 4d (3 g,10.83 mmol) was dissolved in 40 ml of dry pyridine and stirred at0 C under inert atmosphere. Cinnamoyl chloride 6a (2.16 g,13 mmol) was dissolved in 20 ml dry DCM and added dropwise toabove stirred solution at 0 C. The reaction mixture was stirred for 3 h. After completion of the reaction, the reaction mixture wasdiluted with 40 ml water and 60 ml ethyl acetate followed by 2 NHCl to make it acidic. The organic layer was separated and againwashed with 2 N HCl followed by saturated bicarbonate solution(2 50 ml) and brine solution. The organic layer was dried overanhydrous sodium sulfate and was evaporated under reducedpressure. The crude product was recrystallized from ethyl acetateand hexane to afford 3.25 g of 7d. Off-white solid; Yield 73.86%; mp186-188 C; IR (KBr pellets, cm1): 3335, 3106, 2976, 2822, 1689,1624, 1521, 1423, 1232, 1173, 971, 827, 763; 1H NMR (400 MHz,CDCl3) d (ppm): 1.41 (9H, s, CH3), 3.12 (4H, t, J 4.15 Hz), 3.71 (4H, t,J 4.12 Hz), 6.75 (1H, d, J 14.8 Hz, PheCH]CHe), 7.09e7.45 (9H,m, AreH), 7.71 (1H, d, J 14.8 Hz, PheCH]CHe), 8.61 (1H, s,CONH); 13C NMR (100 MHz, CDCl3) d (ppm): 28.37, 51.48, 80.43,118.47, 121.14, 121.38, 127.97, 128.83, 129.84, 134.74, 141.93, 154.43,164.33; HR-MS m/z: 407.2267 (M)., 170911-92-9

As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.

Reference£º
Article; Patel, Kavitkumar N.; Telvekar, Vikas N.; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 43 – 56;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2. Preparation of 4-[4-(4-trifluoromethyl-phenyl)-piperazin-l- yl]-butyric acid ethyl ester intermediate.Ethyl-4-bromobutyrate (390 mg, 2.00 mmol) and triethylamine (280 muL; 2.00 mmol) were added to a solution of l-(4-trifluoromethylphenyl)-piperazine (460 mg; 2.00 mmol) in tetrahydrofuran (3 mL). Potassium iodide (332 mg; 2.00 mmol) was added and the resulting suspension is irradiated in a mono-mode microwave oven for 2 hours at 1000C. The suspension is then diluted with dichloromethane (15 mL) and washed twice with water (5 mL). The organic phase is then dried over sodium sulphate and is concentrated under reduced pressure to afford the desired product (660 mg; 1.96 mmol)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; INTERVET INTERNATIONAL B.V.; CHASSAING, Christophe Pierre Alain; MEYER, Thorsten; WO2010/115688; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: In an oven-dried RB flask, 4-chloro-2-phenyl-1H-pyrrolo[3,2-c]pyridine 6b (250 mg, 1.09 mmol) and formaldehyde solution, 37 wt.percent in H2O (0.2 mL, 2.73 mmol) were mixed in glacial acetic acid(5 mL). N-methyl piperazine (273.8 mg, 2.73 mmol, CAS 109-01-3)was added drop wise at 0¡ãC. The resulting mixture was stirred atroom temperature for 12 h. After completion of the reaction, the excess solvent was evaporated to dryness under reduced pressure.The residue was neutralized with 10percent NaHCO3 solution, the solidf ormed was collected by filtration, washed with water and dried.The crude product was purified by silica gel column chromatographyto provide title compound as an off-white solid (326.3 mg,88percent)., 4318-42-7

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jose, Gilish; Suresha Kumara, Tholappanavara H.; Sowmya, Haliwana B.V.; Sriram, Dharmarajan; Guru Row, Tayur N.; Hosamani, Amar A.; More, Sunil S.; Janardhan, Bhavya; Harish; Telkar, Sandeep; Ravikumar, Yalegara Siddappa; European Journal of Medicinal Chemistry; vol. 131; (2017); p. 275 – 288;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5464-12-0, 1-(2-Hydroxyethyl)-4-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5464-12-0, 10.373 g 4-bromo-2-chlorophenol (50 mmol), 14.442 g 2-(4-methylpiperazin-l-yl)ethanol (100 mmol) and 26.229 g PPh3 (100 mmol) were dissolved in 250 mL dry toluene under N2 atmosphere, then 23.027 g DTAD (100 mmol) was added. The mixture was stirred at 50 ¡ãC until no further conversion was observed. The volatiles were evaporated under reduced pressure and the residue was purified via flash chromatography using EtOAc and MeOH as eluents. MS (M+H): 333.0

As the paragraph descriping shows that 5464-12-0 is playing an increasingly important role.

Reference£º
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; BALINT, Balazs; CSEKEI, Marton; SZABO, Zoltan; SZLAVIK, Zoltan; KOTSCHY, Andras; CHANRION, Maia; GENESTE, Olivier; CHEN, I-Jen; DAVIDSON, James Edward Paul; MURRAY, James Brooke; SIPOS, Szabolcs; ONDI, Levente; PROSZENYAK, Agnes; (164 pag.)WO2016/207217; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5625-67-2, Piperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5625-67-2, To a stirred solution of piperazin-2-one CK (3 g, 30 inmol) in CHjCfe (50 mL) under argon atmosphere were added tiiethylamine (8.65 mL. 60 mmol) and di-t-buryi dicarbonate (Boc anhydride, 8.2 mL, 36 niniol) at 0 C. The reaction was wanned to RT and stirred for 16 h. The reaction was diluted with water (100 mL) and the product was extracted with CC (2 x 100 mL). The combined organic layers were dried over anhydrous Na S< and concentrated under reduced pressure to obtain Compound CO (4 g, 20 mmol, 66 %) as a white solid, which was used in the next step without further purification. H NMR (400 MHz, CDCi3): delta 6.90 (br s. IH), 4.08 (s, 2H), 3.63-3.59 (m, 2H), 3.35-3.31 (m, 2H), 1.44 (s. 9H). 5625-67-2 Piperazin-2-one 231360, apiperazines compound, is more and more widely used in various fields. Reference£º
Patent; VIAMET PHARMACEUTICALS, INC.; YATES, Christopher, M.; SHAVER, Sammy, R.; HOEKSTRA, William, J.; (455 pag.)WO2017/117393; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Scheme 3: Synthesis of ie/t-butyl 3-ethoxy-5,6-dihydropyrazine-l(2H)-carboxylate laTo a pre-made solution of triethyloxonium tetrafluoroborate (2.3 g, 0.012 mol) in anhydrous DCM (20 mL) was added 1.2a (2 g, 0.01 mol) at 0 C. After the addition was completed, the ice-bath was removed, and the reaction mixture was allowed to warm to RT and stirred for an additional hour (reaction progress monitored by LCMS). Upon completion of the reaction, a saturated solution of NaHC03 (500 mL) was slowly added to the reaction mixture and it was stirred for 5 min. The organic layer was separated and the aqueous layer was further extracted with DCM (200 mL). The combined organic layers were subsequently washed with brine, dried over MgS04, filtered and further dried in vacuo to obtain the title intermediate la as viscous yellow oil. Yield: 2.03 g (88 %).1H NMR (CDC13): delta: 4.1 (q, J = 7.1, 2H), 3.85 (s, 2H), 3.5 (m, 1H), 3.35 (t, J = 5.1, 2H), 1.45 (s, 9H), 1.3 (t, J = 7.1, 3H)., 76003-29-7

The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EUROSCREEN S.A.; HOVEYDA, Hamid; DUTHEUIL, Guillaume; FRASER, Graeme; ROY, Marie-Odile; EL BOUSMAQUI, Mohamed; BATT, Frederic; WO2013/50424; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics