Heterocyclic Building Blocks-piperazine

On December 31, 1990, Chapman, David R.; Bauer, Ludwig; Waller, Donald P.; Zaneveld, Lourens J. D. published an article.Recommanded Product: 67914-60-7 The title of the article was Synthesis of diastereomeric ketoconazole analogs. And the article contained the following:

Syntheses of trans-isomers of ketoconazole (I) and the corresponding des-acetyl, 1-Me, 1-formyl and 1-methanesulfonyl analogs were investigated. These isomers, along with the corresponding cis-diastereomers were characterized by their carbon-13 NMR spectra. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 67914-60-7

The Article related to ketoconazole diastereomer, imidazolylmethyldioxolanylmethoxyphenylpiperazine, piperazinophenol imidazolylmethyldioxolanylmethanesulfonate reaction, nmr ketoconazole, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 30, 2005, Liu, Yong; Wang, Jingkang; Yin, Qiuxiang published an article.Electric Literature of 86393-32-0 The title of the article was Determination of the space group for ciprofloxacin hydrochloride monohydrate crystals. And the article contained the following:

Ciprofloxacin hydrochloride monohydrate (CPFX) crystals were obtained exptl. The deaquation, melting, decomposing apex temperatures and water content of ciprofloxacin hydrochloride monohydrate crystals were measured by DSC and TG techniques resp. The data of X-ray powder diffraction (XRPD) of these crystals were collected exptl. The indexing results by the software Cerius2 were obtained. The results showed that the crystal of ciprofloxacin hydrochloride monohydrate belonged to monoclinic, and the unit cell parameters a, b, c and β were 12.93×10-10 m, 19.56×10-10 m, 7.07×10-10 m, and 91.10° resp. Based on the indexing results and the extinction principle, the space group for ciprofloxacin hydrochloride monohydrate crystals produced in crystallization experiment was P21/c. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0

The Article related to ciprofloxacin hydrochloride monohydrate x ray powder diffraction space group, unit cell parameter, Crystallography and Liquid Crystals: Crystallographic Methods and Apparatus For Structure Determination and other aspects.Electric Literature of 86393-32-0

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On May 31, 2018, Komami, Narumi; Matsuoka, Keitaro; Yoshino, Tatsuhiko; Matsunaga, Shigeki published an article.Related Products of 67914-60-7 The title of the article was Palladium-Catalyzed Germylation of Aryl Bromides and Aryl Triflates Using Hexamethyldigermane. And the article contained the following:

Pd-catalyzed germylation of aryl bromides and aryl triflates using com. available hexamethyldigermane is described. Optimized reaction conditions afforded various functionalized aryltrimethylgermanes, including drug-like mols., in moderate to good yields, demonstrating the versatility of the presented protocols. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Related Products of 67914-60-7

The Article related to palladium catalyst aryl bromide triflate germylation hexamethyldigermane aryltrimethylgermane preparation, Organometallic and Organometalloidal Compounds: Groups Iva, Va, Via – Ge, Sn, Pb, As, Sb, Bi, Se, Te, Po and other aspects.Related Products of 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On April 14, 1994, Bourzat, Jean Dominique; Commercon, Alain published a patent.Formula: C8H18Cl2N2O2 The title of the patent was Preparation of taxol analogs as antiproliferatives. And the patent contained the following:

Title compounds [I; R1 = (cyclo)alkyl, aryl, heterocyclyl, etc.; R2 = aminohydroxypropionyl group Q; R = Ph, OR6; R3 = aryl; R6 = (cyclo)alk(en)yl, Ph, N-containing heterocyclyl, etc.] were prepared as antiproliferatives (no data). Thus, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α,10β-trihydroxy-9-oxo-7β-triethylsilyloxy-11-taxene was acylated by 3-morpholinopropionic acid and the product acylated by (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid to give, in 2 addnl. steps, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-10β-(3-morpholinopropionyloxy)-9-oxo-11-taxen-13α-yl (2R,3S)-3-tert-butyloxy-2-hydroxy-3-phenylpropionate. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2

The Article related to taxol analog preparation antiproliferative, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Formula: C8H18Cl2N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On January 22, 1998, Shimizu, Hideaki; Abe, Atsuhiro; Yaegashi, Takashi; Sawada, Seigo; Nagata, Hiroshi published a patent.HPLC of Formula: 53788-12-8 The title of the patent was Preparation of taxane derivatives as antitumors and pharmaceuticals containing them. And the patent contained the following:

The title compounds [I; X, Y = CO-A-B; A = bond, -R-CO-, -R-OCO-, -R-NHCO-; R = alkylene, phenylene; B = (un)substituted heterocyclyl, e.g., piperazin-1-yl; Z = H, trialkylsilyl, trihaloalkoxycarbonyl; Bz = benzoyl], II [R7 = H, alkoxycarbonyl, aralkyloxycarbonyl; R8, R9 = H, alkyl, haloalkyl, etc.] or their salts are prepared Thus, 7-O-triethylsilyl-10-deacetylbaccatin III was reacted with 4-(dimethylamino)piperidinocarbonyl chloride (also prepared) in THF-hexane containing BuLi at -40° to room temperature to give 90% 10-O-(4-dimethylaminopiperidinocarbonyl)-7-O-triethylsilyl-10-deacetylbaccatin III. This was reacted with (4S,5R)-3-(benzyloxycarbonyl)-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid to give the title compound III. These compounds exhibit a high solubility in water and showed excellent antitumor activity. In an ELISA screening using human oral cancer KB cells, the GI50 for 13-O-[3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionyl]-10-O-(4-dipropylaminopiperidinocarbonyl)-10-deacetylbaccatin III (also prepared) was 0.78 ng/mL vs. 2.0 ng/mL for taxol. The solubility of 13-O-[3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionyl]-10-O-(4-dimethylaminopiperidinocarbonyl)-10-O-deacetylbaccatin III (also prepared) in water was 1260 μg/mL vs. 0.4 μg/mL for taxol. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).HPLC of Formula: 53788-12-8

The Article related to taxane derivative preparation antitumor solubility, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.HPLC of Formula: 53788-12-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On August 1, 2012, Li, Qingeng; Wang, Tao; Xia, Biao; Guo, Bin published a patent.Category: piperazines The title of the patent was Novel 7,10-O,O-dimethyldocetaxel derivative, its preparation process and application for treating cancers. And the patent contained the following:

The invention disclosed a kind of 7,10-O,O-dimethyldocetaxel derivatives and their salts, preparation method and medical application as antitumor agents. The claimed title compounds are shown in structure I (R = H, Me, Et, Pr, iso-Pr, Bu, iso-Bu, or CH2-Ph; HB = inorganic or organic acid from HCl, HBr, HNO3, acetic acid, lactic acid, or tartaric acid etc.). The claimed compounds are prepared with II via esterification etc. multiple steps (procedure given). The obtained compounds and pharmaceutically acceptable salts can be used for preparing water-soluble medicals for treating cancers such as breast cancer, lung cancer and ovarian cancer without side effect, high safety and controlled quality (no data provided). The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Category: piperazines

The Article related to dimethyldocetaxel derivative salt synthesis esterification antitumor agent, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On November 30, 2013, Kavitha, Channappa N.; Jasinski, Jerry P.; Anderson, Brian J.; Yathirajan, H. S.; Kaur, Manpreet published an article.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was 1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanone. And the article contained the following:

In the title compound, C12H16N2O2, the piperazine ring has a chair conformation. The dihedral angle between the mean planes of the benzene ring and the acetyl group is 48.7 (1)°. In the crystal, mols. are linked via O-H···O hydrogen bonds, forming chains propagating along [010]. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to hydroxyphenylpiperazinylethanone crystal structure, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.Safety of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On February 28, 2014, Mghandef, Marwa; Boughzala, Habib published an article.COA of Formula: C12H16N2O2 The title of the article was 1-(4-Hydroxyphenyl)piperazine-1,4-diium tetrachloridocobalt(II) monohydrate. And the article contained the following:

The asym. unit of the title inorganic-organic hybrid compound, (C10H16N2O)[CoCl4]·H2O, consists of a tetrahedral [CoCl4]2- anion, together with a [C10H18N2O]2+ cation and a water mol. Crystal cohesion is achieved through N-H···Cl, O-H···Cl and N-H···O hydrogen bonds between organic cations, inorganic anions and the water mols., building up a three-dimensional network. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).COA of Formula: C12H16N2O2

The Article related to cobalt hydroxyphenylpiperazinedium tetrachloride monohydrate crystal structure, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.COA of Formula: C12H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2021, Mastuo, Kasumi; Kuriyama, Masami; Yamamoto, Kosuke; Demizu, Yosuke; Nishida, Koyo; Onomura, Osamu published an article.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Nickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents. And the article contained the following:

The nickel-catalyzed hydrodeoxygenation of aryl sulfamates ROS(O)2R1 [R = 2-propanoylbenzen-1-yl, 1-ethyl-1H-indol-4-yl, 4-(4-acetylpiperazin-1-yl)benzen-1-yl, etc.; R1 = dimethylaminyl, piperidin-1-yl, bis(propan-2-yl)aminyl, etc.] has been developed with alcs. as mild reductants. A variety of functional groups and heterocycles were tolerated in this reaction system to give the desired products RH in high yields. In addition, the gram-scale process and stepwise cine-substitution were also achieved with high efficiency. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to aromatic hydrocarbon preparation, aryl sulfamate hydrodeoxygenation nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On April 18, 2019, Miracle, Gregory Scot; Valenti, Dominick Joseph; Dey, Sanjeev Kumar; Qin, Haihu; Freund, Wesley A. published a patent.Formula: C13H16N2O2 The title of the patent was Leuco colorants as bluing agents in laundry care compositions. And the patent contained the following:

A laundry care composition including (a) at least one laundry care ingredient and (b) at least one fluorescent moiety covalently bound to at least one second moiety selected from the group consisting of leuco moieties and chromophore moieties. A method of treating a textile includes the steps of (a) providing such a laundry care composition; (b) adding the laundry care composition to a liquid medium; (c) placing textile articles in the liquid medium; (d) optionally, rinsing the textile; and (e) drying the textile articles. The experimental process involved the reaction of 4-(4-Acetylpiperazin-1-yl)benzaldehyde(cas: 890092-19-0).Formula: C13H16N2O2

The Article related to leuco colorant bluing laundry care, Surface Active Agents and Detergents: Dry-Cleaning Solvents and Laundering Detergents (Cleaning Of Finished Garments) and other aspects.Formula: C13H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics