Category: piperazines

381242-61-1, 1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (1) (1.65 g, 0.005 mol), C2H5OH (30 mL) and N(C2H5)3 (3 mL), 1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine (2) (1.65 g, 0.006 mol) was added and heated at 70-80 C for 5 h. The reaction was monitored by TLC. After filtration, the filtrate was evaporated under reduced pressure. Water (30 mL) was added to the residue, which was then extracted with ethyl acetate (80 mL ¡Á 3). The extract was washed with saturated NaCl solution (20 mL ¡Á 3), dried over anhydrous Na2SO4 and evaporated. The residue was crystallized from C2H5OH to afford a white solid 3 1.92 g, in 75% yield: m.p. 115-117 C. 1H NMR (DMSO-d6): 6.80-8.48 (6H, m, Ar-H), 7.81, 8.13 (2H, ss, triazole-H), 4.51-4.60 (2H, dd, J = 15 Hz, triazole-CH2-), 2.50-3.01 (8H, m, piperazine-H), 2.73-3.17 (2H, dd, J = 15 Hz, CH2-piperazine-), 5.10 (1H, s, OH). IR (KBr): 3200, 2940, 2893, 1605, 1514, 1338, 1257, 1136, 918 cm-1. LC-MS, m/z Calcd. for C22H21F5N6O3, 512.2, found [M + H]+ 513.3., 381242-61-1

As the paragraph descriping shows that 381242-61-1 is playing an increasingly important role.

Reference£º
Article; Chai, Xiaoyun; Zhang, Jun; Cao, Yongbing; Zou, Yan; Wu, Qiuye; Zhang, Dazhi; Jiang, Yuanying; Sun, Qingyan; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 3167 – 3176;,
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30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 [0116] 0.61 g (1.29 mmol) of betulonic acid chloride was dissolved in 40 mL of anhydrous dichloromethane (CH2Cl2), and then 0.72 mL (5.16 mmol) of anhydrous triethylamine and 0.60 g (2.58 mmol) of 1-(4-trifluoromethylphenyl)piperazine were added thereto, and then stirred at 25 C. for 48 hours. The resulting product was washed with 10% HCl (40 mL¡Á3), further washed with pure water (40 mL¡Á3), and then a solvent layer was dried by 10 g of anhydrous Na2SO4. A dichloromethane (DCM) layer was evaporated and dried to obtain 0.85 g of light brown solids. These light brown solids were dissolved in ethanol to prepare a sample, and then this sample was fractionated by RP C18 semi-prep HPLC, and then completely evaporated and dried to obtain 0.64 g (yield: 74.9%) of 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid. [0117] 1H NMR (600 MHz, CDCl3): [0118] A white crystalline solid, m.p. 229-230 C. IR (ATR) umax cm-1: 2944, 1704 (C?O), 1616 (CONH), 1525, 1458, 1332, 1230, 1112, 1073, 1023, 885, 830. 1H NMR (600 MHz, CDCl3): 0.93 (3H, s, Me-25), 0.96 (1H, m, H-12), 0.97 (3H, s, Me-27), 0.98 (3H, s, Me-26), 1.02 (3H, s, Me-24), 1.06 (3H, s, Me-23), 1.19 (1H, m, H-15), 1.30-1.52 (12H, m, H-1, 5, 6, 6, 7, 7, 9, 11, 11, 15, 16, 21), 1.59 (2H, m, H-12, 18), 1.69 (3H, s, Me-30), 1.75 (1H, m, H-22), 1.89 (2H, m, H-1, 21), 2.01 (1H, m, H-22), 2.16 (1H, m, H-16), 2.39 (1H, m, H-2), 2.49 (1H, m, H-2), 2.92 (1H, m, H-13), 3.00 (1H, dt, J1=11.4 Hz, J2=4.2 Hz, H-19), 3.41 (4H, m, H-3?, 3?, 5?, 5?), 3.78 (4H, m, H-2?, 2?, 6?, 6?), 4.74 and 4.60 (2H, both br. s, H-29), 6.94 (2H, d, J=8.4 Hz, H-2?, 6?), 7.51 (2H, d, J=8.4 Hz, H-3?, 5?). [0119] C41H59N2O2F3, 4-(4?-trifluoromethylphenylpiperazine-1-yl) amide betulonic acid 7, 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KOREA INSTITUTE OF ENERGY RESEARCH; Chue, Kuck-Tack; Kim, Tae-Hwan; Ten, Leonid; US2014/243527; (2014); A1;,
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109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 29 2-(4-Chlorophenoxy)ethyl 3-(3-methyl-1-piperazinyl)-2-pyrazinyl Ether The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine* (150 mg, 0.53 mmol) and 2-methylpiperazine (256 mg, 2.56 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 143 mg (77%) of the title product. HRMS m/z calcd for C17H21ClN4O2 (M)+348.1353, found 348.1370. Anal. (C17H21ClN4O2) C, H, N. *Prepared according to the procedure described in Example 4, Step 1., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biovitrum AB; US6465467; (2002); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

Example 7 N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-6-[2-(4-methylpiperazin-1-yl)ethoxy]-1H-indole-2-carboxamide To 85 mg (0.25 MM) 6-Hydroxy-1H-indole-2-carboxylic acid [2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide in 5 ml dichloromethane at 0¡ã C. was added 144 mg (1 MM) 2-(4-Methyl-piperazin-1-yl)-ethanol, 262 mg (1 MM) triphenylphosphine and 131 mg (0.75 MM) DEAD. After several hours the mixture was allowed to warm to room temperature and stir overnight.The reaction mixture was purified directly on a preparative TLC plate and eluted with 10percent methanol/dichloromethane.The product was then partitioned between 1 M HCl and ethyl acetate, the aqueous layer was neutralized and extracted with ethyl acetate, dried over magnesium sulfate and stripped to give 18.9 mg 6-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-1H-indole-2-carboxylic acid [2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide. Similarly prepared were: N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-1-methyl-6-(2-morpholin-4-ylethoxy)-1H-indole-2-carboxamide using Mitsunobu coupling with 2-Morpholin-4-yl-ethanol. N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-6-(2-morpholin-4-ylethoxy)-1H-indole-2-carboxamide using Mitsunobu coupling with 2-morpholin-4-yl-ethanol., 5464-12-0

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard; US2004/77646; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To a stuffed solution of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HC1, 575 mg, 3.0 mmol) in DMF at 0 C,2-picolinic acid (246 mg, 2.0 mmol) was added followed by addition of hydroxybenzotriazole(HOBt, 405 mg, 3.0 mmol) and the final reaction mixture was stuffed at 0C. After 30 mm 6-fluoro-1- methyl-4-oxo-7-(piperazin- 1 -yl)- 1 H,4H- [1,3] thiazeto[3 ,2-a] -quinoline-3 -carboxylic acid (700 mg, 2.01 mmol) and N,N-diisopropylethylamine(0.53 ml, 3 mmol) were added and reaction mixture was allowed to stir at room temperature for overnight. After completion, the reaction mixture wasevaporated, remaining mass was triturated 2-3 times and dried to obtain compound 3las an off white solid (250 mg, 28%). 1H NMR (DMSO-d6): oe 14.61 (brs, 1H, COOH), 8.62 (d, 1H, JAB = 4.5 Hz, ArH), 7.96 (t, 1H, JAB = 7.5 Hz, ArH), 7.82 (d, 1H, JAB = 13.5 Hz, ArH), 7.64 (d, 1H, JAB = 7.5 Hz, ArH), 7.52 (dd, 1H, JAB = 7.0 Hz, Jm = 5.0 Hz, ArH), 6.98 (d, 1H, JAB = 7.0 Hz, ArH), 6.36 (q, 1H, JAB = 6.0 Hz,SCHN), 3.89-3.81 (m, 2H, CH2N), 3.66-3.52 (m, 2H, C?H2N), 2.11 (d, 3H, JAB = 6.5Hz, CH3). ESI-MS (mlz): 454.92 (M+H)., 112984-60-8

As the paragraph descriping shows that 112984-60-8 is playing an increasingly important role.

Reference£º
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; GHOSH, Shamik; GHOSH, Sumana; SINHA, Mau; SADHASIVAM, Suresh; BHATTACHARYYA, Anamika; MAVUDURU, Siva Ganesh; TANDON, Nupur; KUMAR, Deepak; (149 pag.)WO2017/17631; (2017); A2;,
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67455-41-8,67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Argon was passed through the suspension of bis-chloride (1) (0.419 g, 1 mmol) in dry pyridine(15 mL) at room temperature over 15 min. Amine (2.5 mmol) was added and the reaction mixture wasbubbled with argon for a further 15 min. The mixture was then stirred at room temperature for 7 days.The solid product was filtered off and washed with dry ether. The raw product was purified throughrecrystallization from ethanol.

67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various.

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Article; Zieba, Andrzej; Latocha, Ma?gorzata; Sochanik, Aleksander; Nycz, Anna; Ku?mierz, Dariusz; Molecules; vol. 21; 11; (2016);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

70261-82-4, To a 250 mL round bottom flask was added 7.5 g (36.6 mmol) of crude I-a ‘4-nitro-1H-pyrazole-3-carboxylic acid 6.3 g(40.1 mmol),EDC ¡¤ HCl 8.4 g (44.0 mmol)HOBt 6.0 g (44.4 mmol) and dry DMF 100 mL,Stir at room temperature for 24 h TLC detects the disappearance of the starting material (methanol: chloroform = 1:10).The reaction solution was poured into 200 mL of ice water,Precipitation of a large number of light yellow solid, standing, take the yellow solid,The crude product was recrystallized from a mixed solvent of ethyl acetate and methanol to give 11.1 g of (I-e)Yield 88.2%.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
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30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-bromo-3 ,5-dinitrobenzene (2.84g 11.50mmol), N-(trifluoromethylphenyl)piperazine (2.66g 11.50mmol), Xphos (0.493g 1.035mmol), palladium(II) acetate (0.077g 0.345mmol), potassiumcarbonate (2.225g16.1mmol) and tert-butanol (23ml) then stirred reaction mixture at 95C for 3 hours under nitrogen atmosphere. 1-(3,5-dinitrophenyl)-4-(4- (trifluoromethyl) phenyl)piperazine (2.87g 7.25mmol) Yield: 63% white solid obtained.

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Taewon SISChem co.,Ltd; Choe, Sung Muk; Myung, Do; Sung, Gyung Hwan; Jang, Sung Hwa; (20 pag.)KR101589584; (2016); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 147Preparation of 2-[4-(4-methylpiperazin-1-yl)phenyl]-4,5,6,7-tetrahydro-1 ,3- benzothiazol-7-ol Step A: 4-(4-Methylpiperazin-1-yl)benzonitrile A mixture of 4-bromobenzonitrile (1.82 g, 10 mmol), 1 -methyl piperazine (2.0 g, 10 mmol), tris(dibenzylideneacetone)dipalladium(0) (50 mg), rac-2,2′-bis(diphenylphosphino)-1,1′- binaphthyl (50 mg), and sodium te/f-butoxide (1.92 g, 20 mmol) in 20 ml. of toluene is stirred at 80 C for 18 hours and then concentrated. The residue is chromatographed over silica gel, eluting with a gradient of ethyl acetate to 20% methyl alcohol in ethyl acetate. Concentration provides 4-(4-methylpiperazin-1-yl)benzonitrile as a tan solid (1.6 g).

109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; WYETH; WO2009/120826; (2009); A1;,
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Piperazines – an overview | ScienceDirect Topics

883554-88-9, 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound 4-carbamoyl-piperazine-1-carboxylate (0.16g, 0.7mmol) was dissolved in dichloromethane(2mL) was added HCl The ethyl acetate solution (4M, 2mL), stirred at rt for 30min, the solvent was removed togive 0.16g of white solid: piperazin-1-carboxamide hydrochloride Salt, yield: 100%.

883554-88-9 4-Carbamoyl-piperazine-1-carboxylic acid tert-butyl ester 17750351, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
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Piperazines – an overview | ScienceDirect Topics