Category: piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.

Intermediate 3 (2.63 g, 13.1 mmol) was dissolved in DCE (60 mL). Cyclobutanone (1.38 g, 19.7 mmol) and acetic acid (0.75 mL, 13.1 mmol) were added and the mixture stirred at rt for 30 min. NaBH(OAc)3 (4.18 g, 19.7 mmol) was added portionwise and the mixture was stirred at rt overnight. Sat. Na2CO3 (50 mL) was added and the aq. layer was extracted with DCM (3¡Á75 mL). The combined organic phases were dried over Na2SO4, filtered and concentrated under reduced pressure to provide 2.58 g title compound (77%) as an oil. 1H NMR (300 MHz, CDCl3) delta ppm 0.97 (d, J=6.4 Hz, 3H) 1.45 (s, 9H) 1.61-1.70 (m, 2H) 1.81-1.91 (m, 1H) 1.93-2.00 (m, 2H) 2.03-2.14 (m, 2H) 2.41-2.51 (m, 1H) 2.58-2.65 (m, 1H) 2.94-3.05 (m, 1H) 3.06-3.16 (m, 1H) 3.29-3.58 (m, 3H).

163765-44-4, The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; US2010/216812; (2010); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

General procedure: An aqueous solution of sodium bicarbonate (0.57g, 6.78mmol) (20mL) was stirred at r.t. for 10min, and then compound 5a (0.50g, 2.26mmol) in dichloromethane (10mL) was added under ice-cooling. Thiophosgene (0.39g, 3.39mmol) in dichloromethane solution (5mL) was added dropwise for 0.5h. Reaction was stirred under ice-cooling for 6h. The aqueous phase was extracted with dichloromethane (20mL¡Á3). The combined organic phase was washed twice with saturated brine (20mL¡Á2) and dried over anhydrous MgSO4. After filtration, the solvent of filtrate was removed in vacuo, and the residue was purified by silica gel column chromatography (DCM : MeOH=100 : 1) to afford compound 6a as a pale-yellow solid; Yield: 63%, 55121-99-8

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A previously described method [19] was followed for the syntheses of 1-5, 7, 8, 10 and 20. Briefly, equimolar quantities of the amine and the acridine/quinoline were dissolved in ethanol, 2 drops of conc. HCl were added and the mixture refluxed for ca 24 h. On cooling, NaOH (1 M) or ammonia solution (25%) was added, followed by dichloromethane to extract the product. Alternatively, if the product precipitated out of solution on alkalinization, it was removed by filtration and purified by column chromatography.

115619-01-7, 115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Nguyen, Thuy; Sakasegawa, Yuji; Doh-Ura, Katsumi; Go, Mei-Lin; European Journal of Medicinal Chemistry; vol. 46; 7; (2011); p. 2917 – 2929;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138775-02-7,(R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

(2R)-4-[(benzyloxy)carbonyl]-1 -[(ie f-butoxy)carbonyl]piperazine-2-carboxylic acid (4.00 g, 1 1 .0 mmol), DIPEA (5.1 mL, 27.4 mmol), HATU (5.01 g, 13.2 mmol) and Nu,Omicron- dimethylhydroxylamine hydrochloride (1.29 g, 13.2 mmol) in DMA (40 mL) are stirred at RT for 3 days. The reaction mixture is diluted with EtOAc, washed with water and brine. The organic layer is dried over MgS04, filtered and concentrated under reduced pressure. The residue is purified by silica gel column chromatography to give the title compound. (0523) Yield: 4.44 g (99%) ESI-MS: m/z = 408 (M+H)+

138775-02-7, As the paragraph descriping shows that 138775-02-7 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BOUYSSOU, Thierry; GOTTSCHLING, Dirk; HEINE, Niklas; SMITH KEENAN, Lana Louise; LOWE, Michael D.; RAZAVI, Hossein; SARKO, Christopher Ronald; SURPRENANT, Simon; TAKAHASHI, Hidenori; TURNER, Michael Robert; WU, Xinyuan; (182 pag.)WO2019/81637; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55083-85-7,1-(4-Chlorophenyl)piperazin-2-one,as a common compound, the synthetic route is as follows.,55083-85-7

4-Methoxy-3-(pyridin-2-ylethynyl)benzoic acid (51 mg, 0.2 mmol), 1-(4- chlorophenyl)piperazin-2-one (74 mg, 0.3 mmol), and triethylamine (105 uL, 0.75 mmol) were dissolved in 3 ml. of CH2CI2 and treated with HOBt (34 mg, 0.25 mmol) and EDC (48 mg, 0.25 mmol). The reaction was stirred at room temperature overnight and directly purified by flash chromatography on silica gel (CH2CI2/Et0Ac) to yield 85 mg (95%) of the product as a white solid.

The synthetic route of 55083-85-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WYETH; WO2009/143404; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.

76003-29-7, A mixture of 2,5-dibromopyridine (1.0 g, 4.21 mmol), pyrrolidin-2-one (2.54 g, 12.7 mmol),K2C03 (1.16 g, 8.42 mmol) , Cul (40 mg , 0.21 mmol), Ni Ni ,N2,N2-tetramethylethane-1,2-diamine (92mg 0.63 mmol) and dioxane (10 mL) was stirred at 110C for 12 h. The mixture was added water (30 mL), extracted with EA(20 mL x 3), the organic layers were washed with water (25 mL x 3) and brine (20 mL x 3), dried over Na2SO4, concentrated and purified by flash chromatography (silica gel, 40 g, PE/EA = 100/i to2/1) to give the title compound (750 mg, 50%) as a gray solid. LC-MS: [M+H] = 356.1.

The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; CHAN, Ho Man; FU, Xingnian; GU, Xiang-Ju Justin; HUANG, Ying; LI, Ling; MI, Yuan; QI, Wei; SENDZIK, Martin; SUN, Yongfeng; WANG, Long; YU, Zhengtian; ZHANG, Hailong; ZHANG, Ji Yue (Jeff); ZHANG, Man; ZHANG, Qiong; ZHAO, Kehao; (148 pag.)WO2017/221100; (2017); A1;,
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Piperazines – an overview | ScienceDirect Topics

5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5521-39-1, Into a Microwave vial , 7-Bromo-2-methanesulfinyl-pyrrolo[2,l-f][l,2,4]triazine (0.480 g, 0.00184 mol), 2-[4-(4-Amino-phenyl)-piperazin-l-yl]-ethanol (0.8984 g, 0.004060 mol) and l-Methoxy-2-propanol (3.50 mL, 0.0358 mol) were added. The reaction was microwaved on 300 watts , 1800C for 60 minutes . The solvent was removed under vacuum. The desired product was isolated via ISCO column chromatograpy with DCM and methanol as eluant (0 to 7% methanol). The collected fractions afforded2-{4-[4- (7-Bromo-pyrrolo[2,l-fJ[l,2,4]triazin-2-ylamino)-phenyl]-piperazin- 1-yl} -ethanol as a yellow solid (280mg, 36%).

As the paragraph descriping shows that 5521-39-1 is playing an increasingly important role.

Reference£º
Patent; CEPHALON, INC.; BRESLIN, Henry J.; CHATTERJEE, Sankar; DIEBOLD, James L.; DORSEY, Bruce D.; DUNN, Derek; GINGRICH, Diane E.; HOSTETLER, Greg A.; HUDKINS, Robert L.; HUNTER, Rachael; JOSEF, Kurt; LISKO, Joseph; MESAROS, Eugen F.; MILKIEWICZ, Karen L.; OTT, Gregory R.; SUNDAR, Babu G.; THEROFF, Jay P.; THIEU, Tho; TRIPATHY, Rabindranath; UNDERINER, Theodore L.; WEINBERG, Linda; WELLS, Gregory J.; ZIFICSAK, Craig A.; WO2010/71885; (2010); A1;,
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Piperazines – an overview | ScienceDirect Topics

655225-01-7, tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

655225-01-7, Example 63B; tert-butyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-l-yl)ethyl)piperazine-l- carboxylate; To a solution of 3,3-bis(4-fluorophenyl)pyrrolidin-2-one (Example 58B, 1.37 g, 5.00 mmol) in tetrahydrofuran (30 mL) was added potassium t-butoxide (1.0 M in tetrahydrofuran) (7.5 mL, 7.5 mmol) followed by the product from Example 63A (1.47 g, 5.00 mmol). The reaction mixture was heated at 75 0C for 18 hours. The reaction was concentrated, diluted with ethyl acetate, washed with water and brine, dried with MgSO4, filtered and concentrated. The residue was purified with silica gel chromatography eluting with 3percent methanol/dichloromethane to give the title compound. MS (DCI) m/z 486.3(M+H)+.

655225-01-7 tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate 15946441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; BHATIA, Pramila, A.; DOHERTY, George, A.; DRIZIN, Irene; MACK, Helmut; PERNER, Richard, J.; STEWART, Andrew, O.; ZHANG, Qing Wei; WO2010/39947; (2010); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-35-9,tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,154590-35-9

To a solution of 4-(4-Amino-2-fluoro-phenyl)-piperazine-1 -carboxylic acid te/t-butyl ester (0.50 g, 1.7 mmol) and (0.38 g, 1.9 mmol) in CH2CI2 (30 ml_) was added 1 -hydroxybenzotriazole hydrate (0.27 g, 2.0 mmol), and 1 -[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.38 g, 2.0 mmol). After stirring at room temperature for 18 h, the reaction was diluted with 1 N NaOH (50 ml_) and extracted with CH2CI2 (3×50 ml_). The organic extracts were combined, dried (Na2SO4), and concentrated. Chromatography of the resulting residue (SiO2: EtOAc/hexanes) yielded 4-{4- [(biphenyl-2-carbonyl)-amino]-2-fluoro-phenyl}-piperazine-1 -carboxylic acid tert- butyl ester, which was further dissolved in MeOH (20 ml_) and 4N HCI in dioxanes. After stirring for 5 h, the reaction mixture was concentrated down, neutralized with 1 N NaOH, and extracted with EtOAc (3x75ml_). The orgranic extracts were combined, dried (Na2SO4), and the solvent was evaporated under reduced pressure to yield the title compound.MS (ESI): mass calcd. for 023Hz2FN3O, 375.17; m/z found, 376.3 [IvRH]+.

The synthetic route of 154590-35-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2009/6185; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57260-71-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 108 (E)-4-(3-(3,3,6,6-tetramethylcyclohex-1-enyl)acryloyl) piperazine-1 -carboxamideExample 108a. Tert-Butyl 4-carbamoylpiperazine-1-carboxylate To a solution of terf-butyl piperazine-1 -carboxylate (5.0 g, 26.8 mmol) in acetic acid (15 mL) and water (25 mL) was added a solution of potassium cyanate (11.25 g, 138.9 mmol) in water (25 mL) dropwise. After addition the mixture was stirred at rt for 4h, during which time a solid precipitated. The solid was collected by filtration, re-dissolved in dichloromethane (20 mL), dried oversodium sulfate, and filtered. The filtrate was concentrated to give the title compound as a white solid (3.3 g, yield: 53%), which was used in the next step without further purification. 1H NMR (400 MHz, DMSO-d6) delta 6.04 (s, 2H), 3.26 (s, 8H), 1.41 (s, 9H)

As the paragraph descriping shows that 57260-71-6 is playing an increasingly important role.

Reference£º
Patent; BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd; WO2010/147653; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics