Category: piperazines

21043-40-3, 1-Cyclopentylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4 g (22 mmol) N-(2-chloro-pyridin-4-yl)-N-methyl-acetamide and 3.5 g (23 mmol) l-(cyclopentyl)-piperazine was heated to 120 0C for 24 h. The crude product was purified by flash column chromatography on silica eluting with a gradient formed from heptane and ethyl acetate (0.1% NEt3) to yield after evaporation of the product fractions 3.3 g (50%) of the title compound as light brow oil. MS: (m/e): 303.3 (MH+)., 21043-40-3

The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63718; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

55112-42-0, Example 6: Preparation of Zopiclone in ACN[0069] To a slurry of l-chlorocarbonyl-4-methyl piperazine hydrochloride(CMP) (4.92g) in acetonitrile (ACN) (75 ml), stirred mechanically at Room temperature and under nitrogen, was added tri-ethyl amine (Et^N) (4.42g). After Et3N addition ended, DMAP (0.46g) was added to the slurry, and after 1-2 min of stirring, 7-OH -Py (5g) was added. The slurry changed its appearance at 7-OH addition. The stirring was applied for 2h at about 00C, then at room temperature for 14h.The reaction was completed after an additional heating (about 9h) at 400C. After cooling to the room temperature the solvent was evaporated, to give a yellowish-brown solid, that was dissolved in CH2CI2 (40 ml) and water (50 ml). Phases were separated while the interphase was left in the aqueous phase. The aqueous phase was extracted with CH2CI2 (40 ml). The combined organic phases were washed with water (50 ml), dried over MgSO4 filtered and evaporated to dryness to give zopiclone crude product (6.17g, yield 82.2%; purity 98.24% by HPLC).

The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
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103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of hydroxyethyl piperazine (13 ml) in acetone (200 ml), a 10% solution of sodium hydrogencarbonate (254 ml) was added under vigorous stirring. Subsequently, the reaction mixture was cooled to 0 C. and benzyl chloroformate (17.92 ml) was added in drops. The reaction mixture was stirred for 4 hours at room temperature. After removing the acetone under vacuum, the aqueous phase was extracted with acetic acid ethyl ester (3¡Á250 ml). The combined organic phases were washed once with a saturated solution of sodium chloride, dried over sodium sulfate, filtered, concentrated and resulted in the desired product (28.2 g).MS (EI): m/z: 265 [M+H]+

103-76-4, 103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Morphochem Aktiengesellschaft Fur Kombinatorische Chemie; US2010/324030; (2010); A1;,
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74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

74879-18-8, General procedure: To a stirred solution of 39 (5.0 g, 13.5 mmol) in DMF (42 mL) were added triethylamine (3.8 mL) and 1-(pyridin-3-ylmethyl)-piperazine (3.2 g, 18.1 mmol) at room temperature under nitrogen. The stirred mixture was heated at 50C for 3 h. The reaction mixture was cooled to room temperature and diluted with water, THF and EtOAc. The organic extract was washed with water, dried over Na2SO4, filtrated and then concentrated. The crude solid was washed with Et2O/EtOAc and filtrated to afford the title compound 40 as a white solid (6.33 g, 12.4 mmol, 91.5%).

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nagao, Satoshi; Yamane, Yoshinobu; Funasaka, Setsuo; Tanaka, Keigo; Miyazaki, Kazuki; Kotake, Yoshihiko; Kamata, Jun-Ichi; Watanabe-Miyano, Saori; Toyama, Osamu; Ozawa, Yoichi; Mizui, Yoshiharu; Okamoto, Kiyoshi; Ito, Daisuke; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5513 – 5529;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

To a mixture of IIc (9.54 g, 74.4 mmol) and K2CO3 (11.7 g, 85.1 mmol) in DMF (60 mL) 1-fluoro-2-nitrobenzene Ib (10.0 g, 70.9 mmol) was added at 25C. Obtained reaction mixture was stirred at 50C for 17 h and then water (200 mL) was added. The product was extracted to EtOAc (3 x 150 mL), combined organic layers were washed with water (3 x 100 mL) and brine (2 x 100 mL), dried over MgSO4, and solvent was evaporated to afford the title compound IIIc as orange oil which solidified upon standing. Orange crystals (17.4 g, 99% yield): 1H NMR (CDCl3, 500 MHz) delta 2.13 (s, 3H), 3.05 (m, 4H), 3.62 (m, 2H), 3.77 (m, 2H), 7.10-7.17 (m, 2H), 7.51 (m, 1 H), 7.80 (m, 1 H); MS (ESI) m/z: 250 [MH]+.

13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; LEK Pharmaceuticals d.d.; The designation of the inventor has not yet been filed; EP2894154; (2015); A1;,
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169447-86-3, (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compounds according to this embodiment are shown in Table 3, below. Synthesis of the relevant compounds is shown in FIGS. 1 1 A and 11 B., 169447-86-3

169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITY OF SOUTH FLORIDA; YALE UNIVERSITY; WO2008/79945; (2008); A2;,
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4318-42-7,4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step B: r5-(4-lsopropyl-piperazine-1 -carbonvD-benzoribithiophen-3-yli- piperidin-1 -yl-methanone; . To a suspension of (5-bromo-benzo[iotab]thiophen-3-yl)- piperidin-1 -yl-methanone (370 mg, 1.2 mmol), 1 -isopropyl-piperazine (147 mg, 1.2 mmol), Na2CO3 (607 mg, 5.7 mmol), and Hermann’s catalyst (54 mg, 0.06 mmol) in H2O (2 ml_) was added Mo(CO)6 (151 mg, 0.57 mmol) and the reaction mixture was sealed and heated at 130 0C with microwave irradiation for 10 min. The solution was concentrated and the resulting residue was partitioned betweenEtOAc and 1 N NaOH (50 ml_). The organic layer was washed with brine (50 ml_), dried, and concentrated. The resulting residue was purified by FCC to provide 193 mg (41 percent) of the title compound as a tan foam. LC/MS: Rt = 4.43. MS (ESI): mass calcd. for C22H29N3O2S, 399.56; m/z found, 400.2 [M+H]+. 1H NMR (CDCI3): 7.87 (d, J = 8.3, 1 H), 7.86 (s, 1 H), 7.57 (s, 1 H), 7.38 (d, J = 8.3, 1 H), 3.79 (br s, 4H), 3.59 (br s, 2H), 3.55 (br s, 2H), 2.71 (h, J = 6.5, 1 H), 2.58 (br s, 2H), 2.42 (br s, 2H), 1.66 (br s, 4H), 1.56 (br s, 2H), 1.02 (d, J = 6.5, 6H).

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/109333; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.

5464-12-0, A one dram vial was charged with solid potassium tert-butoxide (54 mg, 0.48 mmol), 2-(4-methylpiperazin-l-yl)ethanol (0.075 g, 0.52 mmol), and tert-butanol (0.3 mL, 3.4 mmol). The mixture was stirred at ambient temperature for 30 minutes. N-(3-cyclopropyl-l-((l-methyl-2-oxo-l,2-dihydropyridin-3- yl)methyl)-lH-indazol-4-yl)-7-fluoroimidazo[l,2-a]pyridine-3-carboxamide (0.032 g, 0.070 mmol) was added in one portion. The mixture was heated at 88 ¡ãC with stirring for 16 hours. The mixture was cooled to ambient temperature and diluted with water until a precipitate formed. The precipitate was isolated by filtration and dried under high vacuum. Purification using silica preparative thin layer chromatography plate (20 x 20 cm, 0.5 mm) developed in a chamber with 10percent methanol/dichloromethane with 0.6percent concentrated ammonium hydroxide gave the product. MS (APCI), positive scan, m/z = 581.2 (M+).

As the paragraph descriping shows that 5464-12-0 is playing an increasingly important role.

Reference£º
Patent; ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; BRADLEY, Michael; DELISLE, Robert Kirk; HENNINGS, D. David; KENNEDY, April L.; MARMSATER, Fredrik P.; MEDINA, Matthew; MUNSON, Mark C.; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian; WO2011/79076; (2011); A1;,
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Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

74879-18-8, To (S)-2-methyl piperazine (0.150 g, 1.5 mmol) was added 4-bromobenzotrifluoride (0.225g, 1.0 mmol), dichloro-bis(tri-o-tolyphosphine) palladium (II) (0.236 g, 0.3mmol), and sodium t-butoxide (0.144 g, 1.5 mmol), and toluene (2 mL) sequentially. After nitrogen was bubbled through the mixture for 15 minutes, the reaction was heated to lOO’C. The reaction was stirred at 1000C for 2 hr. The reaction was filtered through celite and concentrated under reduced pressure. The residue was then purified on a 1000 micron preparative thin layer chromatography plate eluting with 5% MeOH in dichloromethane to yield the title compound as an oil. IH NMR (500 MHz, CDCl3) delta 7.5 (d, 2H, J=8.7Hz), 6.95 (d, 2H, J = 8.7 Hz), 3.71 (d, 2H, J=IOHz), 3.20 (m, IH), 3.04 (m, 2H), 2.85 (m, 1H),2.48 (m, IH), 1.24 (d, 3H, J=7.2Hz). LC/MS 247 (M+l); HPLC 2.41 min

As the paragraph descriping shows that 74879-18-8 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2007/70173; (2007); A2;,
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Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

C. Preparation of (S)-5-bromo-4-(3-methylpiperazin-1-yl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine. To a mixture of pyrrolopyrimidine from step B (76 mg, 0.2 mmol) and (S)-2-methylpiperazine (21 mg, 0.2 mmol) in isopropanol (2 ml) was added triethylamine (0.11 ml, 0.8 mmol). The mixture was heated at 80 C. for 5 mins via microwave and concentrated under vacuum to give crude (S)-5-bromo-4-(3-methylpiperazin-1-yl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (65 mg, 0.15 mmol, 75%) which was used directly for the next step. MS (ES+) [M+H]+=437., 74879-18-8

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Harrison, Bryce Alden; Kimball, Spencer David; Mabon, Ross; Rawlins, David Brent; Rice, Dennis S.; Voronkov, Michael Victor; Zhang, Yulian; US2009/42893; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics