Category: piperazines

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%)., 694499-26-8

694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
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30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-(Thiophen-2-yl)pentanoic acid (72 mg, 0.39 mmol), HOBt (58 mg, 0.43 mmol), TBTU (138 mg, 0.43 mmol), anhydrous triethylamine (86 ??, 0.62 mmol) and dry DMF (2 ml) were placed in an oven-dried Schlenk tube under a nitrogen atmosphere. The resulting solution was stirred at room temperature for 15 minutes. A second Schlenk tube was prepared containing 1-(4-trifluoromethyl phenyl) piperazine (100 mg, 0.43 mmol) and dry DMF (1 ml) under a nitrogen atmosphere. The resulting solution was stirred until complete dissolution of the piperazine had occurred. The piperazine solution was then transferred, via a cannula, to the first Schlenk tube containing the carboxylic acid. The resulting solution was stirred for 24 hrs, under nitrogen, and monitored by TLC. After 24 hrs, the DMF was removed under reduced pressure and the resulting oil was acidified using a 0.1 M hydrochloric acid solution. The aqueous mixture was extracted with dichloromethane (20 ml, followed by 4 x 10 ml) and the organic layer washed with a saturated sodium bicarbonate solution (3 x 20 ml) and brine (3 x 20 ml). The organic layer was dried over magnesium sulphate and evaporated under reduced pressure. The residue was purified using flash chromatography (3:2, EtOAc:n-hexane) to obtain the desired product in an 25 % yield. H NMR (300 MHz, CDCI3) ? 7.49 (d, 2H), 7.09 (dd, 1 H), 6.89-7.01 (m, 3H), 6.79-6.84 (m, 1 H), 3.76 (t, 2H), 3.59 (t, 2H), 3.23 (t, 4H), 2.85 (t, 2H), 2.37, (t, 2H), 1.74-1.82 (m, 4H). MS (+ESI) calcd for C20 H23 F3 N2 O m/z: [M + H]+ , 396.1468; found 397.1556 [Diff(ppm) = -3.75]., 30459-17-7

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH; STEPHENS, John; FINDLAY, John; KINSELLA, Gemma; MARTIN, Darren; DEVINE, Robert; VELASCO-TORRIJOS, Trinidad; WO2013/60860; (2013); A1;,
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163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound ferf-butyl (3R)-3-methylpiperazine-1-carboxylate (25g, 124.8 mmol) was dissolved in DMSO (50 mL). To reaction mixture was added 6-chloronicotinonitrile (19 g, 137.3 mmol), K2CO3 (32.7g, EPO 235.9 mmol) and Cu(MeCN)4PF6 (0.42 g, 1.12 mmol) then warmed to 140 0C for 4h. The solution was cooled to 25 0C and diluted with EtOAc (200 mL) then partitioned between aqueous HCI (3 X 50 mL 0.1 N) and saturated aqueous sodium bicarbonate (2 X 50 mL). The organic layer was dried over sodium sulfate, filtered through silica (50 mL) and concentrated. The residue was purified by crystallizing from 20 mL of warm EtOAc after standing for 2h at 25 0C. The mother liquor was decanted, the solid rinsed with EtOAc (2 x 10 mL) and placed under high vacuum for 2h that afforded the title compound 23(0 as a white crystalline solid (32.6 g, 96%). HPLC Rt: 3.444 (95.4%). 1H NMR (400MHz, CDCI3) delta: 8.42 (s, 1 H), 7.63 (dd, J = 9.1 , 2.3 Hz, 1 H), 6.56 (d, J = 9.1 Hz, 1 H), 5.30 (s, 1 H), 4.53 (bs, 1 H), 4.13 (bs, 1 H), 3.94 (bs, 1 H), 3.26-3.21 (m, 2H), 2.99 (bs, 1 H), 1.49 (s, 9H), 1.20 (d, J = 6.8 Hz, 3H). LCMS (ESI): mlz: 303.3., 163765-44-4

The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PFIZER INC.; WO2006/106423; (2006); A2;,
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55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55121-99-8, Compound 6 A flask was charged with intermiediate 1 (150mg, 0.5 mmol), l-(4-aminobenzoyl)-4-m ethyl piperazine (109 mg, 0.5 mmol), TFA (50uL), isopropanol (3mL). The reaction was heated to 100C for 4h. The reaction mixture was basified with a saturated aqueous sodium bicarbonate solution and then was extracted with DCM/ (10 mlx3). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The crude product was purified with flash chromatography (0-10% MeOH-in DCM) to afford the desired product as light yellow solids (160 mg, 66% yield). 1H MR (400 MHz, DMSO-d6) delta 11.36 (br, 1H), 10.17 (br, 1H), 8.34 (s, 1H), 7.63 (d, J = 8.8 Hz, 2H), 7.39 (d, J = 8.8 Hz, 2H), 7.13 (d, J = 8.4 Etazeta, IotaEta), 6.96 (t, J = 7.6 Hz, 1H), 6.24 (s, 1H), 3.80-3.40 (br, 4H), 2.40 (s, 3H), 2.36-2.24 (br, 4H), 2.19 ( s, 3H); ESI-MS: calcd for (C26H24FN702) 485, found 486 (MH+).

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; POLAT,, Tulay; WEINGARTEN, Paul; NALLAN, Laxman; ARP, Forrest; WANG, Qinwei; HO, David; (129 pag.)WO2016/138527; (2016); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630125-91-6,4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.,630125-91-6

Into a solution of 4-(4-Ethyl-piperazin-l-ylmethyl)-3-trifluoromethyl- phenylamine (8.0 g, 27.9 mmol, 1.0 eq.) in dichloromethane (140 ml) is added diisopropylethyl amine (5.27 ml, 30.69 mmol, 1.1 eq.). The solution is cooled to O0C, after which 4-Methyl-3- nitrobenzoylchloride (4.18 ml, 28.73 mmol, 1.03 eq.) is added in portions into the reaction EPO mixture which is further equilibrated for 30 minutes. The reaction mixture is then partitioned between dichloromethane and water. The organic layer is separated and the aqueous layer is extracted with dichloromethane. The combined organic extracts are washed with water, dried over Na2SO4, filtered and concentrated to afford the desired product which is used in the next step without further purification.

630125-91-6 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 59134564, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; IRM, LLC; WO2006/124462; (2006); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8

To a solution of 1 i (28 mg, 0.089 mmol) in acetonitrile (2 mL) were added DIPEA (48 muIota_, 0.267 mmol), 1j (15 muIota_, 0.107 mmol) and HATU (41 mg, 0.107 mmol). The resulting mixture was stirred at room temperature for 2 h and purified by reversed phase prep HPLC to give title compound 1 as white solid (36 mg, 90% yield). The mass of the compound was obtained by Shimadzu LCMS-2020, MS(ESI) : m/z = 451 [M+H]

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ETERNITY BIOSCIENCE INC.; LIU, Dong; ZHANG, Minsheng; HE, Kan; ZHANG, Lianshan; WO2012/125521; (2012); A1;,
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314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (2.5 g, 11.56 mmol), 2-fluoro-5-nitro-benzonitrile (1.92 g, 11.6 mmol) and DiPEA (2.47 ml, 13.9 mmol) were dissolved in 1,4-dioxane (25 ml). The reaction was heated to 80 C. for 24 hours then increased to 90 C. for a further 18 hours. The reaction was concentrated in vacuo. The residue obtained was purified via flash column chromatography using gradients of 0 to 100% EtOAc in heptane, followed by 0 to 100% MeOH in EtOAc. The fractions containing product were combined and concentrated in vacuo to afford the title compound as a yellow gel (4.07 g, 67%). LCMS Method 3-Tr=0.61 min (ES+) (M+H+) 363.2

314741-40-7, As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
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Piperazines – an overview | ScienceDirect Topics

55121-99-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

(11) methyl 3-(Z)-[1-{4-[(4-methyl-piperazin-1-yl)-carbonyl]-phenylamino}-1-phenyl-methylidene]-2-indolinone-6-carboxylate Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-(4-methyl-piperazin-1-yl-carbonyl)-aniline. Yield: 0.1 g (23% of theoretical), Melting point: 196-197 C.

As the paragraph descriping shows that 55121-99-8 is playing an increasingly important role.

Reference£º
Patent; Roth, Gerald Juergen; Heckel, Armin; Lehmann-Lintz, Thorsten; Kley, Joerg; Hilberg, Frank; Van Meel, Jacobus; US2003/92756; (2003); A1;,
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639068-43-2, tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,639068-43-2

3,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester (1.676 g) and 2-chloropyrimidine (716 mg) were combined, melted in an oil bath at 120¡ãC, and stirred for 5 hr 30 min. Water (10 ml) was added and the mixture was stirred, extracted with ethyl acetate (30 ml), and washed with saturated brine. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated. The obtained residue was purified by column chromatography (Yamazen HI-FLASH.(TM). COLUMN size L, elution solvent: hexane/ethyl acetate) to give the title compound (333 mg). 1H-NMR (CDCl3)delta:1.25(6H,d,J=6.9 Hz), 1.51(9H,s), 2.97-3.08(2H,m), 3.95-4.16(2H,m), 4.65-4.82(2H,m), 6.51(1H,t,J=4.5 Hz), 8.34(2H,d,J=4.8 Hz). MS:237 (M++1 when tert-butyl group was cleaved).

639068-43-2 tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 22219990, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; EP2154135; (2010); A1;,
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25057-77-6, 1,2-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 65: tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1- yl)methyl)phenyl)ethyl carbamateA solution of (S)-tert-butyl 1 -(4-formylphenyl)ethylcarbamate (84.1 mg, 0.337 mmol) [obtained from (S)-1-(4-bromophenyl)ethanamine following the procedure of Hashihayata, Takashi PCT Int. Appl., 2008081910, 10 Jul 2008] and 1 ,2- dimethylpiperazine (86.3 mg, 0.756 mmol, 2.24 equiv) in THF (1.5 mL) was stirred at room temperature for 65 min and treated with sodium triacetoxyborohydride (277.2 mg, 1 .308 mmol, 3.88 equiv). The resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was quenched with saturated aqueous solution of NaHCO-3(15 mL) and extracted with EtOAc (5 x 15 mL). Combined organics were dried over Na2S04, filtered and concentrated. Silica gel column chromatography (MeOH/CH2Cl2 0 to 20%) provided tert-butyl (1 S)-1 -(4-((3,4-dimethylpiperazin-1-yl)methyl)phenyl)ethyl carbamate (90.7 mg) in 34.5% yield. 1 H NMR (400 MHz, CD3OD) delta 7.29 (s, 4 H), 4.68 (br s, 1 H), 3.54 – 3.47 (m, 2 H), 3.37 (s, 1 H), 2.84 – 2.74 (m, 3 H), 2.38 (td, J = 12, 2.5 Hz, 1 H), 2.31 (s, 3 H), 2.28 – 2.22 (m, 2 H), 1.94 – 1.89 (m, 1 H), 1.40 (br s, 9 H), 1.38 (d, J = 6.9 Hz, 3 H), 1 .06 (d, J = 6.3 Hz, 3 H); MS m/z 348.2 (M + H)

25057-77-6, As the paragraph descriping shows that 25057-77-6 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; TOURE, Bakary-Barry; YANG, Fan; CAFERRO, Thomas; LEI, Huangshu; LENOIR, Francois; LIU, Gang; PALERMO, Mark G.; SHULTZ, Michael David; SMITH, Troy; COSTALES, Abran Q.; PFISTER, Keith Bruce; SENDZIK, Martin; SHAFER, Cynthia; SUTTON, James; ZHAO, Qian; WO2013/46136; (2013); A1;,
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Piperazines – an overview | ScienceDirect Topics