Category: piperazines

120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12A tert-butyl (2R)-2-methyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate The product from Example 1D (200 mg, 0.56 mmol) was subjected to the conditions described in Example 11, substituting (R)-tert-butyl 2-methylpiperazine-1-carboxylate for 4-(piperidin-4-yl)morpholine to give the titled compound (242 mg, 74%)., 120737-78-2

The synthetic route of 120737-78-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; Bogdan, Andrew; Cowart, Marlon D.; DeGoey, David A.; Jinkerson, Tammie K.; Koenig, John R.; Kort, Michael E.; Liu, Bo; Matulenko, Mark A.; Nelson, Derek W.; Patel, Meena V.; Peltier, Hillary; Scanio, Marc J.; Wakefield, Brian D.; US2015/218102; (2015); A1;,
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109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-2-fluoropyridine (0.100 mL, 0.972 mmol) in N,N-dimethylformamide (4.0 mL) was added triethylamine (0.284 mL, 2.04 mmol) and 1-methylpiperazin-2-one hydrochloride (0.161 g, 1.07 mmol). The resulting mixture was heated at 100 C. for 12 h then cooled to room temperature, diluted with DCM, washed with water and brine. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on a silica gel column eluting with 0 to 100% EtoAc/Hexanes to give the desired product. LC-MS calculated for C10H13BrN3O (M+H)+: m/z=270.0. found 270.0., 109384-27-2

As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.

Reference£º
Patent; Incyte Corporation; Wu, Liangxing; Courter, Joel R.; He, Chunhong; Li, Jingwei; Lu, Liang; Sun, Yaping; Wang, Xiaozhao; Yao, Wenqing; Zhang, Colin; Zhuo, Jincong; (87 pag.)US2016/9720; (2016); A1;,
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59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 10-(benzyloxy)-4-bromo-2-(4-fluorobenzyl)-8-methyl-7,8- dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione (0.10 g, 0.19 mmol; Example 160, Step 1) and 1-methylpiperazin-2-one (2 mL) was heated in a sealed tube in an oil bath at 100 ¡ãC overnight. The benzyl protecting group was also cleaved in the process. The reaction mixture was subjected to reverse phase preparative HPLC purification. Collection and lyophilization of appropriate fractions provided the title compound. 1H NMR (400 MHz, DMSO-d6) No. 7.33 (dd, J = 8.6,5.7 Hz, 2H), 7.14 (t, J = 9.0 Hz, 2H), 5.08 (s, 2H), 4.49 (br s, 2H), 3.68 (m, 2H), 3.30 (m, 2H), 2.99 (s, 3H), 2.83 (s, 3H). ES MS M+l = 455, 59702-07-7

As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2005/110414; (2005); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

694499-26-8, j00607j A solution of 3-Iodo4-rnethylbenzoyl chloride (6.98 g, 20.0 rnrnol), prepared from the reaction of 3.-iodoAme(hylbenzoic acid and oxalyl chloride, was charged to a solution of 4-((4-niethylpiperazin- I -yl) rnethyl)-3 -(trifluoromethyl) aniline (6.80 g, 20.0 mmol), N, N-diisopropylettyiamine (3.86 g, 29,0 rnmol), and a catalytic amount of DMAP in THF (75 rnL).The reaction mixture was stirred at room temperature for 4 h, then diluted with water (20 rnL) and extracted with EtOAc (3 X 50 rnL). The combined organic layers were dried over anhydrous Na2504, filtered and concentrated in vacuo resulting in a crude compound which purified by chromatography on silica gel, eluting with 5% methanol in DCM and niethano] presaturated with ammonia gas to give 9.6 g, 74% yield of the title compound as an offwhite solid. ?H NMR (400 MHz, CDC13): oe = 8.28 (d, J= 1.9 Hz, 1H), 7.70 – 7.89 (m, 5H), 7.34 (d, J= 7.9 Hz, 1H), 3.63 (d, J= 1.8 Hz, 2H), 2.49 (s, 3H), 2.41(m, 8H) 2.29 (s, 3H). MS (ES): m/z= 518.22 [M+H] LCMS: tR = 2.33 mm.

As the paragraph descriping shows that 694499-26-8 is playing an increasingly important role.

Reference£º
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1 ,1-dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate (1.5g, 7.5 mmol) in anhydrous DCM (3OmL) was added triethylamine (2.59ml_, 19 mmol) and 2,4-difluoro-1-isocyanatobenzene (0.88ml_, 7.5 mmol) the sample was stirred under an argon atmosphere at room temperature for 2hours. The reaction was evaporated and the residue was suspended DCM (3OmL) which was washed with 0.5M aqueous HCI (10OmL), and then water (10OmL). The collected organic layer was dried (MgSO4), filtered and evaporated, the residue was dried in a vac-oven at 400C overnight (approx 18hours) to yield the title compound as a white solid (2.41 g, 91%).1H NMR (CDCI3) 51.22 (3H, d, J=6.58Hz), 1.48 (9H, s), 3.11 (1 H, m), 3.22 (1 H, m), 3.34 (1 H, dd, J=13.37, 3.95Hz), 3.71 (1 H, m), 3.92 (1 H, m), 4.31 (1 H, br m), 6.39 (1 H, NH, br m), 6.85 (2H, m), 7.99 (1 H, m)., 169447-70-5

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BESWICK, Paul, John; CAMPBELL, Alister; CRIDLAND, Andrew; GLEAVE, Robert, James; PAGE, Lee, William; WO2010/102663; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.208167-83-3,tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A suspension of IX-214 (30 mg; 0.065 mmol; Example 1), potassium carbonate (9 mg; 0.065 mmol) and potassium iodide (2 mg; 0.012 mmol) in ethanol (1 mL) was stirred 5 min at room temperature, was supplemented with /-butyl 4-(2-chloroethyl)piperazine-l-carboxylate (24.3 mg; 0.098 mmol; Acros Organics), and was stirred 6 h at 80C. The reaction mixture was evaporated, re-dissolved in 10 mL water, and extracted with dichloromethane (3 x 10 mL). The pooled extracts were dried over anhydrous sodium sulfate, filtered, and evaporated, and the product was purified by silica chromatography (methanol/di chloromethane gradient).Yield: 34.4 mg; 79%., 208167-83-3

The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; EBRIGHT, Richard H.; EBRIGHT, Yon W.; LIN, Chih-Tsung; (85 pag.)WO2019/226915; (2019); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

To a mixture of 2-(3-bromo-phenyl)-6-chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester (410 mg, 1 mmol), palladium acetate (6.73 mg, 0.03 mmol), cesium carbonate (0.65 g, 2 mmol), xantphos (23 mg, 0.04 mmol) and N-acetylpiperazine (192 mg, 1.5 mmol) in toluene (10 mL) was stirred at 120 C. for 12 hours. Then the reaction mixture was concentrated in vacuo and the residue was extracted with ethyl acetate (2¡Á100 mL), washed with saturated aqueous sodium chloride (2¡Á50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo. Purification on flash silica gel chromatography (silica gel from QingDao, 200-300 mesh, glass column from Shanghai SD company) (20% ethyl acetate/hexanes) to afford 2-[3-(4-acetyl-piperazin-1-yl)-phenyl]-6-chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester (0.25 g, 54%) as a white solid: LC/MS m/e calcd for C25H30ClN3O3 M+: 455.99, observed: 456.1, 13889-98-0

The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chen, Li; Feng, Lichun; Huang, Mengwei; Liu, Yongfu; Wu, Guolong; Wu, Jim Zhen; Zhou, Mingwei; US2011/257151; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-29-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.

A 60% dispersion of sodium hydride in mineral oil (3.6 g, 150 mmol, 1.5 equiv) was added in portions to a solution of tert- butyl 3-oxopiperazine-l-carboxylate (20.02 g, 100 mmol, 1 equiv) in anhydrous THF (400 mL) at 5 C and the mixture was stirred at room temperature for 1.5 hours. Benzyl bromide (14.27 mL, 120 mmol, 1.2 equiv) was added and the mixture was stirred at room temperature for 15 hours. Water (100 mL) was carefully added to quench the reaction and the mixture was extracted with ethyl acetate (3 x 200 mL). The combined organic layers were washed with saturated brine (200 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was triturated with heptanes (200 mL) to give tert-butyl 4-benzyl-3-oxopiperazine-l- carboxylate (23.5 g, 81% yield) as a white solid.

The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CONATUS PHARMACEUTICALS, INC.; SPADA, Alfred, P.; TERNANSKY, Robert, J.; (0 pag.)WO2020/6341; (2020); A1;,
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5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5308-25-8, Step 7: 1-ethyl-4-(5-nitropyridin-2-yl)piperazine 2-Chloro-5-nitropyridine (800 mg, 5.05 mmol) was dissolved in dioxane (20 mL) and then 1-ethylpiperazine (1.7 g, 15.15 mmol) and N,N-diisopropylethylamine (927 mL, 5.05 mmol) were added. The reaction mixture solution was stirred at 70 C. for a day. The reaction solution was cooled to room temperature, diluted with ethyl acetate, and then washed with brine. The organic layer was concentrated by drying with magnesium sulfate. The target compound (1.05 g, 87% yield) was used in the following reaction without purification. MS m/z: 237.51 [M+1].

5308-25-8 1-Ethylpiperazine 79196, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Sim, Tae Bo; Hah, Jung Mi; Choi, Hwan Geun; Ham, Young Jin; Lee, Jung Hun; Park, Dong Sik; Kim, Hwan; US2013/12703; (2013); A1;,
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Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: A mixture of 0.2 g (0.50 mmol) intermediate II.5 step 1 , 70 mg (0.61 mmol) 1 – Methylpiperazin-2-one, 90 mg (0.65 mmol) K2C03 and acetonitrile is heated to 80¡ãC in a pressure tube for 3.5 h. After cooling to RT the solvent is evaporated and DCM and water are added. The organic phase is separated, dried, filtered and evaporated. (0548) Yield: 0.1 g (Yield 59percent), ESI-MS: m/z = 436 M+H+, R,(HPLC) : 0.25 min (HPLC-W), 59702-07-7

As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BLUM, Andreas; WO2015/169677; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics