Category: piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

A solution of methyl (Z)-3-(chloro(4-ethylphenyl)methylene)-2-oxoindoline-5-carboxylate (100 mg, 0.29 mmol), N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide (88 mg, 0.34 mmol) and TEA (0.08 mL, 0.59 mmol) in EtOH (1.0 mL) was stirred under refluxed for overnight. The reaction solvent was evaporated under reduced pressure, and the residue was purified by column chromatography with dichloromethane/ethanol (50/1, v/v) to obtain the final compound 95 as a yellow solid (166 mg, quant. yield): 1H NMR (500 MHz, DMSO-d6) _ 11.95 (s, 1H), 11.13 (s, 1H), 7.58 (dd, J = 8.2, 1.7 Hz, 1H), 7.42 – 7.38 (m, 5H), 7.13 (d, J = 8.2 Hz, 2H), 6.93 (d, J = 8.2 Hz, 1H), 6.89 (d, J = 8.2 Hz, 2H), 6.51 (s, 1H), 3.62 (s, 3H), 3.05 (bs, 2H), 2.72 (q, J = 7.6 Hz, 2H), 2.68 (bs, 2H), 2.18 (bs, 2H), 2.10 (s, 3H), 1.27 (t, J = 7.6 Hz, 3H); 13C NMR (125 MHz, DMSO-d6) _ 170.4, 168.6, 166.4, 157.3, 146.4, 140.4, 139.8, 137.5, 129.5, 128.9, 128.5, 127.7, 125.6, 124.0, 123.6, 121.3, 119.5, 108.9, 97.5, 59.2, 54.6, 52.4, 51.5, 45.8, 36.7, 28.3, 15.8; HRMS (ESI-TOF) m/z calcd for C31H32N6O6 [M + H+] 567.2846 found 568.2941., 262368-30-9

262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; DALBY, Kevin N.; EDUPUGANTI, Ramakrishna; TALIAFERRO, Juliana; LEE, Juhyeon; (0 pag.)WO2018/160967; (2018); A1;,
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103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Substituted amine (1.2 equiv) was added to a mixture of 4-fluoronitrobenzene (1 equiv) and K2CO3 (2.0 equiv) in DMF (7mL/g). The reaction mixture was stirred at 40C and followed by TLC. After completion of the reaction, the mixture was poured into stirring ice-water. The resulting precipitate was filtered and dried to obtain compounds 11 as a yellow solid.

103-76-4, The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 690 – 709;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compound 6 (1mmol) was dissolved in freshly distilled dichloromethane (5mL) under nitrogen atmosphere. Then HOBt (1.1mmol), EDC,HCl (1.1mmol) were added to it. The reaction mixture was stirred for 5min, secondary amine 7a-l (1.2mmol) was added in a slow stream and followed by the addition of triethylamine (2mmol) and the reaction mixture was stirred for 24hat room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, water (10mL) was added to the reaction mixture and extracted with dichloromethane. Organic layer was collected and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure and the crude product was purified by silica gel chromatography using an eluent of 50% ethyl acetate in hexane., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Banu, Saleha; Bollu, Rajitha; Bantu, Rajashaker; Nagarapu, Lingaiah; Polepalli, Sowjanya; Jain, Nishant; Vangala, Radhika; Manga, Vijjulatha; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 400 – 410;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound (S) -5- (1 – ((tert-butoxycarbonyl) amino) ethyl) -2- (3- (cyclopropylmethoxy) -4-(difluoromethoxy) phenyl ) -oxazole-4-carboxylic Acid (0.6g, 1.28mmol), 1-Boc-3- methyl piperazine (376mg,1.54mmol), 1- ethyl-3- (3-dimethylaminopropyl) carbodiimide salts Salt (368mg, 1.92mmol) and N- hydroxy-7-aza-benzotriazole (435mg, 3.20mmol) was dissolved in dichloromethane (20mL) The conditions at 0 C tothis solution was added dropwise N, N- diisopropylethylamine (0.89mL, 5.12mmol), stirred at rt for 6h,Saturated chlorinated Sodium solution (15mL ¡Á 3) washing the organic phase dried over Na 2 SO 4 anhydrous,solvent was removed concentrate was subjected to column chromatography (eluent: Petroleumether / EtOAc (v/ v) = 4/1), to give 714mg white solid, yield: 80%.

129799-08-2, 129799-08-2 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 2756819, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
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Piperazines – an overview | ScienceDirect Topics

1072027-36-1, 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INTERMEDIATE: (S)-tert-butyl-4-(5-(3-fluoropyrrolidin-l-yl)-7H-pyrrolor2,3- dlpyrimidin-4-yl) piperazine- 1 -carboxylate.Chemical Formula C19H27FN6O2 Exact Mass 390 22 1H-NMR (DMSO-d6/300 MHz): 11.44 (s, IH), 7.97 (d, J= 1.9 Hz, IH), 5.60 (d, J= 69 Hz, IH), 5.32 (s, IH), 3.66 (m, 4H), 3.36 (m, 10H), 1.38 (s, 9H). MS (ES+, m/z): 391.2 (M++., 100.0).

1072027-36-1, 1072027-36-1 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine 58497312, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SUPERGEN, INC.; WO2008/128072; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1-CYCLOPROPYL-6, 7-difluoro-1, 4-DIHYDRO-8-METHOXY-4-OXO-3- quinoline carboxylic acid (100G), 2-methylpiperazine (67.8gs) and anhydrous DMSO (300 ml) were stirred for 40-45 hrs at 60-65C. The reaction mass was then diluted with 1500 ml isopropyl alcohol. It was then stirred for 30 min at 25-30C followed by cooling at 5 to 10 C along with stirring for 2 hours. The product was obtained by filtration, which was washed with 3 x 50 ml isopropyl alcohol followed by drying at 50 to 55C for 4 hours to provide 71 g Gatifloxacin (Yield 55. 9%) Example 2: Step A: A mixture of L-CYCLOPROPYL-6, 7-difluoro-1, 4-dihydro-8-methoxy-4-oxo-3- quinoline carboxylic acid (120Kg) 2-methylpiperazine (40.8 Kg), and anhydrous DMSO (361 lit) was heated to 60-65C temperature and stirred for 2 hrs. A second lot of 2-methylpiperazine (10.2 Kg) was added, and stirred for next 1 hr, at 60-65C. followed by the addition of a third lot of 2-methylpiperazine (10.2Kg). The mixture was stirred for next 2 hrs at 60-65C. A fourth lot of 2-methylpiperazine (20.4Kg) was added to the mixture and the stirring was continued for the next 24 hrs maintaining the temperature at 60-65C followed by cooling to 25-35C. This reaction mass was added in 1802-1 isopropyl alcohol. Reaction mass was then stirred for 30 min at 25- 30C followed by cooling at 5 to 10 C along with stirring for 2 hours. Product so obtained was centrifuged, washed with 3 x 60-1 isopropyl alcohol. The wet cake of PRODUCT WAS MIXED WITH 241-LIT METHANOL AND STIRRED FOR 1 HR. , AGAIN THE PRODUCT WAS centrifuged followed by washing with 59 lit of methanol. The wet Gatifloxacin was dried at 60 to 65C for 6 hrs to yield 81. 92 Kg dry Gatifloxacin (Yield= 53.7%) HPLC Purity = 99.74% M/C=3. 42%, 109-07-9

109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; CADILA HEALTHCARE LIMITED; WO2004/101527; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,934-98-5

General procedure: To the suspension of sodium hydride (60percent, 0.23 g, 5.66 mmol) in dried dimethyl formamide (15 mL) was added 6-bromo (or 7-bromo)-[1,2,4]triazolo[1,5-a]pyridin-2-amine (0.60 g, 2.82 mmol),stirred for 10 min at room temperature, added N,N’-carbonyldimidazole(CDI, 1.37 g, 8.46 mmol), stirred at 60 ¡ãC until the starting material consumed, then added amine (9.87 mmol) and stirred at 60 ¡ãC for 6 h. The volatile was removed under reduced pressure to give a white pale yellow residue. Water (30 mL) was added tothe residue. The mixture was stirred. The precipitate was collected by filtration, dried to afford the expected product as a white solid. 5.1.1.7 1-(6-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-3-(2-(4-methylpiperazin-1-yl)ethyl)urea (2g) White solid; yield: 81.0percent; mp: 182-184 ¡ãC; 1H NMR (CDCl3): delta 9.60 (s, 1H, NH), 8.80 (s, 1H, Ar-H), 8.46 (s, 1H, NH), 7.63 (m, 2H, Ar-H), 2.60 (m, 10H, CH2 * 5), 2.36 (s, 3H, CH3). MS m/z (ESI): 382.1 [M+H]+.

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Article; Wang, Xiao-Meng; Mao, Shuai; Cao, Lei; Xie, Xiao-Xiao; Xin, Min-Hang; Lian, Jia-Fang; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5662 – 5671;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 49 4-Benzyloxycarbonyl-1-(4-methyl-5-isoquinolinesulfonyl)-2-methylpiperazine To a solution of 1-benzyloxycarbonyl-3-methylpiperazine (5.09 g) in chloroform (150 ml), a solution of triethylamine (3.0 ml) and 4-methyl-5-isoquinolinesulfonyl chloride (6.05 g) in chloroform (50 ml) was gradually added dropwise. After completion of the dropwise addition, the resultant mixture was continuously stirred at 60C for 20 hours.The reaction mixture was washed first with water (100 ml x 2) and then with a saturate aqueous solution of sodium chloride (100 ml), and was then dried over anhydrous magnesium sulfate. The solvent was then distilled off under reduced pressure. The resulting residue was purified by chromatography on a silica gel column (chloroform), whereby 3.95 g of the target compound were obtained. 1H-NMR (270 MHz, CDCl3) delta: 9.15(1H,s), 8.54(1H,s), 8.37(1H,dd,J=7.92,1.32Hz), 8.17(1H,dd,J=7.92,1.32Hz), 7.61(1H,t,J=7.59Hz), 7.36(5H,m), 5.17(2H,dd,J=14.85,12.21Hz), 4.05-4.18(3H,m), 3.33-3.55(3H,m), 3.04(3H,s), 1.34(3H,d,J=6.60Hz)., 84477-85-0

As the paragraph descriping shows that 84477-85-0 is playing an increasingly important role.

Reference£º
Patent; Hidaka, Hiroyoshi; EP1074545; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

112257-24-6, 1-Boc-3-Carbamoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-acryloyl-3-carbamoylpiperazine-1-carboxylate To a solution of tert-butyl 3-carbamoylpiperazine-1-carboxylate (300 mg, 1.31 mmol) and Et3N (396 mg, 3.93 mmol) in DCM (5 mL) at 0 C., acryloyl chloride (130 mg, 1.44 mmol) in DCM (1 mL) was added and the resulting mixture was stirred at room temperature for 1.5 h. The mixture was partitioned between DCM and saturated NaHCO3 aqueous solution. The organic layer was washed with saturated NaHCO3 and brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (DCM/MeOH=30:1) to afford the desired product (200 mg, 53.9% yield) as an off-white solid.

112257-24-6, 112257-24-6 1-Boc-3-Carbamoylpiperazine 11042527, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao; US2014/288045; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 98 Preparation of 2-(4-((4-Isopropylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one To a mixture of 4-(bromoethyl)benzaldehyde (0.200 g, 1.0 mmol) and K2CO3 (0.277 g, 2.0 mmol) in DMF (5 mL) was added N-isopropylpiperazine (0.129 g, 1.0 mmol) and the reaction was stirred at room temperature for 5 hours, then concentrated in vacuo. The resulting mixture was diluted with H2O and extracted with EtOAc. The organics were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford 4-((4-Isopropylpiperazin-1-yl)methyl)benzaldehyde (0.240 g, 97percent).

4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Resverlogix Corp.; Hansen, Henrik C.; (96 pag.)US9238640; (2016); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics