Category: piperazines

639068-43-2, tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

639068-43-2, 2) Synthesis of cis-1-tert-butoxycarbonyl-3,5-dimethyl-4-benzyl piperazine To a suspension of 10 g (46.66 mmol.) of cis-1-tert-butoxycarbonyl-3,5-dimethyl piperazine and 12.90 g (93.3 mmol.) of potassium carbonate in N,N-dimethylformamide (100 ml) was added, at room temperature, 11.97 g (70 mmol.) of benzyl bromide. The mixture was stirred for 16 hours at 120¡ã C. To the reaction system was added water, which was subjected to extraction with ethyl acetate. The organic layer was washed with a saturated aqueous saline solution, which was dried over magnesium sulfate, followed by distilling off the solvent. The residue was purified by means of a column chromatography (ethyl acetate/hexane 30percent) to give the object compound as a pale yellow oily product. The yield was 13.56 g (95percent). 1H-NMR (CDCl3, 200 MHz) delta: 1.04 (6H, d, J=5.8 Hz), 1.45 (9H, s), 2.45-2.75 (4H, m), 3.67-3.92 (2H, m), 3.81 (2H, s), 7.15-7.39 (5H, m). IR (neat): 2980, 1693, 1423, 1136, 1061, 924, 883, 766, 729, 700 cm-1.

639068-43-2 tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 22219990, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6235731; (2001); B1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Intermediate 51 : (3-Methyl-piperazin- 1 -yl)-(l -m-tolyl- 1 H-[ 1 ,2,4]triazol-3-yl)-methanone 51.1 : 2-Methyl-4-(l-m-tolyl-lH-[l ,2,4]triazole-3-carbonyl)-piperazine-l-carboxylic acid tert- butyl ester 2.00 g (9.84 mmol) l-m-tolyl-lH-[l ,2,4]triazole-3-carboxylic acid was stirred with 3.30 g (10.3 mmol) TBTU and 2.50 mL (14.6 mmol) DIPEA in 30 mL DCM at RT. After 10 min, 2.05 g (9.84 mmol) 2-methyl-piperazine-l-carboxylic acid tert-butyl ester was added and the reaction mixture was stirred at RT for 12 h. The solvent was removed by distillation. The residue was taken up in water and extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by flash chromatography (EtOAc). Yield: 4.00 g (95 %), purity: 90% ESI-MS: m/z = 386 (M+H)+ Rt(HPLC) : 1.48 min (method 8)

120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd; WO2013/87805; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of (R) -tert-butyl 3-methylpiperazine-1-carboxylate (300 mg, 1.5 mmol) , butyric acid (200 mg, 2.3 mmol) , EDCI (595 mg, 3.0 mmol) and HOAT (306 mg, 2.3 mmol) in DCM (10 mL) was stirred at 0 , and DIPEA (0.76 mL, 4.5 mmol) was added dropwise. After the addition, the mixture was stirred at rt for 10 h and washed with water (10 mL ¡Á 3) . The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 2/1 to give (R) -tert-butyl 4-butyryl-3-methylpiperazine-1-carboxylate as colorless liquid (370 mg, 91) .1H NMR (600 MHz, CDCl3) : delta ppm 4.74-4.81, 4.34-4.41 (m, 0.5H, 0.5H) , 3.80-4.12, 3.53-3.60 (m, 2.5H, 0.5H) , 3.26-3.35, 2.75-2.98 (m, 0.5H, 2.5H) , 2.26-2.35 (m, 2H) , 1.61-1.69 (m, 2H) , 1.47 (s, 9H) , 1.13-1.24 (m, 3H) , 1.12 (t, J 7.3 Hz, 3H) and MS-ESI: m/z 215.10 [M-55] +., 163765-44-4

The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.

The [4-CHLORO-3-CYANO-6-METHOXY-7- [3- (4-METHYLPIPERAZIN-1-YL)] propoxy] quinoline used as a starting material was prepared as follows:- A mixture of 3-bromopropanol (20 ml), [N-METHYLPIPERAZINE] (29 ml), potassium carbonate (83 g) and ethanol (200 ml) was stirred and heated to reflux for 20 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was evaporated and the residue was triturated under diethyl ether. The resultant mixture was filtered and the filtrate was evaporated. The residue was purified by distillation at about [60-70C] under about [0.] 2 mm Hg to give [1- (3-HYDROXYPROPYL)-4-METHYLPIPERAZINE] (17 g); NMR Spectrum: (CDC13) 1.72 (m, 2H), 2.3 (s, 3H), 2.2-2. [8] [(M,] 8H), 2.6 (t, 2H), 3.8 (t, 2H), 5.3 (br s, 1H).

109-01-3, 109-01-3 1-Methylpiperazine 53167, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/5284; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314729-14-1, 1-(3-Methyl-piperazin-1-yl)-ethanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 : l-(4-(3-Chloropyrazin-2-yl)-3-methylpiperazin-l-yl)ethanone The titled compound was prepared by the reaction of 2,3-dichloropyrazine (100 mg, 0.67 mmol) with l-(3-methylpiperazin- l-yl)ethanone (119 mg, 0.84 mmol) in the presence of cesium carbonate (437 mg, 1.34 mmol) in acetonitrile (5.0 mL) as per the procedure described in Step 1 of Intermediate 7 to yield 46 mg of the product; APCI-MS (m/z) 255 (M+H)+.

314729-14-1, As the paragraph descriping shows that 314729-14-1 is playing an increasingly important role.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; DAS, Sanjib; GHARAT, Laxmikant Atmaram; HARDE, Rajendra Laxman; SHELKE, Sandeep Yadunath; PARDESHI, Shailesh Ramesh; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; BAJPAI, Malini; (181 pag.)WO2017/21879; (2017); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-40-7,(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

60% Sodium hydride (154 mg, 3.85 mmol) was added portionwise to te/t-butyl (S)-3- (hydroxymethyl)piperazine-l-carboxylate (832 mg, 3.85 mmol) in THF (15 ml) cooled to 0C over a period of 5 minutes under nitrogen. The resulting mixture was stirred at 0C for 10 minutes then allowed to warm to room temperature and stirred for 20 minutes. 7-Bromo-8-chloro-5- fluoroquinazolin-4-ol (970 mg, 3.5 mmol) was added and the mixture heated at 65C and stirred for 2 hours then cooled to room temperature. Further 60% sodium hydride (154 mg, 3.85 mmol) was added and then heated at 65C and stirred for a further 2 hours before cooling to room temperature. The reaction mixture was diluted with EtOAc (100 ml), and water (25 ml). The aqueous phase was taken to pH 5 with acetic acid and separated. The aqueous phase was extracted with EtOAc (100 ml) and the organic phases combined, dried and evaporated. The residue was purified by flash silica chromatography, elution gradient 0 to 20% MeOH in DCM. Pure fractions were evaporated to dryness to afford te/t-butyl (S)-3-(((7-bromo-8-chloro-4-hydroxyquinazolin-5-yl)oxy)methyl)piperazine-l- carboxylate (1.35 mg, 82%) as pale yellow foam. 1H NM (500 M Hz, DMSO, 27C) 1.38 (9H, s), 2.53 – 2.68 (2H, m), 2.68 – 2.85 (2H, m), 2.85 – 2.97 (2H, m), 3.72 (1H, d), 3.87 – 3.99 (2H, m), 4.1 – 4.19 (1H, m), 7.38 (1H, s), 8.14 (1H, s). m/z: ES+ [M+H]+ 473., 314741-40-7

The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; KETTLE, Jason, Grant; BAGAL, Sharanjeet, Kaur; BOYD, Scott; EATHERTON, Andrew, John; FILLERY, Shaun, Michael; ROBB, Graeme, Richard; RAUBO, Piotr, Antoni; (144 pag.)WO2018/206539; (2018); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

Step 1 l-Isopropyl-4-(4-niotatro-phenyl)-piotaperaziotane[00393] To a solution of 4-fluoromtrobenzene (5g, 35 4mmol) m THF (5OmL), 1- lsopropylpiperazme (4 54g, 35 4mmol) and K2CO3 (7 35g, 53 2mmol) are added The reaction mixture is stirred at room temperature overnight The solvent is removed in vacuo and the residue is partitioned between EtOAc and water The organic layer is washed with brine, dpied over MgSO4, filtered and concentrated The crude compound is purified by silica gel column chromatography using 99 1 and 98 2 DCM NH3 (7M in MeOH) to give the title compound (8 2g, 94percent)

4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

General procedure: The mixture of 2-amino-5-bromobenzoic acid (1.00 g,4.63 mmol), triethyl orthoformate (1.00 mL, 6.02 mmol), amine(6.02 mmol), iodine (0.12 g, 0.046 mmol) and anhydrous ethanol(20 mL) was refluxed under nitrogen atmosphere for 4-6 h, thenconcentrated under vacuum to give a residue which was dissolvedin ethyl acetate (90 mL). The ethyl acetate solution was washedwith 1 N aqueous sodium hydroxide (20 mL 3) and brine(30 mL 3), dried over anhydrous sodium sulfate and concentratedto give a white or light yellow solid.

70261-82-4, The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Hao; Xin, Min-Hang; Xie, Xiao-Xiao; Mao, Shuai; Zuo, Sai-Jie; Lu, She-Min; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7765 – 7776;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1) 3-Methylpiperazine-1-carboxylic acid tert-butyl ester Di-tert-butyl dicarbonate (21.7 g) was added at room temperature to 2-methylpiperazine (10.0 g) in methanol (200 mL), followed by stirring for 24 hours. The reaction solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform – methanol), to thereby give 3-methylpiperazine-1-carboxylic acid tert-butyl ester as an oily product (19.3 g, 96.5percent). 1H-NMR (300MHz, CDCl3) delta: 1.04 (3H, d, J=6.24Hz), 1.46(9H,s), 2.39(1H,br s), 2.70-2.77(3H,m), 2.94(1H,br s), 3.93(2H,br s). MS(FAB)m/z:201(M+H)+.

109-07-9, As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1621537; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.

1-( ( 4′-chloro-S ,S-dimethyl-3 ,4,S,6-tetrahydro-[ 1,1 ‘-bipheny 1]-2-yl)methyl)piperazine(12.3 g) was dissolved in dimethyl sulfoxide (8S mL) under nitrogen atmosphere and added dibasic potassium phosphate (20.6 g) at 29C and stirred for 5 minutes at the sametemperature. Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate (8.5 g) wasadded to the reaction mixture at at 29C and stirred for 5 minutes at the same temperature.Heated the reaction mixture to 120C and stirred for 24 hours at the same temperature.The reaction mixture was cooled to 30C and quenched with cold water (255 mL) slowlyin 20 minutes. The reaction mixture was stirred for 30 minutes at the 30C and filtered.The compound was dissolved in ethyl acetate (85 mL) and washed with saturated aqueoussodium bicarbonate (2 x 50 mL) and brines solution (25 mL). The separated organic layerwas dried over sodium sulfate and evaporated the solvent completely to obtain crudecompound. The crude compound was purified by column chromatography using 60-120silica gel mesh and 60% ethyl acetate – hexane as eluent followed by recrystallization indiethyl ether and petroleum ether to obtain title compound as white solid. Yield: 11.4 g;Purity by HPLC: 99.052%

1228780-72-0, The synthetic route of 1228780-72-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; JURUPULA, Ramprasad; BAIG, Mohammed Azeezulla; CHAKKA, Ramesh; THIPPARABOINA, Rajesh; PEDDY, Vishweshwar; RAO, Pallavi; ORUGANTI, Srinivas; DAHANUKAR, Vilas Hareshwar; (88 pag.)WO2017/212431; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics