Category: piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16154-72-6,3-Chloro-4-(4-methylpiperazin-1-yl)benzenamine,as a common compound, the synthetic route is as follows.

General procedure: Method y: A mixture of 4-anilino-pyrimidine intermediate 3 (50 mg, 1.0 equiv.), the corresponding aniline B-ring aniline (1.0 equiv.), 2 drops of 4 M HC1, and EtOH (1 mL) was heated in a microwave reactor at 100 C for 1 h. Sodium bicarbonate (ca. 100 mg) was added to the mixture, stirred for 30 min at room temperature, and concentrated under reduced pressure. Unless otherwise mentioned, all products were purified via column chromatography using DCM/MeOH (0-10%).

16154-72-6, As the paragraph descriping shows that 16154-72-6 is playing an increasingly important role.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; (257 pag.)WO2016/22460; (2016); A1;,
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59702-31-7, 1-Ethylpiperazine-2,3-dione is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-31-7, EXAMPLE 6 1-Ethyl-4-(mercaptomethyl)-Piperazine-2,3-dione To a solution of 1-ethylpiperazine-2,3-dione (2.13 g, 15 mmol) in 30% aqueous (methanol free) formaldehyde (15 mmol) potassium hydroxide (150 mg, 2.7 mmol) was added and the mixture stirred at 50 C. for 7 days. It was neutralized with 5 N aqueous hydrochloric acid (50 mul) to pH=7. The mixture was evaporated at 15 mm and then dried in high vacuo (0.0013 mbar) (0.001 mm) to give 1-ethyl-4-(hydroxymethyl)-piperazine-2,3-dione as a colourless solid (100%). NMR-spectrum in CDCl3: 1.15 (broad signal, 1H), 1.15 (t, 3H, J=7 Hz), 3.47 (q, 2H, J=7 Hz), 3.54 (m, 2H), 3.68 (m, 2H), 4.88 (s, 2H) ppm.

The synthetic route of 59702-31-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfaendler, Hans Rudolf; US2001/31749; (2001); A1;,
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Piperazines – an overview | ScienceDirect Topics

5271-27-2,5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20. (5-chloro-2,4-dihydroxyphenyl)(4-methyl-2-phenylpiperazin-1-yl)methanone (11j) Compound 18 (0.20 g, 1.05 mmol), 1-methyl-3-phenylpiperazine (0.28 g, 1.58 mmol), 1-ethyl-3-(3-dimethylaminopropyl) (0.40 g, 2.10 mmol), 1-hydroxybenzotriazole (0.14 g, 1.05 mmol) and N,N-diisopropylethylamine (0.19 mL, 1.05 mmol) were dissolved in 4 ml of DMF and stirred at 120¡ã C. for 3 hours under a microwave irradiation (Biotage Initiator). The reaction mixture was diluted with ethyl acetate and the organic layer was washed with 1 N HCl solution. It was dried over Na2SO4, concentrated under pressure and purified by MPLC to obtain Compound 11j in a yield of 23percent. Rf=0.21 (8:2 ethyl acetate:hexane). 1H NMR (400 MHz, CDCl3) delta 7.46 (d, J=4.4 Hz, 2H), 7.37 (t, J=7.2 Hz, 7.2 Hz, 2H), 7.27 (t, J=7.2 Hz, 6.8 Hz, 1H), 7.17 (s, 1H), 6.61 (s, 1H), 5.58 (s, 1H), 4.24 (s, 1H), 3.24 (d, J=12.0 Hz, 1H), 3.22 (t, J=12.4 Hz, 10.4 Hz, 1H), 2.81 (d, J=10.8 Hz, 1H), 2.50 (dd, J=12.0 Hz, 4.0 Hz, 1H), 2.32 (s, 3H), 2.21-2.14 (m, 1H).

5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY; SEO, Young Ho; (32 pag.)US2019/31620; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

74879-18-8, To a solution of 2-(S)-methylpiperazine (3.79 g, 37.9 mmol) in CHCl3 (100 ML) was trityl chloride (10.56 g, 37.9 mmol) added in one portion.The exothermic reaction was stirred at ambient temperature for two hours, the organic phase was washed three times with water, dried (MgSO4) and the solvent was evaporated at reduced pressure to give 12.5 g (96%) of a colorless foam that solidified to a crisp over night. 1H NMR (CDCl3) delta1.06 (d, J=5.5 Hz, 3 H), 1.35 (m, 1 H), 1.61 (m, 1 H), 3.01 (m, 3 H), 3.14 (m, 1 H), 3.31 (m, 1 H), 7.08 (m, 3 H), 7.16 (m, 6 H), 7.35 (m, 6 H).13C NMR (CDCl3) delta18.17, 44.46, 46.68, 51.59, 54.03, 126.26, 127.13, 127.68, 129.07 br. The racemate of the title compound is reported in Bioorg. Med. Chem. Lett. 2000, 10, 2643-2646.

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Nilsson, Bjorn M.; Ringberg, Erik; US2003/232814; (2003); A1;,
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20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20327-23-5, Step 1 : 3-(4-Cyclopropyl-piperazin-1-yl)-6-(3-nitro-phenyl)-pyridazine: To a solution of 3-chloro-6-(3-nitro-phenyl)-pyridazine (10.0 g, 424 mmol) in n-BuOH (150 mL) was added 1 -cyclopropyl-piperazine (8.55 g, 678 mmol) and NH4CI (2.27 g, 424 mmol) and the mixture was stirred for 48 h at 800C. The solvent was removed under reduced pressure, and the residue was diluted with water. After alkalization with ammonia, the mixture was extracted with ethyl acetate. The extract was dried (Na2SO4) and concentrated to give 7.2 g of crude 3-(4-cyclopropyl-piperazin-1 -yl)-6-(3-nitro-phenyl)-pyridazine. 1H NMR (300 MHz, DMSO-c(6) delta 8.85 (s, 1 H), 8.45 (d, 1 H), 8.22 (d, 1 H), 8.1 1 (d, 1 H), 7.89- 7.66 (m, 1 H), 7.39 (d, 1 H), 3.69-3.65 (m, 4H), 2.80-2.76 (m, 4H), 1 .78-1.65 (m, 1 H), 0.54- 0.38 (m, 4H).

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/3604; (2007); A2;,
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Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[1458] A solution of 2-methylpiperazine (1.0 g, 0.01 mol, racemic mixture) and 2-bromopyridine (10 mL, 0.1 mol) was heated to 120 C. for 16 hours. The reaction mixture was cooled to room temperature and partitioned between ethyl acetate and water. The layers were separated, and the water layer was concentrated under reduced pressure. The residue was triturated with ethyl acetate, dichloromethane, and methanol to afford 460 mg (26% yield) of racemic 3-methyl-1-pyridin-2-yl-piperazine hydrobromide as an off-white solid. 1H NMR (300 MHz, DMSO-d6) delta1.27 (d, J=6.6 Hz, 3H), 2.90 (dd, J=10.5, 14.1 Hz, 1H), 3.10 (m, 2H), 3.40 (m, 2H), 4.32 (m, 2H), 6.77 (dd, J=4.8, 6.9 Hz, 1H), 6.98 (d, J=8.1 Hz, 1H), 7.64 (m, 1H), 8.15 (m, 1H), 8.63 (br s, 1H), 8.92 (br s, 1H); MS (APCI) m/e 178 (M+H) +., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.; US2003/229094; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 25A (3S)-3-methyl-1-pyridin-2-ylpiperazine (S)-(+)-2-Methylpiperazine (0.50 g, 0.005 mol, Aldrich) and 2-bromopyridine (5 mL, 0.05 mol) were combined and heated at 120 C. for 14 hours. The reaction mixture was allowed to cool to 23 C. and partitioned between ethyl acetate and water. The layers were separated, and the water layer extracted twice with ethyl acetate. The aqueous phase was brought to pH ~11 with a solution of saturated sodium bicarbonate and solid sodium carbonate. Sodium chloride was added, and the saturated aqueous solution was extracted with ethyl acetate (2*) and dichloromethane (2*). The combined organic extracts were dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure to afford 0.6 g (67% yield) of the title compound. 1H NMR (400 MHz, DMSO-d6) delta 1.02 (d, J=6.0 Hz, 3H), 2.27 (dd, J=10, 12 Hz, 1), 2.67 (m, 3H), 2.92 (m, 1H), 4.07 (m, 2H), 6.58 (dd, J=6, 8 Hz, 1H), 6.77 (d, J=8 Hz, 1H), 7.49 (m, 1H), 8.08 (m, 1H); MS (ESI) m/e 178 (M+H)+., 74879-18-8

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey; US2002/169166; (2002); A1;,
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Piperazines – an overview | ScienceDirect Topics

303-26-4, 1-((4-Chlorophenyl)(phenyl)methyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 4 10 gr. (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.8 gr. of ethyl 2-chloroethoxyacetate, 0.4. gr. of tetrabutylammonium iodide and 50 ml. of triethylamine were introduced into a pressure vessel and treated as described in example 1. 13.2 gr. of ethyl [2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetate is obtained (90.8% yield).

303-26-4, 303-26-4 1-((4-Chlorophenyl)(phenyl)methyl)piperazine 9340, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Chemagis Ltd.; EP952153; (1999); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Example 37Te/t-butyl 4-(4-(6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-3H-imidazo[4,5- ?>]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-chloro-4-(4-(4-chlorobenzyl)piperazin-1-yl)-3-nitropyridin-2-amine (prepared as described in example 37 of PCT/GB2006/004854; 0.042 g, 0.11 mmol) and EtOH (7 mL) was added te/t-butyl 4-(4-formylphenyl)piperazine-1-carboxylate (0.039 g, 0.14 mmol) followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.44 mL, 0.44 mmol). The reaction mixture was stirred at 80 0C for 20 h, then allowed to cool to room temperature and concentrated in vacuo. The residue was absorbed on silica gel, and the free-running powder was placed on a 10 g isolute silica column. Elution with ethyl acetate / dichloromethane (v:v; 1 :1), and then 2.5% methanol in ethyl acetate / dichloromethane (v:v; 1 :1 ) afforded the title compound as an off-white solid (0.023 g, 34%). 1H-NMR (500 MHz, DMSO-d6) 1.43 (s, 9H, OC(CHa)3), 2.58 (br t, 4H), 3.48 (br t, 4H), and 3.67 (br s, 4H) (piperazine N(CH2)2), 3.56 (s, 2H, NCH2-C6H4CI), 7.41 (m, 4H, C6H4CI), 7.06 (d, J = 8.8 Hz1 2H) and 8.03 (d, J = 7.7 Hz, 2H) (2,6-C6H4 and 3,5-C6H4), 8.04 (s, 1 H, imidazo[4,5-iotab]pyridine 5-H), 13.18 (br s, 1H, imidazo[4,5-/b]pyridine N-H);LC (Method B) – MS (ESI1 m/z): Rt = 4.45 min – 622, 624, 626 [(M+H)+, Cl2 isotopic pattern].

197638-83-8, As the paragraph descriping shows that 197638-83-8 is playing an increasingly important role.

Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-38-0,2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.,5521-38-0

A stirred solution of 2-(4-(4-nitrophenyl)piperazin-1- yl)ethanol (1.2 g, 4.78 mmol) in ethanol (20 mL) washeated to 50 C. 10% palladium on carbon (0.254 g, 0.239 mmol) was added followed by portionwise addition of ammonium formate (1.506 g, 23.88 mmol) and the suspension was stirred for 1 hour. The suspension was filtered through Celite washing with fresh ethanol (20 mL) . Theethanol was removed in vacuo to give the title compound(1.10 g, 104 %) . ?H NMR (400 MHz, CDC13) : 3 6.81 (d, 2H),6.66 (d, 2H), 3.69 (t, 2H), 3.09 (t, 4H), 3.02 (br s,3H), 2.74 (t, 4H), 2.66 (t, 2H) . LCMS (Method C): =0.13 mi m/z = 222 [M+H].

As the paragraph descriping shows that 5521-38-0 is playing an increasingly important role.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics