Category: piperazines

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 1 -(tert-butyl) 3-methyl piperazine-1 , 3-d icarboxy late (CAS Number 129799-08-2; 0.500 g, 2.05 mmol) in DCM (5 ml) were added phenylboronic acid (0.347 g, 3.07 mmol) and copper acetate (0.1 1 1 g, 0.614 mmol) at rt. The reaction mixture was stirred at rt for 16 h. The resulting reaction mixture was poured into water (50 ml) and extracted with EtOAc (2 x 25 ml). The combined organic phase was collected, dried over Na2S04, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography (10% MeOH in DCM) yielding 1 -(tert-butyl) 3-methyl 4-phenylpiperazine-1 ,3- dicarboxylate (0.200 g, 0.625 mmol). LCMS: Method C, 2.385 min, MS: ES+ 321 .53.

129799-08-2, 129799-08-2 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 2756819, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MISSION THERAPEUTICS LIMITED; STOCKLEY, Martin Lee; KEMP, Mark Ian; MADIN, Andrew; (167 pag.)WO2018/65768; (2018); A1;,
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278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

diisopropylethylamine (156 mL, 894 mmol) was added to a stirred, room temperaturemixture of 3-(2-Bromo-acetyl)-6-fluoro-2-methyl-benzonitrile (176 g, 688 mmol) and (R)-4-N-Boc-2-hydroxymethylpiperazine(149 g, 688 mmol) in THF (3500 mL) and the mixture was stirred at room temperature for 18 h. Thereaction was diluted with 3 L EtOAc, washed twice with 1500 mL 10% NaHCO3 aqueous solution, dried over MgSO4,filtered and concentrated. The residue was purified by column chromatography on silica gel (40-80% EtOAc/Hexanes,linear gradient), to provide the title compound.Step E: 17C and 17D: A 5000-mL, three-necked,, 278788-66-2

As the paragraph descriping shows that 278788-66-2 is playing an increasingly important role.

Reference£º
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

Step A: To a solution of 4-bromo-benzaldehyde (1.8 g, 9.73 mmol), 4-methylpiperazine-2-one (1.44 g, 12.6 mmol), Pd2(dba)3 (768 mg, 0.84 mmol), Xantphos (435 mg, 0.75 mmol) and cesium carbonate (5.48 g, 16.8 mmol) in dioxan (30 mL) was added water (1 drop). The mixture was stirred under nitrogen atmosphere at 90C for 1.5 h. After cooling, the mixture was filtered. The filtrate was concentrated to dryness under vacuum. The residue was purified with silica gel chromatography to give 4-(4-methyl-2-oxopiperazine-1-yl)benzaldehyde(1.8 g, 84.8%) as white solid. MS(ESI)m/z:219[M+H+].

34770-60-0, The synthetic route of 34770-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; DING, Zhaozhong; WU, Hao; SUN, Fei; WU, Lifang; YANG, Ling; (60 pag.)EP3190113; (2017); A1;,
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934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2,4-dichloro-7-trifluoromethyl-3-nitroquinoline (6.54 gm, 2.0¡Á10?2 moles) in 2-methyl tetrahydrofuran (50 mL) is stirred as diisopropylethylamine (2.84 gm, 2.2¡Á10?2 moles) and N-2-aminoethyl-N? methylpiperazine (3.15 gm, 2.2¡Á10?2 moles) are added. This solution is stirred at room temperature overnight. The yellow reaction mixture is diluted with more 2-methyl-tetrahydrofuran (50 mL) and this is washed with water (100 mL) followed by brine (50 mL). After being dried over magnesium sulfate, the solution is filtered and the solvent is removed under reduced pressure. The oily residue is stirred with diethyl ether (25 mL) and this is cooled on ice causing the product to crystallize. The solid yellow product is isolated by filtration, washed with ether and dried. The yield is about 5.0 gm., 934-98-5

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; JANUS BIOTHERAPEUTICS, INC.; Lipford, Grayson B.; Zepp, Charles M.; (72 pag.)US9873694; (2018); B2;,
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70261-81-3, 1-Methyl-4-(4-nitrobenzyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-81-3, A mixture of 1-methyl-4-(4-nitro-benzyl)-piperazine (3.09 g, 13.1 mmol), zinc dust (4.29 g, 65.6 mmol) and ammonium chloride (2.81 g, 52.5 mmol) in methanol (100 mL) was refluxed 1h, cooled, filtered through Celite (washing with methanol) and evaporated to provide 4-(4-methyl-piperazin-1-ylmethyl)-phenylamine (2.67 g, 99% yield) as a pale yellow, waxy solid. 1H-NMR (DMSO-d6, 500 MHz) 6.89 (d, 2H), 6.49 (d, 2H), 4.89 (s, 2H), 3.24 (s, 2H), 2.3 (br m, 8H) ppm; MS (FIA) 206.2 (M+H); HPLC (Method A) co-elutes with solvent front.

As the paragraph descriping shows that 70261-81-3 is playing an increasingly important role.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2004/46120; (2004); A2;,
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934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

934-98-5, Example 59: Formation of N-[2-(4-methylpiperazin-1 -yl)ethyl]-N’-{6-[3- (methylsulfonyl)phenyl]-1 ,3-benzothiazol-2-yl}urea (59) A solution of Lambda/-{6-[3-(methylsulfonyl)phenyl]-1 ,3-benzothiazol-2-yl}-1 /-/-imidazole-1- carboxamide (100 mg, 0.25 mmol) and 1-(2-aminoethyl)-4-methyl-piperazine (36 mg, 0.25 mmol) in anhydrous DMA (2 ml.) was heated at 1800C for 15 min under microwave irradiation. The reaction mixture was diluted with EtOAc and washed with water (4x). The organic layer was dried (MgSO4) and the solvents were removed under reduced pressure. The residue was purified by flash chromatography (silica, DCM/MeOH) to give the title compound (59) as a yellow oil. HPLC, Rt: 2.4 min (purity: 99.8percent). LC/MS, M+(ESI): 473.9, M-(ESI): 472.1.

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31321-68-3,(R)-Piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

S-127 (200 mg) was converted to S-128 using B0C2O in the presence of NaOH in dioxane and H2O. The reaction was stirred at room temperature for 12 hours. After purification, 400 mg of S-128 was obtained., 31321-68-3

As the paragraph descriping shows that 31321-68-3 is playing an increasingly important role.

Reference£º
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (207 pag.)WO2019/136244; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To solution of compound 3 (1 equiv) in 20 ml of ACN,NaI (1.2 equiv) was added and the mixture was refluxed for 30 min and cooled to room temperature. Subsequently,K2CO3 (1.2 equiv) and appropriate phenylpiperazine derivative(1.2 equiv) were added. Then the mixture was refluxedfor 4h. At the end of this period, the mixture was evaporatedto dryness then the product was solidified with ice-cold waterand crystallized from appropriate solvent., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kilic, Burcu; Erdogan, Merve; Gulcan, Hayrettin O.; Aksakal, Fatma; Oruklu, Nihan; Bagriacik, Emin U.; Dogruer, Deniz S.; Medicinal Chemistry; vol. 15; 1; (2019); p. 59 – 76;,
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474711-89-2,474711-89-2, Piperazine-1-carboxamide hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EDAC.HCl (44 mg, 0.229 mmol) was added to a stirred solution of compound 82 (55 mg, 0.176 mmol), compound 83 (35 mg, 0.211 mmol), HOAt (31 mg, 0.229 mmol), and NMM (48 muL, 0.440 mmol) in CH2Cl2 (0.70 mL) at room temp. After 24 hr the reaction mixture was conc. and the residue was partitioned between EtOAc and 5% KHSO4. The organic phase was isolated, washed with sat. NaHCO3, sat. NaCl, dried (MgSO4), and conc. to give 43 mg (58%) of compound 84.

As the paragraph descriping shows that 474711-89-2 is playing an increasingly important role.

Reference£º
Patent; Bisacchi, Gregory S.; Sutton, James C.; Slusarchyk, William A.; Treuner, Uwe; Zhao, Guohua; US2004/147502; (2004); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

30459-17-7, Example 88 [00202] To a solution of Compound 88a (25 mg, 0.077 mmol) in DMF (0.6 mL) was added DIEA (0.041 mL, 0.23 mmol) followed by l-(4-(trifluoromethyl)phenyl)piperazine (36 mg, 0.16 mmol). To the stirring solution was added BOP reagent (41 mg, 0.093 mmol) then the reaction mixture heated at 80 C for 2 h then 100 C for 2 h. The reaction mixture was allowed to cool to rt, diluted with ACN then purified by prep HPLC (RT = 1 1.0 min using Axia Luna 5u C 18 30x100mm column with flow rate of 40 mL/min over 10 min period. Solvent A = 10/90/0.1% ACN/H20/TFA to solvent B = 90/10/0.1 , 20 to 100% B). The fractions containing product were evaporated to remove the ACN, then lyophilized. This material was chromatographed on silica gel eluting with 0 to 20% EtOAc/DCM to give Example 88 (3.0 mg, 7% yield) as a yellow solid. LCMS = 2.37 min using analytical method (B), 536.2 (M+H). NMR (400MHz, CDC13) delta 8.42 (d, J=8.8 Hz, IH), 8.21 (d, J=1.3 Hz, IH), 7.86 (dd, J=8.8, 1.8 Hz, IH), 7.69 (d, J=7.3 Hz, 2H), 7.55 (d, J=8.5 Hz, 2H), 7.51 (t, J=7.4 Hz, 2H), 7.46 – 7.39 (m, IH), 7.00 (d, J=8.5 Hz, 2H), 3.98 – 3.90 (m, 4H), 3.48 – 3.42 (m, 4H). EL IC50 494nM.

30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; TORA, George O.; FINLAY, Heather; HU, Carol Hui; JIANG, Ji; JOHNSON, James A.; KIM, Soong-Hoon; LLOYD, John; PARKHURST, Brandon; PI, Zulan; QIAO, Jennifer X.; WANG, Tammy C.; WO2014/42939; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics