Category: piperazines

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of substituted piperazine (10 mmol), 4-uoroben-zaldehyde (10 mmol) and K2CO3 (2 mmol) were reuxed at130 C in DMF for 15-24 h. Thereafter, the reaction mixture waspoured into ice cold water and the precipitate that appeared wasltered and dried to accomplish formyl derivatives (14-25) in ayield of 80-90%

13754-38-6, 13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Mishra, Chandra Bhushan; Manral, Apra; Kumari, Shikha; Saini, Vikas; Tiwari, Manisha; Bioorganic and Medicinal Chemistry; vol. 24; 16; (2016); p. 3829 – 3841;,
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112257-12-2, tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step G. 6-Chloro-12-(2-oxo-2-piperazin-1-ylethoxy)-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene bis(trifluoroacetate) 6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-ol (100 mg, 0.30 mmol), potassium carbonate (102 mg, 0.74 mmol), and tert-butyl 4-(bromoacetyl)piperazine-1-carboxylate (181 mg, 0.59 mmol) were stirred in N,N-dimethylformamide (2 mL) for 16 hours at 70 C. Purification by preparative LCMS (pH 2) and treatment with 1:1 trifluoroacetic acid and methylene chloride followed by evaporation gave the desired compound (33 mg, 19%). LCMS for C24H26ClN6O2 (M+H)+: m/z=465.2.

112257-12-2, 112257-12-2 tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate 15829155, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; INCYTE CORPORATION; US2009/286778; (2009); A1;,
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120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: To a 50 mL screw-cap round bottom flask equipped with a stir bar were added 1 -bromo-2,4-dichlorobenzene (2.0 g, 8.85 mmol), 2-methyl-piperazine-l -carboxylic acid tert-butyl ester (2.13 g, 10.6 mmol), palladium acetate (0.199 g, 0.89 mmol), 2-di-tert- butylphosphenylbiphenyl (0.264 g, 0.48mmol), sodium tert-butoxide (1.02 g, 10.6 mmol) and toluene (20 mL). The reaction flask was sealed and the reaction mixture was heated at 1 10 C overnight. The reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated in vacuo. The residue was dissolved in ethyl acetate and washed with water (2 x 50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified on silica gel using hexanes.diethyl ether = 95:5 to 90:10 in a gradient fashion, to give the desired product as yellow oil (858 mg, 28 %). 1H NMR (300 MHz, CDCl3): delta 7.28 (d, IH), 7.11 (dd, IH)5 6.85 (d, IH)5 4.28 (bs, IH), 3.89 (d, IH), 3.22 (m, IH), 3.08 (m, 2H), 2.67 (m, 2H), 1.43 (s, 9H), 1.34 (d, 3H).

120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
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13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 18 To a solution of Compound A (0.25 g, 0.60 mmol) in acetonitrile (6 mL) at room temperature were added diisopropylethylamine (0.42 mL, 2.4 mmol) and 1-acetylpiperazine (0.116 g, 0.90 mmol) and the reaction mixture was heated to 80 C. On heating, the reaction mixture became clear and after 15 min commencement of precipitation of solid was observed. Heating was continued for 3 hr and then the reaction mixture was cooled. The solid obtained was collected by filtration, washed with acetonitrile and dried under vacuum. LC/MS: (M+H)+: 503. An NMR spectrum is provided in FIG. 18.Yield: 0.26 g (85%)., 13889-98-0

13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.,5271-27-2

(S)-1 -methyl-3-phenylpiperazine.(+)Anicyphos salt 100 g of (R,S)-1-methyl-3-phenylpiperazine (1 ) (567 mmole) and 154.5 g of (+)- Anicyphos (571 mmole) were dissolved in 250 ml of water by heating the mixture to reflux. After cooling down to room temperature a seed crystal was added. After two hours, the white crystals formed were collected by filtration and dried in a vacuum oven at 40 0C for 21 hours. This provided 121 g (48 percent) with an ee of 85.5percent. The crystals were dissolved in water (119 ml) at reflux temperature. After cooling down the crystallization started. After one hour the crystals were collected by filtration and dried in a vacuum oven at 40 0C. The yield of the crystals of (S)-1-methyl-3- phenylpiperazine.Anicyphos salt was 105.8 g (42 percent, ee 99.0percent). The ee was determined by HPLC analysis: Chiralcel OD 250*4.6mmlD (Daicel), 5 percent iso-propylalcohol in hexane, flow rate 1.0 ml.min”1, UV-detector, column temperature 40 0C, retention times 5.6 min, 6.3 min.

As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; WO2008/125578; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630125-91-6,4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.,630125-91-6

3-((6-chloropyrimidin-4-yl)oxy)-N-(4-((4-ethylpiperazin-l-yl)methyl)-3- (trifluoromethyl)phenyl)-4-methylbenzamide: To a solution of 3-((6-chloropyrimidin-4- yl)oxy)-4-methylbenzoic acid (210 mg, 0.8 mmol), HATU (365 mg, 0.96 mmol), DMAP (117 mg, 0.96 mmol) and iPr2NEt (350uL, 2.0 mmol) in CH2C12 (4 mL) was added 4-((4- ethylpiperazin-l-yl)methyl)-3-(trifluoromethyl)aniline (230 mg, 0.8 mmol) and the resulting mixture was stirred at room temperature for 24 hours. The solution was filtered to remove solids, concentrated and purified column chromatography to yield 360 mg (84%) of product as a pale yellow oil. MS (ESI) m/z +.

630125-91-6 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 59134564, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; TREON, Steven, P.; BUHRLAGE, Sara, Jean; GRAY, Nathanael; TAN, Li; YANG, Guang; WO2015/89479; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.

Step 1 A solution of 4-fluoro-2-nitrobenzaldehyde (0.20 g, 1.2 mmol) in DMSO (3.5 mL) was added with 1-methanesulfonylpiperazine (0.71 g, 3.5 mmol), followed by stirring at 100 C for 1 hour. The reaction mixture was added with water and the organic layer was extractd with hexane/ethyl acetate (4/1) to remove impurities. The aqueous layer was extracted with ethyl acetate and the obtained organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure to obtain 4-(4-methanesulfonylpiperazin-1-yl)-2-nitrobenzaldehyde (0.36 g, 96%). 1H-NMR (270 MHz, DMSO-d6) delta 2.92 (s, 3H), 3.23 (t, J = 5.1 Hz, 1H), 3.63 (t, J = 5.1 Hz, 1H), 7.31 (dt, J = 8.9 Hz, 2.4 Hz, 1H), 7.49 (d, J = 2.4 Hz, 1H), 7.85 (d, J = 8.9 Hz, 1H), 9.86 (s, 1H). APCI-MS (m/z); 314 [M+H]+, 55276-43-2

The synthetic route of 55276-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1847532; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5317-33-9, Di-tert-butyl azodicarboxylate (0.478 g, 2.08 mmol) was added portionwise to a mixture of 4-chloro-7-hydroxy-6-methoxyquinazoline (0.350 g, 1.66 mmol), 3-(4-methyl-piperazin-1-yl)-propan-1-ol (Intermediate 9, 0.276 g, 1.74 mmol), and triphenylphosphine (0.544 g, 2.08 mmol) in dichloromethane (20 mL) at r.t.. If necessary, further alcohol was added. After stirring for 2 h, the solution was concentrated to 10 mL, mounted on silica and chromatographed (gradient, dichloromethane to dichloromethane : methanol = 3:2 within 1 h) to obtain 4-chloro-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline (brownish solid, 0.431 g, 1.23 mmol, 74 %). LC/ESI-MS: m/z = 351 [M(35Cl) +H]+; Rt = 1.88 min. Cf. also WO 04/043472, page 32.

As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.

Reference£º
Patent; 4SC AG; EP1674466; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-85-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84477-85-0,Benzyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

3-Methyl-l-piperazinecarboxylic acid, phenylmethyl ester (380 mg), the product from example 13 part (a) (400 mg) and MgSO4 were stirred in THF (30 ml) for 20 h. Sodium triacetoxy borohydride (510 mg) was added and stirred for 2 h. The mixture was quenched with water, extracted with EtOAc, washed with water and brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by chromatography on silica with 20%EtOAc/isohexane as eluent to yield the sub-title compound (500 mg).MS: APCI (+ve): 490 (M+l) 1H NMR (DMSO-d6) 6 7.34 (m, 6H), 7.23 (dd, IH), 6.88 (d, IH), 5.08 (dd, 2H), 4.68 (s, 2H),3.80 (m, IH), 3.66 (m, IH), 3.34 (m, 2H), 3.21 – 3.08 (m, IH), 3.05 – 2.81 (m, IH), 2.65 (m,IH), 2.46 (m, IH), 2.14 (m, IH), 1.41 (s, 9H), 1.03 (d, 3H)

84477-85-0 Benzyl 3-methylpiperazine-1-carboxylate 10421542, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/56752; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-chlorophenyl isothiocyanate (8.0 g, 47.17 mmol) in dichloromethane (250 mL) was added dropwise over 30 minutes to an ice cooled solution of 2-methylpiperazine (9.45 g, 94.33 mmol) in dichloromethane (250 mL). Once the addition was complete, the reaction was stirred at room temperature for an hour. The reaction was then washed with water (3¡Á), dried over MgSO4 and concentrated under reduced pressure, to give the title compound as a white solid, 11.8 g. 1H NMR (400 MHz, CDCl3): delta 1.08 (d, 3H), 2.70 (m, 1H), 2.88 (m, 2H), 3.02 (m, 2H), 4.43 (m, 2H), 7.10 (m, 2H), 7.29 (m, 2H). LCMS: m/z ES+270.1 [MH]+

109-07-9, The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US2005/154024; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics