Category: piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8

To a solution of 4 (0.5g, 2.5mmol) in THF was added Et3N (0.52mL, 3.76mmol) and N-(2-aminoethyl)acetamide (0.25g, 2.5mmol). The mixture was stirred at 30C for 1h, cooled to room temperature and concentrated in vacuo. The residue was suspended in water and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated by evaporation in vacuo. Solid was recrystallized from toluene to afford 12. Recrystallized from acetonitrile as a white solid (55% yield).

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference£º
Article; Bolteau, Raphael; Caignard, Daniel H.; Delagrange, Philippe; Descamps, Florian; Ettaoussi, Mohamed; Melnyk, Patricia; Yous, Said; European Journal of Medicinal Chemistry; vol. 189; (2020);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.181955-79-3,1,4-Di-Boc-piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

1,4-Di(tert-butoxycarbonyl)piperazine-2-carboxylic acid (14 g, 42.37 mmol) was sequentially added to a dry reaction flask.Potassium carbonate (11.7 g, 84.7 mmol),Acetone (200mL),Methyl iodide (5.3 mL, 85 mmol),Stir at room temperature for 12 h.Filtration, the filtrate was evaporated under reduced pressure, and the residue was diluted with EA (200 mL) and water (200 mL), and the organic phase was washed with saturated brine.Dry, dry anhydrous sodium sulfate, concentrated under reduced pressure,The title compound was obtained as a white solid (13.55 g, 93%)., 181955-79-3

The synthetic route of 181955-79-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Xinchang; Ren Qingyun; Yan Guanghua; S ¡¤geerdeman; Zhang Yingjun; (200 pag.)CN109678859; (2019); A;,
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5747-48-8,5747-48-8, 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2: l-(4-Dibenzo[b,f] [l,4]thiazepin-ll-yl-piperazin-l-yl)-propan-l-oneA suspension of propionic acid (1 mmol) and 1-hydroxybenzotriazole (1 mmol) in dichloromethane (4 rnL) is treated with l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.1 mmol) and triethylamine (1.2 mmol). A solution of PDBTZ (1 mmol) in dichloromethane (4 mL) is added and the mixture is stirred at ambient temperature for 20 hours. The reaction mixture is washed (water, brine), dried (sodium sulfate), and evaporated. The crude material is purified by flash chromatography to provide the title compound.

As the paragraph descriping shows that 5747-48-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2008/79838; (2008); A1;,
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129722-25-4, 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

129722-25-4, To a solution of dehydro-Aripiprazole (1.5 g, 3.36 mmol)2-methyltetrahydroffiran (30 mE) was added silver carbonate (1.853 g, 6.72 mmol) and hexyl iodomethyl carbonate (2.021 g, 7.05 mmol) in 2-methyltetrahydrofuran (4 mE) at room temperature. The reaction was stirred for 4.5 days. The reaction was quenched with H20 (30 mE) and filtered through celite. The reaction was extracted with ethyl acetate (3×20 mE), washed with brine (20 mE), dried over MgSO4 and concentrated. The product was purified by column chromatography on silica eluting with 1:1 ethyl acetate to dichloromethane to 2% MeOR in 1:1 ethyl acetate to dichloromethane to provide Compound-1240 (1.08 g) as a yellow oil.?H-NMR (300 MHz, CDC13) oe 7.96 (1H, d), 7.60 (1H, d),7.21 (1H, m), 7.14 (2H, m), 7.03 (1H, dd), 6.94 (1H, m), 6.81(1H, d), 6.26 (2H, s), 4.18 (2H, m), 4.12 (2H, t), 3.09 (4H, m),2.68 (4H, m), 2.53 (2H, m), 1.91 (2H, m), 1.78 (2H, m), 1.63(2H, m), 1.28 (6H, m), 0.86 (3H, t). [M+H]=604.2

The synthetic route of 129722-25-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Alkermes Pharma Ireland Limited; Blumberg, Laura Cook; Remenar, Julius F.; Almarsson, Orn; Zeidan, Tarek A.; US9102618; (2015); B2;,
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197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,197638-83-8

Compound 23 was synthesized as show n Scheme 4.

The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; COMBS, Colin; MULLER, Gerhard; DAMEN, Eddy; NAGAMOTO-COMBS, Kumi; (73 pag.)WO2017/100703; (2017); A1;,
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1403898-64-5, (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred solution of 113 7-bromo-4,6-dichloro-8-fluoro-3-nitroquinoline (2 g, 5.88 mmol) and 180 tert-butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (1.355 g, 5.88 mmol) in 142 MeCN (30 mL) was treated with 56 DIPEA (1.025 mL, 5.88 mmol) and the reaction mixture stirred at 80 C. for 75 min. The reaction mixture was concentrated in vacuo and purified by flash silica chromatography (0 to 40% 57 EtOAc in 58 heptane) to give 444 tert-butyl (2R,5R)-4-(7-bromo-6-chloro-8-fluoro-3-nitroquinolin-4-yl)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (2.6 g, 83%) as a yellow solid; m/z: ES+ [M+H]+ 533/535.

1403898-64-5, The synthetic route of 1403898-64-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

EXAMPLE 2 1-Methyl-4-[N-(3,4,5-trimethoxyphenyl)-carbamoyl]piperazine (hydrochloride) A solution of 10 g (0.061 mole) 1-methyl-4-chloroformyl-piperazine in 100 ml dry methylene chloride is added to a solution of 11.2 g (0.061 mole) 3,4,5-trimethoxy-aniline in a 100 ml methylenechloride. After stirring at ambient temperature for 24 hours, the solvent is evaporated off in vacuo; the residue is dissolved in the minimum of ethanol and then the crude hydrochloride precipated by the addition of diethyl ether, and dried. Purification by recrystallisation from an acetone 3-ethanol 1 mixture gives the pure product (9.4 g; 44% yield) which melts at 184-86 C., 39539-66-7

As the paragraph descriping shows that 39539-66-7 is playing an increasingly important role.

Reference£º
Patent; Metabio-Joullie; US4252804; (1981); A;,
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163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid (100mg, 0.254 mmol) in 2 mL of D F, was added HBTU (144 mg, 0.381 mmol) and DI PEA (0.177 mL, 1 .016 mmol). The reaction mixture was stirred at rt for 30 min, (R)-3-methyl-piperazine- 1 -carboxylic acid tert-butyl ester (76 mg, 0.381 mmol) was added and the resulting reaction mixture stirred for a further 2h at rt. The reaction was quenched with H20, and extracted with CH2CI2. The organic layer was washed with brine, dried over MgS04, filtered and evaporated under vacuum. The residue was dissolved in 3ml of CH2CI2 and TFA ( 1 ml) was added. The reaction mixture was stirred at ambient temperature for 2h. After this period of time, the mixture was concentrated and purified by preparative reverse phase Gilson H PLC and subsequent neutralization of the combined fractions over PL-HC03 MP gave the title compound (29 mg, 26% yield) as a white powder. 1H-N R (400 MHz, DMSO-d8, 298 K): delta ppm 1 .23 (d, 3 H) 2.55-3.2 (m, 7 H) 3.91 (s, 3H) 6.95 (d, 1 H) 7.62 (d, 1 H) 7.72 (t, 1 H) 7.81 (s, 1 H) 7.98 (d, 1 H) 8.1 1 (d, 1 H) 8.22 (d, 2 H) 8.38 (d, 1 H) 8.59 (s, 1 H) 9.38 (s, 1 H). MS: 440.1 [M-H ] Rt(2”= 0.89 min., 163765-44-4

163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOeGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; WO2013/88404; (2013); A1;,
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479353-63-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479353-63-4,1-Boc-4-(4-Carboxybenzyl)piperazine,as a common compound, the synthetic route is as follows.

Step 4) Preparation of tert-butyl 4-(4-(2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)benzyl)piperazine-1-carboxylate [0365]2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-4-amine (250 mg, 1.02 mmol), 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)benzoic acid (360 mg, 1.12 mmol), and HATU (583 mg, 1.53 mmol) in DMF (10 mL) was added N,N?-diisopropylethylamine (0.5 mL, 3.06 mmol). The mixture was stirred 18 h at room temperature, diluted with water (40 mL), and extracted with CH2Cl2 (10 mL¡Á3). The combined organics layers were washed with brine, dried and concentrated. The residue was purified by silica gel column chromatography (17% to 50% Ethyl acetate in petroleum ether) to obtain tert-butyl 4-(4-(2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)benzyl)piperazine-1-carboxylate as a yellow solid (270 mg, 48% yield). MS (ESI) calcd for C29H31ClN6O3: 546. found: 547[M+H].

The synthetic route of 479353-63-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dai, Han; Riera, Thomas V.; Stein, Ross L.; Szczepankiewicz, Bruce; US2013/102009; (2013); A1;,
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5294-61-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5294-61-1,N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

Part C. Synthesis of N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-4phenylbutanoyl) piperazinyl]acetamide (7) To a solution of 5 in 10ml DMF (0.263g, 1.07mmol) was added compound 6 (0.25g, 1.39mmol), HBTU (0.526g, 1.4mmol), triethylamine (0.108g, 1.07mmol) and DMAP (0.030g, 0.25mmol). The solution was allowed to stir at room temperature for 48h. The solution was concentrated in vacuo. The residue was taken into EtOAc (100ml) and washed with saturated sodium bicarbonate (3*50ml). The organic layer was dried over sodium sulfate and concentrated in vacuo. The residue was purified using prep. TLC (10:1 DCM/MeOH) to afford compound 7: Mass spectrum (M+1)=410.44.

The synthetic route of 5294-61-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Blackburn, Brent K.; Zablocki, Jeff; Elzein, Elfatih; Nudelman, Grigory; US2001/44541; (2001); A1;,
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