Category: piperazines

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound, is a common compound. In a patnet, author is Baptista-Hon, Daniel T., once mentioned the new application about 16153-81-4, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Activation of mu-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives

Background and Purpose A fluorinated derivative (2F-MT-45) of the synthetic mu-opioid receptor agonist MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) was recently identified in a seized illicit tablet. While MT-45 is a Class A drug, banned in a number of countries, nothing is known about the pharmacology of 2F-MT-45. This study compares the pharmacology of MT-45, its fluorinated derivatives and two of its metabolites. Experimental Approach We used a beta-arrestin2 recruitment assay in CHO cells stably expressing mu receptors to quantify the apparent potencies and efficacies of known (MT-45, morphine, fentanyl and DAMGO) and potential agonists. In addition, the GloSensor protein was transiently expressed to quantify changes in cAMP levels. We measured Ca2+ to investigate whether MT-45 and its metabolites have effects on GluN1/N2A NMDA receptors stably expressed in Ltk- cells. Key Results The fluorinated MT-45 derivatives have higher apparent potencies (2F-MT-45: 42 nM) than MT-45 (1.3 mu M) for inhibition of cAMP accumulation and beta-arrestin2 recruitment (2F-MT-45: 196 nM; MT-45: 23.1 mu M). While MT-45 and 2F-MT-45 are poor recruiters of beta-arrestin2, they have similar efficacies for reducing cAMP levels as DAMGO. Two MT-45 metabolites displayed negligible potencies as mu receptor agonists, but one, 1,2-diphenylethylpiperazine, inhibited the NMDA receptor with an IC50 of 29 mu M. Conclusion and Implications Fluorinated derivatives of MT-45 are potent mu receptor agonists and this may pose a danger to illicit opioid users. Inhibition of NMDA receptors by a metabolite of MT-45 may contribute to the reported dissociative effects.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 16153-81-4. The above is the message from the blog manager. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Wang, Chuanfeng, once mentioned the application of 5625-37-6, Formula: C8H18N2O6S2, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is C8H18N2O6S2, molecular weight is 302.37, MDL number is MFCD00006159, category is piperazines. Now introduce a scientific discovery about this category.

In-situ synthesis of PA/PVDF composite hollow fiber membranes with an outer selective structure for efficient fractionation of low-molecular-weight dyes-salts

A polyamide/poly(vinylidene fluoride) composite hollow fiber membrane (HFM) was designed by in situ interfacial polymerization (IP) during the fiber spinning process. Using a piperazine aqueous solution as the bore fluid and a dual-bath coagulation, the PA outer layer was formed via IP of the PIP in the bore fluid and TMC in the second reactive bath during phase inversion process. Chemical structure, membrane morphology and surface property were characterized by using Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscope (XPS), scanning electron microscope (SEM), and zeta potential. The effects of several parameters involved in the membrane fabrication (e.g., piperazine concentration, bore fluid flow rate, residence time and heat treatment temperature) on the morphology and performance of resultant composite HFMs were investigated. The composite HFM showed a performance that is comparable favorably with conventional nanofiltration membranes in terms of showed water permeability (10.2 L/m(2).h.bar), high rejection to dyes (i.e., 100% for CR and EBT, 99.99% for RhB and MB, 98.3% for MO) and low salt rejections (NaCl 6.2%). Moreover, the newly developed composite HFM showed good stability and flux recovery with simple water rinsing for treatment of simulated textile wastewater. This work is expected to provide a new approach to designing composite HFMs for the treatment and reuse of textile wastewater.

If you are interested in 5625-37-6, you can contact me at any time and look forward to more communication. Formula: C8H18N2O6S2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 111974-74-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, SMILES is [H]Cl.[H]Cl.C12=CC=CC=C1N=C(N3CCNCC3)C4=CC=CC=C4S2, belongs to piperazines compound. In a article, author is Esmaeili, Arash, introduce new discover of the category.

Modeling and validation of carbon dioxide absorption in aqueous solution of piperazine plus methyldiethanolamine by PC-SAFT and E-NRTL models in a packed bed pilot plant: Study of kinetics and thermodynamics

A pilot plant with a closed cycle of the absorption/desorption process has been taken into account for the simulation of carbon dioxide (CO2) capture by piperazine (PZ) + methyldiethanolamine (MDEA) solution using Aspen Plus rate-based model with all design and operational parameters such as the hydraulic specifications of absorber and stripper as well as inlet flue gas conditions which are present in a commercial gas-fired burner for heating houses. Metal FLEXIPAC 250Y has been considered as the packing type to apply the model to the proposed correlations on Aspen Plus for calculation of flooding and pressure drop. In order to simulate the process, a new property package has been developed by electrolyte non-random two-liquid (E-NRTL) model and perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state which are used for the calculation of activity and fugacity coefficients respectively. The model has been compared with some experimental data e.g. CO2 absorption efficiency and CO2 loading and demonstrated good agreement with them. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Reference of 111974-74-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 111974-74-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, belongs to piperazines compound. In a document, author is Shi, S. K., introduce the new discover, Recommanded Product: 300543-56-0.

A Keggin-Type Tungstovanadate-Based Hybrid Compound: Synthesis, Crystal Structure, and Electrocatalytic Oxidation of Ascorbic Acid

A new V-centered Keggin polyoxometalate-based inorganic-organic hybrid (HPpz)(3)[VW12O40] (I) (Ppz = piperazine) has been hydrothermal synthesized and characterized by IR spectroscopy, UV-Vis spectroscopy, elemental analysis and single-crystal X-ray diffraction (CIF file CCDC no. 1835683). Compound I belongs to the rhombohedral space group R (3) over barc and displays a three-dimensional supramolecular structure. The band gap energy value calculated for compound I was observed to be 1.30 eV using UV-Vis-NIR absorption spectrum. Furthermore, electrocatalytic performance of I has also been investigated in details.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 300543-56-0. Recommanded Product: 300543-56-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, SMILES is Cl.Cl.CN1CCN(CC1)CC2=CC=C(C(=O)O)C=C2, in an article , author is Ju, Huiyeong, once mentioned of 106261-49-8, Formula: C13H20Cl2N2O2.

Temperature-Dependent Supramolecular Isomeric Zn(II)-Metal-Organic Frameworks and Their Guest Exchange

A pair of three-dimensional metal-organic framework supramolecular isomers (1a and 2a) prepared from the solvothermal reactions of Zn(NO3)(2)center dot 4H(2)O, 1,4-bis(4-pyridyl)piperazine (bpp), and 4,4′-oxybis(benzoic acid) (H(2)obc) in different temperatures was structurally elucidated, and a series of guest exchanges on these isomers were performed without the loss of single crystallinity. At 110 and 130 degrees C in DMF/H2O, an 8-fold [4 + 4] interpenetrated coordination polymer {[Zn(bpp)(obc)]center dot 3H(2)O}(n) (1a) with sra topology and a self-penetrated coordination polymer {[Zn-3(bpp)(3)(obc)(3)]center dot 2DMF center dot 4H(2)O}(n) (2a) with a new topology were isolated, respectively. In the guest-exchange experiments, water molecules in isomer 1a were displaced by acetone and ethylene glycol molecules, while dimethylformamide molecules in isomer 2a were replaced by acetone and ethylene glycol as well as bulkier diethylene glycol due to its larger void. Photoluminescence properties of two isomers and their guest-exchanged products were also measured and discussed.

Interested yet? Read on for other articles about 106261-49-8, you can contact me at any time and look forward to more communication. Formula: C13H20Cl2N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Ang, Micah Belle Marie Yap, once mentioned the application of 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, molecular formula is C17H19ClN2, molecular weight is 286.8, MDL number is MFCD11519277, category is piperazines. Now introduce a scientific discovery about this category, Recommanded Product: (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine.

Merits of using cellulose triacetate as a substrate in producing thin-film composite nanofiltration polyamide membranes with ultra-high performance

Choosing the property of the supporting membrane is crucial in preparing high performing nanofiltration membranes through interfacial polymerization. In this study, an oxygen rich membrane – cellulose triacetate (CTA) – was used to fabricate the support membrane. Polyamide was deposited onto the CTA support using interfacial polymerization of piperazine (PIP) and trimesoyl chloride (TMC). The concentration of the monomers was optimized. Furthermore, the polyamide layer prepared on CTA support exhibited higher separation efficiency for sodium sulfates and dyes compared to using traditional polysulfone (PSf) support. The oxygen groups of CTA facilitate better adsorption of amines on the surface; thus, using low concentration of PIP could still provide a defect-free polyamide layer. Utilizing the optimum condition, the polyamide/CTA membrane delivered a high pure water flux (operating at 6 bar) of 179.5 L/m(2)h with the following rejections: Na2SO4 = 98.4%; MgSO4 = 60.3%; MgCl2 = 15.0%; NaCl = 3.7%; Rose Bengal = 95.5%; Brilliant Blue R = 99.9%; Amido Black 10B = 90.6%; Orange G = 67.3%. Moreover, the polyamide/CTA membrane had excellent stability at a wide range operating conditions. (C) 2020 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, Name: 4-(4-Methylpiperazin-1-yl)phenylamine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound. In a document, author is Wang, Liyan.

Piperazine-tuned benzimidazole-based multifunctional fluorescent sensor for the detection of mercury (II) ion and pH

An organic chemical sensor (P) based on benzimidazole for detecting Hg2+ and pH in semi-aqueous media was described. P has a very high sensitivity and selectivity for Hg2+ in semi-aqueous media, and P monitoring Hg2+ with excellent anti-interference performance. Interestingly, H+ can remove Hg(2+ )from the [P-Hg2+] complex and restore the spectral signal of P. The sigmoidal fitting of pH-dependent fluorescence intensity provided an apparent pK(a) value of 6.51. This research may enrich the field of multi-functional chemosensors in natural products.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 16153-81-4, in my other articles. Name: 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Murugesh, V, once mentioned the application of 16153-81-4, Recommanded Product: 4-(4-Methylpiperazin-1-yl)phenylamine, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, molecular weight is 191.27, MDL number is MFCD00172703, category is piperazines. Now introduce a scientific discovery about this category.

Ruthenium Catalyzed Regioselective beta-C(sp(3))-H Functionalization of N-Alkyl-N ‘-p-nitrophenyl Substituted Piperazines using Aldehydes as Alkylating Agents

Herein, we disclose a ruthenium-catalyzed regioselective beta-C(sp(3))-H bond functionalization on the piperazine core using aldehydes as alkylating agents. The present transformation appears to go through the dehydrogenation of the piperazine to propagate to enamine in situ, followed by nucleophilic addition to the aldehyde and hydrogenation to result in the regioselective beta-C(sp(3))-H alkylation. A variety of aromatic, heteroaromatic, aliphatic aldehydes were employed for the C-3 alkylation of N-alkyl-N ‘-p-nitrophenyl substituted piperazines.

If you are interested in 16153-81-4, you can contact me at any time and look forward to more communication. Recommanded Product: 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, SMILES is O=S(CCN1CCN(CCS(=O)(O)=O)CC1)(O)=O, belongs to piperazines compound. In a document, author is Chen, Yu-Hao, introduce the new discover, Product Details of 5625-37-6.

Synthesis and characterization of low-temperature polyamide 6 (PA6) copolyamides used as hot melt adhesives and derived from the comonomer of novel aliphatic diamine bis(2-aminoethyl) adipamide and adipic acid

A novel aliphatic PA6 copolyamide (PA6(BAEA/AA))-based hot melt adhesive was synthesized from epsilon-capmlactam with the organic salt of bis(2-aminoethyl) adipamide (BAEA) and adipic acid (AA), with BAEA/AA content ranges from 5 to 15 mol%. The chemical structures of BAEA diamine, BAEA/AA organic salt, PA6(BAEA/AA) copolyamides, and neat PA6 were obtained using FT-IR and 1H NMR. Determined by the comonomer compositions, the relative viscosity (eta(r)) and molecular weight (M-w) of the PA6(BAEA/AA) were from 2.29 to 2.74 and from 14,530 to 19,500 g mol(-1) , respectively. Adding the BAEA/AA structure strongly affected the crystallization behavior and thermal properties of the copolyamides. DSC results revealed that the melting temperature (T-m) of the copolyamides declined as the mole% of BAEA/AA increased in the range 5-15 mol%, and a TGA test revealed that the thermal decomposition of the copolyamides was similar to that of neat PA6. The T-m , glass transition temperature (T-g), and thermal stability (T-d5%) with a BAEA/AA salt content of 10 mol% had the lowest values of 162.2, 40.3, 354.6 degrees C, respectively, while the fusion enthalpy (Delta H-m) was lowest at 15 mol% (21.2 Jg(-1)). Most remarkably, PA6(BAEA/AA) exhibits much better mechanical properties such as tensile strength (33.6-52.6 MPa) and elongation at breakage (114.7-584.5%), than the PA6 homopolymer. The peel strength of PA6 reached a maximum value of 53.4 N cm(-1) at 10 mol% of BAEA/AA salt, and this value is better than those of commercial hot melt adhesives.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5625-37-6 is helpful to your research. Product Details of 5625-37-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, Computed Properties of C11H15BrN2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Ang, Micah Belle Marie Yap.

Assessing the Performance of Thin-Film Nanofiltration Membranes with Embedded Montmorillonites

In this study, the basal spacing of montmorillonite (MMT) was modified through ion exchange. Two kinds of MMT were used: sodium-modified MMT (Na-MMT) and organo-modified MMT (O-MMT). These two particles were incorporated separately into the thin-film nanocomposite polyamide membrane through the interfacial polymerization of piperazine and trimesoyl chloride in n-hexane. The membrane with O-MMT (TFNO-MMT) has a more hydrophilic surface compared to that of membrane with Na-MMT (TFNNa-MMT). When various types of MMT were dispersed in the n-hexane solution with trimesoyl chloride (TMC), O-MMT was well-dispersed than Na-MMT. The poor dispersion of Na-MMT in n-hexane led to the aggregation of Na-MMT on the surface of TFNNa-MMT. TFNO-MMT displayed a uniform distribution of O-MMT on the surface, because O-MMT was well-dispersed in n-hexane. In comparison with the pristine and TFNNa-MMT membranes, TFNO-MMT delivered the highest pure water flux of 53.15 +/- 3.30 L center dot m(-2)center dot h(-1) at 6 bar, while its salt rejection for divalent ions remained at 95%-99%. Furthermore, it had stable performance in wide operating condition, and it exhibited a magnificent antifouling property. Therefore, a suitable type of MMT could lead to high separation efficiency.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 130307-08-3, in my other articles. Computed Properties of C11H15BrN2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics