Category: piperazines

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O. In an article, author is Bitencourt, Monalisa,once mentioned of 5294-61-1, Recommanded Product: N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Buclizine crystal forms: First Structural Determinations, counter-ion stoichiometry, hydration, and physicochemical properties of pharmaceutical relevance

Buclizine (BCZ) is a chiral synthetic piperazine derivative which has antihistaminic, anti-muscarinic and antiemetic properties, and has been reintroduced as an appetite stimulant, especially for pediatric patients. Structural information about this drug, as well as other buclizine crystalline forms (solvates, salts and co-crystals) including the BCZ free-base (BCZ-FB), is non-existent. Here, we present for the first time the crystal structure of the monohydrochloride monohydrate salt of BCZ (BCZHCl center dot H2O), and of its anhydrous form, BCZHCl. Interestingly, BCZHCl center dot H2O was obtained by recrystallization from the raw material (BCZH(2)Cl(2)) in ethanol:water solution showing that BCZ anhydrous dihydrochloride salt changes easily to a monohydrochloride monohydrate salt modification, which raise concerns about formulation quality control. BCZHCl center dot H2O and BCZHCl crystallize in the orthorhombic space groups (Pna2(1) and Pca2(1)) belonging to the mm2 point group and are thus classified as non-centrosymmetric achiral structures (NA). Intuitively, we expect these salts to crystallize in a space group with a center of symmetry, since less than 5% of the known racemic compounds crystallize in the NA type. The crystal structures of BCZH(2)Cl(2) and BCZ-FB were not determined, but their existence was verified by other techniques (chloride ion analysis, PXRD, HPLC, FT-IR, DSC, TGA) and by comparison of the obtained results with those found for BCZHCl. Additionally, we have also performed an evaluation of the equilibrium solubility (at six different aqueous media) and the dissolution profile of the BCZHCl salt compared to the raw material and BCZ-FB. Different equilibrium solubility values were found comparing the three forms in acidic and neutral pH ranges and all of them were insoluble at pH > 7.0. Moreover, tablets prepared with BCZH(2)Cl(2), BCZHCl or BCZ-FB show significant differences in terms of dissolution profile.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C23H32N6O5S, belongs to piperazines compound. In a document, author is Villiou, Maria, introduce the new discover, Name: 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion

Hydrogels for wound management and tissue gluing applications have to adhere to tissues for a given time scale and then disappear, either by removal from the skin or by slow degradation for applications inside the body. Advanced wound management materials also envision the encapsulation of therapeutic drugs or cells to support the natural healing process. The design of hydrogels that can fulfill all of these properties with minimal chemical complexity, a stringent condition to favor transfer into a real medical device, is challenging. Herein, we present a hydrogel design with a moderate structural complexity that fulfills a number of relevant properties for wound dressing: it can form in situ and encapsulate cells, it can adhere to tissues, and it can be degraded on demand by light exposure under cytocompatible conditions. The hydrogels are based on starPEG macromers terminated with catechol groups as cross-linking units and contain intercalated photocleavable nitrobenzyl triazole groups. Hydrogels are formed under mild conditions (N-(2-hydroxyethyl)piperazine-N’-ethanesulfonic acid (HEPES) buffer with 9-18 mM sodium periodate as the oxidant) and are compatible with encapsulated cells. Upon light irradiation, the cleavage of the nitrobenzyl group mediates depolymerization, which enables the on-demand release of cells and debonding from tissues. The molecular design and obtained properties reported here are interesting for the development of advanced wound dressings and cell therapies and expand the range of functionality of current alternatives.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 139755-85-4. Name: 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, SMILES is Cl.Cl.CN1CCN(CC1)CC2=CC=C(C(=O)O)C=C2, in an article , author is Kettenmann, Sebastian Doniz, once mentioned of 106261-49-8, Name: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Copper(II) Complexes with Tetradentate Piperazine-Based Ligands: DNA Cleavage and Cytotoxicity

Five-coordinate Cu(II) complexes, [Cu(L-n)X]ClO4/PF6, where L-n = piperazine ligands bearing two pyridyl arms and X = ClO4- for L-n = L-1 (1-ClO4), L-2 (2-ClO4), L-3 (3-ClO4), and L-6 (6-ClO4) as well as [Cu(L-n)Cl]PF6 for L-n = L-1 (1-Cl), L-4 (4-Cl), and L-5 (5-Cl) have been synthesized and characterized by spectroscopic techniques. The molecular structures of the last two complexes were determined by X-ray crystallography. In aqueous acetonitrile solutions, molar conductivity measurements and UV-VIS spectrophotometric titrations of the complexes revealed the hydrolysis of the complexes to [Cu(L-n)(H2O)](2+) species. The biological activity of the Cu(II) complexes with respect to DNA cleavage and cytotoxicity was investigated. At micromolar concentration within 2 h and pH 7.4, DNA cleavage rate decreased in the order: 1-Cl approximate to 1-ClO4 > 3-ClO4 >= 2-ClO4 with cleavage enhancements of up to 23 million. Complexes 4-Cl, 5-Cl, and 6-ClO4 were inactive. In order to elucidate the cleavage mechanism, the cleavage of bis(4-nitrophenyl)phosphate (BNPP) and reactive oxygen species (ROS) quenching studies were conducted. The mechanistic pathway of DNA cleavage depends on the ligand’s skeleton: while an oxidative pathway was preferable for 1-Cl/1-ClO4, DNA cleavage by 2-ClO4 and 3-ClO4 predominantly proceeds via a hydrolytic mechanism. Complexes 1-ClO4, 3-ClO4, and 5-Cl were found to be cytotoxic against A2780 cells (IC50 30-40 mu M). In fibroblasts, the IC50 value was much higher for 3-ClO4 with no toxic effect.

Interested yet? Read on for other articles about 106261-49-8, you can contact me at any time and look forward to more communication. Name: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Jia, Zehui, once mentioned the application of 111974-74-4, SDS of cas: 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S, molecular weight is 368.3239, MDL number is MFCD08703302, category is piperazines. Now introduce a scientific discovery about this category.

Rapid degradation of ciprofloxacin over BiOCl: Insight into the molecular structure transformation and antibacterial activity elimination

Currently, the widespread usage of antibiotics brings great challenge to sustainable water environment due to the production of drug-resistant bacteria, the rapid and effective removal of antibiotics attracts more and more attention. Herein, a BiOCl microsphere prepared by a facile hydrolysis method via controlling the EG-H2O ratio was found to have unexpected photocatalytic activity for ciprofloxacin (CIP) removal. The photodegradation rate of CIP over optimal BiOCl-20 reached 92.9% in only 3 min of simulated sunlight irradiation, and the mineralization rate was 30.8% after 60 min reaction. The antibacterial tests of CIP solution under different irradiation minutes were evaluated using Escherichia coli (E. coli) as the model bacteria. The results indicated that CIP photodegradation intermediates had also certain antimicrobial potency, which could be eliminated almost completely after 3 min irradiation, although there still had some incompletely mineralized intermediates. In view of these results, the macroscopic degradation behavior of CIP over BiOCl-20 as well as the microscopic existence state and reaction behavior of the intermediates should be clarified. A ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed for determination of CIP and its intermediates. Ten primary intermediates were separated and identified, and their corresponding molecular structures were elucidated. Three main photodegradation pathways were deduced, and the correlation between molecular structure transformation and antibacterial activity of CIP was established. Because of the destruction of piperazine ring and defluorination of quinolone ring, the antibacterial activity of the treated CIP solution was weakened or even eliminated. Finally, a possible photodegradation mechanism was proposed, the OVs, O-center dot(2)-, h(+) and (OH)-O-center dot played significant roles in the CIP photodegradation. This work does have great perspective for BiOCl potential application in CIP wastewater treatment.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 1-Methylpiperazine109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a article, author is Cui, Qiufang, introduce new discover of the category.

CO2 capture cost saving through waste heat recovery using transport membrane condenser in different solvent-based carbon capture processes

In this study, the waste heat from the hot stripping gas was recovered by adopting the transport membrane condenser (TMC) in the monoethanolamine (MEA)-, diethanolamine (DEA)-, piperazine (PZ)- and potassium glycinate (PG)-based rich-split modified carbon capture processes. A 220-h test showed that TMC can exhibit a good stability on the waste heat recovery performance. The PZ-based TMC-modified rich-split process (i.e., PZ-case) achieved a highest waste heat recovery performance, followed by the PG-case, MEA-case and DEA-case. A strong linear relationship between the heat and water fluxes was observed during the waste heat recovery. Three scenarios were considered for comparing the CO2 capture cost savings of 4 cases. When the TMC area was fixed meaning the same additional investment of rich-split modification, PZ-case gained the highest CO2 capture cost saving ($6.40/t-CO2), followed by PG, MEA- and DEA-case. When a fixed waste heat recovery performance of 600 kJ/kg-CO2 was required for obtaining the same revenue after rich- split modification, PZ- and PG-case obtained the same CO2 capture cost saving of $4.22/t-CO2. Moreover, when the reboiler duty reduction potential was aimed at 15%, PG-case achieved the maximum CO2 capture cost saving ($4.56/t-CO2). (C) 2020 Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 109-01-3. Recommanded Product: 1-Methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3. In an article, author is Sharif, Maimoona,once mentioned of 16153-81-4, Category: piperazines.

Evaluation of CO2 absorption performance by molecular dynamic simulation for mixed secondary and tertiary amines

CO2 emission to the atmosphere is the most prominent cause of climate change and a major risk to environmental health. Although several techniques are very promising to reduce the CO2 emission from central emission points, the CO2 absorption by amines remains the most mature and reliable technology. Yet, there is more potential to improve absorption performance by choosing suitable solvents. Thus, the present research is intended to explore a better solvent combination for CO2 absorption by adopting the amine absorption process using molecular dynamic simulation. The study is designed to compare the intermolecular interactions of N-C and N-H bond between single 2EAE, DMAE (or 2DMAE), and blended solvent, i.e., 2EAE/PZ, 2DMAE/PZ with carbon dioxide and water and then to catch the effect of piperazine on these amines. The molecular dynamic simulations were performed by using the Material Studio application. The solvent concentration, 30 wt% under the condition of 313 K temperature at 0.1 MPa pressure, was taken for solvent systems. The results were interpreted by the Radial Distribution Function analysis. It was found that the blend of secondary and tertiary amines with piperazine 2EAE/PZ, DMAE/PZ reflect higher intermolecular interaction with CO2 as compared to single DMAE & 2EAE. This finding shows that piperazine acts as a promoter on 2EAE and 2DMAE when interacting with CO2.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a document, author is Lai, Weikang, introduce the new discover, Name: 1-Benzhydrylpiperazine.

BiVO4 prepared by the sol-gel doped on graphite felt cathode for ciprofloxacin degradation and mechanism in solar-photo-electro-Fenton

In this research, bismuth vanadate-doped graphite felt (GF-BiVO4) was successfully prepared by sol-gel method, in which BiVO4 owned superior electro-Fenton (EF) and solar-photo-electro-Fenton (SPEF) performance. Combined with the analysis by X-ray diffractometer (XRD), field emission transmission electron microscopy (FE-TEM), nitrogen adsorption-desorption isotherms and cyclic voltammetry (CV), the changes of electrodes were reflected in structure and physicochemical properties. The doping of monoclinic BiVO4 endued GF with a higher surface area and more electro-active sites and better electrode activity in comparison to Raw-GF. Then, the GFs were used as cathodes to detect center dot OH concentration with coumarin (COU) as probe molecule and to evaluate photoelectric performance with ciprofloxacin (CIP) in photocatalysis, EF and SPEF processes. The resultYs demonstrated that the concentration of center dot OH followed an order of SPEF > EF > photocatalysis, which was consistent with the removal rate of CIP (99.8%, 99.4% and 21.2%, respectively) on GF-BiVO4 at 5 min. Further, five degradation pathways of CIP in SPEF system were proposed including the attack on piperazine ring, oxidation on cyclopropyl group, decarboxylation and hydroxyl radical addition, oxidation on benzene group and defluorination. The study provides insights into the enhancement of EF and SPEF performance and the degradation pathway of CIP in SPEF.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 841-77-0 is helpful to your research. Name: 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a document, author is Yang, Pei-Chia, introduce the new discover, Recommanded Product: 147081-29-6.

Determination of Hg(II) based on the inhibited catalytic growth of surface-enhanced Raman scattering-active gold nanoparticles on a patterned hydrophobic paper substrate

Anthropogenic mercury (Hg) presents serious risks to the surroundings and public health due to its toxicity and bioaccumulation. In this study, a new assay was developed to combat mercury-related issues, and it is based on surface-enhanced Raman scattering (SERS) on an active paper substrate for rapid Hg(II) determination. The sensing principle is based on the hindering effect of Hg(II) on the catalytic growth of SERS-active gold nanoparticles (AuNPs) on a hydrophobically patterned paper substrate. 4-mercaptobenzonic acid (4-MBA) was chosen as an effective Raman reporter molecule, and its Raman signal was enhanced by surface plasmonic 2-[4-(2-hydroxyethel) piperazine-1-yl]ethanesulfonic acid-stabilized gold nanostars (HEPES-AuNSs) on a piece of paper with a hydrophobic surface. After adding a Hg(II) analyte solution to this SERS substrate, an amalgam formed at the solid-liquid interface of the HEPES-AuNSs. The formation of the AuHg amalgam resulted in the dissolution of the branches of the HEPES-AuNSs. In the presence of a growth solution (mixture of Au(III), HCl, and H2O2), the remaining HEPES-AuNSs and the AuHg amalgams acted as seeds to form small AuNPs, resulting in a weak SERS signal of 4-MBA (Raman shift at 1590 cm(-1)). Solution concentration, temperature, and treatment time were optimized to realize a significant decrease in the Raman intensity of 4-MBA when the paper sensor was exposed to Hg(II). The Raman intensity decreased with the increasing concentration of Hg(II) ions in the range of 0.1 nM-1.0 mu M (R-2 = 0.98), with a limit of detection (S/N = 3.0) of 0.03 nM. For practicality, the proposed paper substrate was examined by estimating Hg(II) concentrations in environmental water samples (i.e., seawater and pond water) and the certified standard of SRM 1641d through standard addition and a recovery study. The promising selectivity, sensitivity, and reproducibility of the proposed paper sensor constitute substantial progress toward the portable detecting mercury in real water samples, which can facilitate crucial surrounding monitoring.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 147081-29-6 is helpful to your research. Recommanded Product: 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 16153-81-4, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Rai, Sunil K., introduce new discover of the category.

Salts and Cocrystal of Etodolac: Advantage of Solubility, Dissolution, and Permeability

Etodolac (ETD) is a nonsteroidal anti-inflammatory drug (NSAID) approved by the United States Food and Drug Administration (US-FDA) in 1991 for the treatment of rheumatoid arthritis. Because of its poor aqueous solubility and high permeability, ETD falls under Biopharmaceutics Classification System (BCS) Class II drug. The present study was aimed to screen stable salts and cocrystals of ETD using Generally Recognized as Safe (GRAS) and a few non-GRAS coformers. Crystallization of five salts (i.e., isopropylamine = isoPA, n-hexylamine = nHA, cyclohexylamine = cycloHA, 2-phenylethylamine = phEA, piperazine = PPZ) and one cocrystal (isonicotinamide = INT) was successful. These products were characterized by single crystal X-ray and powder diffraction. Differential scanning calorimetry (DSC) showed a single endotherm for the salts, which confirmed their thermal stability and phase homogeneity, except for ETD(-center dot)phEA(+) where a solid-solid transition at 152 degrees C was observed with an enthalpy of transition Delta H approximate to 16 J/g. Among the five salts, ETD(-center dot)isoPA(+) showed the highest solubility of 267.50 mg/mL and similar to 20 times faster intrinsic dissolution rate than ETD in pH 7.0 phosphate buffer medium. The salts are stable under solubility and dissolution conditions as confirmed by fitting the powder X-ray diffraction profile of each sample after the experiment with the calculated lines from the X-ray structure. Permeability and flux analysis of ETD salts showed that ETD(-center dot)isoPA(+) exhibits a high flux rate across the semipermeable membrane due to a higher molecular mobility and greater concentration gradient.

Electric Literature of 16153-81-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16153-81-4 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C13H20Cl2N2O2, belongs to piperazines compound. In a document, author is Gu, Yufan, introduce the new discover, Product Details of 106261-49-8.

Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement

During routine screening of illegal adulterants in health supplements, a novel sildenafil analogue was discovered, and subsequently isolated by recrystallization. Its structure was elucidated by extensive analyses of high resolution mass spectrometry (HR-MS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data. The analogue was finally determined as hydroxycarbodenafil, featuring a hydroxyethyl group instead of an ethyl group on piperazine ring in comparison with carbodenafil. (C) 2020 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 106261-49-8. Product Details of 106261-49-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics