Category: piperazines

Synthetic Route of 139755-85-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, belongs to piperazines compound. In a article, author is Kamaal, Saima, introduce new discover of the category.

A Three-Dimensional Pentanuclear Co(II) Coordination Polymer: Structural Topology, Hirshfeld Surface Analysis and Magnetic Properties

A 3D pentanuclear coordination polymer of Co(II); {[Co-5(L2-)(4)(HL-)(2)(bpmp)(2) (H2O)(2)].(H2O)(5)}(n) (CP1) was synthesized by the self-assembly of semi-flexible 5-benzylamino-isophthalic acid (H2L) and N-donor auxiliary ligand 1,4-bis(4-pyridinylmethyl)piperazine (bpmp) using Co(NO3)(2) . 6H(2)O under hydrothermal condition. The CP1 has been structurally characterized by elemental analysis, TGA, Powder-XRD and IR spectroscopy which was further corroborated by single crystal X-ray studies. Structurally, it is a 3D pentanuclear cobalt cluster secondary building units (SBUs) which are formed by carboxylates oxygen of H2L and nitrogen of bpmp. The topological analysis revealed that CP1 possesses a 2-nodal 5,6-connected three-dimensional (3D) coordination framework with pcu net. Variable temperature magnetic measurements demonstrate that CP1 shows antiferromagnetic behavior.

Synthetic Route of 139755-85-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 139755-85-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 5308-25-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, belongs to piperazines compound. In a article, author is Ooi, Zhe Lun, introduce new discover of the category.

Amine-based solvent for CO2 absorption and its impact on carbon steel corrosion: A perspective review

Carbon dioxide (CO2) is one of the commonly emitted gaseous by-products in industrial processes. While CO2 gas is the main cause to greenhouse effect, various CO2 capture technologies have been proposed and implemented to sequester the CO2 before the waste gases being released into the atmosphere. One of the mature technologies for CO2 absorption is by using amine-based solvents. In this regard, different single amine solvents or blended amine solvents have been proven for their capability to remove CO2. However, the dissolution and reaction of CO2 gas with the amine solvents turn the solution corrosive. Such phenomenon is undesired as it posts corrosion problem to the absorption column, which normally built of carbon steel material. Henceforth, understanding the behaviour of different amine-based solvents in absorbing CO2 and its subsequent impact on carbon steel corrosion is very significant. In this review article, we will outline some of the more commonly used solvents and their respective advantages and disadvantages, motivating further investigation into the corrosion tendency. Meanwhile, existing gaps in this research area are discussed for future investigation. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.

Electric Literature of 5308-25-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 5308-25-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2. In an article, author is Ramdane, Khaled Ait,once mentioned of 5308-25-8, Category: piperazines.

Crystal structure, characterization and chemical reactivity of novel piperazine derivative ligand for electrochemical recognition of nitrite anion

A novel piperazine derivative (3E,3E)-3,3-(((piperazine-1,4-diyl bis (ethane-2,1-diyl)) bis (azanediyl)) bis (ethan1-yl-1-ylidene)) bis (6-methyl-2H-pyran-2,4(3H)-dione) (2E-Peaemp) has been synthesized and characterized by ESI-MS, Single-crystal X-ray diffraction, NMR (H-1 NMR, C-13 NMR and 2D NMR), ATR-FTIR, UV-Visible and SEM. The theoretical study of chemical reactivity of 2E-Peaemp was investigated using DFT method. The oxidation-reduction processes and interaction between 2E-Peaemp and nitrite ions were studied using cyclic voltammetry technique. In addition, the detection of NO2- was investigated in 0.1 M PBS solution (pH = 7.0) using a carbon paste electrode modified with reduced graphene oxide-graphite carbon/2E-Peaemp system (rGO-GC/2E-Peaemp). XRD study showed that 2E-Peaemp crystallizes in a monoclinic system with P2(1)/c space group, and the results obtained from theoretical study well support the experimental results. According to DFT study, HOMO (Highest Occupied Molecular Orbitals)-LUMO (Lowest Unoccupied Molecular Orbitals) energy gap (E-gap) and other reactivity descriptors were calculated. The results showed that the ligand exhibits a high chemical reactivity and low kinetic stability. Finally, the cyclic voltammetry measurements showed significant current responses of rGO-GC/2E-Peaemp electrode towards NO2- in the concentration range of 0-4 mM with a low limit of detection (LOD = 0.83 mu M).Graphic abstract New ligand (2E-Peaemp: (3E,3 ‘ E)-3,3 ‘-(((piperazine-1,4-diyl bis (ethane-2,1-diyl)) bis (azanediyl)) bis (ethan1-yl-1-ylidene)) bis (6-methyl-2H-pyran-2,4(3H)-dione)) has been synthesized and characterized by XRD technique. The reactivity descriptors have been calculated by DFT. The ligand was used for electrochemical recognition of nitrite anion. The cyclic voltammetry showed that the modified electrode with 2E-Peaemp exhibits low detection limit towards NO2-.

Interested yet? Keep reading other articles of 5308-25-8, you can contact me at any time and look forward to more communication. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Yu, Jinsong, once mentioned the application of 5308-25-8, SDS of cas: 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, molecular weight is 114.1888, MDL number is MFCD00059912, category is piperazines. Now introduce a scientific discovery about this category.

Mechanisms of Cd (II) binding to GMP and UMP: a combined conductometry, isothermal titration calorimetry and NMR study

In this research, conductometry was applied as a rapid method to screen functional ligands of cadmium ion-imprinted polymers for the first time. To better understand the binding mechanisms of Cd(II) to nucleoside monophosphates (NMPs), isothermal titration calorimetry (ITC) and nuclear magnetic resonance spectroscopy (NMR) experiments were carried out. First, the magnitude of conductivity change, Delta sigma, was found to be proportional to the ligand’s binding capacity to cadmium, and the Delta sigma(GMP) approximate to Delta sigma(dGMP) = 103.5 mu s center dot cm(-1). Second, the ITC experiments indicated that the coordination binding of Cd(II) and guanosine monophosphate (GMP) in 4-(2-hydroxyerhyl)piperazine-1-erhanesulfonic acid (HEPES)/boric acid buffers were demonstrated as different thermodynamic process: an exothermic process (Delta H = -1.446 kcal center dot mol(-1)) in HEPES, and an exothermic process (Delta H = – 1.495 kcal center dot mol(-1)) followed by an endothermic one (Delta H = 1.383 kcal mol(-1)) in boric acid. In contrast, the formation of the Cd(II)-uridine monophosphate (UMP) system was an endothermic process in both buffers. NMR experiments indicated that the shift Delta delta of the GMP’s proton signals were different, especially for H-1: 0.37 ppm in HEPES, and 0.03 ppm in boric acid. Referring to the results of ITC experiments, the major Cd(II) binding sites of GMP in HEPES buffer was the guanosine group, and phosphate group was another site in the boric acid buffer. By contrast, the major Cd(II) binding site of UMP was the phosphate group in both buffers. In general, investigating the functional ligand-cadmium binding mechanism has provided important theoretical and experimental guidance for the subsequent preparation of cadmium ion-imprinted materials.

If you are interested in 5308-25-8, you can contact me at any time and look forward to more communication. SDS of cas: 5308-25-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 111974-74-4, 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S, belongs to piperazines compound. In a document, author is Zhang, Li, introduce the new discover.

Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents

A total of 26 compounds based on osthole skeleton were designed, synthesized. Their cytoprotective abilities of antioxidation, anti-inflammation and A beta(42)(Amyloid beta-protein 42)-induced neurotoxicity were evaluated by MTT assays. Mechanism of the action of selected compounds were investigated by molecular docking. AlogP, logS and blood-brain barrier (BBB) permeability of all these compounds were simulated by admetSAR. Most of the compounds showed better antioxidative and anti-inflammatory activities compared with osthole, especially OST7 and OST17. The compound OST7 showed relative high activity in neuroprotection against H2O2 (45.7 +/- 5.5%), oxygen glucose deprivation (64.6 +/- 4.8%) and A beta(42) (61.4 +/- 5.2%) at a low concentration of 10 mu M. EC50 of selected compounds were measured in both H2O2 and OGD induced cytotoxicity models. Moreover, NO inhibiting ability of OST17(50.4 +/- 7.1%) already surpassed the positive drug indomethacin. The structure activity relationship study indicated that introduction of piperazine group, tetrahydropyrrole group and aromatic amine group might be beneficial for enhancement of osthole neuroprotective properties. Molecular docking explained that the reason OST7 exhibited relatively stronger neuroprotection against A beta because of the greater area of interactions between molecule and target protein. OST7 and OST17 both provided novel methods to investigate osthole as anti-AD drugs.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 111974-74-4. Product Details of 111974-74-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 147081-29-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Gupta, Anoop K., introduce new discover of the category.

A Three-Dimensional Cu(II)-MOF with Lewis acid-base dual functional sites for Chemical Fixation of CO2 via Cyclic Carbonate Synthesis

A 3D porous Cu(II)-MOF (1), having Lewis acid-base dual-functional sites, has been utilized, whose frameworks have two types of 1D channels decorated with both axially water-bound metal sites and weak base, i.e., tertiary amine groups in the crystallographic c-axis. Upon activation under a high vacuum at 120 degrees C, the axial water molecule is removed and affords a solvent-free and unsaturated Lewis acidic Cu(II) containing framework (1′). The piperazine functionalities from the linkers enhance the selective adsorption of CO2 which, in turn, facilitate the further interaction with the open Cu(II) metal centres, leading to catalytic chemical fixation of CO2 into five-membered cyclic carbonates, in the presence of epoxides and co-catalyst TBAB, under mild and solvent-free reaction conditions. The significance of dual functionalization and the synergy with TBAB on adeptly catalyzed CO2 fixation are explored using several epoxides, and substantial conversion is achieved. Moreover, the catalyst 1′ displays satisfactory stability and easy recyclability for five consecutive cycles without any appreciable loss in its catalytic activity. The results are compared with various MOFs based catalysts at the closest reaction conditions and, based on literature and experimental inferences, a possible mechanism of chemical fixation of CO2 with epoxide catalyzed by 1′ has been proposed.

Reference of 147081-29-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3. In an article, author is Qiu, Xiang,once mentioned of 16153-81-4.

Design, synthesis and anti-inflammatory study of novel N-heterocyclic substituted Aloe-emodin derivatives

A novel series of Aloe-emodin derivatives containing N-heterocyclic moieties was designed and synthesized. The structure-activity relationship studies (SARs) indicated that the replacement of hydroxyethyl and benzhydryl piperazine groups could improve efficacy. Compounds12rand14a-14cexhibited a higher inhibitory effect on LPS-induced nitric oxide (NO) production in RAW264.7 macrophages than Aloe-emodin did. Among them,12rshowed the most potent inhibition with an IC(50)value of 5.66 +/- 0.47 mu M. Further toxicity and pharmacokinetic studies were carried out and12rwas found to be the most active structure with low toxicity risk and good metabolic properties. It could also decrease the levels of IL-1 beta, TNF-alpha, PGE(2)and inhibit the activation of nuclear factor-kappa B signalling pathway. Importantly,12rshowed oral bioavailability of up to 55.16% and attenuated the inflammatory symptoms in an ulcerative colitis mouse model in vivo. These results indicate that12ris suitable for development as an anti-inflammatory agent.

If you¡¯re interested in learning more about 16153-81-4. The above is the message from the blog manager. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, HPLC of Formula: C5H12N2, begins with the direct observation of nature¡ª in this case, of matter.109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a document, author is Mu, Tong, introduce the new discover.

Three-channel capillary nanofiltration membrane with quaternary ammonium incorporated for efficient heavy metals removal

High-performance nanofiltration (NF) membranes have profound implications for water purification. Here, we reported a novelty polyamide NF membrane through introducing bis (2-hydroxyethyl) dimethyl-ammonium chloride (BHDA) in interfacial polymerization (IP) process on three-channel substrate membrane. This new monomer bearing abundant quaternary ammonium (N+) and hydroxyl could participate in the reaction between piperazine (PIP) and trimesoyl chloride (TMC). Then, not only was positive charge introduced into the NF membrane, but the hydrophilic of the resultant NF membrane was also significantly improved. Thus, the as-prepared PIP/BHDA-TMC (MPQ) membrane exhibited enhanced pure water flux (12.9 L.m(-2).h(-1).bar(-1)) which is 2.4 times as high as that of the PIP-TMC (MP) membrane, coupled with the salt rejection sequence as MgSO4 (93.46%) > Na2SO4 (91.61%) > MgCl2 (88.15%) > NaCl (22.03%). Meanwhile, MPQ exhibited a promising separation performance to various heavy metal salts (96.43% CuSO4, 96.16% ZnSO4, 91.69% Cu(NO3)(2), 89.69% ZnCl2, 88.37% Pb(NO3)(2)). The stability of MPQ was tested with simulated wastewater, and the results illustrated that it has a potential applicability for heavy metals removal.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 109-01-3. HPLC of Formula: C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, SMILES is CN1CCN(C2=CC=C(Br)C=C2)CC1, belongs to piperazines compound. In a document, author is Manasa, Kesari Lakshmi, introduce the new discover, Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Design and synthesis of beta-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability

A series of new beta-carboline linked aryl sulfonyl piperazine congeners have been synthesized by coupling various beta-carboline acids with substituted aryl sulfonyl piperazines. Evaluation of their anticancer activity against a panel of human cancer cell lines such as colon (HT-29), breast (MDA-MB-231), bone osteosarcoma (MG-63), brain (U87 MG), prostate (PC- 3) and normal monkey kidney (Vero) cell line has been done. Among the series, compound 8ec and 8ed has shown most potent cytotoxicity with an IC50 values of 2.80 +/- 0.10 mu M and 0.59 +/- 0.28 mu M respectively against MG-63 cell line and also potent on other cell lines tested. Compounds 8ec and 8ed was found to inhibit Topo II that is confirmed by specific Topo II inhibition assay. DNA binding studies, cell cycle analysis, Annexin V study indicate that these compounds has potential anticancer activity. Molecular docking studies for compound 8ec and 8ed are incorporated to understand the nature of interaction with topoisomerase IIa and dsDNA.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 130307-08-3 is helpful to your research. Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 300543-56-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, belongs to piperazines compound. In a article, author is Gao, Peng, introduce new discover of the category.

High-Flux Fine Hollow Fiber Nanofiltration Membranes for the Purification of Drinking Water

High-flux fine hollow fiber nanofiltration (HFNF) membranes were prepared by interfacial polymerization (IP) using polysulfone (PSF) ultrafiltration (UF) membranes with an outer diameter of 425 mu m as the substrate for the treatment of drinking water. Trimesoyl chloride (TMC) was selected as the organic phase monomer, while poly(vinyl alcohol) (PVA) was added into piperazine (PIP) aqueous phase solution to reduce the surface defects and to enhance the separation performance of the NF membrane. The as-prepared fine HFNF membranes had a large packing density and effective area. The optimal preparation conditions of the fine HFNF membrane were determined by orthogonal experiments in which the flux of the membrane reached 34.2 +/- 1.5 L.m(-2).h(-1).bar(-1), while its salt rejection sequence was as follows: Na2SO4 (97.6 +/- 1.5%) > MgSO4 (96.1 +/- 1.8%) > MgCl2 (83.5 +/- 2.1%) > NaCl (27.9 +/- 2.6%). During the long-term stability test for 132 h, the membrane retained a high flux (>23.7 +/- 1.5 L.m(-2).h(-1).bar(-1)) and high Na2SO4 rejection (>97.2 +/- 1.1%). Additionally, it exhibited huge potential for application in drinking water purification in which the as-prepared NF membrane exhibited excellent antifouling performance for bovine serum albumin (BSA).

Electric Literature of 300543-56-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 300543-56-0 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics