Category: piperazines

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Computed Properties of C14H21N3O5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, belongs to piperazines compound. In a article, author is Hayat, Faisal, introduce new discover of the category.

Antimony(III) dithiocarbamates: Crystal structures, supramolecular aggregations, DNA binding, antioxidant and antileishmanial activities

Herein, we report the synthesis and characterization of four piperazine based homoleptic antimony(III) dithiocarbamates, i.e. Sb[S2CN(CH2)(4)N(Bn)](3) (1), Sb[S2CN(CH2)(4)NCH-(Ph)(2)](3) (2), Sb[S2CN(CH2)(4)N(2-MeO-C6H4)] (3) (3) and Sb[S2CN(CH2)(4)N(C6H4-NO2)](3 center dot)CH2Cl2 (4), by means of elemental analysis and many spectroscopic techniques, like FT-IR, NMR (H-1 and C-13) and single crystal XRD. The XRD data revealed a distorted trigonal antiprismatic geometry around the central antimony atom for 2 and 3, with the trigonal space groups R-3 and R3c respectively, while a distorted pentagonal pyramidal geometry was found for 4, with the triclinic space group P-1. The trigonal antiprismatic complexes (2 and 3) feature fascinating 2-D supramolecular layers, extending into 3-D networks in a stacked fashion, while for the pentagonal pyramidal complex 4, the dimensionality is lowered to linear chains. Some of these complexes (1, 2 and 4) were further checked for their biological potential (DNA binding, using UV-Visible spectroscopy, antioxidant, cytotoxic and antileishmanial). They showed moderately stronger binding with the DNA base-pairs via the intercalative mode, as suggested by hypochromism in their electronic spectra. Interestingly, complex 2 was more active than the standard drug ascorbic acid for its antioxidant action, while complex 4 showed high activity in both the cytotoxic and antileishmanial assays. (C) 2020 Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5294-61-1. Computed Properties of C14H21N3O.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S, belongs to piperazines compound. In a document, author is Zhu, Fang, introduce the new discover, Quality Control of 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride.

Degradation mechanism of norfloxacin in water using persulfate activated by BC@nZVI/Ni

In this work, biochar-supported nano zero-valent iron/nickel bimetallic composite (BC@nZVI/Ni) was synthesized using liquid phase reduction method and used to activate persulfate (PS) to degrade norfloxacin (NOR) in water. The synthesized BC@nZVI/Ni was characterized using scanning electron microscope (SEM), X-ray diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS). The effects of various reaction parameters, such as mass ratio of nZVI/Ni to BC, PS concentration, initial pH value, temperature, humic acid and the inorganic anions on NOR degradation were investigated using the system of nZVI/Ni/PS. The results showed that the system of nZVI/Ni/PS showed the higher degradation efficiency. The quenching experiments and EPA analysis manifested that center dot SO4- was the predominant radical species in acidic and neutral conditions, while center dot OH played an important role in alkaline environment. Matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF MS) analysis illustrated that NOR can be degraded through multiple routes, such as decarboxylation, defluorination and cleavage of piperazine ring in the presence of center dot SO4- and center dot OH. These results demonstrated that nZVI/Ni/PS process was a promising strategy for treating norfloxacin-containing wastewater.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 111974-74-4. Quality Control of 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is , belongs to piperazines compound. In a document, author is Ji, Haodong, Formula: C23H32N6O5S.

Adsorptive removal of ciprofloxacin with different dissociated species onto titanate nanotubes

Exploring the specific characteristics of pharmaceuticals and personal care products (PPCPs) via adsorption and degradation are scientific and practical significance to control their release to water matrix. In this work, a good adsorbent and ion-exchange material, i.e., titanate nanotubes (TNTs), was employed for adsorption of ciprofloxacin (CIP, a model PPCPs). The adsorption behaviors and mecha-nisms of CIP with different dissociated species by TNTs were studied through both experimental and theoretical calculations. The multilayered TNTs with high BET surface area (272.3 m(2)/g) and large pore volume (1.26 cm(3)/g) exhibited good adsorption property for CIP. The CIP species (i.e., CIP+, CIP +/-, CIP-) at various pH exhibited significantly different adsorption favorability. Adsorption kinetics and isotherms data revealed that TNTs offered the high uptake for CIP+ (Q(max)= 464.47 mmol/g or 153.90 mg/g at pH 5) than CIP +/- and CIP-. Characterizations indicated the formation of Ti-O-N linkage between CIP molecules and TNTs after adsorption, suggesting the chemical interaction between CIP and TNTs. Density functional theory (DFT) calculations reveal variation on pH affects the protonation/deprotonation state of CIP, and then changes the distribution of molecular orbitals and the electrostatic potential (ESP) energy of CIP. ESP follows the trend as: CIP+ (180.57 kcal/mol) > CIP +/- (146.78 kcal/mol) > CIP- (12.30 kcal/mol), indicating the side of piperazine ring in CIP oriented to TNTs dominates the CIP adsorption. The integrated experimental and theoretical results, for the first time, suggest that ESP energy can serve as the indicator and predictor of adsorption ability for the PPCPs molecules with various speciation, and can help to deeply describe the adsorption mechanism of PPCPs. In addition, TNTs have great application for the removal of PPCPs through adsorption in practical wastewater treatment area. (C) 2020 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 139755-85-4, Formula: C23H32N6O5S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, SMILES is [H]Cl.[H]Cl.C12=CC=CC=C1N=C(N3CCNCC3)C4=CC=CC=C4S2, in an article , author is Napoletano, Flavia, once mentioned of 111974-74-4, Computed Properties of C17H19Cl2N3S.

The Psychonauts’ World of Cognitive Enhancers

Background There is growing availability of novel psychoactive substances (NPS), including cognitive enhancers (CEs) which can be used in the treatment of certain mental health disorders. While treating cognitive deficit symptoms in neuropsychiatric or neurodegenerative disorders using CEs might have significant benefits for patients, the increasing recreational use of these substances by healthy individuals raises many clinical, medico-legal, and ethical issues. Moreover, it has become very challenging for clinicians to keep up-to-date with CEs currently available as comprehensive official lists do not exist. Methods Using a web crawler (NPSfinder(R)), the present study aimed at assessing psychonaut fora/platforms to better understand the online situation regarding CEs. We compared NPSfinder(R)entries with those from the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and from the United Nations Office on Drugs and Crime (UNODC) NPS databases up to spring 2019. Any substance that was identified by NPSfinder(R)was considered a CE if it was either described as having nootropic abilities by psychonauts or if it was listed among the known CEs by Froestl and colleagues. Results A total of 142 unique CEs were identified by NPSfinder(R). They were divided into 10 categories, including plants/herbs/products (29%), prescribed drugs (17%), image and performance enhancing drugs (IPEDs) (15%), psychostimulants (15%), miscellaneous (8%), Phenethylamines (6%), GABAergic drugs (5%), cannabimimetic (4%), tryptamines derivatives (0.5%), and piperazine derivatives (0.5%). A total of 105 chemically different substances were uniquely identified by NPSfinder(R). Only one CE was uniquely identified by the EMCDDA; no CE was uniquely identified by the UNODC. Conclusions These results show that NPSfinder(R)is helpful as part of an Early Warning System, which could update clinicians with the growing numbers and types of nootropics in the increasingly difficult-to-follow internet world. Improving clinicians’ knowledge of NPS could promote more effective prevention and harm reduction measures in clinical settings.

Interested yet? Read on for other articles about 111974-74-4, you can contact me at any time and look forward to more communication. Computed Properties of C17H19Cl2N3S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn, Quality Control of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, Especially from a beginner¡¯s point of view. Like 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is piperazines, belongs to piperazines compound. In a document, author is Lipin, Raju, introducing its new discovery.

Piperazine-substituted derivatives of favipiravir for Nipah virus inhibition: What do in silico studies unravel?

Favipiravir is found to show excellent in-vitro inhibition activity against Nipah virus. To explore the structure-property relationship of Favipiravir, in silico designing of a series of piperazine substituted Favipiravir derivatives are attempted and computational screening has been done to evaluate its bimolecular interactions with Nipah virus. The geometrical features of all the molecules have been addressed from Density Functional Theory calculations. Chemical reactivity descriptor analysis was carried out to understand various reactivity parameters. The drug-likeness properties were estimated by a detailed ADMET study. The binding ability and the mode of binding of these derivatives into the Nipah virus are obtained from molecular docking studies. Our calculations show greater binding ability for the designed inhibitors compared to that of the experimentally reported molecule. Overall, the present work proves to offers new insights and guidelines for synthetic chemists to develop new drugs using piperazine substituted Favipiravir in the treatment of Nipah virus.

If you are hungry for even more, make sure to check my other article about 5294-61-1, Quality Control of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Recommanded Product: 147081-29-6, begins with the direct observation of nature¡ª in this case, of matter.147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a document, author is Ercan, A., introduce the new discover.

An allomaltol derivative triggers distinct death pathways in luminal a and triple-negative breast cancer subtypes

Breast cancer is the most common cancer in women that shows a predisposition to metastasize to the distant organs. Kojic acid is a natural fungal metabolite exhibiting various biological activities. Compounds derived from kojic acid have been extensively studied and proved to demonstrate anti-neoplastic features on different cancer types. In the present study, allomaltol-structural analog of kojic acid and its seven derivatives including four novel compounds, have been synthesized, characterized and their possible impact on breast cancer cell viability was investigated. It was discovered that compound 5, bearing 3,4-dichlorobenzyl piperazine moiety, could decrease the viability of both MCF-7 and MDA-MB-231 cell lines distinctively. To ascertain the death mechanism, cells were subjected to different tests following the application of IC50 concentration of compound 5. Data obtained from lactate dehydrogenase activity and gene expression assays pointed out that necrosis had taken place predominantly in MDA-MB-231. On the other hand, in MCF-7 cells, the p53 apoptotic pathway was activated by overexpression of the pro-apoptotic TP53 and Bax genes and suppression of the anti-apoptotic Mdm-2 and Bcl-2 genes. Furthermore, Bax/Blc-2 ratio was escalated by 3.5 fold in the study group compared to the control. Compound 5 did not provoke drug resistance in MCF-7 cells since the Mdr-1 gene expression, drug efflux, and H2O2 content remained unaltered. As for MDA-MB-231 cells, only a 1.4 fold increase in the Mdr-1 gene expression was detected. These results indicate the advantage of the allomaltol derivative over the chemotherapeutic agents conventionally used for breast cancer treatment that can be highly toxic and mostly lead to drug resistance. Thus, this specific allomaltol derivative offers an alternative therapeutic approach for breast cancer which needs further investigation.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 147081-29-6. Recommanded Product: 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is , belongs to piperazines compound. In a document, author is Xie, Yu, Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.

Scaling up microreactors for kilogram-scale synthesis of piperacillin: Experiments and computational fluid dynamics simulations

In this study, two membrane dispersion microreactors in series are used to synthesize piperacillin with low impurity content in kilogram scale. By combining experiments and computational fluid dynamics simulations, the membrane size and cross-sectional area are scaled up from 2 mm x 0.7 mm and 2 mm x 1 mm to 6.5 mm x 2.5 mm and 6.5 mm x 3.5 mm, respectively, and the reaction time is extended from similar to 10 to similar to 60 min, which achieves that the synthesis scale of each batch is increased from 15 g to 1 kg. Subsequently, the effects of distance between ammonia feed and 4-ethyl-2,3-dioxo-1-piperazine carbonyl chloride feed, pH, circulation flow rate, and dispersed phase flow rate on solution concentration are discussed. The final piperacillin product with an average yield of similar to 94.70%, a purity exceeding 99.7%, the impurity D content similar to 0.077% and E content similar to 0.045%, satisfies the requirements of pharmacopeia regarding antibiotic impurities.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5625-37-6, in my other articles. Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, formurla is C14H21N3O. In a document, author is Heydarifard, Mohammad, introducing its new discovery. Category: piperazines.

Numerical simulation of CO2 chemical absorption in a gas-liquid bubble column using the space-time CESE method

In this study, numerical simulation of the removal process of CO2 using aqueous solutions of piperazine (PZ) in a bubble column has been done. The main focus of this work is to investigate the applicability of the space-time conservation element and solution element (CESE) method for the numerical solution of the coupling of hydrodynamics, mass transfer and chemical reactions. The reactive absorption process has been investigated by means of experiments and numerical simulation. A two-dimensional computational fluid dynamics (CFD) model in the Eulerian framework has been used to describe the gas-liquid system. To obtain the numerical solution, the CESE method based on a uniform rectangular mesh has been implemented by developing a computer code. Experimental study and CFD simulations have been carried out at different conditions of CO2 partial pressure (20 and 36 kPa) and solution concentration (0.1, 0.3 and 0.5 M). The simulation results were in reasonable agreement of 5.226 % and 4.575 % with the experimental values for gas holdup and mass transfer flux, respectively. The comparisons prove that the CESE method can be considered as a proper numerical method for the simulation of complex multiphase flows due to its simplicity, accuracy and low computational costs.

If you are hungry for even more, make sure to check my other article about 5294-61-1, Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is , belongs to piperazines compound. In a document, author is Zhou, Guan, HPLC of Formula: C23H32N6O5S.

SLAP reagents for the photocatalytic synthesis of C3/C5-substituted, N-unprotected selenomorpholines and 1,4-selenazepanes

Herein, we disclose the first set of unique selenium-containing SLAP (SiLicon Amine Protocol) reagents for the direct synthesis of C3/C5-substituted selenomorpholines and 1,4-selenazepanes from diverse (hetero)aldehydes under mild photocatalytic conditions. Enantiomerically pure 1,2-amino alcohol/alpha-amino acid versions of these heterocycles were also synthesized. Further, we have shown the late-stage modification of certain biologically active agents using the developed seleno-SLAP reagents.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 139755-85-4, in my other articles. HPLC of Formula: C23H32N6O5S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Application of 111974-74-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, SMILES is [H]Cl.[H]Cl.C12=CC=CC=C1N=C(N3CCNCC3)C4=CC=CC=C4S2, belongs to piperazines compound. In a article, author is Hosseini-Ardali, Seyed Mohsen, introduce new discover of the category.

Multi-objective optimization of post combustion CO2 capture using methyldiethanolamine (MDEA) and piperazine (PZ) bi-solvent

Global warming is becoming a critical issue in 21st century which is mainly due to the growing rate of greenhouse gas emissions. This is mostly due to the large amount of CO2 emission from power generation activity using fossil fuels. One of the main methods of fighting global warming and reducing CO2 emission into atmosphere is to perform carbon capture, sequestration and utilization. Carbon capture can be performed through different ways, in which post combustion CO2 capture (PCC) has been developed and both economic and technically wise is in state of art. One of the disadvantages of PCC is its high efficiency penalty due to energy consumption in the reboiler for solvent regeneration. Many efforts have been done to reduce the consumption of energy in the reboiler via different strategies including process parameters optimization, solvent development and novel process configuration. This investigation used different blends of PZ and MDEA as solvent and process parameters optimization via evolutionary algorithm and multi-objective optimization. The optimization was performed on a conventional process flow diagram. CO2 capture efficiency and reboiler heat duty were used as the objective functions and main decision variables are solvent flowrate and MDEA/PZ concentration. Flue gas CO2 capture of 90, 91, 92, 93, and 94% corresponded to regeneration energy consumption of 2.68, 2.71, 2.72, 2.75, and 2.76 E-regen/t(CO2); respectively. These optimized values showed a higher energy efficiency compared to MEA and MDEA/PZ in conventional process configuration. (C) 2020 Elsevier Ltd. All rights reserved.

Application of 111974-74-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 111974-74-4 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics