Category: piperazines

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Computed Properties of C11H17N3, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound. In a document, author is Okhlopkova, L. S., introduce the new discover.

Mononuclear Antimony(V) Catecholate Complexes with Additional Pyridine Ligands

A series of triarylantimony(V) complexes withp-dimethylaminopyridine andp-cyanopyridine of the general formulas [(Cat)SbAr3(p-Me2N-Py)] (complexesI-IV) and [(Cat)SbAr3(p-CN-Py)] (complexesV-VII) has been synthesized. Their molecular structures and electrochemical properties have been studied. 3,6-Di-tert-butyl-o-benzoquinone, 4,5-piperazine-1,4-diyl-3,6-di-tert-butyl-o-benzoquinone, and 4,5-dichloro-3,6-di-tert-butyl-o-benzoquinone are used as redox-active ligands. The molecular structures of several complexes in the crystalline state are determined by X-ray diffraction analysis (CIF files CCDC nos. 1974173 (I. 0.5toluene), 1974174 (II. 2toluene), 1974175 (V), 1974176 (VI. hexane), and 1974177 (VII)). All complexes have a distorted octahedral structure, and an additional neutral pyridine ligand occupies one of the apical positions. Electrochemical transformations of the complexes are studied by cyclic voltammetry in a dichloromethane solution. The introduction of substituted pyridine into the molecule of the complex does not change the electrooxidation mechanism of the complexes. For all complexes withp-dimethylaminopyridine, both oxidation potentials are shifted to the cathodic region (0.13-0.21 V for the potential of the first oxidation process and to 0.3-0.4 V for the potential of the second oxidation process). A similar shift for the complex withp-cyanopyridine is less pronounced (0.05 V for the potential of the first oxidation process of complexVas compared to that of complexI).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 16153-81-4. Computed Properties of C11H17N3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a document, author is Chen, Zhuoyao, introduce the new discover, Computed Properties of C5H12N2.

Anodic oxidation of ciprofloxacin using different graphite felt anodes: Kinetics and degradation pathways

Ciprofloxacin (CIP) is ubiquitous in the environment which poses a certain threat to human and ecology. In this investigation, the physical and electrochemical properties of graphite felt (GF) anodes which affected the anodic oxidation (AO) performance, and the CIP removal effect of GF were evaluated. The GFs were used as anodes for detection of center dot OH with coumarin (COU) as molecule probe and removal of CIP in a 150 mL electrolytic cell with Pt cathode (AO-GF/Pt system). The results showed that hydrophilic GF (B-GF) owned higher sp(3)/sp(2) and more oxygen-containing and nitrogen-containing functional groups than the hydrophobic GF (A-GF). Moreover, B-GF possessed higher oxygen evolution potential (1.12 V), more active sites and stronger center dot OH generation capacity. Above mentioned caused that B-GF exhibited more superior properties for CIP removal. The best efficiencies (96.95%, 99.83%) were obtained in the AO-B-GF/Pt system at 6.25 mA cm(-2) after 10 min (k(1), 0.356 min(-1)) and 60 min (k(2), 0.224 min(-1)), respectively. Furthermore, nine degradation pathways of CIP in AO-B-GF/Pt system were summarized as the cleavage of the piperazine ring, cyclopropyl group, quinolone ring and F atom by center dot OH. It provides new insights into the removal and degradation pathways of CIP with GF in AO system.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 109-01-3 is helpful to your research. Computed Properties of C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Gungor, Tugba, once mentioned of 841-77-0, Name: 1-Benzhydrylpiperazine.

Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation

In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized. The final compounds were identified using FT-IR, H-1 NMR, C-13 NMR as well as elemental analyses. Enzymatic activities of compounds were conducted by using HPLC analysis to investigate the interaction of substrates with Ssap-NtrB nitroreductase enzyme. MTT assay was performed to evaluate the toxic effect of compounds against Hep3B and PC3 cancer cell lines and healthy HUVEC cell. It was observed that synthesized compounds NHN1-16 exhibited different cytotoxic profiles. Pyrimidine derivative NHN3 and triazine derivative NHN5 can be good drug candidates for prostate cancer with IC50 values of 54.75 mu M and 48.9 mu M, respectively. Compounds NHN6, NHN10, NHN12, NHN14 and NHN16 were selected as prodrug candidates because of non-toxic properties against three different cell models. The NHN prodrugs and Ssap-NtrB combinations were applied to SRB assay to reveal the prodrug capabilities of these selected compounds. SRB screening results showed that the metabolites of all selected non-toxic compounds showed remarkable cytotoxicity with IC50 values in the range of 1.71-4.72 nM on prostate cancer. Among the tested compounds, especially piperazine derivatives NHN12 and NHN14 showed significant toxic effect with IC50 values of 1.75 nM and 1.79 nM against PC3 cell compared with standart prodrug CB1954 (IC50: 1.71 nM). Novel compounds NHN12 and NHN14 can be considered as promising prodrug candidates for nitroreductase-prodrug based prostate cancer therapy.

Interested yet? Read on for other articles about 841-77-0, you can contact me at any time and look forward to more communication. Name: 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 106261-49-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, SMILES is Cl.Cl.CN1CCN(CC1)CC2=CC=C(C(=O)O)C=C2, belongs to piperazines compound. In a article, author is Huang, Zhehao, introduce new discover of the category.

Novel piperazine-2,5-dione analogs bearing 1H-indole: Synthesis and biological effects

In this work, a series of novel piperazine-2,5-dione derivatives bearing indole analogs (2a-2q) was designed and synthesized. The synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR spectroscopy, and ESI-MS. They were then evaluated for their anti-depressant, anti-inflammatory, and analgesic activities in vivo. The experimental results revealed that all the compounds showed clear anti-depressant, anti-inflammatory, and analgesic effects at a dose of 10 mg/kg. Among them, compounds 2e and 2q exhibited the best anti-depressant effects (the percent decreases in the duration of immobility were 70.2% and 71.2%, respectively), which were similar to that of fluoxetine (67.9%) in the forced swim test. Additionally, compounds 2e and 2q also displayed good anti-inflammatory and analgesic activities. Literature reports have highlighted the anti-inflammatory and analgesic effects of anti-depressant drugs, suggesting that they may have a similar mechanism of action. Therefore, further studies to investigate the possible mechanisms of action of compounds 2e and 2q are warranted.

Synthetic Route of 106261-49-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 106261-49-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2. In an article, author is Waltemate, Jana,once mentioned of 109-01-3, SDS of cas: 109-01-3.

10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization

As part of our continuing search for potent inhibitors of tubulin polymerization, two novel series of 42 10-(4-phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and N-benzoylated acridones were synthesized on the basis of a retrosynthetic approach. All newly synthesized compounds were tested for antiproliferative activity and interaction with tubulin. Several analogs potently inhibited tumor cell growth. Among the compounds tested, 10-(4-(3-methoxyphenyl)piperazine-1-carbonyl)acridin-9(10H)-one (17c) exhibited excellent growth inhibitory effects on 93 tumor cell lines, with an average GI(50) value of 5.4 nM. We were able to show that the strong cytotoxic effects are caused by disruption of tubulin polymerization, as supported by the EBI (N,N’-Ethylenebis(iodoacetamide)) assay and the fact that the most potent inhibitors of cancer cell growth turned out to be the most efficacious tubulin polymerization inhibitors. Potencies were nearly comparable or superior to those of the antimitotic reference compounds. Closely related to this, the most active analogs inhibited cell cycling at the G2/M phase at concentrations down to 30 nM and induced apoptosis in K562 leukemia cells. We believe that our work not only proves the excellent suitability of the acridone scaffold for the design of potent tubulin polymerization inhibitors but also enables synthetic access to further potentially interesting N-acylated acridones.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is C10H20N2O2. In an article, author is Sinha, Rajeev K.,once mentioned of 147081-29-6, Recommanded Product: 147081-29-6.

Structural elucidation of Levofloxacin and Ciprofloxacin using density functional theory and Raman spectroscopy with inexpensive lab-built setup

In the present work, we have investigated the structures of fluoroquinolones Levofloxacin and Ciprofloxacin using Raman spectroscopy and density functional theory calculations. The Raman spectra of Levofloxacin and Ciprofloxacin were recorded with lab-built inexpensive Raman spectroscopy setup that uses 638 nm laser diode. Raman spectra in the fingerprint spectral region (900-1800 cm(-1)) were investigated for both the molecules. The density functional theory (DFT) utilizing B3LYP functional with 6-31+G(d,p) basis set was used to investigate the minimum energy structures of two molecules along with the calculation of Raman spectrum. Molecular complexes of Levofloxacin and Ciprofloxacin with one and two water molecules were also studied to see the effect of H-bonding on Raman spectra. It was found that the conformation and orientation of piperazine ring along with the orientation of hydroxyl group plays a vital role in determination of the minimum energy structure. The calculated Raman spectra of bare molecules and their complexes with water molecules were compared to the experimental Raman spectra. The calculated Raman spectrum of minimum energy structure was found to be in good agreement with the experimental spectrum. Further it was observed that the experimental Raman spectrum is better explained when H-bonding is considered, which could be due to the water molecule or the dimer formation of the molecules under investigation. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate. In a document, author is Anju, introducing its new discovery. HPLC of Formula: C10H20N2O2.

5-HT1A targeting PARCEST agent DO3AM-MPP with potential for receptor imaging: Synthesis, physico-chemical and MR studies

Contrast enhancement in MRI using magnetization or saturation transfer techniques promises better sensitivity, and faster acquisition compared to T-1 or T-2 contrast. This work reports the synthesis and evaluation of 5-HT1A targeted PARACEST MRI contrast agent using 1,4,7,10-tetraazacycloDOdecane-4,7,10-triacetAMide (DO3AM) as the bifunctional chelator, and 5-HT1A-antagonist methoxyphenyl piperazine (MPP) as a targeting unit. The multistep synthesis led to the MPP conjugated DO3AM with 60% yield. CEST-related physicochemical parameters were evaluated after loading DO3AM-MPP with paramagnetic MRI active lanthanides: Gadolinium (Gd-DO3AM-MPP) and Europium (Eu-DO3AM-MPP). Luminescence lifetime measurements with Eu-DO3AM-MPP and computational DFT studies using Gd-DO3AM-MPP revealed the coordination of one water molecule (q = 1.43) with metal-water distance (r(M)-H2O) of 2.7 angstrom and water residence time (tau(m)) of 0.23 ms. The dissociation constant of K-d 62 +/- 0.02 pM as evaluated from fluorescence quenching of 5-HT1A (protein) and docking score of -4.81 in theoretical evaluation reflect the binding potential of the complex Gd-DO3AM-MPP with the receptor 5-HT1A. Insights of the docked pose reflect the importance of NH2 (amide) and aromatic ring in Gd-DO3AM-MPP while interacting with Ser 374 and Phe 370 in the antagonist binding pocket of 5-HT1A. Gd-DO3AM-MPP shows longitudinal relaxivity 5.85 mM(-1)s(-1) with a water residence lifetime of 0.93 ms in hippocampal homogenate containing 5-HT1A. The potentiometric titration of DO3AM-MPP showed strong selectivity for Gd3+ over physiological metal ions such as Zn2+ and Cu2+. The in vitro and in vivo studies confirmed the minimal cytotoxicity and presential binding of Gd-DO3AM-MPP with 5-HT1A receptor in the hippocampus region of the mice. Summarizing, the complex Gd-DO3AM-MPP can have a potential for CEST imaging of 5-HT1A receptors.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 147081-29-6 help many people in the next few years. HPLC of Formula: C10H20N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O. In an article, author is Suresh, Gangadhari,once mentioned of 5294-61-1, SDS of cas: 5294-61-1.

DNA Binding, DFT and Spectroscopic Studies of a Charge Transfer Complex Consisting of a Bioactive Donor 1-(2-Methylbenzyl)piperazine

A bioactive donor, 1-(2-methylbenzyl)piperazine is used to synthesize a new charge transfer complex (CTC) with the p-acceptor p-chloranil (p-CHL), which is characterized spectrophotometrically. The quantitative estimation of electronic interaction of the acceptor with the donor has been examined in acetonitrile (AN). The 1:1 composition of the CTC is confirmed by Jobs’ method of continuous variation and spectrophotometric (at max 554 nm) methods at 298 K. The Benesi-Hildebrand method gives the formation constant (KCT) and molar extinction coefficient (e) values of CTC. The spectral analysis was used to characterize CTC and its stability in solution and in the crystalline form. A DNA binding study of the CT-complex was carried out using UV-visible spectroscopy. A density functional theory (DFT) study of the CTC (gas phase/PCM) at using the B3LYP functional and 6-31G(d,p) basis set supports the experimental work. The optimization of the frontier molecular orbital surfaces was carried out by using the DFT-gasphase/PCM correlation methods. Mulliken atomic charges and reactive parameters of acceptor and donor recommend the MBPZ acts as a good electron donor and p-CHL acts as a good electron acceptor to form a highly stable electron transfer complex.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine. In a document, author is Rolfe, Alan, introducing its new discovery. Name: (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine.

Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1

Carbamoyl phosphate synthetase 1 (CPS1) is a potential synthetic lethal target in LKB1-deficient nonsmall cell lung cancer, where its overexpression supports the production of pyrimidine synthesis. In other cancer types, CPS1 overexpression and activity may prevent the accumulation of toxic levels of intratumoral ammonia to support tumor growth. Herein we report the discovery of a novel series of potent and selective small-molecule inhibitors of CPS1. Piperazine 2 was initially identified as a promising CPS1 inhibitor through a high-throughput screening effort. Subsequent structure-activity relationship optimization and structure-based drug design led to the discovery of piperazine H3B-616 (25), a potent allosteric inhibitor of CPS1 (IC50 = 66 nM).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 300543-56-0 help many people in the next few years. Name: (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S. In an article, author is Malasala, Satyaveni,once mentioned of 111974-74-4, HPLC of Formula: C17H19Cl2N3S.

Copper mediated one-pot synthesis of quinazolinones and exploration of piperazine linked quinazoline derivatives as anti-mycobacterial agents

A facile method was developed for the synthesis of quinazolinone derivatives in a one-pot condensation reaction via in situ amine generation using ammonia as the amine source and with the formation of four new C-N bonds in good to excellent yields. With the optimised method, we synthesized a library of piperazine linked quinazoline derivatives and the synthesized compounds were evaluated for their inhibitory activity against Mycobacterium tuberculosis. The compounds 8b, 8e, 8f, 8m, 8n and 8v showed potent anti-mycobacterial activity with MIC values of 2-16 mu g mL(-1). All the synthesized compounds follow Lipinski’s rules for drug likeness.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics