Category: piperazines

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate. In a document, author is Wang, Pei-Yi, introducing its new discovery. Category: piperazines.

Novelpiperazine-tailoredursolic acid hybrids as significant antibacterial agents targeting phytopathogensXanthomonas oryzaepv.oryzaeandX. axonopodispv.citriprobably directed by activation of apoptosis

BACKGROUND Induced apoptosis is an effective technique that can reprogram cellular physiological and pathological processes to eradicate undesirable cells using their innate systems. Inspired by this, numerous apoptosis inducers have been developed to treat animal diseases, especially in the anticancer field. However, few studies have reported on the development of inductive agents that attack plant pathogens by activation of apoptosis. With the aim of exploring and discovering apoptosis inducers that target phytopathogens, a cluster of piperazine-tailored ursolic acid (UA) hybrids was systematically fabricated. RESULTS In vitrotesting showed that the title molecules could inhibit the growth of two intractable bacterial strains, defined asXanthomonas oryzaepv.oryzaeandX. axonopodispv.citri. The corresponding lowest EC(50)values were 0.37 and 1.08 mu g mL(-1), which exceed those of UA (>400 mu g mL(-1)) and positive controls. Moreover, compounds5uand5vcould manage bacterial blightin vivousing pot experiments. Flow cytometer analysis indicted that the title compounds could induce distinct apoptotic behaviors on tested bacteria. In-depth study revealed that the introduction of designed compounds could reduce the enzyme activities of catalase and superoxide dismutase, subsequently leading to the accumulation of reactive oxygen species. CONCLUSION This study promoted the development of apoptosis initiators for managing bacterial infections in agriculture by an innovative mode of action. (c) 2020 Society of Chemical Industry

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 147081-29-6 help many people in the next few years. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, COA of Formula: C11H15BrN2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Abdelrahman, Maha M..

Ecofriendly Validated Chromatographic Methods for Quantitation of Cyclizine and Its Toxic Impurities in Its Parenteral Formulation

Cyclizine (CYZ) abuse is commonly reported, either through oral or intravenous routes, for its euphoric or hallucinatory effects. The concomitant misuse of CYZ among addicted teenagers leads to life-threatening neuromuscular disorders. Consequently, two green and validated chromatographic methods were developed for the determination of CYZ, an antiemetic drug, in its parenteral formulation in the presence of 1-methyl piperazine and diphenylmethanol (benzhydrol) as the pharmacopeial stated impurities of CYZ. The first method was TLC-densitometry that relied on using a mixture consisting of ethyl acetate:isopropanol:ammonia (9.5:1:0.5, by volume) as a developing system, TLC 60 F-254 silica gel plates as a stationary phase and detection of the scanned bands was performed at 210.0 nm. On the other hand, the second method was UPLC which based on the separation of CYZ and its impurities using a mobile phase consisting of ethanol and acidic water at pH 5 adjusted by phosphoric acid in the ratio of (60:40, %v/v) at flow rate 0.2 mL min(-1) and UV detection were carried out at 210.0 nm. The greenness profile of the established methods was evaluated and calculated for the first time for CYZ and its toxic impurities through different assessment tools like analytical eco-scale, analytical method volume intensity and greenness profile methods. Validation of the developed methods was carried out in accordance with the guidelines of the International Conference on Harmonization. The suggested methods were accurate, reliable, time and cost-saving. Therefore, they could be used in quantification of CYZ abuse and its toxic impurities in parenteral formulation for routine quality control. The results achieved by applying the suggested methods were statistically analyzed and compared with those given by reported one and no significant differences were obtained regarding both precision and accuracy.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 130307-08-3, in my other articles. COA of Formula: C11H15BrN2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Related Products of 130307-08-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, SMILES is CN1CCN(C2=CC=C(Br)C=C2)CC1, belongs to piperazines compound. In a article, author is Khan, Bilal Alam, introduce new discover of the category.

Energy Minimization in Piperazine Promoted MDEA-Based CO2 Capture Process

A piperazine (PZ)-promoted methyldiethanolamine (MDEA) solution for a carbon dioxide (CO2) removal process from the flue gas of a large-scale coal power plant has been simulated. An Aspen Plus was used to perform the simulation process. Initially, the effects of MDEA/PZ concentration ratio and stripper pressure on the regeneration energy of CO2 capture process were investigated. The MDEA/PZ concentration ratio of 35/15 wt.% (35 wt. MDEA and 15 wt.% PZ) was selected as an appropriate concentration. The reboiler duty of 3.235 MJ/kg CO2 was obtained at 35/15 wt.% concentration ratio of MDEA/PZ. It was considered a reference or base case, and process modifications including rich vapor compression (RVC) process, cold solvent split (CSS), and the combination of both processes were investigated to check its effect on the energy requirement. A total equivalent work of 0.7 MJ(e)/kg CO2 in the RVC and a reboiler duty of 2.78 MJ/kg CO2 was achieved in the CSS process. Similarly, the total equivalent work, reboiler duty, and condenser duty of 0.627 MJ(e)/kg CO2, 2.44 MJ/kg CO2, and 0.33 MJ/kg CO2, respectively, were obtained in the combined process. The reboiler duty and the total equivalent work were reduced by about 24.6 and 16.2%, respectively, as compared to the reference case. The total energy cost saving was 1.79 M$/yr. Considering the additional equipment cost in the combined process, the total cost saving was 0.67 M$ per year.

Related Products of 130307-08-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 130307-08-3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C13H20Cl2N2O2, belongs to piperazines compound. In a document, author is Jiang, Kaiqi, introduce the new discover, Recommanded Product: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Advancement of ammonia-based post-combustion CO(2 )capture technology: Process modifications

Aqueous ammonia (NH3)-based capture process has the potential to simultaneously remove NOx/SO2/CO2 pollutants at low cost, but conventional NH3-based process suffers high NH3 slip, high energy consumption and high capital investment. The present study aims to advance the NH3-based scrubbing technology to overcome these technical issues. We used inter-cooled CO2 absorber to mitigate the NH3 emission and enhance CO2 absorption, while employed advanced flash stripper configuration to significantly decrease the absorbent regeneration duty. We also proposed an effective NOx/SO2 removal process by utilizing the slipped NH3 for multi-pollutant emission control. A validated model was used to gain insight into the techno-economic performance of this advanced NH3-based NOx/SO2/CO2 removal process, and important process parameters such as absorption temperature, NH3 concentration and flue gas NOx/SO2 concentrations were investigated in detail. The results indicate that the advanced NH3 process enabled great capital saving by 23% and energy saving by 42%, resulting in a low CO2-avoided cost of USS44.3/t CO2, which is 42.8% lower than the baseline NH3 process.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 106261-49-8. Recommanded Product: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is C8H18N2O6S2, belongs to piperazines compound. In a document, author is Konduri, Srihari, introduce the new discover.

Design and synthesis of purine connected piperazine derivatives as novel inhibitors of Mycobacterium tuberculosis

A series of novel purine linked piperazine derivatives were synthesized to identify new, potent inhibitors of Mycobacterium tuberculosis. The compounds were designed to target MurB disrupting the biosynthesis of the peptidoglycan and exert antiproliferative effects. The first series of purine-2,6-dione linked piperazine derivatives were synthesized using an advanced intermediate 1-(3,4-difluorobenzyl)-7-(but-2-ynyl)-3-methyl-8-(piperazin-1-yl)-1H-purine-2,6(3H,7H)-dione hydrochloride (6) which was coupled with varied carboxylic acid chloride derivatives. Following this piperazine linked derivatives were also synthesized from 6 using diverse isocyanate partners. The anti-mycobacterial activity of the analogues was tested against Mycobacterium tuberculosis H37Rv which revealed a cluster of six analogues (11, 24, 27, 32, 33 and 34), possessed promising activity. In comparison, a set of these new compounds possessed greater potencies relative to current drugs used in the clinic such as Ethambutol. These results were also correlated with computational molecular docking analysis, providing models for strong interactions of the inhibitors with MurB providing a template for the future development of preclinical agents against Mycobacterium tuberculosis.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of 1-Ethylpiperazine5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, belongs to piperazines compound. In a article, author is Hu, Zhi, introduce new discover of the category.

Flame retardancy, thermal properties, and combustion behaviors of intumescent flame-retardant polypropylene containing (poly) piperazine pyrophosphate and melamine polyphosphate

A (poly) piperazine pyrophosphate (PIPP) was synthesized and its chemical structure was confirmed via Fourier transform infrared spectroscopy,H-1 nuclear magnetic resonance, and(31)P nuclear magnetic resonance. PIPP was used together with melamine polyphosphate (MPP) as an ammonium polyphosphate (APP)-free intumescent flame retardant (IFR) to prepare several flame-retardant polypropylene (FRPP) composites. The flame retardancy and burning behaviors of the composites were investigated via limiting oxygen index (LOI) determination, vertical burning tests (UL-94), and cone calorimeter tests. The thermal properties were investigated by means of thermogravimetric analysis under nitrogen and air atmosphere. Use of PIPP and MPP together yielded an increase in the LOI value, a UL-94 V-0 rating, and a decrease in both the values of PHRR and THR in cone calorimetric analysis. Visual observations and scanning electronic microscopy confirmed the occurrence of char formation, which acted as a heat and fire barrier in the condense phase.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5308-25-8. Application In Synthesis of 1-Ethylpiperazine.

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Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Kettle, Jason G., once mentioned the application of 5308-25-8, Application In Synthesis of 1-Ethylpiperazine, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, molecular weight is 114.1888, MDL number is MFCD00059912, category is piperazines. Now introduce a scientific discovery about this category.

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS(G12C)

Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS(G12)C mutant represents an Achilles heel and has recently yielded to covalent targeting with small molecules that bind the mutant cysteine and create an allosteric pocket on GDP-bound RAS, locking it in an inactive state. A weak inhibitor at this site was optimized through conformational locking of a piperazine-quinazoline motif and linker modification. Subsequent introduction of a key methyl group to the piperazine resulted in enhancements in potency, permeability, clearance, and reactivity, leading to identification of a potent KRAS(G12C) inhibitor with high selectivity and excellent cross-species pharmacokinetic parameters and in vivo efficacy.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, molecular formula is C17H19ClN2, belongs to piperazines compound. In a document, author is Salaciak, Kinga, introduce the new discover, Product Details of 300543-56-0.

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and beta-arrestin signalling

Background: Our previous studies showed that xanthone derivatives with N-(2-methoxyphenyl)piperazine fragment have an affinity to the 5-HT1A receptor and show antidepressant-like properties in rodents. In this study, we tested three xanthone derivatives, HBK-1 (R, S) and its enantiomers, in which we increased the distance between the piperazine and xanthone fragments by using a hydroxypropoxy linker. We hypothesized that this would increase the binding to the 5-HT1A receptor and consequently, pharmacological activity. Aims: We aimed to assess the in vitro and in vivo pharmacological activity of the xanthone derivatives. Methods: We evaluated the in vitro affinity for serotonin 5-HT1A and 5-HT2A receptors and serotonin transporter. We also determined the intrinsic activity at the 5-HT1A receptor. We investigated the antidepressant-like properties and safety after acute administration (dose range: 1.25-20 mg/kg) using the forced swim, tail suspension, locomotor activity, rotarod and chimney tests in mice. We also evaluated the basic pharmacokinetic parameters. Results: Our results indicated that the compounds showed a high affinity for the 5-HT1A receptor but very weak antagonistic properties in the Ca2+ mobilization assay; however, they showed significant agonistic properties in the beta-arrestin recruitment assay. In both behavioural tests the studied xanthone derivatives showed antidepressant-like activity. Pre-treatment with p-chlorophenylalanine or WAY-100635 abolished their antidepressant-like activity. None of the compounds caused motor impairments at antidepressant-like doses. The racemate penetrated the blood-brain barrier and had a relatively high bioavailability after intraperitoneal administration. Conclusions: Xanthone derivatives with N-(2-methoxyphenyl)piperazine fragment and hydroxypropoxy linker show increased binding to the 5-HT1A receptor and may represent an attractive putative treatment candidate for depression.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 300543-56-0. Product Details of 300543-56-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, formurla is C13H20Cl2N2O2. In a document, author is Liu, Biming, introducing its new discovery. Application In Synthesis of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Enhanced oxidative degradation of norfloxacin using peroxymonosulfate activated by oily sludge carbon-based nanoparticles CoFe2O4/OSC

In this study, oily sludge (OS) was pyrolyzed into an environmentally friendly OS carbon (OSC) material, which was used as the carrier of CoFe2O4 nanoparticles to prepare a heterogeneous catalyst CoFe2O4/OSC, and it was used to catalyze the degradation of norfloxacin (NFC) by peroxymonosulfate (PMS). X-ray diffraction (XRD) and transmission electron microscope (TEM) characterization results show that CoFe2O4/OSC had a spinel structure under high temperature pyrolysis conditions. The effects of initial pH, PMS dosage, catalyst dosage, and temperature on NFC degradation efficiency were also studied. Under a temperature of 25 degrees C, an initial pH of 7, a catalyst amount of 0.5 g/L, and a PMS dosage of 0.8 mM, the reaction rate constant reached 0.051 min(-1), and the degradation efficiency and total organic carbon of NFC reached 90.8% and 62%, respectively, within 60 min. Trace amounts of Co and Fe ions were leached from the system (both less than 30 mu g/L). After ten cycles, the degradation efficiency of NFC decreased to 69.8%. Radical quenching experiments, electron paramagnetic resonance, and X-ray fluorescence spectroscopy characterization proved that free-radical ((OH)-O-center dot, SO4 center dot-, and O-2(center dot-)) and nonradical (O-1(2)) active species were present in the system. Moreover, the CoFe2O4/OSC/PMS system involved the participation of two pairs of redox couples (Fe(II)/Fe(III) and Co(III)/Co(II)). Results from matrix-assisted laser desorption ionization time-of-flight mass spectrometry and ion chromatography proved that the main oxidation pathways of NFC were formed through the fragmentation of heterocycles, defluorination of benzene rings, decarboxylation reactions, and piperazine ring-opening process. At the same time, NFC was eventually oxidized to fluoride. This study provides potential for the resource utilization of OS and the application of sludge-type catalysts in PMS-activated oxidation systems.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is C8H18N2O6S2, Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, belongs to piperazines compound, is a common compound. In a patnet, author is Caram, Hugo S., once mentioned the new application about 5625-37-6.

A simple thermodynamic tool for assessing energy requirements for carbon capture using solid or liquid sorbents

Carbon capture and sequestration is known to be energy intensive and will result in 20-30 % reduction in net output of a power plant. However, a simple thermodynamic tool is currently unavailable for assessing the work of CO2 separation using a given solid or liquid sorbent. This paper provides rigorous yet simple framework of equivalent work to assess the energy requirement for CO2 capture using liquid amines or solid adsorbents. First, the theoretical minimum work is determined by assuming that each step in the sorption – desorption cycle is thermodynamically reversible. Then, irreversible heat transfer losses are added to calculate total work for the actual process. The model provides useful insights into the sorbent and process selection. The minimum work for reversible separation can be calculated merely from CO2 sorption equilibria at ambient temperature without requiring laborious data or complex models. A sorbent with low ab/adsorption heat does require less thermal energy, but this thermal energy is required at a higher temperature. Thus, contrary to conventional thinking, the equivalent work is not reduced. The irreversible heat transfer losses for the amines are mostly dictated by the amine’s circulation rate which will be minimized by using amines with the highest CO2 capacity. On an energy requirement basis, the solid adsorbent based processes cannot compete with amines because practical methods of heat recuperation from the hot regenerated adsorbent are unavailable. Without heat recuperation, the solid adsorbent processes will be attractive only if their capital advantage outweighs their higher energy use.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 5625-37-6 help many people in the next few years. Application In Synthesis of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics