Category: piperazines

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is , belongs to piperazines compound. In a document, author is Manasa, Kesari Lakshmi, Formula: C10H20N2O2.

Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition

A library of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone derivatives were designed, synthesized and screened for their in vitro cytotoxic activity against BT-474, HeLa, MCF-7, NCI-H460 and HaCaT cells by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all the synthesized analogues, compound 10ec displayed the highest cytotoxicity with the IC50 value of 0.99 +/- 0.01 mu M towards BT-474 cancer cell line. The target compound (10ec) was also evaluated for its tubulin polymerization inhibition study. Detailed biological studies such as acridine orange/ethidium bromide (AO/EB), DAPI and annexin V-FITC/propidium iodide staining assay suggested that compound 10ec induced the apoptosis of BT-474 cells. The clonogenic assay revealed that the inhibition of colony formation in BT-474 cells by 10ec in concentration-dependent manner. Moreover, the flow cytometric analysis revealed that 10ec induced apoptosis via cell cycle arrest at the sub-G1 and G2/M phase. In silico studies of sulfonyl piperazine-integrated triazole conjugates unveil that they possess drug-like properties. According to the molecular modelling studies, compound 10ec binds to the colchicine binding site of the tubulin.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 147081-29-6, in my other articles. Formula: C10H20N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of 1-Benzhydrylpiperazine, 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Liu, Ke, once mentioned of 841-77-0.

Synthesis and biological evaluation of pyranocarbazole derivatives as Anti-tumor agents

A series of pyrano[3,2-a]carbazole alkaloids were designed and synthesized as derivatives of Girinimbine. The anticancer activities of these derivatives (3, 4a-j, 5a, 5c, 5f, 5i, 6c, 7a, 7c, 7f, 7i) against 10 cancer cell lines were studied. Among them, compounds 3 and 7i with N-methyl piperazine showed significant anticancer activity against MCF-7 cell lines with the IC50 values of 1.77 and 4.32 mu M, respectively. Furthermore, their effects on altering cell morphology, inducing cell cycle arrest and apoptosis in MCF-7 cells were studied in vitro. In addition, the molecular docking study was carried out by using Discovery Studio software to predict the interactions between these derivatives and tubulin. All in all, these consequences reveal that pyranocarbazole derivatives with N-methyl piperazine can be used as potential anticancer lead compounds and provide useful points for the further optimization of pyranocarbazole alkaloids.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 841-77-0, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-Benzhydrylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C5H12N2, 109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, in an article , author is Lin, Yuqing, once mentioned of 109-01-3.

Custom-tailoring metal-organic framework in thin-film nanocomposite nanofiltration membrane with enhanced internal polarity and amplified surface crosslinking for elevated separation property

A polyamide (PA) thin-film nanocomposite (TFN) membrane embedded with post-synthetically functionalized metal-organic framework (MOF) nanofillers of imidazole-2-carbaldehyde (ICA) decorated UiO-66-NH2 nano fillers (ICA_d_UiO-66-NH2) was developed using the interfacial polymerization method. The ICA_d_UiO-66-NH2 nanofiller couples a surface water-capturing ICA decoration, facilitating the rapid transport of water molecules owing to the enhanced internal polarity, while achieving an amplified crosslinking between the terminal amine groups of ICA and trimesoyl chloride, enabling the perfect incorporation of MOF nanofillers within the PA matrix. The resultant ICA_d_UiO-66-NH2@PA TFN membrane with elevated separation property performed comparably high water permeance of 9.4 l m(-2) h(-1) bar(-1) (achieving a nearly 2-fold increase from the initial value of the thin-film composite membrane), and a favorable rejection ratio of 97.4% (Na2SO4). Owing to the unique hierarchical surface microstructure embedded with the intrinsically hydrophilic ICA_d_UiO-66-NH2 nanofillers, the newly-developed TFN membrane exhibited superior antifouling properties. Furthermore, the ICA_d_UiO-66-NH2@PA TFN membrane also retained excellent reusability and durability without significant compromise even after long-term salt, and acid/alkali treatments. Overall, this work provides an insight into the embedding of different functionalized nanofillers inside TFN membranes with elevated separation properties.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 109-01-3, you can contact me at any time and look forward to more communication. Computed Properties of C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a document, author is Oa, Seyeon, introduce the new discover, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Effects of carbonation on carbon dioxide capture and the mechanical properties of concrete with amine sorbents

Carbon dioxide (CO2) uptake and the mechanical strength of concrete with and without carbon-dioxide-philic (CDP) amine sorbents were assessed in this study. Cement pastes with three amine-based sorbents (5-amino-1 pentanol, piperazine and 3-amino-1-propanesulfonic acid) were hydrated for 28 d. They were then assessed for carbon dioxide uptake and compressive/bending strength. The carbon dioxide in the atmosphere was sequestrated into the concrete as simulated carbonation weathering occurred, and the carbon dioxide uptake was measured using thermogravimetric analysis. Carbon dioxide uptake increased when CDP amine sorbents were mixed into the concrete specimens, with 5-amino-1-pentanol and piperazine showing the best efficiency, with carbon dioxide uptakes of 2.44% and 2.24%, respectively. The compressive and bending strengths also increased with carbonation. The strengths of the concretes with CDP sorbents were higher than that of ordinary concrete due to the microstructurel densification, indicating that urban carbon dioxide sequestration can be performed using concrete structures without damaging their structural strength.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16153-81-4 is helpful to your research. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is an experimental science, Name: 1-(4-Bromophenyl)-4-methylpiperazine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Xia, Fangbo.

Quantitative profiling of eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids by twin derivatization strategy combined with LC-MS/MS in patients with type 2 diabetes mellitus

Eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids (PUFAs), serving as important signaling molecules, are implicated in many physiological and pathological processes, including Type 2 diabetes mellitus (T2DM). However, the quantification of endogenous eicosanoids is challenged by high structural similarity, low abundance in biological sample and poor electrospray ionization efficiency. In the current study, a sensitive and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to quantify 65 eicosanoids derived from n-6 and n-3 PUFAs in plasma samples using twin derivatization strategy with a pair of reagents, 5-(dimethylamino) naphthalene-1-sulfonyl piperazine (Dns-PP) and (diethylamino) naphthalene-1-sulfonyl piperazine (Dens-PP). Dns-PP-derivatized plasma sample was mixed with the equal volume of Dens-PP-derivatized eicosanoid internal standards for LC-MS/MS analysis in multiple reaction monitoring (MRM) mode. After Dns-PP derivatization, the ionization efficiency and separation performance were substantially improved, resulting in the enhanced sensitivity by 446- to 1009-folds compared to intact eicosanoids. The quantitative accuracy determined by twin derivatization method was found to be comparable with stable isotope labeled internal standards (SIL-IS) method. The newly proposed method was successfully employed to quantify the target eicosanoids in plasma samples from healthy controls and the patients with T2DM. N-6 PUFA-derived eicosanoids, PGF2 alpha, PGD2, PGE2, PGA2, PGB2, 20-HETE and LTC4, significantly increased in plasma sample of T2DM patients. Oppositely, n-3 PUFA-derived eicosanoids, RvE1, 12(S)-HEPE and RvD1, remarkably decreased. Spearman’s correlation analysis indicated the strong correlations between these highlighted eicosanoids and clinical parameters of T2DM. Collectively, the sensitive and reliable eicosanoid quantification method may facilitate to elucidate the characteristics of eicosanoid metabolism and understand the role of eicosanoids in the pathogenesis of T2DM and other diseases. (C) 2020 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 130307-08-3, in my other articles. Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C13H20Cl2N2O2. In an article, author is Pal, Avishek,once mentioned of 106261-49-8.

Probing the charged nature and ion-exclusion mechanism of fluorine-enriched non-ionogenic polyamide derived thin film composite nanofiltration membranes

A thin film composite (TFC) nanofiltration (NF) membrane comprising a novel fluorine-enriched polyamide (FPA) as a skin layer polymer has been developed by in situ interfacial polycondensation between a cyclo-aliphatic diamine monomer, piperazine, and an acyclic fluorodiacyl chloride monomer, tetrafluorosuccinyl chloride. Instrumental investigations carried out by FTIR and XPS showed that the structure of FPA is devoid of intra- as well as inter-molecular H-bonds, which seems to be a rare finding in NF type membranes with decent performances. Stereoelectronic effects of the FPA structure, owing to the configurational mobility of polymer chains, electron-withdrawing ability of fluorine and lack of cohesive non-covalent type interactions, strongly influenced the surface morphology, topography and hydrophilicity of the TFC-NF membranes. The active skin layer of the membranes exhibited uniform charge-atmosphere in spite of not having any fixed charged groups in the polymer structure constituting it. Zeta potential measurement of the membranes revealed low values (-4.4 to -7 mV), indicating their low surface charge. However, a high Donnan-exclusion was observed towards a solute with multivalent anion (Na2SO4, solute rejection: 87-93%) as opposed to that with monovalent anion (NaCl, solute rejection: 23-26%), with a solvent flux as high as 54 L m(-2) h(-1) at 15 bar transmembrane pressure. The current class of TFC-NF membranes with unique physicochemical attributes thus provides a promising scope for a variety of nanofiltration applications.

If you¡¯re interested in learning more about 106261-49-8. The above is the message from the blog manager. Quality Control of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 300543-56-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, belongs to piperazines compound. In a article, author is Guo, Shaochen, introduce new discover of the category.

In vitro and in vivo antimicrobial activities of a novel piperazine-containing benzothiazinones candidate TZY-5-84 against Mycobacterium tuberculosis

A piperazine-containing benzothiazinones lead compound PBTZ169, served as DprE1 inhibitor, displays nanomolar bactericidal activity against Mycobacteria tuberculosis. Here, we systematically evaluate anti-tuberculosis activity of one of PBTZ169 analogues, TZY-5-84, in vitro and in vivo. The MIC value of TZY-5-84 against M. tuberculosis H37Rv ranged from 0.014 to 0.015 mg/L, lower than those of INH, RFP and BDQ. Five susceptible and thirteen drug-resistant clinical isolates were also susceptive to TZY-5-84. It had anti-tuberculosis activity against intracellular bacilli in infected macrophage model. It exhibited its activity in time-dependent manner and against intracellular bacilli in infected macrophage cells. However, the MIC of TZY-5-84 against three laboratory PBTZ169-induced resistant isolates increased four-fold increment compared to that of H37Rv. No antagonism was observed in any combination between TZY-5-84 and seven commonly used anti-tuberculosis drugs in an in vitro checkerboard assay. In murine infection model, TZY-5-84 at lower dosage (12.5 mg/kg) was found to be comparatively efficacious as PBTZ169 at 25 mg/kg. Our research suggests TZY-5-84 can be a promising preclinical candidate for further study on TB treatment.

Reference of 300543-56-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 300543-56-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Formula: C17H19Cl2N3S, begins with the direct observation of nature¡ª in this case, of matter.111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, SMILES is [H]Cl.[H]Cl.C12=CC=CC=C1N=C(N3CCNCC3)C4=CC=CC=C4S2, belongs to piperazines compound. In a document, author is Jiang, Jin-Ke, introduce the new discover.

Crystal structure of catena-poly[aqua(mu(6)-piperazine-1,4-bisethanesulfonato-kappa(6) N:N ‘:O:O ‘:O ”:O ”’)(mu(2)-pyrazinyl-kappa N-2:N ‘)disilver(I) sesquihydrate], C12H30Ag2N4O11S2

C12H30Ag2N4O11S2, monoclinic, I2/a (no. 15), a = 12.2643(8) angstrom, b = 7.1481(4) angstrom, c =26.2858(16) angstrom, beta = 93.119(6)degrees, V = 2301.0(2) angstrom(3), Z = 4, R-gt(F) = 0.0186, WRref(F-2) = 0.0462, T = 298(2) K.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 111974-74-4. Formula: C17H19Cl2N3S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Lei, Hongrui, once mentioned of 841-77-0, Formula: C17H20N2.

Catalyst-Free Cyclization- and Curtius Rearrangement-Induced Functional Group Transformation: An Improved Synthetic Strategy of First-in-Class ATX Inhibitor Ziritaxestat (GLPG-1690)

A practical and highly efficient protocol for the production of Autotaxin (ATX) inhibitor Ziritaxestat (1) was described. The procedure began with a catalyst-free bicomponent cyclization for the construction of the imidazo[1,2-a]pyridine skeleton 16. Subsequently, a typical Curtius rearrangement of carboxylic acid 17 followed by nucleophilic attacking of 3,5-dichlorobenzyl alcohol 18f led to the carbamate analogue 19f. N-methylated 20 was readily deprotected through HBr/HOAc treatment, which further conveniently took part in an alternative K2CO3-induced N-alkylation reaction with 9 to give 10. 10 coupled directly with piperazine to furnish 13, which ideally circumvent the removal of the Boc group. As a result, the hypertoxic KCN and the hypertoxic and costly isonitrile 3 involved in the tricomponent cyclization were carefully avoided. Ultimately, a novel, scalable, and cost-effective route was favorably developed to afford Ziritaxestat in a 20.4% overall yield.

Interested yet? Read on for other articles about 841-77-0, you can contact me at any time and look forward to more communication. Formula: C17H20N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, in an article , author is Jacob, John, once mentioned of 139755-85-4, COA of Formula: C23H32N6O5S.

In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae

Angiostrongylus cantonensis is the leading cause of eosinophilic meningitis worldwide, with life-threatening complications if not managed correctly. Previous in vitro studies have utilized change in motility patterns of adult female worms to assess the efficacy of anthelmintics qualitatively. However, it is the third stage larvae (L3) that are infectious to humans. With differential staining using propidium iodide penetration as the indicator of death, we can distinguish between dead and live larvae. This assay has enabled us to quantify the in vitro efficacy of nine clinically established anthelmintics on A. cantonensis L3. All drugs were tested at a 1 mm concentration. Piperazine and niclosamide were ineffective in inducing larval death; however, albendazole sulfoxide, pyrantel pamoate, diethylcarbamazine, levamisole and praziquantel were effective as compared to unexposed controls (P < 0.05). Ivermectin and moxidectin did not induce significant levels of mortality, but they considerably reduced larval motility almost immediately. This study indicates the need for further in vivo studies to determine the optimal dose and time frame for post-infection treatment with anthelmintics that demonstrated efficacy. Interested yet? Read on for other articles about 139755-85-4, you can contact me at any time and look forward to more communication. COA of Formula: C23H32N6O5S.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics