Category: piperazines

Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors was written by Bao, Jiyin;Liu, Haichun;Zhi, Yanle;Yang, Wenqianzi;Zhang, Jiawei;Lu, Tao;Wang, Yue;Lu, Shuai. And the article was included in Bioorganic Chemistry in 2020.Recommanded Product: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate This article mentions the following:

A series of compounds I [R¹ = H, Me, F, MeO; R² = diethylamino, piperidinyl, piperazin-1-yl, etc.; R³ = Ph, pyridin-3-yl, pyridin-4-yl, etc.] were designed and synthesized based on benzo[d]oxazole-2-amine scaffold to discover new potent Fms-like tyrosine kinase 3 inhibitors. During the medicinal chem. works, flexible mol. docking was used to provide design rationale and study the binding modes of the target compounds Through the mixed SAR exploration based on the enzymic and cellular activities, compound I [R¹ = MeO; R² = piperazin-1-yl; R³ = 3-carbamoylphenyl] was identified with potent FLT3-ITD inhibitory (IC₅₀: 0.41 nM) and anti-proliferative (IC₅₀: 0.037渭M against MV4-11 cells) activities. And the binding mode of I [R¹ = MeO; R² = piperazin-1-yl; R³ = 3-carbamoylphenyl] with ”DFG-in” FLT3 was simulated by a 20-ns mol. dynamics run, providing some insights into further medicinal chem. efforts toward novel FLT3 inhibitors in AML therapy. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (cas: 154590-34-8Recommanded Product: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate).

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (cas: 154590-34-8) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Recommanded Product: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

An LD₅₀ model for predicting psychotropic drug toxicity using biopartitioning micellar chromatography was written by Quinones-Torrelo, C.;Sagrado-Vives, S.;Villanueva-Camanas, R. M.;Medina-Hernandez, M. J.. And the article was included in Biomedical Chromatography in 2001.Computed Properties of C22H30N4O2S2 This article mentions the following:

The LD₅₀ determination is the main way to measure the acute toxicity of all types of substances. At the present time, however, there is increasing opposition to the use of living animals in research and testing activities from animal rights groups as well as some scientists. Nevertheless, the need to have a tool for estimating the potential toxicity of new compounds for human consumption has encouraged the development of alternative methods. Under adequate conditions, the partitioning in micellar liquid chromatog. can describe the drug biopartitioning. We have named this chromatog. system biopartitioning micellar chromatog. (BMC). In this paper, an LD₅₀ QRAR model developed for psychotropic drugs from their retention data in BMC, is described. The model’s ability to predict new psychotropic drug toxicity is statistically proved. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Computed Properties of C22H30N4O2S2).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Computed Properties of C22H30N4O2S2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Impact of Heat Inactivation of Blood Samples on Therapeutic Drug Monitoring of 5 Second-Generation Antipsychotics and Their Metabolites was written by Ding, Jing;Yang, Liu;Zhang, Yan;Zhang, Suo;Meng, Zhuocheng. And the article was included in Therapeutic Drug Monitoring in 2022.COA of Formula: C23H25Cl2N3O2 This article mentions the following:

The severe acute respiratory syndrome coronavirus 2 outbreak has been classified as a pandemic. Because many coronaviruses are heat sensitive, heat inactivation of patient samples at 56掳C before testing reduces the risk of transmission. The aim of this study is to assess the impact of heat inactivation of patient blood samples on plasma concentrations of 5 second-generation antipsychotics and their metabolites. Blood samples were collected during routine clin. therapeutic drug monitoring examination between Apr. 3, 2021, and Apr. 19, 2021. Samples were divided into 2 groups: group A, noninactivated raw sample, and group B, inactivated samples. Inactivation was performed by a 30-min incubation at 56掳C. The levels of the 5 drugs and their metabolites before and after sample heat inactivation were measured using liquid chromatog.-tandem mass spectrometry and compared. Furthermore, correlation and Bland-Altman analyses were conducted. No statistically significant difference was observed between the levels of the 5 drugs and their metabolites (ie, risperidone, 9-OH-risperidone, aripiprazole, dehydroaripiprazole, olanzapine, quetiapine, norquetiapine, clozapine, and norclozapine) in the noninactivated group A and the inactivated group B (P 掳 0.05). Each drug鈥瞫 concentration values in inactivated and noninactivated treatments correlated (Spearman rs 掳 0.98; P 0.001). The results of the noninactivated treatment methods and samples alone showed good consistency via Bland-Altman anal. Blood sample heat inactivation had no significant effect on the therapeutic drug monitoring of 5 second-generation antipsychotics and their metabolites. This inactivated treatment method should be recommended to effectively protect laboratory staff from virus contamination. In the experiment, the researchers used many compounds, for example, 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4COA of Formula: C23H25Cl2N3O2).

7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C23H25Cl2N3O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Positive- and negative-ion mass spectrometry and rapid clean-up of 19 phenothiazines was written by Ishikawa, Yasunobu;Suzuki, Osamu;Hattori, Hideki. And the article was included in Forensic Science International in 1990.Product Details of 316-81-4 This article mentions the following:

Pos.-ion electron impact (PIEI), pos.-ion chem. ionization (PICI), and neg.-ion chem. ionization (NICI) mass spectra of 19 phenothiazines are presented. In the PIEI mode, peaks due to M, M minus side chain (M – R₁), M – R₁ + H, and side chain itself (R₁) appeared for most compounds The M – R₁ ions were very useful for drug screening. In the PICI mode, most spectra showed base or intense peaks due to M + H, and small peaks due to M + C₂H₅; peaks due to M – R₁ also appeared in many compounds In the NICI mode, fragmentation modes were different in different compound groups; mol. or [M – H]^– quasimol. anions appeared in many compounds with aliphatic side chains. Anions at m/z 98 and 115 were characteristic for compounds with (N-methylpiperazinyl)propyl side chains. Selected ion monitoring in the PIEI mode generally gave much higher sensitivity than in the PICI and NICI modes. Phenothiazines present in urine or plasma could be rapidly isolated by use of Sep-Pak C₁₈ cartridges. Thirteen of 19 phenothaizines could be detected by HP-17 wide-bore capillary gas chromatog. with satisfactory separation from impurities in their underivatized forms. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Product Details of 316-81-4).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Product Details of 316-81-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Power generation and autonomous glucose detection with an integrated array of abiotic fuel cells on a printed circuit board was written by Gonzalez-Solino, Carla;Bernalte, Elena;Metcalfe, Benjamin;Moschou, Despina;Di Lorenzo, Mirella. And the article was included in Journal of Power Sources in 2020.Safety of Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate This article mentions the following:

Wearable technologies can enable effective management of life-threatening diseases. In such systems, miniaturization leads to minimally invasive and light weight devices that, while ensuring safety, allow patients to perform their everyday activities freely. By generating direct and continuous energy from physiol. fluids at body temperature, glucose fuel cells (GFCs) provide an attractive and easy-to-miniaturize power source alternative to lithium batteries. In this context, we explore for the first time the use of printed circuit boards (PCBs) for the development of integrated arrays of abiotic GFCs and successfully demonstrate their operation at physiol. concentrations of glucose, both in a phosphate buffer and in synthetic interstitial fluid. Each GFC consists of a porous gold anode and a Pt/Au cathode in a single layer, and generates a maximum power of 14.3渭W cm^-2 (in 6 mM of glucose), with a linear response to glucose within a concentration range that includes hypo- and hyper-glycemic values. We also demonstrate linear power output scale-up by elec. connecting in parallel four GFCs on PCB. Considering the simplicity of the system architecture and the ease of integration provided by PCBs, our pioneering work paves the way for exciting opportunities in the field of self-powered wearable diagnostics. In the experiment, the researchers used many compounds, for example, Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate (cas: 75277-39-3Safety of Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate).

Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate (cas: 75277-39-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Safety of Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Treatment of cerebellar ataxia with 5-HT1A agonist was written by Takei, Asako;Hamada, Takeshi;Yabe, Ichiro;Sasaki, Hidenao. And the article was included in Cerebellum in 2005.Application of 112457-95-1 This article mentions the following:

Effective, pharmacol. approaches to the treatment of cerebellar ataxia are lacking or inadequate. We recently reported preliminary evidence that tandospirone citrate (tandospirone), a 5-HT1A agonist, improved cerebellar ataxia in patients with Machado-Joseph disease (MJD). In the course of that study, we found that such treatment also alleviated the pain associated with cold sensations in the legs, insomnia, anorexia, and depression, all of which are thought to be mediated through activation of the 5-HT1A receptor. In this paper, we reviewed the few published clin. trials that involved the use of 5-HT 1A receptor agonists for the treatment of cerebellar ataxia, and discussed the current theories regarding their mechanism of action. Cortical cerebellar atrophy (CCA) was reported, in a double-blind study, to be amenable to treatment with tandospirone. Other types of spinocerebellar degeneration (SCD) i.e., olivopontocerebellar atrophy (OPCA) and Machado-Joseph disease (MJD) have also been reported to respond to the drug, but these have been small studies. Responsive patients exhibited only mild ataxia. The doses of 5-HT1A agonists that have been used successfully ranged from 12.5 mg/day to 60 mg/day (or 1mg/kg), and were well tolerated by most patients. In the experiment, the researchers used many compounds, for example, rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1Application of 112457-95-1).

rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application of 112457-95-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization was written by Obreque-Balboa, Jose Esteban;Sun, Qiu;Bernhardt, Guenther;Koenig, Burkhard;Buschauer, Armin. And the article was included in European Journal of Medicinal Chemistry in 2016.Recommanded Product: 72141-41-4 This article mentions the following:

A series of chromones, bearing substituted amino groups or N-substituted carboxamide moieties in position 2, was synthesized and characterized in cellular assays for modulation of the ABC transporters ABCC1 (MDCKII-MRP1 cells), ABCB1 (Kb-V1 cells) and ABCG2 (MCF-7/Topo cells). The most potent ABCC1 modulators identified among these flavonoid-type compounds were comparable to the reference compound reversan regarding potency, but superior in terms of selectivity concerning ABCB1 and ABCG2 (2-[4-(Benzo[c][1,2,5]oxadiazol-5-ylmethyl)piperazin-1-yl]-5,7-dimethoxy-4H-chromen-4-one: ABCC1, IC₅₀ 11.3 渭M; inactive at ABCB1 and ABCG2). This compound was as effective as reversan in reverting ABCC1-mediated resistance to cytostatics in MDCKII-MRP1 cells and proved to be stable in mouse plasma and cell culture medium. Modulators, such 2-[4-(Benzo[c][1,2,5]oxadiazol-5-ylmethyl)piperazin-1-yl]-5,7-dimethoxy-4H-chromen-4-one, were of potential value as pharmacol. tools for the investigation of the (patho)physiol. role of ABCC1. In the experiment, the researchers used many compounds, for example, (4-Nitrophenyl)(piperazin-1-yl)methanone (cas: 72141-41-4Recommanded Product: 72141-41-4).

(4-Nitrophenyl)(piperazin-1-yl)methanone (cas: 72141-41-4) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 掳C and boils at 125鈥?30 掳C. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Recommanded Product: 72141-41-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates was written by Zhuang, Z.-P.;Kung, M.-P.;Hou, C.;Skovronsky, D. M.;Gur, T. L.;Ploessl, K.;Trojanowski, J. Q.;Lee, V. M.-Y.;Kung, H. F.. And the article was included in Journal of Medicinal Chemistry in 2001.Formula: C12H16N2O This article mentions the following:

We report for the first time that small mol.-based radioiodinated ligands, showing selective binding to A尾 aggregates, cross the intact blood-brain barrier by simple diffusion. Four novel ligands showing preferential labeling of amyloid aggregates of A尾(1-40) and A尾(1-42) peptides, commonly associated with plaques in the brain of people with Alzheimer’s disease (AD), were developed. Two ¹²⁵I-labeled styrylbenzenes, (E,E)-1-iodo-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene, I (ISB), and (E,E)-1-iodo-2,5-bis(3-hydroxycarbonyl-4-methoxy)styrylbenzene, II (IMSB), and two ¹²⁵I-labeled thioflavins, 2-[4′-(dimethylamino)phenyl]-6-iodobenzothiazole, III (TZDM), and 2-[4′-(4”-methylpiperazin-1-yl)phenyl]-6-iodobenzothiazole, IV (TZPI), were prepared at a high specific activity (2200 Ci/mmol). In vitro binding studies of these ligands showed excellent binding affinities with K_d values of 0.08, 0.13, 0.06, and 0.13 nM for aggregates of A尾(1-40) and 0.15, 0.73, 0.14, and 0.15 nM for aggregates of A尾(1-42), resp. Interestingly, under a competitive-binding assaying condition, different binding sites on A尾(1-40) and A尾(1-42) aggregates, which are mutually exclusive, were observed for styrylbenzenes and thioflavins. Autoradiog. studies of postmortem brain sections of a patient with Down’s syndrome known to contain primarily A尾(1-42) aggregates in the brain showed that both [¹²⁵I]-III and [¹²⁵I]-IV labeled these brain sections, but [¹²⁵I]-II, selective for A尾(1-40) aggregates, exhibited very low labeling of the comparable brain section. Biodistribution studies in normal mice after an iv injection showed that [¹²⁵I]-III and [¹²⁵I]-IV exhibited excellent brain uptake and retention, the levels of which were much higher than those of [¹²⁵I]-I and [¹²⁵I]-II. These findings strongly suggest that the new radioiodinated ligands may be useful as biomarkers for studying A尾(1-40) as well as A尾(1-42) aggregates of amyloidogenesis in AD patients. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Formula: C12H16N2O).

4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Formula: C12H16N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Isolation, molecular detection and antimicrobial susceptibility profile of Salmonella from raw cow milk collected from dairy farms and households in southern Ethiopia was written by Gebeyehu, Alemayehu;Taye, Mestawet;Abebe, Rahmeto. And the article was included in BMC Microbiology in 2022.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid This article mentions the following:

Salmonella is one of the foodborne pathogens affecting public health around the globe. A cross-sectional bacteriol. study was conducted from Dec. 2019 to Nov. 2020. This study aimed to isolate, molecularly detect and determine antibiotic susceptibility patterns of Salmonella from raw cows’ milk collected from dairy farms and households in Hawassa, Arsi Negele, and Dale districts. A total of 384 raw milk samples were collected using a simple random sampling technique. Standard bacteriol. and biochem. tests were used to isolate Salmonella. The pos. samples were further confirmed by the mol. test. Kirby-Bauer disk diffusion method was used for antimicrobial susceptibility testing of Salmonella. Using bacteriol. and biochem. detection tests, Salmonella was isolated from 10.42% (N = 40) of the total sample. However, in mol. detection, only 32 of the 40 isolates were confirmed to be Salmonella using PCR test. The prevalence was 8.54, 12.69, and 10.46% in Hawassa, Dale, and Arsi Negele districts, resp. Bacteriol. prevalence did not vary significantly between the districts (P > 0.05). Likewise, no significant (P > 0.05) variation was observed in the Salmonella isolation rate between households (12.5%) and farms (8.33%) as well as between dry (8.85%) and wet (11.98%) seasons. Based on herd size, the isolation rate of Salmonella was significantly higher (P < 0.05) in large-scale farms (19.51%) than in small (5.1%) or medium (5.6%) scale dairy farms. The result of the antibiotic susceptibility test showed that Salmonella isolates were 100% resistant to ampicillin, while they were 100% sensitive to ciprofloxacin. Multi-drug resistance (MDR) was demonstrated in all isolates. This study showed that Salmonella is widespread in the raw milk samples and developing MDR, which may be of public health concern in the study area. It is therefore important that dairy farmers and raw milk sellers in the study area take serious measures to avoid contamination of the milk with Salmonella spp. In addition, the active commitment of the animal health departments in the resp. districts to sensitizing dairy farmers and the sensible use of antibiotics at the farm level can help to reduce the antibiotic resistance of Salmonella spp. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Hydroxyzine dihydrochloride was written by Tsau, Josef;DeAngelis, Nicholas. And the article was included in Analytical Profiles of Drug Substances in 1978.Application In Synthesis of 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride This article mentions the following:

A review with 38 references on hydroxyzine-2HCl (I) [2192-20-3] including phys. properties, synthesis, stability, distribution, and methods of anal. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3Application In Synthesis of 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride).

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application In Synthesis of 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics