Category: piperazines

Antibiotics and microbial community-induced antibiotic-resistant genes distribution in soil and sediment in the eastern coastline of China was written by Lu, Jiarui;Yuan, Qingbin;Wang, Xiaolin;Gong, Lulin;An, Xinyi;Liu, Jiayang. And the article was included in Environmental Monitoring and Assessment in 2022.Related Products of 70458-96-7 The following contents are mentioned in the article:

The health risk of antibiotic-resistant genes (ARGs) has been a global concern, while the report on occurrence and prevalence of ARGs in coastal zone is relatively scarce. This study investigated typical ARGs in soil and sediment in coastal line of eastern China and assessed its relationship with antibiotics and heavy metals as well as microbial community. Results showed that eight ARGs were all detected in the samples, and β-lactam resistance gene blaTEM reached the highest absolute abundance (6.28 × 10⁷ ∼ 6.48 × 10⁸ copies/g) and relative abundance (2.3 × 10^-2 copies/16S rRNA) among samples. Amoxicillin and tetracycline were most frequently detected with the average concentration of 2.28μg/kg and 3.48μg/kg, resp. Cr and Zn were found to be most abundant heavy metals with average value of 82.1 and 59.1 mg/kg, resp. Proteobacteria, Campilobacterota, Bacteroidota, and Firmicutes were dominant phyla in most samples, while bacterial community varied significantly among samples. Redundancy analyses (RDA) showed that microbial community and antibiotics (amoxicillin and tetracycline) were driving factors of ARGs distribution, while heavy metals were not significantly correlated with ARGs. This study is helpful to understand the fate of ARGs in coastal zone. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Related Products of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Related Products of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Magnetic Mesoporous Silica Nanoparticles for Drug Delivery Systems: Synthesis, Characterization and Application as Norfloxacin Carrier was written by Otalvaro, Julian Ortiz;Alvarez, Tamara Rodriguez;Gurovic, Maria Soledad Vela;Lassalle, Veronica;Agotegaray, Mariela;Avena, Marcelo;Brigante, Maximiliano. And the article was included in Journal of Pharmaceutical Sciences in 2022.Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Mesoporous silica nanoparticles, with and without the inclusion of a magnetic core, were hydrothermally synthesized and employed as carrier of the antibiotic norfloxacin (NFX). The antibiotic-loaded materials were prepared by wet impregnation. Differences in drug content (and in further release profile) were directly related to changes in surface area, particle aggregation and hydrophobicity of the solids. The kinetics of NFX release has been studied in batch experiments In all cases, more than 55% of the antibiotic was quickly desorbed during the first 5 min due to the localization of NFX on the external surface of the nanoparticles. The rest of the drug (situated inside the mesopores) was released through a diffusion-controlled transport and the rate was strongly dependent of the pH, reaching its min. value at neutral pH. The calculated activation energy confirmed that the release was controlled by a diffusion process. Breaking of H-bonds and electrostatic and hydrophobic interactions appear to be responsible for NFX desorption from the solid surface. Such interactions increase, however, the thermal stability of the drug when the NFX and the carriers are combined. The antimicrobial activities of the drug loaded nanoparticles and the free antibiotic were compared and discussed. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Recommanded Product: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Characterization of Escherichia coli isolated from urinary tract infection and association between virulence expression and antimicrobial susceptibility was written by Derakhshan, Safoura;Ahmadi, Sanaz;Ahmadi, Erfan;Nasseri, Sherko;Aghaei, Abbas. And the article was included in BMC Microbiology in 2022.Computed Properties of C16H18FN3O3 The following contents are mentioned in the article:

The capacity of antibiotics to modulate bacterial virulence has raised concerns over the appropriateness of antibiotic therapies, including when dosing strategies fall below sub-therapeutic levels. In this work, we investigated the ability of antibiotics to influence virulence in Escherichia coli isolated from urinary tract infection (UTI). Out of 120 isolates, 32.5% carried pap, 21.7% carried hlyA, and 17.5% carried cnf. The predominant B2 phylogroup was significantly associated with the quinolone-resistant isolates. A significant association was seen between the presence of hlyA hemolysin and susceptibility to ceftriaxone and ciprofloxacin (P < 0.05). Sub-inhibitory concentrations of both antibiotics reduced the levels of hlyA expression and hemolysis in isolates treated with antibiotics compared to untreated isolates (P < 0.05). Growth rate assay showed that the decrease in hlyA expression was not an effect of decreased growth rate. Our study indicated the inhibitory effect of ciprofloxacin and ceftriaxone on the level of hemolysis, suggesting that the sub-inhibitory concentrations of these antibiotics may affect the outcome of infections. Further studies, including animal models may elucidate the outcome of virulence modulation by these antibiotics in UTI pathogenesis. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Computed Properties of C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Computed Properties of C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Carbon fiber coated by quinoa cellulose nanosheet with outstanding scaled salt self-cleaning performance and purification of organic and antibiotic contaminated water was written by Yang, Jie;Suo, Xidong;Zhao, Jingjing;Wang, Jing;Zhou, Runye;Zhang, Yu;Zhang, Yifei;Qiao, Hongtao;Luo, Xiaohang. And the article was included in Scientific Reports in 2022.Computed Properties of C16H18FN3O3 The following contents are mentioned in the article:

To date, various solar driven evaporation technologies have been developed for treatment of seawater and wastewater but with the threat from salt polluted and single treatment of seawater. Herein, we develop a multifunctional evaporator constructed by carbon fiber coated by quinoa cellulose nanosheet (CFQC) with outstanding self-cleaning performance and good purification property for treatment of organic and antibiotic polluted water. The resulting Zn-CFQC exhibits good light to thermal performance which can absorb about 86.95% lights in the range of UV-Vis-NIR (200-2500 nm); therefore, the wet and dry surface temperatures of Zn-CFQC are held at 62.1 and 124.3° C resp., and keep a speed of 3.2 kg m^-2 h^-1 for water evaporating under 1000 W m^-2 illumination. Such good light-to-thermal capabilities can be mainly imputed to the unique surface microstructures of the carbon fiber which decorated by two-dimension cellulose and activated by ZnCl₂. Addnl., Zn-CFQC shows good salt automatic-cleaning capability at night and corresponding mechanism has been simply elucidated according to the chem. potential theory. The method of treatment of carbon fiber opens a new way for com. carbon fiber utilization of solar assisted water purification This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Computed Properties of C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Computed Properties of C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A tiered probabilistic approach to assess antibiotic ecological and resistance development risks in the fresh surface waters of China was written by Zhang, Jiawei;Ge, Hui;Shi, Jianghong;Tao, Huanyu;Li, Bin;Yu, Xiangyi;Zhang, Mengtao;Xu, Zonglin;Xiao, Ruijie;Li, Xiaoyan. And the article was included in Ecotoxicology and Environmental Safety in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Exposure to antibiotics can result in not only ecotoxicity on aquatic organisms but also the development of antibiotic resistance. In the study, the ecotoxicity data and min. inhibitory concentrations of the antibiotics were screened to derive predicted no-effect concentrations of ecol. (PNEC_eco) and resistance development risks (PNEC_res) for 36 antibiotics in fresh surface waters of China. The derived PNEC_eco and PNEC_res values were ranged from 0.00175 to 2351μg/L and 0.037-50μg/L, resp. Antibiotic ecol. and resistance development risks were geog. widespread, especially in the Yongding River, Daqing River, and Ziya River basins of China. Based on the risk quotients, 11 and 14 of 36 target antibiotics were at high ecol. risks and high resistance development risks in at least one basin, resp. The higher tiered assessments provided more detailed risk descriptions by probability values and β-lactams (penicillin and amoxicillin) were present at the highest levels for ecol. and resistance development risks. Although there was uncertainty based on the limited data and existing methods, this study can indicate the overall situation of the existing risk levels and provide essential insights and data supporting antibiotic management. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Prediction of pharmaceutical and personal care products elimination during heterogeneous catalytic ozonation via chemical kinetic model was written by Liu, Xinghao;Yang, Zhaoguang;Zhu, Wenxiu;Yang, Ying;Li, Haipu. And the article was included in Journal of Environmental Management in 2022.Quality Control of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Prediction of the removal of pollutants is important for the process design and optimization of wastewater treatment. In this study, the heterogeneous catalytic ozonation chem. kinetic model based on reaction kinetic constants between O₃ (and •OH) and pollutants, and pseudo-first order rate constants for pollutant adsorption was established. The model parameters were obtained via O₃ and p-chlorobenzonic acid decay curves, and adsorption kinetic experiments, resp. Higher •OH exposures were obtained at the expense of lower O₃ exposures during catalytic ozonation compared to simple ozonation. Importantly, the exptl. measured and model-predicted removal ratios correlated well in all reaction systems, with correlation coefficients above 0.950 in synthetic solution and 0.893-0.979 in secondary effluent. Furthermore, the model revealed that pollutants were degraded mainly by O₃ and/or •OH oxidation during catalytic ozonation, while adsorption of pollutants on catalysts contributed negligibly. Hence, the degradation ratios of pollutants could be satisfactorily predicted using the simplified model based only on the O₃ and •OH exposures in the heterogeneous catalytic ozonation systems with low adsorption capacity catalysts. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Quality Control of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Quality Control of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Norfloxacin adsorption and subsequent degradation on ball-milling tailored N-doped biochar was written by Wu, Jingqi;Wang, Tongshuai;Liu, Yuyan;Tang, Wei;Geng, Shuyu;Chen, Jiawei. And the article was included in Chemosphere in 2022.Reference of 70458-96-7 The following contents are mentioned in the article:

N-doping is an effective way to modify biochar for enhancing the adsorption capacity. The synthesis of N-doped biochar by the ball-milling method has been attractive due to its facile and eco-friendly approach with low energy consumption. However, the commonly used N-precursor NH₃·H₂O is environmentally harmful. It is needed to prepare safe and non-toxic N-doped biochar for large-scale production Here, a urea N-doped biochar (U-MBC) was prepared by the ball-milling method and used for norfloxacin (NOR) removal. The results showed that U-MBC exhibited almost 4-fold higher adsorption capacity for NOR than pristine biochar in a wide pH range (3-9). The adsorption enhancement was owing to the enhancement of H-bonds, π-π electron donor-acceptor, and pore-filling interactions due to the N-doping and ball-milling method. Addnl., 89% of adsorbed NOR can be further removed after 6 h milling. The regenerated U-MBC still had a good adsorption capacity (46.27 mg g^-1) and performed well in three cycles. The knowledge gained from this study could encourage researchers to use urea or similar safe N-precursors with the ball-milling method for the large-scale production of N-doped biochar to remove antibiotic organic pollutants in the environment. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Reference of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Enhanced photo-fenton and photoelectrochemical activities in nitrogen doped brownmillerite KBiFe₂O₅ was written by Vavilapalli, Durga Sankar;Behara, Santosh;Peri, Raja Gopal;Thomas, Tiju;Muthuraaman, B.;Rao, M. S. Ramachandra;Singh, Shubra. And the article was included in Scientific Reports in 2022.Application of 70458-96-7 The following contents are mentioned in the article:

Visible-light-driven photo-fenton-like catalytic activity and photoelectrochem. (PEC) performance of nitrogen-doped brownmillerite KBiFe₂O₅ (KBFO) are investigated. The effective optical bandgap of KBFO reduces from 1.67 to 1.60 eV post N-doping, enabling both enhancement of visible light absorption and photoactivity. The photo-fenton activity of KBFO and N-doped KBFO samples were analyzed by degrading effluents like Methylene Blue (MB), Bisphenol-A (BPA) and antibiotics such as Norfloxacin (NOX) and Doxycycline (DOX). 20 mmol of Nitrogen-doped KBFO (20N-KBFO) exhibits enhanced catalytic activity while degrading MB. 20N-KBFO sample is further tested for degradation of Bisphenol-A and antibiotics in the presence of H₂O₂ and chelating agent L-cysteine. Under optimum conditions, MB, BPA, and NOX, and DOX are degraded by 99.5% (0.042 min^-1), 83% (0.016 min^-1), 72% (0.011 min^-1) and 95% (0.026 min^-1) of its initial concentration resp. Photocurrent d. of 20N-KBFO improves to 8.83 mA/cm² from 4.31 mA/cm² for pure KBFO. Photocatalytic and photoelectrochem. (PEC) properties of N-doped KBFO make it a promising candidate for energy and environmental applications. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Application of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Application of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cobalt/calcium bimetallic oxides based on bio-waste eggshells for the efficient degradation of norfloxacin by peroxymonosulfate activation was written by Zhang, Xinyi;Yang, Zhiquan;Cui, Xiandi;Liu, Wanhui;Zou, Baosheng;Liao, Wenning. And the article was included in Journal of Colloid and Interface Science in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Cobalt-calcium bimetallic oxide (ECCO) was successfully prepared using eggshells and cobalt nitrate, which could be used to activate peroxymonosulfate (PMS) to remove norfloxacin (NOR). The compositional structure and surface properties of the catalysts were explored by various characterization anal. The degradation efficiency of ECCO was 7.86 and 440 times higher than that of cobalt oxide and calcium oxide, resp. The prepared ECCO (0.1 g/L) had a high degradation efficiency of over 90% against NOR (10 mg/L, 100 mL) by activating the PMS (0.15 g/L) at a wide pH range of 3.0-9.0 in 35 min. With a NOR removal efficiency of 91.4% after five cycles, the catalyst showed good reusability. The high degradation efficiency of NOR was resulted from enhanced electron transfer capability, the low point of zero charge and diversified reactive oxygen species (ROS). The ROS were identified as SO₄^•-, •OH and ¹O₂, which were produced by activating PMS on the active sites of Co and oxygen vacancies. It is the first report of the use of eggshells to synthesize cobalt-calcium bimetallic oxides ECCO for the activation of PMS to eliminate NOR, which is important for the development of green and efficient catalysts. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Contamination, transport, and ecological risks of pharmaceuticals and personal care products in a large irrigation region was written by Wang, Cong;Lu, Yonglong;Sun, Bin;Zhang, Meng;Wang, Rui;Li, Xiaoqian;Mao, Ruoyu;Cao, Zhiwei;Song, Shuai. And the article was included in Science of the Total Environment in 2022.Electric Literature of C16H18FN3O3 The following contents are mentioned in the article:

Pharmaceuticals and personal care products (PPCPs) have attracted widespread attention owing to their extensive use and potential adverse effects on human and ecosystem health. There is a lack of information regarding the occurrence and environmental fate of PPCPs in large agricultural irrigation areas in China. In this study, we conducted a comprehensive survey on 30 PPCPs in water from Hetao Irrigation District, one of the three largest irrigation areas in China. The ΣPPCP-concentrations ranged 82.13-1409.24 ng/L in August and 40.53-887.20 ng/L in Nov., with caffeine (CAF), norfloxacin (NOR), erythromycin (ERY), sulfamethoxazole (SMX) and ofloxacin (OFL) being the predominant compositions Spatially, the average ΣPPCP concentrations increased from irrigation to drainage water, and then decreased in Wuliangsuhai Lake. Less PPCP mass loading (55.05 kg/y) migrated from Wuliangsuhai Lake to Yellow River than that from the Yellow River to Hetao Irrigation District (425.88 kg/y), indicating that Wuliangsuhai Lake plays an important role in improving water quality. An ecol. risk assessment showed that it is worthwhile to consider the presence of CAF, ERY, NOR, and OFL in natural surface water and to control their potential risks. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Electric Literature of C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics