Category: piperazines

New intermediates for the selective synthesis of 1-methyl-3-phenylpiperazine and some phenylpiperazine derivatives was written by Rao, Divvela V. N. Srinivasa;Dandala, Ramesh;Handa, Vijay Kumar;Sivakumaran, Meenakshisunderam;Naidu, Andra. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2006.Electric Literature of C15H20N2O3 The following contents are mentioned in the article:

New intermediates 4-protected-1-alkyl-2-oxo-3-phenylpiperazines and 1-alkyl-2-oxo-3-phenylpiperazines for the selective synthesis of 1-alkyl-3-phenylpiperazines, e.g., I, are described. First method involves the reduction of the 4-protected-1-alkyl-2-oxo-3-phenylpiperazines followed by deprotection giving the 1-alkyl-3-phenylpiperazines. Second method involves the deprotection of 4-protected-1-alkyl-2-oxo-3-phenylpiperazines followed by reduction giving the 1-alkyl-3-phenylpiperazines. This study involved multiple reactions and reactants, such as tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate (cas: 911705-40-3Electric Literature of C15H20N2O3).

tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate (cas: 911705-40-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Electric Literature of C15H20N2O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification was written by Komoriya, Satoshi;Kobayashi, Shozo;Osanai, Ken;Yoshino, Toshiharu;Nagata, Tsutomu;Haginoya, Noriyasu;Nakamoto, Yumi;Mochizuki, Akiyoshi;Nagahara, Takayasu;Suzuki, Makoto;Shimada, Takashi;Watanabe, Kengo;Isobe, Yumiko;Furugoori, Taketoshi. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Category: piperazines The following contents are mentioned in the article:

Serine protease factor Xa (fXa) inhibitor I showed good ex vivo anti-fXa activity upon oral administration in rats. However, it has been revealed that I had low metabolic stability against human liver microsomes. To improve the metabolic stability, we attempted to modify the S1 and S4 ligands of I. These modifications resulted in a compound which exhibited selective anti-fXa activity and excellent anti-coagulation activity. This study involved multiple reactions and reactants, such as Methyl 2-(1,4-dibenzylpiperazin-2-yl)acetate (cas: 183742-32-7Category: piperazines).

Methyl 2-(1,4-dibenzylpiperazin-2-yl)acetate (cas: 183742-32-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Dehydrated crystalline form of (3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl) acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester ethanesulfonate was written by Anonymous. And the article was included in IP.com Journal in 2015.Application of 656247-18-6 The following contents are mentioned in the article:

Described herein after is a dehydrated form of the hemihydrate form of (3Z)-2,3-dihydro-3- [[[4-[methyl[2-(4-methyl-1-piperazinyl) acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H- indole-6-carboxylic acid Me ester ethansulfonate (referred to as Compound A). The water content of the dehydrated form is of about 0.32%, determined by Karl Fischer (KF) method, whereas the theor. value of water content for Compound A as a hemihydrate form is 1.37%. This study involved multiple reactions and reactants, such as (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6Application of 656247-18-6).

(Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Application of 656247-18-6

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthetic approaches to the 2014 new drugs was written by Flick, Andrew C.;Ding, Hong X.;Leverett, Carolyn A.;Kyne, Robert E. Jr.;Liu, Kevin K.-C.;Fink, Sarah J.;O’Donnell, Christopher J.. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Quality Control of (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate The following contents are mentioned in the article:

A review. New drugs introduced to the market every year represent privileged structures for particular biol. targets. These new chem. entities (NCEs) provide insight into mol. recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of thirty-seven NCEs that were approved for the first time in 2014 and one drug which was approved in 2013 and was not covered in a previous edition of this review. This study involved multiple reactions and reactants, such as (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6Quality Control of (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate).

(Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Quality Control of (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Identification of 1-X-2,4-dinitro arenes with a sterically demanding substituent and their mono-reduction products using IR-spectroscopy was written by Begunov, R. S.;Shvyrkova, N. S.;Yakovleva, Yu. S.;Kosareva, T. N.. And the article was included in Bashkirskii Khimicheskii Zhurnal in 2008.Category: piperazines The following contents are mentioned in the article:

IR-spectral characteristic of title compounds were investigated. The more high-frequency component of antisym. valence vibrations in IR-spectrum of 1-substituted 2,4-dinitrobenzenes was proved by the exptl. method to cover a nitro group located in ortho position to the substituent. The isomeric nitroanilines forming in the process of their mono-reduction can be identified with absorption bonds of nitro group. This study involved multiple reactions and reactants, such as 2-(4-Methylpiperidin-1-yl)-5-nitroaniline (cas: 188604-99-1Category: piperazines).

2-(4-Methylpiperidin-1-yl)-5-nitroaniline (cas: 188604-99-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mechanism of monoreduction by variable valency metal salts in unsymmetrical heterocycle-containing dinitrobenzenes was written by Begunov, R. S.;Demidova, N. Yu.;Brodskii, I. I.;Orlov, V. Yu.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2004.SDS of cas: 188604-99-1 The following contents are mentioned in the article:

The behavior of nitrogroups in 1-substituted saturated heterocycle-containing 2,4-dinitrobenzenes under Sn(II) and Ti(III) monoredn. has been investigated. A model of the process explaining the mechanism of conversion has been suggested. This study involved multiple reactions and reactants, such as 2-(4-Methylpiperidin-1-yl)-5-nitroaniline (cas: 188604-99-1SDS of cas: 188604-99-1).

2-(4-Methylpiperidin-1-yl)-5-nitroaniline (cas: 188604-99-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.SDS of cas: 188604-99-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

An improved process for the synthesis of nintedanib esylate was written by Arava, Veerareddy;Gogireddy, Surendrareddy. And the article was included in Synthetic Communications in 2017.Safety of (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate The following contents are mentioned in the article:

Nintedanib esylate was synthesized via novel intermediates of (Z)-Me 3-(acetoxy-phenyl)methylene-1-acetyl-2-oxoindoline-6-carboxylate and N-(4-aminophenyl)-2-chloro-N-methylacetamide in good yields. This study involved multiple reactions and reactants, such as (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6Safety of (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate).

(Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Safety of (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Towards the rapid detection of multiple antibiotics in eggs by Surface-enhanced Raman spectroscopy coupled with hollow fiber micro-extraction was written by Jin, Mengke;Wang, Xue;Russel, Mohammad;Shan, Jiajia. And the article was included in Microchemical Journal in 2022.Safety of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Surface-enhanced Raman Spectroscopy (SERS) is an alternative tool in the field of food safety detection. Complicated food sample preparations are the key challenges to use SERS anal. for rapid food test. This study proposed a novel, facile and sensitive hollow fiber liquid-phase micro-extraction coupled with SERS (HF-LPME-SERS) technique for rapid detection of multiple antibiotic residues in eggs samples. The parameters affecting the extraction efficiency were optimized, and the optimized HF-LPME method could extract antibiotics from egg samples directly. That is eased up to sample preparation steps and promotes the SERS to rapid food testing. Moreover, here reported a simple preparation and cost-effective laser induced self-assembly SERS substrate; and applied it to SERS spectra measurement of the extract The min. detection concentration was 10 ng/g achieved for multiple antibiotics, which demonstrated the superior SERS performance. The proposed HF-LPME-SERS method provides easy sample operation, low reagent cost and high sensitivity, which would be a green and rapid anal. approach to detect the trace amount of hazardous substances in food. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Safety of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Safety of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Human daily dietary intakes of antibiotic residues: Dominant sources and health risks was written by Ben, Yujie;Hu, Min;Zhong, Fengxia;Du, Erhu;Li, Yu;Zhang, Hong;Andrews, Charles B.;Zheng, Chunmiao. And the article was included in Environmental Research in 2022.SDS of cas: 70458-96-7 The following contents are mentioned in the article:

Antibiotic use in crops is an emerging concern, however, human exposure to antibiotics residues through consumption of plant-derived food has generally been neglected. This study is a comprehensive evaluation based on full consideration of exposure sources and anal. for nearly 100 antibiotics. A total of 58 antibiotic compounds were detected in drinking water (n = 66) and 49 in food samples (n = 150) from Shenzhen, China. The probable daily intake from drinking water and food consumption based on the total concentration of all the detected antibiotic compounds was 310, 200, and 130 ng/kg-body weight/day for preschool children, adolescents, and adults, with a maximum of up to 1400, 970 and 530 ng/kg-bw/day, resp. Consumption of plant-derived food products, rather than animal-derived food, was the main source of the daily intake, and drinking water was a minor source. Risk assessment suggested a potentially unacceptable health risk from daily intake of norfloxacin, lincomycin and ciprofloxacin. Further research is warranted to alleviate food safety concerns related to antibiotic residues in plant-derived and animal-derived food products. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7SDS of cas: 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synchronously activated strontium aluminate nanoflakes anchored functionalized carbon nanofiber nanocomposite for sensitive amperometric detection of food additive: Propyl gallate was written by Priscillal, I. Jenisha Daisy;Wang, Sea-Fue. And the article was included in Food Chemistry in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

The contemporary dietary pattern is ruined by taste enhancers, flavoring agents, and preservatives. Pr gallate (PG) is an imperative phenolic antioxidant cast-off to inhibit the oxidative mutilation in foodstuffs thereby preventing rancidity. Determination and annihilation of PG are extensively concerned because of its probable lethal effects on human well-being. Herein, we report an electrochem. sensor using SrAl2O4/f-CNF nanocomposite as an efficient electrode modifier with peculiar synergistic quantum confinement effects supporting the formation of heterojunction to facilitate electron transportation between its counterparts. The structural, morphol., and crystalline features of SrAl2O4/f-CNF nanocomposite was thoroughly examined The proposed sensor possesses a wide linear range (0.1-1104.75μM) with a remarkably low limit of detection (0.075μM) and sensitivity (1.142μA·μM^-1·cm^-2) measured at 0.2 V (vs. Ag/AgCl). The reliability of this sensor was evidenced through real-time monitoring of PG in edible oil which is beneficial for food quality monitoring and dropping the danger of abuse of PG in foods. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics