Category: 98105-99-8

Assessment of a specific sample cleanup for the multiresidue determination of veterinary drugs and pesticides in salmon using liquid chromatography/tandem mass spectrometry was written by Castilla-Fernandez, Delia;Moreno-Gonzalez, David;Bouza, Marcos;Saez-Gomez, Andrea;Ballesteros, Evaristo;Garcia-Reyes, Juan F.;Molina-Diaz, Antonio. And the article was included in Food Control in 2021.Recommanded Product: 98105-99-8 This article mentions the following:

A novel sample treatment approach based on a modified QuEChERS method was evaluated for the simultaneous determination of veterinary drug and pesticide residues in salmon in this work. To improve the QuEChERS performance, Enhanced Matrix Removal-Lipid dSPE cleanup sorbent was evaluated for the first time for the simultaneous anal. of these organic contaminants in salmon samples. Due to this sorbent can effectively remove coextd. families of lipids. To cover a wide range of polarities, 65 pesticides and 41 veterinary drugs with log Kow ranging from -1.4 to 5.5 were selected. Extracts after cleanup were analyzed by ultra-high-performance liquid chromatog.-tandem mass spectrometry for analyte confirmation and quantitation. Outstanding results were obtained for both extraction efficiency and matrix removal. A negligible matrix effect was obtained for 57% of the studied compounds, whereas the rest presented a soft matrix effect. The recovery for spiked samples was in agreement with the current European Union recommendations for most compounds The rest of the parameters were also satisfactory, reaching quantification limits lower than 3.7μg kg-1 in all cases. The precision was better than 20% in all cases. Finally, the method performance was successfully demonstrated with 20 salmon samples, five of which contained pesticide or veterinary drug residues. In the experiment, the researchers used many compounds, for example, 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8Recommanded Product: 98105-99-8).

6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Recommanded Product: 98105-99-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Rapid and ultra-trace levels analysis of 33 antibiotics in water by on-line solid-phase extraction with ultra-performance liquid chromatography-tandem mass spectrometry was written by Shen, Fei;Xu, Yan-Juan;Wang, Ye;Chen, Jing;Wang, Shuo. And the article was included in Journal of Chromatography A in 2022.Application In Synthesis of 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid This article mentions the following:

A method was developed for the determination of 33 antibiotics belonging to 4 different antibiotic groups, including sulfonamides (16), fluoroquinolones (12), macrolides (1), and tetracyclines (4) in water samples using online solid-phase extraction-ultra performance liquid chromatog.-electrospray ionization tandem mass spectrometry (online SPE-UPLC-MS/MS). The enrichment and anal. conditions were optimized for the determination of trace concentrations (nanogram per L). Aliquots of the water samples (5 mL) were filtered through a membrane and enriched on an online polymeric column with hydrophilic-lipophilic balance (HLB). The analyte was eluted by the mobile phase during online SPE and separated on an Acquity BEH130 column, detected by tandem mass spectrometry, and quantified using an external standard method. The optimization of the anal. methods was discussed, which included optimization of pH of the sample, filtration membrane, Na2EDTA, chromatog. column, formic acid and aqueous ammonia in mobile phase. The detection limit for all test compounds by this method was in the range of 0.2-1.5 ng/L, with recoveries of 76.6-118%. The precision of the method, as indicated by the relative standard deviation, was 2.4-7.9%. Results of anal. of surface water samples demonstrated the ability of the proposed method to analyze ultra-trace levels of antibiotics, without the need for complex manual pretreatment. In the experiment, the researchers used many compounds, for example, 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8Application In Synthesis of 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Application In Synthesis of 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

NanoMIP-Based Solid Phase Extraction of Fluoroquinolones from Human Urine: A Proof-of-Concept Study was written by Chiarello, Matteo;Anfossi, Laura;Cavalera, Simone;Di Nardo, Fabio;Serra, Thea;Baggiani, Claudio. And the article was included in Separations in 2021.Name: 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid This article mentions the following:

NanoMIPs that are prepared by solid phase synthesis have proven to be very versatile, but to date only limited attention has been paid to their use in solid phase extraction Thus, since nanoMIPs show close similarities, in terms of binding behavior, to antibodies, it seems relevant to verify if it is possible to use them as mimics of the natural antibodies that are used in immunoextn. methods. As a proof-of-concept, we considered prepared nanoMIPs against fluoroquinolone ciprofloxacin. Several nanoMIPs were prepared in water with polymerization mixtures of different compositions The polymer with the highest affinity towards ciprofloxacin was then grafted onto a solid support and used to set up a solid phase extraction-HPLC method with fluorescence detection, for the determination of fluoroquinolones in human urine. The method resulted in successful selection for the fluoroquinolone antibiotics, such that the nanoMIPs were suitable for direct extraction of the antibiotics from the urine samples at the μg mL^-1 level. They required no preliminary treatment, except for a 1 + 9 (volume/volume) dilution with a buffer of pH 4.5 and they had good analyte recovery rates; up to 85% with precision in the range of 3 to 4.5%, without interference from the matrix. These exptl. results demonstrate, for the first time, the feasibility of the use of nanoMIPs to develop solid phase extraction methods. In the experiment, the researchers used many compounds, for example, 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8Name: 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 98105-99-8) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Name: 6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics