Category: 928025-56-3piperazines

928025-56-3, (S)-tert-Butyl 3-ethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Intermediate 13 (1 g, 4.61 mmol) in POCI3 (13 mL, 139.17 mmol) was added N,N-dimethylaniline (0.274 g, 2.26 mmol). The reaction mixture was heated at 110C for 6 h, then concentrated in vacuo. The solid obtained was triturated in pentane. To a stirred solution of the unpurified residue (1.3 g, 5.57 mmol) in THF (40 mL) were added triethylamine (6.43 mL, 46.15 mmol) and tert- butyl (3S)-3-ethylpiperazine-l -carboxylate (1.08 g, 5.08 mmol). The reaction mixture was stirred at r.t. for 12 h, then concentrated in vacuo. The residue was dissolved in EtOAc (50 mL). The organic layer was washed with water (50 mL), then dried over anhydrous sodium sulfate and concentrated in vacuo. The crude residue was purified by column chromatography (normal phase; silica gel: 100-200 mesh; 2% EtOAc in hexanes) to afford the title compound (0.62 g, 33%). deltaEta (CDC13, 400 MHz) 7.82 (s, 1H), 4.22-4.10 (m, 2H), 3.40-3.30 (m, 2H), 3.22-3.10 (m, 3H), 2.58 (s, 3H), 1.84-1.74 (m, 2H), 1.48 (s, 9H), 0.98-0.80 (m, 3H). LCMS (ES+) [M+H]+ 413.45, RT 4.20 minutes (method 4)., 928025-56-3

928025-56-3 (S)-tert-Butyl 3-ethylpiperazine-1-carboxylate 24820542, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; HORSLEY Helen Tracey; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193169; A1; (2015);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.928025-56-3,(S)-tert-Butyl 3-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

928025-56-3, INTERMEDIATE 11 7-[(2S)-2-Ethylpiperazin- 1 -yll-3-methylisoxazolo[4,5 -d]pyrimidin-5-amine dihydrochioride Intermediate 10 (2.70 g, 16 mmol) was slurried in phosphorus oxychioride (33 mL) and DIPEA (5.3 mL) was added. The mixture was heated at reflux for 5 h. Upon cooling, the reaction mixture was concentrated in vacuo. The brown oil was partitioned between EtOAc and water. The organic layer was dried over Na2SO4 and concentrated. The resulting crude brown oil was dissolved in DMF (10 mL) and DIPEA (1.3 mL) wasadded, followed by (S)-tert-butyl 3-ethylpiperazine-1-carboxylate (0.96 g, 4.17 mmol).The reaction mixture was stirred at 70C overnight. The resulting solution wasconcentrated in vacuo, and the residue was purified by silica gel chromatography(gradient 40-100% EtOAc in isohexane). The resulting crude material was dissolved inEtOH, then 4M HC1 in 1,4-dioxane (10 mL) was added. The reaction mixture was stirredfor 2 h, then concentrated in vacuo, to give the title compound (1.0 g, 19% overall) as asticky brown solid. LCMS (ES+) MH 263, RT 0.76 minutes (method 1).

The synthetic route of 928025-56-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FORD Daniel James; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193168; A1; (2015);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics