Category: 892242-64-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.892242-64-7,4-((3-(4-Cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acid,as a common compound, the synthetic route is as follows.,892242-64-7

In a flask, Intermediate 6, Pd/C and hydrazine were mixed and heated for about 4 hours. Reaction mixture was cooled to room temperature and filtered, and then it was redissolved in TFA/DMAc and active charcoal, and then filtered through celite. NaHCO3 was added to neutralize the mixture and the solid was collected by filtration. Compound 12 was purified and dried. It gave about 99% (HPLC, area %) purity. Mass spectra gave [M+1]=525.5. 1H-NMR (300 MHz, DMSO-d6), ppm (delta): 12.36 (1H, s), 8.27 (2H, d), 7.95 (2H, d), 7.85 (2H, t), 7.42 (2H, d), 7.25 (1H, s), 2.96 (4H, m), 2.74 (4H, m), 2.27 (2H, m), 1.57-1.80 (6H, m), 1.06-1.23 (5H, m).

As the paragraph descriping shows that 892242-64-7 is playing an increasingly important role.

Reference：
Patent; VM Oncology LLC; Wu, Jay Jie-Qiang; US2015/218132; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.892242-64-7,4-((3-(4-Cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acid,as a common compound, the synthetic route is as follows.,892242-64-7

Example 3 Preparation of sodium 4-((3-(4-cvciohexyipiperazin- I -yfl-6-oxo-6H-anthraj I 9-cdIisoxazol-5- yflamino)benzoate, About SOg of 4-((3-(4-cyclohexyipiperazin- 1 -yl)-6-oxo-6H-anthra[ 1 ,9- cd]isoxazol-5-yl)arnino)henzoic acid was slurred in 2500mL of 0.4 M NaOH/MeOH between 40-45C for 2-4 hours, After confirmed the reaction completion by FIPLC, slowly cooled thereaction to room temperature. The solid was centrifuged and washed with 2OmL of MTBE. The wet cake was re-suspended in about i000mL of O.1M NaOH in MeOH solution under room temperature. It was centrifuged and washed with 224rnL of MTBE again. The filtered solid was suspended in 996nTh of MTBE under room temperature for I -2 hours. The solid was separated and dried at 2530C under pressure for 12-24 hours to obtain the final desired product withpurity more than 99% and about 90% yield. Mass spectra give [M-?-I = 523.2. ?H-NMR (400MHz, DMSO-d6, see Figure 3), ppm (oe): 11.79 (IH, s), 8.48 (111, d), 8.20 (1H, ci), 7.93 (2Ff, d),7.84 (114, t), 7.72 (IH, t), 7.35 (2H, d), 6.39 (1 Fl, s), 3.85 (4ff m), 2.72-2.70 (414, in), 2.28-2.265(IF, m), 1.72-1.78 (4H, in), 1.55-1.58 (IN, m), 1.08-1.23 (SF1, m). Sodium content is 3.8%. TheRaman spectrum is shown in Figure 5. The XRPD, see Table below and Figure 4, confirmed thepolymorphic form.

892242-64-7 4-((3-(4-Cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acid 3666186, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; VM PHARMA LLC; WU, Jay Jie-Qiang; WANG, Ling; (83 pag.)WO2016/43975; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics