The dehydration of ureas by two-phase dichlorocarbene reaction, a synthetic access to substituted cyanamides was written by Schroth, W.;Kluge, H.;Frach, R.;Hodek, W.;Schaedler, H. D.. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1983.SDS of cas: 89026-59-5 The following contents are mentioned in the article:
A wide variety of N,N-disubstituted ureas were dehydrated in the CHCl3/NaOH catalytic 2-phase system under mild conditions. The sequence of urea transamidation and dehydration offers a profitable approach to aprotic cyanamides. Among various phase-transfer catalysts tertiary amines prove to be the most efficient. Tertiary amines may also be used in the transformation of carboxamides and thioamides to the corresponding nitriles. The application of the same technique is less suitable in the case of N-monosubstituted ureas, N,N‘-disubstituted ureas, and N-(dialkylaminomethylene)ureas, since subsequent reactions of the cyanamides predominate. The dehydration mechanism is elucidated in terms of HOMO-perturbation theory. This study involved multiple reactions and reactants, such as 4-(4-Methoxyphenyl)piperazine-1-carboxamide (cas: 89026-59-5SDS of cas: 89026-59-5).
4-(4-Methoxyphenyl)piperazine-1-carboxamide (cas: 89026-59-5) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.SDS of cas: 89026-59-5
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics