Category: 85817-34-1

Related Products of 85817-34-1On May 15, 2007 ,《Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2′-Substituted 6-nitroquipazines》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Lee, Jae Hak; Choi, Yong Hyun; Lim, Yoo Jin; Lee, Byoung Se; Chi, Dae Yoon; Jin, Changbae. The article conveys some information:

Five C2′-substituted 6-nitroquipazine (6-NQ) derivatives were prepared and evaluated in terms of their biol. abilities (Ki) to displace [3H]citalopram binding to serotonin transporter. The relationship between their structure and biol. activities revealed that shorter alkyl groups tend to possess higher binding affinity. Both compounds 12a (I, R1 = OH) and 12c (I, R1 = OEt) were found to have the equally highest binding affinity (Ki = 0.43 ± 0.02 nM). The results came from multiple reactions, including the reaction of (4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1Related Products of 85817-34-1)

(4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1) belongs to piperazines. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines.Related Products of 85817-34-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Naylor, Alan; Judd, Duncan B.; Lloyd, Jane E.; Scopes, David I. C.; Hayes, Ann G.; Birch, Philip J. published an article in Journal of Medicinal Chemistry. The title of the article was 《A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines》.Application In Synthesis of (4-Benzylpiperazin-2-yl)methanol The author mentioned the following in the article:

The synthesis of 4-substituted 1-(arylacetyl)-2-[(alkylamino)methyl]piperazines I [R = CO2Me, R1 = R2 = Me; R = CO2Me, R1R2 = CH2CH:CHCH2CH2; R = COR3, R1R2 = (CH2)4, R3 = H, Me, Et, Pr, CH2OMe, CH:CH2, Ph, PhCH2; R = CO2R4, R1R2 = (CH2)4, R4 = Me, Et, Pr, Ph, PhCH2] and II [X = CHOH, CO, C:CHCO2Me-(E), -(Z)] and their activities as κ-opioid receptor agonists are described. This includes a range of 4-acyl and 4-carboalkoxy derivatives with the latter series showing the greatest κ-agonist activity. In particular, Me 4-[3,4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)methyl]-1-piperazinecarboxylate [I; R = CO2Me; R1R2 = (CH2)4] displays exceptional potency and selectivity. It showed the following activities in functional in vitro assays: rabbit vas deferens (κ-specific tissue) IC50 = 0.041 nM, rat vas deferens (μ-specific tissue) IC50 > 10 000 nM, and hamster vas deferens (δ-specific tissue) IC50 > 10 000 nM. Compound I [R = CO2Me; R1R2 = (CH2)4] is also a highly potent antinociceptive agent, as determined in the mouse acetylcholine-induced abdominal constriction test: ED50 = 0.000 52 mg/kg, s.c. The activity of I resides solely in its 3(R)-enantiomer. The κ-agonist activity in both the 4-acyl and the 4-carbamate series is sensitive to the size of the 4-substituent. In addition, it would appear that an appreciable neg. electrostatic potential in this region of the mol. is an important requirement for optimal potency.(4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1Application In Synthesis of (4-Benzylpiperazin-2-yl)methanol) was used in this study.

(4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application In Synthesis of (4-Benzylpiperazin-2-yl)methanol

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Electric Literature of C12H18N2OOn May 1, 2010 ,《Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Sandanayaka, Vincent; Mamat, Bjorn; Bhagat, Nikhil; Bedell, Louis; Halldorsdottir, Gudrun; Sigthorsdottir, Heida; Andresson, Torkell; Kiselyov, Alex; Gurney, Mark; Singh, Jasbir. The article conveys some information:

Novel piperidine and piperazine derivatives have been designed and tested as inhibitors of LTA4 hydrolase (LTA4H). Most potent compounds showed good potency in both enzymic and functional human whole blood assay. Crystallog. studies further confirmed observed structure-activity relationship and LTA4H binding mode for analogs from the piperidine series. In addition to this study using (4-Benzylpiperazin-2-yl)methanol, there are many other studies that have used (4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1Electric Literature of C12H18N2O) was used in this study.

(4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Electric Literature of C12H18N2O

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Category: piperazinesOn May 1, 2010 ,《Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Sandanayaka, Vincent; Mamat, Bjorn; Bhagat, Nikhil; Bedell, Louis; Halldorsdottir, Gudrun; Sigthorsdottir, Heida; Andresson, Torkell; Kiselyov, Alex; Gurney, Mark; Singh, Jasbir. The article conveys some information:

Novel piperidine and piperazine derivatives have been designed and tested as inhibitors of LTA4 hydrolase (LTA4H). Most potent compounds showed good potency in both enzymic and functional human whole blood assay. Crystallog. studies further confirmed observed structure-activity relationship and LTA4H binding mode for analogs from the piperidine series. In addition to this study using (4-Benzylpiperazin-2-yl)methanol, there are many other studies that have used (4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1Category: piperazines) was used in this study.

(4-Benzylpiperazin-2-yl)methanol(cas: 85817-34-1) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics