Category: 77290-31-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.77290-31-4,tert-Butyl 4-(cyanomethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,77290-31-4

NaHMDS (4.9 mL, 2M) was added to a solution of 6-bromo-2-chlorobenzo[djthiazole (1 g, 4.0 mmol) and tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate (ig, 4.4mmol) in dry THF (20 mL) under Ar atmosphere at 0C. The mixture was stirred overnight at room temperature. Then Ni02H20 (1.77 g, 16.1 mmol) was added and the resulting mixture was stirred for another 10 hrs at room temperature. Solid was filtered off and washed with MeOH. The combined solution was concentrated and purified by silica gel chromatography (silica gel, eluting with 10% EA in PE) to afford tert-butyl 4-(6- bromobenzo[djthiazole-2-carbonyl)piperazine-1-carboxylate (0.6g, 58.8%) as white solid. LC-MS (ESI):426.5 (M + 1).

The synthetic route of 77290-31-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; PINKERTON, Anthony B.; ARDECKY, Robert J.; ZOU, Jiwen; (256 pag.)WO2018/204176; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

77290-31-4, tert-Butyl 4-(cyanomethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77290-31-4, tert-Butyl 4-thiocarbamoylmethylpiperazine-1-carboxylate A solution of tert-butyl 4-cyanomethylpiperazine-1-carboxylate (4.5 g, 0.020 mol) in a 3:1 mixture of triethylamine/pyridine (40 mL) at room temperature was bubbled with hydrogen sulfide for 30 minutes. The reaction mixture was stirred for 18 hours at room temperature and then concentrated under vacuum. The residue was treated with a mixture 1:4 mixture of ethyl acetate/hexane and the resulting solid was collected by filtration and washed with the ethyl acetate/hexane mixture to provide tert-butyl 4-thiocarbamoylmethyl-piperazine-1-carboxylate (3.93 g, 75%). H-NMR (dmso-d6): 9.87 (1H, bs), 9.07 (1H, bs), 3.35 (4H, t), 2.34 (4H, t), 1.29 (9H, s); LC/MS: M+1: 259.6.

The synthetic route of 77290-31-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AXYS PHARMACEUTICALS, INC.; US2002/86996; (2002); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

77290-31-4, tert-Butyl 4-(cyanomethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77290-31-4, Step B: Tert-butyl 4-(lH etrazoi-5-ylmethyl)piperazine-l-carboxylate (i-18); To a stirred suspension of 1.50 g (6.66 mmol) of the title compound from Step A above in 25 mL of anhydrous toluene was added 1.38 g (10.0 mol) of triethylaminehydrochloride followed by 0.65 g (10 mmol) of sodium azide. The resuling mixture was heated to 80 C for 12 h then cooled to ambient temperature. All volatiles were removed in vacuo, and the residue suspended in 5 mL of brine and 1.0 N aqueous hydrogen chloride solution was added until pH of ~4 was achieved. The aqueous phase was extracted with chloroform and the combined organics were dried over magnesium sulfate and evaporated to dryness in vacuo. The residue was purified by silica gel chromatography eluting with a 0-100% acetone in hexanes gradient to afford the title compound (i-18) as white solid (1.1 g, 63%). 1H-NM (500 MHz, DMSOPatent; MERCK SHARP & DOHME CORP.; MORRIELLO, Gregori, J.; WENDT, Harvey, R.; EDMONDSON, Scott, D.; WO2012/12314; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics