Category: 76003-30-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-30-0,1-Boc-2-methyl-3-oxopiperazine,as a common compound, the synthetic route is as follows.

76003-30-0, To a heterogeneous mixture of Lawesson’s reagent (2.11 g, 5.06 mmol) in toluene (18 mL) was added the product of Example 1, step a (1.01 g, 4.73 mmol). The mixture was heated at 80 C for 1 h and then concentrated in vacuo. The residue was dissolved in DCM and filter loaded on Si02 column eluting with EtO Ac/Hex to afford the desired product as an orange solid (1.12 g, 100%).

The synthetic route of 76003-30-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; ANDRES GIL, JOSE IGNACIO; LETAVIC, MICHAEL A; RECH, JASON C; RUDOLPH, DALE A; SOYODE-JOHNSON, AKINOLA; CHROVIAN, CHRISTA C; (158 pag.)JP2017/527588; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-30-0,1-Boc-2-methyl-3-oxopiperazine,as a common compound, the synthetic route is as follows.

76003-30-0, To a heterogeneous mixture of Lawesson’s reagent (2.11 g, 5.06 mmol) in toluene (18 mL) was added the product of Example 1, step a (1.01 g, 4.73 mmol). The mixture was heated at 80 C for 1 h and then concentrated in vacuo. The residue was dissolved in DCM and filter loaded on Si02 column eluting with EtO Ac/Hex to afford the desired product as an orange solid (1.12 g, 100%).

The synthetic route of 76003-30-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; ANDRES GIL, JOSE IGNACIO; LETAVIC, MICHAEL A; RECH, JASON C; RUDOLPH, DALE A; SOYODE-JOHNSON, AKINOLA; CHROVIAN, CHRISTA C; (158 pag.)JP2017/527588; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-30-0,1-Boc-2-methyl-3-oxopiperazine,as a common compound, the synthetic route is as follows.

76003-30-0, To a heterogeneous mixture of Lawesson’s reagent (2.11 g, 5.06 mmol) in toluene (18 mL) was added the product of Example 1, step a (1.01 g, 4.73 mmol). The mixture was heated at 80 C for 1 h and then concentrated in vacuo. The residue was dissolved in DCM and filter loaded on Si02 column eluting with EtO Ac/Hex to afford the desired product as an orange solid (1.12 g, 100%).

The synthetic route of 76003-30-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; ANDRES GIL, JOSE IGNACIO; LETAVIC, MICHAEL A; RECH, JASON C; RUDOLPH, DALE A; SOYODE-JOHNSON, AKINOLA; CHROVIAN, CHRISTA C; (158 pag.)JP2017/527588; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-30-0,1-Boc-2-methyl-3-oxopiperazine,as a common compound, the synthetic route is as follows.

76003-30-0, To a heterogeneous mixture of Lawesson’s reagent (2.11 g, 5.06 mmol) in toluene (18 mL) was added the product of Example 1, step a (1.01 g, 4.73 mmol). The mixture was heated at 80 C for 1 h and then concentrated in vacuo. The residue was dissolved in DCM and filter loaded on Si02 column eluting with EtO Ac/Hex to afford the desired product as an orange solid (1.12 g, 100%).

The synthetic route of 76003-30-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; ANDRES GIL, JOSE IGNACIO; LETAVIC, MICHAEL A; RECH, JASON C; RUDOLPH, DALE A; SOYODE-JOHNSON, AKINOLA; CHROVIAN, CHRISTA C; (158 pag.)JP2017/527588; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-30-0,76003-30-0, 1-Boc-2-methyl-3-oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the product of Example 1, step a (230 mg, 1.08 mmol) in DCM (5 mL) was added trimethyloxonium tetrafluoroborate (194 mg, 1.25 mmol). The reagent slowly dissolved and after stirring overnight all of the starting material was consumed. To this solution was added 2-picolinyl hydrazide (181 mg, 1.29 mmol). After 24 h the reaction was concentrated in vacuo and dissolved in dioxane (2 mL) and saturated aqueous aHC03 solution (2 mL). The mixture was heated for 3 h at 90 C and the dioxane was removed in vacuo and the aqueous layer extracted with DCM and EtOAc. The combined organic extracts were dried over Na2S04 filtered and concentrated in vacuo. Chromatography on Si02 eluting with IPA/EtOAc afforded the title compound (150 mg, 44%).

As the paragraph descriping shows that 76003-30-0 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; ANDRES GIL, JOSE IGNACIO; LETAVIC, MICHAEL A; RECH, JASON C; RUDOLPH, DALE A; SOYODE-JOHNSON, AKINOLA; CHROVIAN, CHRISTA C; (158 pag.)JP2017/527588; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-30-0,1-Boc-2-methyl-3-oxopiperazine,as a common compound, the synthetic route is as follows.,76003-30-0

Step 2: Synthesis of iert-butyl 3-ethoxy-2-methyl-5,6-dihydropyrazine-l(2H)-carboxylate lbTo a solution of 1.2b (24 g, 87 mol) in anhydrous DCM (250 mL) at 0 C under N2 atmosphere was added a pre-made solution of triethyloxonium tetrafluoroborate (19.92 g, 105 mmol) in anhydrous DCM (50 mL). The reaction mixture was allowed to warm to RT and stirred for 30 min whereupon saturated solution of NaHC03 (400 mL) was added. The extracted aqueous layer was then washed with DCM (200 ml) and the combined organic extracts were subsequently washed with brine (300 mL), dried over MgS04, filtered and further dried in vacuo to obtain the title intermediate lbas colorless oil. (20.7 g, 98 ).LCMS: P = 98 , retention time = 1.8 min, (M+H+H20)+: 261; 1H-NMR (CDC13): delta 4.30 (br, 1H), 4.11-4.01 (m, 2H), 3.84 (br, 1H), 3.48-3.40 (m, 2H), 2.90 (br, 1H), 1.32 (d, J = 6.9, 3H), 1.26 (t, J = 7.1, 3H).

76003-30-0 1-Boc-2-methyl-3-oxopiperazine 12638300, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; EUROSCREEN S.A.; HOVEYDA, Hamid; DUTHEUIL, Guillaume; FRASER, Graeme; ROY, Marie-Odile; EL BOUSMAQUI, Mohamed; BATT, Frederic; WO2013/50424; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics