Category: 76003-29-7

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of tert-butyl 4-(4-bromobenzyl)-3-oxopiperazine-] -carboxylate (89)Sodium hydride (60% dispersion in mineral oil, 0.72g, l8mmol) was added to a suspension of 4-Boc-piperazinone (88) (3g, lSmmol) in DMF (30m1) under argon. The reaction mixture was stirred at room temperature for 30 minutes, and 4-bromobenzylbromide (87)(4.5g, l8mmol) was added. The reaction mixture was heated at 60 C for one hour, cooled down, diluted with ethyl acetate (lOOml) and washed with water (1 OOml) and brine (lOOml). The ethylacetate solution was dried over sodium sulfate, and concentrated. The crude material was purified with automated column chromatography using petroleum ether and ethyl acetate as eluents to give 1 -((3,5 ?-bis(trifluoromethyl)- [1,1 ?-biphenyll -4-yl)methyl)piperazin-2-one (89)(5.33g) as off white solid. Yield: 96%. Synthesis confimed by LCMS and MS (positive ion mode).

76003-29-7, The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L.; WO2013/131018; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76003-29-7, To a solution of 1,1-dimethylethyl 3-oxo-1-piperazinecarboxylate (500 mg, 2.497 mmol) in N,N-dimethylformamide (DMF) (8 mL) at room temperature under nitrogen was added sodium hydride (60% w/w in mineral oil, 120 mg, 3.00 mmol) and the resulting suspension was stirred at this temperature for 30 min. 1-Bromo-4-(bromomethyl)benzene (749 mg, 3.00 mmol) in DMF (5 mL) was then added via syringe. The resulting mixture was stirred at room temperature for 1.5 h then partitioned between AcOEt and water. The layers were separated and the aqueous phase was extracted three times with AcOEt. The combined organic phases were washed three times with brine, dried over MgSO4 and concentrated in vacuo. Purification of the residue by SP4 using a 25 G silica cartridge (gradient: 13 to 63% AcOEt in Hexanes) gave 1,1-dimethylethyl 4-[(4-bromophenyl)methyl]-3-oxo-1-piperazinecarboxylate (763 mg, 2.066 mmol, 83% yield) as an oil which solidified to a white solid over 16 h.LCMS (method A): Retention time 1.14 min, [M+H]+=370.95 (1 Br)

As the paragraph descriping shows that 76003-29-7 is playing an increasingly important role.

Reference£º
Patent; Demont, Emmanuel Hubert; Garton, Neil Stuart; Gosmini, Romain Luc Marie; Hayhow, Thomas George Christopher; Seal, Jonathan; Wilson, David Matthew; Woodrow, Michael David; US2012/208798; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.

76003-29-7, In a 500 mL three-necked flask, 12.70 g (63.0 mmol, 1.0 eq.) of Compound 1 was dissolved in 280 mL of dimethylformamide and cooled to 0 C in an ice bath;1.73 g (73.0 mmol, 1.15 equivalents) of sodium hydride were added and stirred under ice cooling for 1 hour.Then 6.60 mL (69.0 mmol, 1.10 equivalents) of methyl bromoacetate was added via syringe.After further stirring for 20 minutes under ice cooling, the reaction solution was warmed to room temperature. After 18 hours, 10 mL of methanol, 10 mL of deionized water and 180 mL of a saturated sodium chloride solution were added to the reaction solution.The aqueous phase the organic phase was extracted once with 250mL to 140mL extracted three times with ether, and the combined dried over magnesium sulfate, and the solvent was evaporated under reduced pressure.Subsequently, it was removed under reduced pressure at a water temperature of 55 C in 2 hours.Residual dimethylformamide. Obtaining 13.4 g of an orange liquid, purified by flash chromatography using petroleum ether/ethyl acetate 4:1? petroleum ether/ethyl acetate 2:1 as eluent.Got a white solid,Yield: 14.16g (82%, 52.0mmol),White solid,

76003-29-7 1-Boc-3-Oxopiperazine 3157178, apiperazines compound, is more and more widely used in various.

Reference£º
Patent; Shaoxing University; Hu Chunqi; Li Xin; Shi Yaru; Du Wenting; Tong Jie; Su Wanting; Xia Weiqi; (21 pag.)CN108610333; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics