Category: 7365-45-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7365-45-9,2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid,as a common compound, the synthetic route is as follows.

7365-45-9, General procedure: Larger Scale Production of Nucleotide Analogs. (0230) The process described for small-scale batches is scalable to larger batches by using proportionate amounts of compounds. As an alternate to the small-scale batches described above, larger scale batches were prepared. Here, reaction mixtures having a total volume of 0.25 ml (>10× the volume of the small-scale batch) and containing 40 mM of a reagent from Table 1, 10 mM magnesium acetate, 80 muM dATP, 50 mug/ml BSA, and 5.84 muM p41 subunit (containing 0.64 M glycerol following dilution in the glycerol diluent described above) were incubated for 30 min at 70 C. Incubation with the p41 subunit and TLC analysis on PEI plates showed greater than 60% conversion of starting material (i.e., the reagent and dNTP) into nucleotide analog products (dNMP derivatives). Experiments were also performed using heavy isotopes incorporated in dNTP, but the presence of a heavy isotope did not alter the utilization of dNTP in the reaction. (0231) Samples from reaction mixtures were analyzed using a capillary reverse phase liquid chromatography system coupled to an Orbitrap Discovery mass spectrometer in negative mode. Negative mode nanospray mode was set to -1.5 kV, and chromatographic flow rate was <20 nl/min. Fragmentation was achieved using high collision dissociation at 45% energy. Isotope-labeled samples were run both individually and combined. By analyzing the mass difference between heavy and light fragmentation pattern, the identity of each fragmentation peak was established. As the paragraph descriping shows that 7365-45-9 is playing an increasingly important role. Reference：
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE; MEMORIAL SLOAN KETTERING CANCER CENTER; UNIVERSITY OF MARYLAND; Marino, John P.; Kelman, Zvi; Hurwitz, Jerard; Giulian, Gary G.; (45 pag.)US9534243; (2017); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

7365-45-9,7365-45-9, 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a typical procedure, 10 mL zinc acetate solution (200 mM) was mixed with 20 mL HEPES solution (200 mM pH 7.4). A microwave and ultrasonic wave combined reactor (XH-300A, Beijing Xianghu Technology Co., Ltd.) provided continuous and homogeneous ultrasonic wave and microwave irradiation for the mixed solutions. Firstly, the mixture was continuously sonicated for 5 min by ultrasonic processor with a power of 1000 W. Then the mixed solution was heated to 110 C within 3 min and kept at this temperature for 17 min under microwave heating combined with discontinuous ultrasonic irradiation (1 s sonication and 2 s interruption) with a power of 500 W. After cooling down to room temperature naturally, the product was collected by centrifugation and washed with deionized water and absolute alcohol for 5 times, then dried in a desiccator for further characterization (S1). Other ZnO samples (S2-S15) were also prepared under identical conditions by varying Zn/HEPES moral ratio, pH value of HEPES solution and Zn precursor. The detailed procedure is same as described above and all the experimental parameters are listed in Table 1.

7365-45-9 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid 23831, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Li, Qin; Li, Hui; Wang, Runming; Li, Guangfang; Yang, Hao; Chen, Rong; Journal of Alloys and Compounds; vol. 567; (2013); p. 1 – 9;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics