Category: 67914-60-7

On December 31, 1990, Chapman, David R.; Bauer, Ludwig; Waller, Donald P.; Zaneveld, Lourens J. D. published an article.Recommanded Product: 67914-60-7 The title of the article was Synthesis of diastereomeric ketoconazole analogs. And the article contained the following:

Syntheses of trans-isomers of ketoconazole (I) and the corresponding des-acetyl, 1-Me, 1-formyl and 1-methanesulfonyl analogs were investigated. These isomers, along with the corresponding cis-diastereomers were characterized by their carbon-13 NMR spectra. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 67914-60-7

The Article related to ketoconazole diastereomer, imidazolylmethyldioxolanylmethoxyphenylpiperazine, piperazinophenol imidazolylmethyldioxolanylmethanesulfonate reaction, nmr ketoconazole, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On September 17, 1998, Tanoury, Gerald J.; Senanayake, Chris H.; Hett, Robert; Kuhn, Amy M.; Kessler, Donald W.; Wald, Stephen A. published an article.Electric Literature of 67914-60-7 The title of the article was Pd-catalyzed aminations of aryltriazolones: effective synthesis of hydroxyitraconazole enantiomers. And the article contained the following:

A palladium-catalyzed amination of triazolone I by piperazine II was used as the key step in an efficient synthesis of highly enantiomerically pure hydroxyitraconazole (III). II (>99% ee) was prepared by reaction of an achiral phenol precursor with the corresponding dioxolyl tosylate (>99% ee). The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Electric Literature of 67914-60-7

The Article related to hydroxyitraconazole asym preparation, amination aryltriazolone palladium, triazolone aryl amination palladium, heck coupling vs palladium catalyzed amination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 30, 2007, He, Qiu Qin; Li, Ke; Cao, Yong Bing; Dong, Huan Wen; Zhao, Li Hua; Liu, Chao Mei; Sheng, Chun Quan published an article.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Design, synthesis and molecular docking studies of novel triazole antifungal compounds. And the article contained the following:

Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds I (R = R1 = Me; R = CMe3, CN, NO2, R1 = H) exhibited strong activities. In addition, the first three also displayed certain activities against fluconazole-resistant fungi. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to triazolylpropanol benzylpiperazinylphenoxy derivative preparation antifungal activity, mol docking triazolylpropanol derivative lanosterol demethylase, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 24, 1992, Rotstein, David M.; Kertesz, Denis J.; Walker, Keith A. M.; Swinney, David C. published an article.COA of Formula: C12H16N2O2 The title of the article was Stereoisomers of ketoconazole: preparation and biological activity. And the article contained the following:

The four stereoisomers of the antifungal agent ketoconazole, (2S,4R)-, (2R,4R)-, (2R,4S)-, and (2S,4S)-(imidazolylmethyl)phenyl{[(acetylpiperazinyl)phenoxy]methyl}dioxolanes I, were prepared and evaluated for their selectivity in inhibiting a number of cytochrome P 450 enzymes. Thus, (bromomethyl)phenyldioxolanes II condensed with 4-(N-acetylpiperazino)phenol and imidazole to give I. II were prepared by bromination of 2′,4′-dichloroacetophenone followed by reaction with (S)- and (R)-solketal tosylate. Large differences in selectivity among the isomers were observed for inhibition of the cytochromes P 450 involved in steroid biosynthesis, whereas little difference was observed for inhibition of those associated with hepatic drug metabolism The cis-(2S,4R) and trans-(2R,4R) isomers are equipotent in inhibiting corticoid 11β-hydroxylase and much more effective than their antipodes. Little selectivity was observed for inhibition of cholesterol side chain cleavage or xenobiotic hydroxylases. These data indicate that the affinity of azoles for cytochrome P 450 enzymes involved in steroid synthesis is high dependent on the stereochem. of the entire mol., whereas binding to drug metabolizing enzymes is a less selective process. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).COA of Formula: C12H16N2O2

The Article related to ketoconazole stereoisomer preparation cytochrome p450 inhibition, imidazolylmethylphenylacetylpiperazinylphenoxymethyldioxolane preparation cytochrome p450 enzyme inhibition and other aspects.COA of Formula: C12H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 2, 2015, Salahifar, Eslam; Nematollahi, Davood; Bayat, Mehdi; Mahyari, Amir; Amiri Rudbari, Hadi published an article.Formula: C12H16N2O2 The title of the article was Regioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives. And the article contained the following:

A regioselective green synthesis of nitroacetaminophen derivatives e. g., I, was carried out by electrochem. oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochem. method for the synthesis of some nitroacetaminophen derivatives The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Formula: C12H16N2O2

The Article related to nitroacetaminophen derivative regioselective synthesis green chem, acetaminophen hydroxyphenylacetamide hydroxyphenylpiperazinylethanone electrochem oxidation nitrite ion and other aspects.Formula: C12H16N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 5, 2018, Raajaraman, BR.; Sheela, N. R.; Muthu, S. published an article.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Investigation on 1-Acetyl-4-(4-hydroxyphenyl) piperazine an anti-fungal drug by spectroscopic, quantum chemical computations and molecular docking studies. And the article contained the following:

The title compound, 1-acetyl-4-(4-hydroxyphenyl)piperazine (1A4HP) has been examined by FT-Raman, FT-IR, 1HNMR, 13CNMR and UV-Visible spectra range. By using the d. functional theory (DFT) by the method B3LYP and basis set 6-311++G(d,p) the optimized figure of 1A4HP, the vibrational modes, the IR penetration intensities and the working of Raman scattering were estimated The optimized mol. figure obtained by the DFT method and its bond length and bond angle computed values are same as the XRD exptl. values. AIM topol. anal. was done on the mol. The HOMO and LUMO energy results show that good exchange of charge happened inside the mol. NBO method was applied to study donor-acceptor interactions. 1H and 13C chem. shift of NMR were estimated using the type gauge-independent AO (GIAO) and the results are related to the exptl. values. The hyperpolarizability computation shows the 1A4HP has very good NLO property. The anal. of Fukui function and Mol. electrostatic potential (MEP) studies were done. The essential thermodn. characters (entropy, enthalpy and heat capacity) of the 1A4HP estimated at various temperatures The best ligand-protein interactions are done by mol. docking with the various antifungal proteins and the ligand 1A4HP. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to acetyl hydroxyphenylpiperazine ir raman nlo property electrostatic potential, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2018, Amani, Ameneh; Nematollahi, Davood published an article.Product Details of 67914-60-7 The title of the article was One-pot electrochemical synthesis of highly symmetric and conjugated coumarin derivative. And the article contained the following:

A facile and one pot electrochem. synthesis of disubstituted hydroquinone generated from the electrochem. oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of 4-hydroxy-6,7-dimethylcoumarin was reported. The results revealed that p-quinone imine derived from oxidation of 4-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone participated in Michael addition reactions with 4-hydroxy-6,7-dimethylcoumarin and followed by a hydrolysis reaction attain to the highly sym. and conjugated coumarin derivative A new product in good yield was derived based on controlled potential electrochem. oxidation at carbon electrode in a divided cell. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Product Details of 67914-60-7

The Article related to hydroxyphenyl piperazinyl ethanone hydroxy dimethylcoumarin one pot electrochem oxidation, dihydroxy phenylene bishydroxy dimethylchromenone preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Product Details of 67914-60-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 3, 2021, Zhao, Liang-Liang; Wu, Yixin; Huang, Shiqing; Zhang, Zengyu; Liu, Wei; Yan, Xiaoyu published an article.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Ortho-Selective Hydrogen Isotope Exchange of Phenols and Benzyl Alcohols by Mesoionic Carbene-Iridium Catalyst. And the article contained the following:

Hydrogen isotope exchange reactions of phenols and benzyl alcs. was achieved by a mesoionic carbene-iridium catalyst with high ortho selectivity and high functional group tolerance. Control experiments indicated that acetate is crucial to realize the ortho selectivity, whereas d. functional theory calculations supported an outer-sphere direction with hydrogen bonding between acetate and the hydroxyl group. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to phenol regioselective deuterium exchange, deuterated phenol preparation, benzyl alc regioselective deuterium exchange, deuterium benzyl alc preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 15, 2014, Tang, Yan-feng; Mao, Jia-rong; Chen, Jiao; Sun, Tong-ming; Wang, Miao; Zhu, Jin-li published an article.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Synthesis of preladenant. And the article contained the following:

An intermediate, 1-(4′-methoxyethoxyl phenyl) piperazine (III), was synthesized from 1-(4′-hydroxylphenyl)-piperazinyl ethanone (I) via etherification and hydrolysis. Another intermediate (VII) with a nitrogen condensed ring was prepared from Me furan-2-carboxylate (IV) by acylation, ring-closure and halogenation. Finally, Preladenant was prepared from the two intermediates by condensation reaction. FTIR, 1HNMR and ESI-MS were employed to characterize these intermediates and the target compound Through common synthetic method, the yields of these 6 steps are 99.0%, 95.4%, 98.0%, 78.9%, 86.9% (calculated by Cl) and 52.5%, resp. To obtain a higher total yield, ultrasonic was used in the last condensation reaction. The results show that the condensation yield reached 85.4% when the reaction conditions were as follows: the ultrasonic power (150 W), the molar ratio of intermediate III to VII (1.2: 1), solvent (DMSO), acid-bonding agent (Na2CO3), reaction temperature (90°C) and reaction time (1.5 h). The yield of the condensation is greatly increased by ultrasonic method. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to preladenant condensation ultrasound, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Name: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On December 31, 2021, Mastuo, Kasumi; Kuriyama, Masami; Yamamoto, Kosuke; Demizu, Yosuke; Nishida, Koyo; Onomura, Osamu published an article.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Nickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents. And the article contained the following:

The nickel-catalyzed hydrodeoxygenation of aryl sulfamates ROS(O)2R1 [R = 2-propanoylbenzen-1-yl, 1-ethyl-1H-indol-4-yl, 4-(4-acetylpiperazin-1-yl)benzen-1-yl, etc.; R1 = dimethylaminyl, piperidin-1-yl, bis(propan-2-yl)aminyl, etc.] has been developed with alcs. as mild reductants. A variety of functional groups and heterocycles were tolerated in this reaction system to give the desired products RH in high yields. In addition, the gram-scale process and stepwise cine-substitution were also achieved with high efficiency. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

The Article related to aromatic hydrocarbon preparation, aryl sulfamate hydrodeoxygenation nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics