Category: 67455-41-8piperazines

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,67455-41-8

Add 2-chloro-4-(cyclopentylamino) pyrimidine-5-carboxylic acid ethyl ester (1.3 g, 4.82 mmol) to an eggplant-shaped bottle containing 20 mL of isopropanol, and add Et3N (0.49 g, 4.82 mmol), 4-Piperazinyl aniline (1.11 g, 6.27 mmol), refluxed after the addition, after 6.0 hours TLC showed that the reaction was complete, and concentrated under reduced pressure to give the target crude product (1.31 g), CH2Cl2: MeOH = 20:1 to obtain pure product (1.06 g, 51.7%).

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference£º
Patent; FIRST AFFILIATED HOSPITAL ZHENGZHOU UNIV; Zhengzhou University The First Affiliated Hospital; KAN QUANCHENG; Kan Quancheng; TIAN XIN; Tian Xin; ZHANG XIAOJIAN; Zhang Xiaojian; YANG ZHIHENG; Yang Zhiheng; DU YUE; Du Yue; CHENG WEIYAN; Cheng Weiyan; YUAN YONGLIANG; Yuan Yongliang; WANG SUHUA; Wang Suhua; (29 pag.)CN108299312; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

EXAMPLE 1 4-[4-(3,3,3-Triphenylpropanoylamino)phenyl]piperazine To an ice cooled and stirred solution of 4-(4-aminophenyl)piperazine (4.29 g, 24.2 mmol) in dichloromethane (100 mL) containing Et3 N (7.42 mL, 52.5 mmol) was added trifluoroacetic anhydride (7.52 mL, 53.2 mmol) in dichloromethane (25 mL) over a 5 minute period. The mixture was allowed to warm to room temperature and stirred two days, then stirred with ice water. The pink solid that separated was isolated by filtration, washed with dichloromethane, aqueous sodium bicarbonate, and water, and dried to obtain 1-(4-(trifluoroacetamido)phenyl)-4-trifluoroacetylpiperazine (4.09 g, 46%, mp 193-194 C.).

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference£º
Patent; Demers; James P.; Johnson; Sigmond; Weidner-Wells; Michele Ann; Kanojia; Ramesh M.; Fraga; Stephanie A.; Klaubert; Dieter; US5874436; (1999); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.,67455-41-8

General procedure: To a solution of arylamine (0.5 mmol, 1.0 equiv) in MeOH(1.0 mL) was added HCl (0.5 mL, 1.5 mmol, 3.0 equiv) followed by H2O (0.5 ml). This mixture was stirred 2 min, and the NaNO2 solution (0.25 mL) was then added. The NaNO2 solution was prepared by dissolving 35 mg of NaNO2 in H2O (0.25 mL). This mixture was stirred 30 minat 0-5 C followed by B2pin2 (2, 381 mg, 1.5 mmol, 3.0equiv) in MeOH (1.0 mL). This mixture was stirred 60 min.H2O (10 mL) was added to the reaction mixture, then extracted with CH2Cl2 (50 mL, 3¡Á). The combined organic layers were washed with sat. NaHCO3, dried over Na2SO4, followed by evaporation, and the crude residue was purified by flash chromatography.

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference£º
Article; Zhao, Cong-Jun; Xue, Dong; Jia, Zhi-Hui; Wang, Chao; Xiao, Jianliang; Synlett; vol. 25; 11; (2014); p. 1577 – 1584;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics