Category: 67455-41-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

67455-41-8, General procedure: A solution of 1mmol amine/thiol and 1.2mmol alpha,beta-unsaturated nitriles or carbonyl compounds was added to bucky gel (0.1mmol) and the mixture was stirred at 25C for 1min. Likewise, the completion of the reaction was monitored using TLC. The product formed in the one-phase system, was further extracted with ether. In the same way as in the above preparation, the resulting organic phase extract was washed with a saturated solution of NaHCO3, water, and dried over Na2SO4. After removal of the solvent, the residue was further purified by recrystallization or silica gel chromatography. The reaction products were then analyzed using 1H and 13C NMR spectroscopy.

67455-41-8 4-(Piperazin-1-yl)aniline 422925, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Attri, Pankaj; Bhatia, Rohit; Arora, Bharti; Kumar, Naresh; Park, Ji Hoon; Baik, Ku Youn; Lee, Geon Joon; Kim, In Tae; Koo, Je Huan; Choi, Eun Ha; Materials Research Bulletin; vol. 58; (2014); p. 6 – 9;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

To a dark transparent solution of 1-(4-aminophenyl)piperazine (300 mg, 1.693 mmol) and triethylamine (0.236 mL, 1.693 mmol) in DCM (30 mL) was added benzyl chloroformate (0.238 mL, 1.693 mmol) dropwise with stirring. The resulting solution was allowed to stir at rt for 1 h, after which HPLC showed reaction completion. Concentration and CombiFlash (10 g, DCM to 10% MeOH/DCM) afforded Cmpd AG as a solid. 1H-NMR (300 MHz, CDCl3) 7.35 (m, 5H), 4.80 (d, J=8.8 Hz, 2H), 6.66 (d, J=8.8 Hz, 2H), 5.16 (d, 2H), 3.65 (m, 4H), 3.49 (br-s, 2H), 2.99 (br-s, 4H), 67455-41-8

The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Vankayalapati, Hariprasad; Liu, Xiao-Hui; Hewitt, William Merton; Gourley, Eric Scott; Xu, Yong; Aavula, Bhasker; US2010/204221; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

67455-41-8, To a solution of 2-chloro-N-cyclohexyl-9-(tetrahydro-2H-pyran-2-yl)-9H- purin-6-amine (0.50 g, 1.5 mmole) in 7.5 ml toluene was added 4-(piperazin-l-yl)aniline (317 mg, 1.8 mmole) and 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (63 mg, 0.15 mmole). The reaction mixture was degassed using Argon for 10 min after which Pd(dppf)Cl2 complex with CH2C12 (61mg, 0.075 mmole) was added, followed by sodium t-butoxide (286 mg, 3.0 mmole). The reaction flask was put into a preheated oil-bath at 100 C and stirred overnight. The mixture was cooled to room temperature. To the mixture, water and EtOAc were added. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layer was dried over Na2S04 and concentrated. The crude product was purified on a silica gel column, eluted EtOAc, then 10% MeOH in EtOAc, then 20%MeOH in EtOAc to get 480mg (68% yield) of N6-cyclohexyl-N2-(4-(piperazin-l- yl)phenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference：
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; LIU, Xuedong; ZHANG, Gan; CHAN, Daniel, Chuen-Fong; PISCOPIO, Anthony, D.; (117 pag.)WO2015/175813; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

67455-41-8, To a solution of 2-chloro-N-cyclohexyl-9-(tetrahydro-2H-pyran-2-yl)-9H- purin-6-amine (0.50 g, 1.5 mmole) in 7.5 ml toluene was added 4-(piperazin-l-yl)aniline (317 mg, 1.8 mmole) and 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (63 mg, 0.15 mmole). The reaction mixture was degassed using Argon for 10 min after which Pd(dppf)Cl2 complex with CH2C12 (61mg, 0.075 mmole) was added, followed by sodium t-butoxide (286 mg, 3.0 mmole). The reaction flask was put into a preheated oil-bath at 100 C and stirred overnight. The mixture was cooled to room temperature. To the mixture, water and EtOAc were added. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layer was dried over Na2S04 and concentrated. The crude product was purified on a silica gel column, eluted EtOAc, then 10% MeOH in EtOAc, then 20%MeOH in EtOAc to get 480mg (68% yield) of N6-cyclohexyl-N2-(4-(piperazin-l- yl)phenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference：
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; LIU, Xuedong; ZHANG, Gan; CHAN, Daniel, Chuen-Fong; PISCOPIO, Anthony, D.; (117 pag.)WO2015/175813; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of amine (1 mmol) and alpha,beta-unsaturated nitriles or carbonyl compounds (1.2 mmol) was added to SWCNT-TEAP (1 mg) and the mixture was stirred at 25 C for 1 min. The completion of the reactions was monitored using TLC. The product formed in the one-phase system, was extracted with diethyl ether. The resulting organic phase extract was washed with a saturated aqueous NaHCO3 solution, and then dried over anhydrous Na2SO4. The solvent was removed and the residue was further purified by recrystallization or silica gel chromatography. The reaction products were analyzed with 1H and 13C NMR spectroscopy. 1H and 13C NMR of entry 1-5 are given below:

67455-41-8, As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference：
Article; Attri, Pankaj; Choi, Eun Ha; Kwon, Gi-Chung; Bhatia, Rohit; Gaur, Jitender; Arora, Bharti; Kim, In Tae; Bulletin of the Korean Chemical Society; vol. 35; 10; (2014); p. 3035 – 3040;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67455-41-8,4-(Piperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.

Amine (2.5 mmol) was added to the mixture of bis-chloride (1) (0.419 g, 1 mmol) in10 mL of dry pyridine and the whole was mixed at 70 C for 12 h. The mixture was cooled down toroom temperature and the formed precipitate was filtered off and washed with ether. The raw productwas purified through recrystallization from ethanol., 67455-41-8

The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Zieba, Andrzej; Latocha, Ma?gorzata; Sochanik, Aleksander; Nycz, Anna; Ku?mierz, Dariusz; Molecules; vol. 21; 11; (2016);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

67455-41-8, To a solution of 2-chloro-N-cyclohexyl-9-(tetrahydro-2H-pyran-2-yl)-9H- purin-6-amine (0.50 g, 1.5 mmole) in 7.5 ml toluene was added 4-(piperazin-l-yl)aniline (317 mg, 1.8 mmole) and 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (63 mg, 0.15 mmole). The reaction mixture was degassed using Argon for 10 min after which Pd(dppf)Cl2 complex with CH2C12 (61mg, 0.075 mmole) was added, followed by sodium t-butoxide (286 mg, 3.0 mmole). The reaction flask was put into a preheated oil-bath at 100 C and stirred overnight. The mixture was cooled to room temperature. To the mixture, water and EtOAc were added. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layer was dried over Na2S04 and concentrated. The crude product was purified on a silica gel column, eluted EtOAc, then 10% MeOH in EtOAc, then 20%MeOH in EtOAc to get 480mg (68% yield) of N6-cyclohexyl-N2-(4-(piperazin-l- yl)phenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine

As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; LIU, Xuedong; ZHANG, Gan; CHAN, Daniel, Chuen-Fong; PISCOPIO, Anthony, D.; (117 pag.)WO2015/175813; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3-(4-(2-chloropyrimidin-4-yl)-lH-pyrazol-l-yl)-3-cyclopentylpropanenitrile (30 mg, 0.1 mmol), 4-(piperazin-l-yl)aniline (28.5 mg, 0.149 mmol), and p-toluenesulfonic acid (14 mg, 0.084 mmol) in dry 1,4-dioxane (0.8 mL) was refluxed overnight, then cooled to room temperature. To the resulting mixture was added 1.0 M sodium carbonate in water (0.8 mL), followed by methanesulfonyl chloride (0.015 mL, 0.20 mmol). The reaction was stirred at room temperature for 30 min and the phases were separated. The organic phase was purified on RP-HPLC at pH 10 to give the desired product as a racemic mixture (33 mg, 63%). LCMS (M+H) 521.1., 67455-41-8

The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INCYTE CORPORATION; WO2009/64835; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,67455-41-8

General procedure: A mixture of compounds 5a-5i (10.0 mmol), concentrated hydrochloricacid (12.2 mmol) and melamine (20.0 mmol) in isopropylalcohol (10.0 mL) was refluxed for 8 h. Progress of reaction wasmonitored by tlc and after complete conversion of starting materialreaction mixture was cooled to rt. The reaction mixture wasquenched in saturated sodium carbonate solution (20.0 mL) andfiltered. The solid was washed with water (50.0 mL). The crudeproduct thus obtainedwas dried at 50 C under reduced pressure toget compounds 6a-6i.

The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Hui; Hu, Xiaoxia; Cao, Kai; Zhang, Yue; Zhao, Kuantao; Tang, Chunlei; Feng, Bainian; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 935 – 945;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

67455-41-8, A mixture of 4-(piperazin-l-yl)aniline (348 mg, 1.968 mmol), (E)-methyl 3-(2-(2-chloropyrimidin-5-yl)vinyl)-5-methoxybenzoate (600 mg, 1.968 mmol) and TFA (672 mg, 5.904 mmol) in propan-2-ol (30 mL) was stirred at 150 C for 40 min under microwave. The resulting mixture was concentrated, basified with ammonia water, purified via ISCO (DCM/MeOH) to afford the title compound as a yellow solid (320 mg, 36.6% yield). MS (m/z): 446.3(M+H)+.

The synthetic route of 67455-41-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; ZHANG, Weihan; LI, Jinshui; WO2014/139145; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics