Category: 66-71-7

Safety of 1,10-Phenanthroline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Zinc(II) complexes of 3,5-dibromo-salicylaldehyde and α-diimines: Synthesis, characterization and in vitro and in silico biological profile. Author is Zianna, Ariadni; Geromichalou, Elena; Geromichalos, George; Fiotaki, Augusta-Maria; Hatzidimitriou, Antonios G.; Kalogiannis, Stavros; Psomas, George.

The synthesis of five neutral zinc(II) complexes of 3,5-dibromo-salicyladehyde (3,5-diBr-saloH) in the presence of nitrogen-donor co-ligands 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-phenanthroline (neoc), or 2,2′-bipyridylamine (bipyam) was undertaken and complexes [Zn(3,5-diBr-salo)2(H2O)2] (1), [Zn(3,5-diBr-salo)2(bipy)] (2), [Zn(3,5-diBr-salo)2(phen)].3,5-diBr-saloH (3), [Zn(3,5-diBr-salo)2(neoc)] (4) and [Zn(3,5-diBr-salo)2(bipyam)] (5) were characterized by various techniques. The crystal structures of complexes 3 and 5 were determined by x-ray crystallog., revealing the coexistence of two different coordination modes of 3,5-diBr-salo- ligands. The new complexes show selective in vitro antibacterial activity against two Gram-pos. and two Gram-neg. bacterial strains. The complexes may scavenge 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radicals and reduce H2O2. The complexes may intercalate in-between the calf-thymus DNA-bases and have exhibited low-to-moderate ability to cleave supercoiled circular pBR322 plasmid DNA. The complexes may bind tightly and reversibly to bovine and human serum albumins. In order to explain the in vitro activity of the compounds, mol. docking studies were adopted on the crystal structure of calf-thymus DNA, human and bovine serum albumin, Escherichia coli and Staphylococcus aureus DNA-gyrase, 5-lipoxygenase, and 5-lipoxygenase activating protein. The employed in silico studies aimed to explore the ability of the compounds to bind to these target biomacromols., establishing a possible mechanism of action and were in accordance with the in vitro studies.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Structural speciation in chemical reactivity profiling of binary-ternary systems of Ni(II) with iminodialcohol and aromatic chelators, the main research direction is preparation nickel iminodialc bipyridine phenanthroline complex reactivity luminescence dft.Reference of 1,10-Phenanthroline.

The importance of structural speciation in the control of chem. reactivity in Ni(II) binary-ternary systems, involving (O,O,N)-containing substrates (1,1′-iminodi-2-propanol), and aromatic chelators (2,2′-bipyridine, 1,10-phenanthroline), prompted the systematic synthesis of new crystalline materials characterized by elemental anal., FTIR, UV-Visible, Luminescence, magnetic susceptibility, and x-ray crystallog. The structures contain mononuclear octahedral assemblies, the lattice architecture of which exemplifies reaction conditions under which conformational variants and solvent-associated lattice-imposed complexes are assembled. Transformations between complex species denote their association with reactivity pathways, suggesting alternate synthetic methodologies for their isolation. Theor. work (Hirshfeld, Electrostatic Potential, DFT) signifies the impact of crystal structure on energy profiles of the generated species. The arisen physicochem. profiles of all compounds portray a well-configured interwoven network of pathways, projecting strong connection between structural speciation and Ni(II) reactivity patterns in organic-solvent media. The collective results provide well-defined parameterized profiles, poised to influence the synthesis of new Ni(II)-iminodialc. materials with specified structural-magneto-optical properties.

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Piperazine – Wikipedia,
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Application In Synthesis of 1,10-Phenanthroline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Tuning the coordination environment of single-atom catalyst M-N-C towards selective hydrogenation of functionalized nitroarenes. Author is Zhou, Dan; Zhang, Leilei; Liu, Xiaoyan; Qi, Haifeng; Liu, Qinggang; Yang, Ji; Su, Yang; Ma, Jingyuan; Yin, Jianzhong; Wang, Aiqin.

Fine-tuning of the coordination environment of single-atom catalysts (SACs) is effective to optimize their catalytic performances, yet it remains challenging due to the vulnerability of SACs. Herein, we report a new approach to engineering the coordination environment of M-N-C (M = Fe, Co, and Ni) SACs by using glutamic acid as the N/C source and pyrolysis atm. as a regulator. Compared with that in N2, NH3 was able to promote the doping of N at T < 700°C yet etch the N-species at higher temperatures, by which the M-N coordination number (CN) and the electronic structure were delicately tuned. It was found that the electron d. of Ni single atoms increased with the decrease of Ni-N CN. As a consequence, the capability of Ni-N-C to dissociate H2 was greatly enhanced and a higher catalytic activity in chemoselective hydrogenation of functionalized nitroarenes was achieved. Moreover, this modulation method could be applied to other transition metals including Fe and Co. In particular, the as-synthesized Co-N-C SAC afforded a turnover frequency of 152.3 h-1 with 99% selectivity to 3-vinylaniline in the hydrogenation of 3-nitrostyrene, which was the highest ever reported thus far and was at least one order of magnitude more active than state-of-the-art noble-metal-free M-N-C catalysts, demonstrating the great potential of engineering the coordination environment of SACs. In some applications, this compound(66-71-7)Application In Synthesis of 1,10-Phenanthroline is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Application In Synthesis of 1,10-Phenanthroline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Preparation, spectroscopic characterization and antitumor-antimicrobial studies of some Schiff base transition and inner transition mixed ligand complexes. Author is Khalil, Eman A. M.; Mohamed, Gehad G..

Mixed ligand complexes of Mn(II), Ni(II), Zn(II), La(III), Er(III) and Yb(III) metal ions were prepared from bidentate Schiff base ligand (L) as a primary ligand, derived from condensation of benzophenone and 1,8-naphthylenediamine, and 1,10-phenanthroline (Phen) as a secondary ligand. The new Schiff base ligand (N1-(diphenylmethylene)naphthalene-1,8-diamine) and its mixed ligand complexes were characterized by using elemental microanal., conductometric measurements, magnetic susceptibility and spectroscopic studies (UV-Vis, mass spectral anal., IR, 1H NMR and SEM). In addition, their thermal anal. (TG and DTG) behavior has been reported. Measurements of the molar conductivity of the complexes in DMF solvent pointed out the electrolytic nature of all complexes except Mn(II) and Zn(II) complexes were non electrolytes. According to the elemental analyses data, it was observed that the mixed ligand chelates had the general formulas [M(L)(Phen)Cl2]Cl.2H2O (M = La(III), Er(III) and Yb(III)), [M(L)(Phen)Cl2].H2O (M = Mn(II) and Zn(II)) and [Ni(L)(Phen)Cl(H2O)]Cl.H2O. Based on these findings, all mixed ligand complexes had octahedral geometry. The SEM image of the Schiff base ligand illustrated its rods like morphol. with and average particle size of 77 nm while, the image of Ni(II) complex showed non-uniform platelets structure with some scattered rods with an average particle size of 54 nm. Considerable applications were done to ensure the biol. significance of Schiff base ligand and its new mixed ligand complexes with Phen against Gram-neg. bacteria (Escherichia coli), Gram-pos. bacteria (Bacillus subtilis) and fungal (Aspergillus flavus and Candida albicans) strains and anti-cancer activities against (MCF7 breast cancer cell line). The results obtained revealed that the complexes exhibited promising biol. and anticancer activity. Moreover, mol. docking studies were applied to determine the probable binding mode among the Schiff base ligand and the active site of the crystal structure of E. coli YcbB acylated with meropenem (PDB ID: 6NTW) and breast cancer estrogen mutant L536S (PDB ID: 6SBO) receptors.

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Piperazine – Wikipedia,
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Synthetic Route of C12H8N2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Synthesis, characterization, crystallographic structure, theoretical studies, and in vitro cytotoxicity assessment of two Gd(III) and Ce(IV) complexes containing pyridine-2,6-dicarboxylate. Author is Zohrevandi, Mina; Abdolmaleki, Sara; Ghadermazi, Mohammad; Gholiee, Yasin; Aliabadi, Alireza; Motieiyan, Elham; Hakimi, Mohammad; Marabello, Domenica.

This paper reports the synthesis of two complexes through one-pot reactions of pyridine-2,6-dicarboxylic acid (pydcH2), phenanthroline, and 2-aminopyridine, with Gd(NO3)3·6H2O and Ce (NO3)3·6H2O metal salts. The new coordination complexes C1 and C2 were identified by spectroscopic methods. The complexes were characterized by x-ray crystallog. The nature of metal-ligand interactions was studied theor. using NBO and EDA-NOCV analyses. The results showed that the contribution of electrostatic interactions in both complexes is considerably larger than that of orbital. However, the contribution of orbital interactions in [CeL3]2-, is more than that in [GdL3]3- (28.8% vs. 21.8%). In following, the cytotoxic effect of synthetic complexes was investigated in vitro using oxaliplatin as a standard against three cancer cell lines including human breast cancer (MCF7), human colon adenocarcinoma (HT29), human lymphocyte (HL60) and also one normal cell, human foreskin fibroblast (HFF). The most significant inhibition activity was observed by both C1 (IC50 = 80.7 μM, Viability inhibition = 83.41%) and C2 (IC50 = 98.3 μM, Viability inhibition = 77.19%) toward the MCF7 cell line.

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Related Products of 66-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Achieving host-free near-ultraviolet electroluminescence via electronic state engineering with phosphine oxide. Author is Chen, Shuo; Zhang, Chunying; Xu, Hui.

Developing near-UV (NUV) emitters with board band gap and high photoluminescence quantum efficiency (PLQY) is a formidable challenge for organic light-emitting diode (OLED) applications. Herein, two NUV emitters PhImPOCz and PhImPOtBuCz were designed on the basis of phosphine oxide (PO) modification. It is showed that based on crescent phenanthrene (Phen) fused with acceptor imidazole (Im) as NUV chromophore, carbazole (Cz) or 3,6-di-tertbutyl carbazole (tBuCz) donors make the mol. bipolar character to balance carrier recombination in emissive layer (EML). More significantly, besides steric hindrance for aggregation suppression, the introduction of triphenylphosphine enhances localized excited feature of the electronic states, and prevents the red shift induced by intra- and inter- mol. charge transfer, which establishes the basis for fabricating host-free NUV OLEDs. The non-doped devices based on the PhImPOCz and PhImPOtBuCz emitters achieved the low turn-on voltages of 4.2 V and 4.4 V, and the state-of-the-art external quantum efficiency (EQE) up to 2.81% and 3.42%, resp. This work demonstrates the significance of electronic state engineering for high-energy OLED applications.

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Piperazine – Wikipedia,
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Abdel-Rahman, Laila H.; Basha, Maram T.; Al-Farhan, Badriah Saad; Ismael, Mohamed published an article about the compound: 1,10-Phenanthroline( cas:66-71-7,SMILESS:C1=CC3=C(C2=NC=CC=C12)N=CC=C3 ).Quality Control of 1,10-Phenanthroline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:66-71-7) through the article.

The emergence of drug-resistant pathogens has greatly limited the use of antibiotics in treating microbial infections. Therefore, Cu complexes have emerged as potential alternatives to ordinary antibiotics. Ternary Cu(II) complexes with N-benzoyl-DL-phenylalanine (Bzphe) and imidazole (Imi), methylimidazole (Mimi), 2,2′-bipyridine (Bipy), and 1,10-phenanthroline (Phen) ligands were prepared and investigated for antimicrobial efficacy against two Gram-pos. bacteria (Bacillus subtilis and Micrococcus luteus), one Gram-neg. bacteria (Escherichia coli), and three fungal cultures (Aspergillus niger, Candida glabrata, and Saccharomyces cerevisiae). The new complexes were characterized by elemental anal., IR spectroscopy, electronic spectroscopy, thermogravimetry, and measurements of their molar conductivity and m.p. The formulas of the new complexes were Cu(Bzphe)2(Imi)2(OH2)2, [Cu(Bzphe)2(Mimi)2(OH2)2], Cu(Bzphe)2(Bipy)(OH2)2, and Cu(Bzphe)2(Phen)(OH2)2. The obtained data revealed that the Bzphe invariably coordinates to the Cu(II) ions through carboxylic oxygen as a monobasic ligand. The addition of secondary ligands such as amines does not affect the unidentate coordination behavior of the Bzphe. The new compounds were screened for antimicrobial activity against different strains of bacteria and fungi. The results for the Bzphe ligand and its mixed-ligand Cu(II) complexes showed that the ligands exhibit low potency to inhibit the growth of both Gram-pos. bacteria (B. subtilis and M. luteus) and Gram-neg. bacteria (E. coli). However, the new ternary complexes greatly suppressed the growth of these pathogens according to the order CuBipyBzphe > CuPhenBzphe > CuMimiBzphe > CuImiBzphe. In addition, computational studies using d. functional theory calculations and mol. docking experiments were carried out to characterize the mol. properties of the new complexes and provide insights into their role in inhibiting the growth of bacterial and fungal strains.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Phenanthroline bridging graphitic carbon nitride framework and Fe (II) ions to promote transfer of photogenerated electrons for selective photocatalytic reduction of Nitrophenols, the main research direction is phenanthroline graphitic carbon nitride nitrophenol photocatalytic reduction; Fe (II); Graphitic carbon nitride; Nitrophenols; Phenanthroline; Selective reduction.Formula: C12H8N2.

Nitrophenols (NPs) are widely used in industries and highly toxic to ecol. environment and human health. Because aminophenols (APs) are important chems., catalytic reduction of NPs via efficient and environment-friendly strategies is of great importance. Herein, we developed a green photocatalysis route to efficiently convert NPs to APs using a Fe (II) modified graphitic carbon nitride (g-C3N4) photocatalyst, where phenanthroline units were employed to bridge Fe (II) and carbon nitride framework. The optimized sample P-CN-8-Fe presented significantly improved absorption of visible light, separation of photogenerated charges and carrier transportation in comparison with the pristine g-C3N4 and the modified samples of CN-Fe and P-CN-8. Accordingly, the P-CN-8-Fe showed a high conversion (97%) of p-nitrophenol (p-NP) to p-aminophenol (p-AP) under 2 h visible light irradiation, and meanwhile possessed high photocatalytic durability. Its high activity was also demonstrated through photocatalytic reduction of other NPs and nitrobenzene compounds Finally, a possible mechanism was proposed for the photocatalytic reduction of p-NP by P-CN-8-Fe. This work provides an effective approach to prepare Fe (II) modified g-C3N4 through the bridging effect of phenanthroline group, which is a potential visible light driven photocatalyst for reduction of nitrobenzene derivatives

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 66-71-7, is researched, SMILESS is C1=CC3=C(C2=NC=CC=C12)N=CC=C3, Molecular C12H8N2Journal, Article, International Journal of Biological Macromolecules called Lignin-based fluorescence-switchable graphene quantum dots for Fe3+ and ascorbic acid detection, Author is Zhu, Lingyan; Li, Dongbing; Lu, Heng; Zhang, Shangkun; Gao, Hao, the main research direction is lignin fluorescence graphene quantum dot ascorbic acid detection; Alkali lignin; Fluorescence sensing; Graphene quantum dots.Quality Control of 1,10-Phenanthroline.

The synthesis of lignin-based graphene quantum dots (GQDs) with excellent fluorescence stability, quantum yield, and biocompatibility for sensitive and selective detection of Fe3+ and ascorbic acid (AA) has remained a challenging endeavor. Using an acidolysis process with 17.5% nitric acid followed by hydrothermal treatment at 200 °C, this study provided an improved synthesis route for the production of high-quality GQDs from alkali lignin. The nitrogen-doped GQDs exhibit remarkable fluorescence stability under a wide range of pH (3-10), duration (1-12 h), and [NaCl] (0-1000 mM) conditions, and have a high quantum yield of 28%. The GQDs or GQDs/Fe3+ sensing systems ([GQDs] at 50 mg L-1, [Fe3+] at 500 °mol L-1, and UV excitation at 370 nm) for fluorescence sensing of Fe3+ or AA have excellent sensitivity, selectivity, and reproducibility. For Fe3+ and AA, the limit of detection is 1.49 and 1.62 °mol L-1, resp. Mechanism investigation shows that photoluminescence quenching is caused by the formation of GQDs-Fe3+ complexes, whereas fluorescence recovery is due to Fe3+ reduction by AA.

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Piperazine – Wikipedia,
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Related Products of 66-71-7. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,10-Phenanthroline, is researched, Molecular C12H8N2, CAS is 66-71-7, about Heteroleptic copper(II) complexes of prenylated flavonoid osajin behave as selective and effective antiproliferative and anti-inflammatory agents. Author is Vanco, Jan; Travnicek, Zdenek; Hosek, Jan; Dvorak, Zdenek.

Heteroleptic copper(II) complexes, containing prenylated flavonoid osajin isolated from the fruits of Maclura pomifera Schneid., were prepared and thoroughly characterized, including single crystal X-ray anal. Some of the following complexes of the general composition [Cu(L)(bpy)]NO3 (1), [Cu(L)(dimebpy)]NO3·2MeOH (2) [Cu(L)(phen)]NO3·H2O (3), [Cu(L)(bphen)]NO3 (4) and [Cu(L)(dppz)]NO3 (5), where HL stands for 3-(4-hydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one (osajin), bpy = 2,2′-bipyridine, dimebpy = 4,4′-dimethyl-2,2′-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline and dppz = dipyrido[3,2-a:2′,3′-c]phenazine, were also monitored for their solution stability and interactions with cysteine and glutathione by mass spectrometry. The in vitro cytotoxicity of the complexes was evaluated against a panel of eight human cancer cell lines: (MCF-7, HOS, A549, PC-3, A2780, A2780R, Caco-2, and THP-1). The results revealed high antiproliferative activity of the complexes with the best IC50 values of 0.5-3.4 μM for complexes (4) and (5), containing the bulkier N,N′-donor ligands (bphen, and dppz, resp.). The complexes also revealed a relatively low toxicity towards human hepatocytes (IC50 values are higher than 100 μM in some cases), and thus proved to be highly selective towards the cancer cells. On the other hand, the complexes showed a strong in vitro nuclease effect using the model pUC-19 plasmid. In the model of lipopolysaccharide-stimulated (LPS) THP-1 monocytes, the complexes revealed ability to lower the activity of nuclear factor kappa-B/activator protein 1 (NF-κB /AP-1) system and decrease the secretion of tumor necrosis factor alpha (TNF-α). Thus, the complexes have been identified as strong antiproliferative and anti-inflammatory compounds

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Reference:
Piperazine – Wikipedia,
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