Category: 59702-31-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-31-7,1-Ethylpiperazine-2,3-dione,as a common compound, the synthetic route is as follows.

The compound (0.15 g) obtained in Reference Example 20, 1-ethylpiperazine-2,3-dione (75 mg), sodium hydride (14 mg) and N,N-dimethylformamide (1 ml) were stirred at room temperature for 1 hr. The reaction mixture was diluted with ethyl acetate (100 ml), washed with 5% aqueous potassium hydrogen sulfate solution, saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. 4N Hydrogen chloride-ethyl acetate solution (10 ml) was added to the residue, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (72 mg) as a colorless powder. melting point 264-271C. Elemental analysis (C15H22ClN3O2¡¤0.1H2O) Calcd.: C, 57.45; H, 7.13; N, 13.40. Found: C, 57.19; H, 7.03; N, 13.40., 59702-31-7

The synthetic route of 59702-31-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1876179; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-31-7,1-Ethylpiperazine-2,3-dione,as a common compound, the synthetic route is as follows.

59702-31-7, 1) taking N-ethyldioxypiperazine 14.2 g (0.10 mol),Transfer to a 500 mL three-necked flask, stir, and add 200 mL of dichloromethane.Cool down to -25 to -20 C, add 16.3 g (0.15 mol) TMCS,Control temperature -25 ~ -20 C, add 11.9g (0.15mol) pyridine,Adding 0.018 g of DMAP, adding 11.9 g (0.04 mol) of triphosgene in batches at a temperature of -25 to -20 C, and maintaining the reaction for 30-60 minutes;After the reaction was completed, suction filtration, washing with 30 mL of dichloromethane and distillation to dryness under reduced pressure.Add 100 mL of n-hexane to crystallize and filter by suction.Drying gave 19.3 g of N-ethylbisoxypiperazine chloride in a yield of 94.3%.

59702-31-7 1-Ethylpiperazine-2,3-dione 108812, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Qilu Tianhe Huishi (Leling) Pharmaceutical Co., Ltd.; Qilu Tianhe Huishi Pharmaceutical Co., Ltd.; Sun Zhengjun; Fan Changying; Sun Yue; Li Yong; (7 pag.)CN109734725; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-31-7,1-Ethylpiperazine-2,3-dione,as a common compound, the synthetic route is as follows.

To N-ethyl-2,3-dioxopiperazine (2.84 g, 20 mmol) in DMF (25 mL) at RT under Argon atmosphere was added NaH (60%, 1.07 g, 26.6 mmol) in 3 portions. The reaction mixture was stirred at RT for 30 min, then tert-butyl bromoacetate (4.14 mL, 28 mmol) was added dropwise. The reaction mixture was stirred at RT for 3 h, quenched with aqueous saturated NH4C1, extracted with EtOAc. The organic extracts were combined, washed with water and brine, dried over Na2S04, concentrated, and purified by flash chromatography on silica gel (hexane-acetone,4: 1-0: 100) to afford the product, 940mg. ESI-MS m/z 257 (MH)+.

59702-31-7, As the paragraph descriping shows that 59702-31-7 is playing an increasingly important role.

Reference£º
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher J.; DAIGLE, Denis; CHU, Guo-Hua; HAMRICK, Jodie; LUCAS, Matthew; BOYD, Steven A.; ZULLI, Allison L.; MESAROS, Eugen F.; CONDON, Stephen M.; TROUT, Robert E. Lee; MYERS, Cullen L.; (186 pag.)WO2018/218190; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics