Category: 59695-29-3

Mrachkovskaya, L. B.; Anisimova, O. S.; Turchin, K. F.; Yakhontov, L. N. published an article in 1976, the title of the article was Formation of the bis(N-methylpiperazide) of monothiooxalic acid from 3-(N-methylpiperazinyl)propionic acid under conditions of the Zelinsky reaction.Formula: C8H18Cl2N2O2 And the article contains the following content:

The title compound I was obtained from piperazinepropionic acid (II) by boiling 2 hr with SOCl2, 2 hr with Br-CHCl3, and 5 hr with EtOH. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2

The Article related to piperazine thiooxalylbismethyl, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Formula: C8H18Cl2N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mrachkovskaya, L. B.; Turchin, K. F.; Yakhontov, L. N. published an article in 1975, the title of the article was Reduction fragmentation of 4-methyl-1-piperazinylmethylidenemalonate.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride And the article contains the following content:

Di-Et 4-methyl-1-piperazinylmethylidenemalonate (I), prepared in 83.5% yield from 1-methylpiperazine (II) and EtOCH:C(CO2Et)2, was reductively cleaved by NaBH4 in absolute EtOH at 20-5° to give 65% of a mixture of II and methylmalonic acid (III). Analogous reduction in dioxane gave 11% II-III and in cyclohexane 5% II-III were obtained. Similar results were obtained by catalytic reduction with Pt. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

The Article related to reduction cleavage piperazinylmethylenemalonic acid, pyruvoyl hydrazone reaction hydrazide, triazole acetyl anilino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On April 14, 1994, Bourzat, Jean Dominique; Commercon, Alain published a patent.Formula: C8H18Cl2N2O2 The title of the patent was Preparation of taxol analogs as antiproliferatives. And the patent contained the following:

Title compounds [I; R1 = (cyclo)alkyl, aryl, heterocyclyl, etc.; R2 = aminohydroxypropionyl group Q; R = Ph, OR6; R3 = aryl; R6 = (cyclo)alk(en)yl, Ph, N-containing heterocyclyl, etc.] were prepared as antiproliferatives (no data). Thus, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α,10β-trihydroxy-9-oxo-7β-triethylsilyloxy-11-taxene was acylated by 3-morpholinopropionic acid and the product acylated by (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid to give, in 2 addnl. steps, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-10β-(3-morpholinopropionyloxy)-9-oxo-11-taxen-13α-yl (2R,3S)-3-tert-butyloxy-2-hydroxy-3-phenylpropionate. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2

The Article related to taxol analog preparation antiproliferative, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Formula: C8H18Cl2N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 15, 2021, Hamilton, Gregory Lawrence; Patwardhan, Neeraj Narendra; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa; Chhabra, Milloni Balwantkumar published a patent.Application of 59695-29-3 The title of the patent was Preparation of lipid nanoparticle compositions for delivery of nucleic acids to cells. And the patent contained the following:

Lipid nanoparticle compositions for delivery of nucleic acids are described. In various embodiments the lipid nanoparticle contains an ionizable lipid of the formula I [R1 = alkyl, alkenyl; X1, X2 = O, (substituted) NH, alkylene, etc.; X3, X4 = heterocyclyl, heteroaryl, aryl, cycloalkyl, etc.; X5 = absent, alkyl, alkylene; X6 = H, alkyl, heteroaryl, heterocyclyl, etc.; A1, A2 = haloalkyl, alkenyl, etc.; n = 1-4]. Methods of using such lipid nanoparticle compositions to achieve targeted delivery of therapeutic cargo without the need for a targeting ligand are also provided. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Application of 59695-29-3

The Article related to lipid nanoparticle preparation nucleic acid delivery, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Application of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 10, 2021, Patwardhan, Neeraj Narendra; Chhabra, Milloni Balwantkumar; Hamilton, Gregory Lawrence; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa published a patent.Recommanded Product: 59695-29-3 The title of the patent was Preparation of lipid nanoparticles for nucleic acid delivery to immune cells. And the patent contained the following:

Lipid nanoparticle compositions comprising a conformationally constrained ionizable lipids useful for delivery of nucleic acids without the need for a targeting ligand are described. Compounds of formula I [wherein R1 = C9-20alkyl or C9-20alkenyl with 1-3 units of unsaturation; X1 and X2 independently = absent, -O-, NR2, -(CH)a-, wherein R2 is C1-6alkyl, and wherein X1 and X2 are not both -O- or NR2; a = integer between 1 and 6; X3 and X4 independently = (un)substituted 4- to 7-membered heterocyclyl or (un)substituted 5- to 6-membered heteroaryl; X5 = -(CH2)b-, wherein b = integer between 0 and 6; X6 = H, C1-6alkyl, (un)substituted 5- to 6-membered heteroaryl] and compositions thereof, are claimed and exemplified. Example compound II was prepared from a multistep process (preparation given). Prepared lipid nanoparticles in which siCD45 had been encapsulated were characterized using high throughput dynamic light scattering (data provided). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Recommanded Product: 59695-29-3

The Article related to lipid nanoparticle preparation nucleic acid deliver immune cell, sirna cd45 lipid nanoparticle encapsulation, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Recommanded Product: 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On April 14, 1994, Bourzat, Jean Dominique; Commercon, Alain published a patent.Formula: C8H18Cl2N2O2 The title of the patent was Preparation of taxol analogs as antiproliferatives. And the patent contained the following:

Title compounds [I; R1 = (cyclo)alkyl, aryl, heterocyclyl, etc.; R2 = aminohydroxypropionyl group Q; R = Ph, OR6; R3 = aryl; R6 = (cyclo)alk(en)yl, Ph, N-containing heterocyclyl, etc.] were prepared as antiproliferatives (no data). Thus, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α,10β-trihydroxy-9-oxo-7β-triethylsilyloxy-11-taxene was acylated by 3-morpholinopropionic acid and the product acylated by (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid to give, in 2 addnl. steps, 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-10β-(3-morpholinopropionyloxy)-9-oxo-11-taxen-13α-yl (2R,3S)-3-tert-butyloxy-2-hydroxy-3-phenylpropionate. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2

The Article related to taxol analog preparation antiproliferative, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Formula: C8H18Cl2N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 15, 2021, Hamilton, Gregory Lawrence; Patwardhan, Neeraj Narendra; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa; Chhabra, Milloni Balwantkumar published a patent.Application of 59695-29-3 The title of the patent was Preparation of lipid nanoparticle compositions for delivery of nucleic acids to cells. And the patent contained the following:

Lipid nanoparticle compositions for delivery of nucleic acids are described. In various embodiments the lipid nanoparticle contains an ionizable lipid of the formula I [R1 = alkyl, alkenyl; X1, X2 = O, (substituted) NH, alkylene, etc.; X3, X4 = heterocyclyl, heteroaryl, aryl, cycloalkyl, etc.; X5 = absent, alkyl, alkylene; X6 = H, alkyl, heteroaryl, heterocyclyl, etc.; A1, A2 = haloalkyl, alkenyl, etc.; n = 1-4]. Methods of using such lipid nanoparticle compositions to achieve targeted delivery of therapeutic cargo without the need for a targeting ligand are also provided. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Application of 59695-29-3

The Article related to lipid nanoparticle preparation nucleic acid delivery, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Application of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 10, 2021, Patwardhan, Neeraj Narendra; Chhabra, Milloni Balwantkumar; Hamilton, Gregory Lawrence; Sago, Cory Dane; Shehata, Mina Fawzy Gaballa published a patent.Recommanded Product: 59695-29-3 The title of the patent was Preparation of lipid nanoparticles for nucleic acid delivery to immune cells. And the patent contained the following:

Lipid nanoparticle compositions comprising a conformationally constrained ionizable lipids useful for delivery of nucleic acids without the need for a targeting ligand are described. Compounds of formula I [wherein R1 = C9-20alkyl or C9-20alkenyl with 1-3 units of unsaturation; X1 and X2 independently = absent, -O-, NR2, -(CH)a-, wherein R2 is C1-6alkyl, and wherein X1 and X2 are not both -O- or NR2; a = integer between 1 and 6; X3 and X4 independently = (un)substituted 4- to 7-membered heterocyclyl or (un)substituted 5- to 6-membered heteroaryl; X5 = -(CH2)b-, wherein b = integer between 0 and 6; X6 = H, C1-6alkyl, (un)substituted 5- to 6-membered heteroaryl] and compositions thereof, are claimed and exemplified. Example compound II was prepared from a multistep process (preparation given). Prepared lipid nanoparticles in which siCD45 had been encapsulated were characterized using high throughput dynamic light scattering (data provided). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Recommanded Product: 59695-29-3

The Article related to lipid nanoparticle preparation nucleic acid deliver immune cell, sirna cd45 lipid nanoparticle encapsulation, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Recommanded Product: 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On June 30, 1980, Carissimi, M.; Picciola, G.; Ravenna, F.; Gentili, P.; Carenini, G. published an article.Reference of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride The title of the article was Antidepressant activity of cyclohexylphenoxymorpholines. And the article contained the following:

2-[(Cyclohexylphenoxy)methyl]morpholines I (R = H, alkyl, aminoalkyl, piperazinopropionyl or -propyl, benzoylalkyl; R1 = 2-, 3-, or 4-cyclohexyl) were prepared by different methods and they showed antidepressant, tranquilizer, analgesic, and spasmolytic activity; I also inhibited blood platelet aggregation. The phenoxyisopropanolamine II reacted with ClCH2COCl to yield a 2-(phenoxymethyl)morpholin-5-one, the product was reduced (LiAlH4) to give a N-benzylmorpholine derivative, and hydrogenolysis of the latter gave I (R = H, R1 = 2-cyclohexyl). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Reference of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

The Article related to morpholine phenoxymethyl preparation antidepressant, phenoxymethylmorpholine preparation antidepressant analgesic, tranquilizer phenoxymethylmorpholine preparation, spasmolytic phenoxymethylmorpholine preparation, blood platelet phenoxymethylmorpholine preparation and other aspects.Reference of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On October 31, 1980, Carissimi, M.; Picciola, G.; Ravenna, F.; Carenini, G.; Gentili, P. published an article.Computed Properties of 59695-29-3 The title of the article was 2-(2-Thienyl)morpholines active on the central nervous system. And the article contained the following:

Morpholinones I [R = H, PhCH2, CHMe2, substituted 3-(1-piperazinyl)propionyl, substituted 3-(1-piperazinyl)propyl; Z = O] underwent LiAlH4 reduction to yield I (Z = H2), which showed antidepressant activity. Cyclocondensation of 2-benzylamin-1-(2-thienyl)ethanol with ClCH2COCl gave I (R = PhCH2, Z = 0). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Computed Properties of 59695-29-3

The Article related to morpholine thienyl preparation antidepressant, thienylmorpholine preparation antidepressant, analgesic thienylmorpholine preparation, antiinflammatory thienylmorpholine preparation and other aspects.Computed Properties of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics