Category: 59695-29-3

On March 16, 1986, Orjales Venero, Aurelio; Toledo Avello, Antonio published a patent.Synthetic Route of 59695-29-3 The title of the patent was Process for the preparation of amide derivatives of 4-amino-1,2,3,4,4a,9b-hexahydro-8,9b-dimethyldibenzofuran-3-one. And the patent contained the following:

The title amides I (R = alkyl; n = 1-4), known to be useful as analgesics and antitussives, are prepared by amidation of the title amine (II) with the corresponding (alkylpiperazinyl)alkanoic acids III in an anhydrous organic solvent and in the presence of a dehydrating agent. Thus, a solution of II.HCl in DMF was neutralized with K2CO3, filtered, and added to a solution of III.2HCl (R = Me, n = 2) and DCC in DMF, followed by workup and acidification, to give 50% I.2HCl (R = Me, n = 2). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Synthetic Route of 59695-29-3

The Article related to dibenzofuranone piperazinylalkanoylamino preparation analgesic antitussive, piperazinylalkanoylaminodibenzofuranone preparation analgesic antitussive, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Synthetic Route of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On March 16, 1986, Orjales Venero, Aurelio; Toledo Avello, Antonio published a patent.Synthetic Route of 59695-29-3 The title of the patent was Process for the preparation of amide derivatives of 4-amino-1,2,3,4,4a,9b-hexahydro-8,9b-dimethyldibenzofuran-3-one. And the patent contained the following:

The title amides I (R = alkyl; n = 1-4), known to be useful as analgesics and antitussives, are prepared by amidation of the title amine (II) with the corresponding (alkylpiperazinyl)alkanoic acids III in an anhydrous organic solvent and in the presence of a dehydrating agent. Thus, a solution of II.HCl in DMF was neutralized with K2CO3, filtered, and added to a solution of III.2HCl (R = Me, n = 2) and DCC in DMF, followed by workup and acidification, to give 50% I.2HCl (R = Me, n = 2). The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Synthetic Route of 59695-29-3

The Article related to dibenzofuranone piperazinylalkanoylamino preparation analgesic antitussive, piperazinylalkanoylaminodibenzofuranone preparation analgesic antitussive, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Synthetic Route of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mrachkovskaya, L. B.; Anisimova, O. S.; Turchin, K. F.; Yakhontov, L. N. published an article in 1976, the title of the article was Formation of the bis(N-methylpiperazide) of monothiooxalic acid from 3-(N-methylpiperazinyl)propionic acid under conditions of the Zelinsky reaction.Formula: C8H18Cl2N2O2 And the article contains the following content:

The title compound I was obtained from piperazinepropionic acid (II) by boiling 2 hr with SOCl2, 2 hr with Br-CHCl3, and 5 hr with EtOH. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2

The Article related to piperazine thiooxalylbismethyl, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Formula: C8H18Cl2N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mrachkovskaya, L. B.; Turchin, K. F.; Yakhontov, L. N. published an article in 1975, the title of the article was Reduction fragmentation of 4-methyl-1-piperazinylmethylidenemalonate.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride And the article contains the following content:

Di-Et 4-methyl-1-piperazinylmethylidenemalonate (I), prepared in 83.5% yield from 1-methylpiperazine (II) and EtOCH:C(CO2Et)2, was reductively cleaved by NaBH4 in absolute EtOH at 20-5掳 to give 65% of a mixture of II and methylmalonic acid (III). Analogous reduction in dioxane gave 11% II-III and in cyclohexane 5% II-III were obtained. Similar results were obtained by catalytic reduction with Pt. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

The Article related to reduction cleavage piperazinylmethylenemalonic acid, pyruvoyl hydrazone reaction hydrazide, triazole acetyl anilino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 15, 2018, Moustakim, Moses; Riedel, Kerstin; Schuller, Marion; Gehring, Andre P.; Monteiro, Octovia P.; Martin, Sarah P.; Fedorov, Oleg; Heer, Jag; Dixon, Darren J.; Elkins, Jonathan M.; Knapp, Stefan; Bracher, Franz; Brennan, Paul E. published an article.Computed Properties of 59695-29-3 The title of the article was Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. And the article contained the following:

The polyadenosine-diphosphate-ribose polymerase 14 (PARP14) has been implicated in DNA damage response pathways for homologous recombination. PARP14 contains three (ADP ribose binding) macrodomains (MD) whose exact contribution to overall PARP14 function in pathol. remains unclear. A medium throughput screen led to the identification of N-(2(-9H-carbazol-1-yl)phenyl)acetamide (GeA-69, 1) as a novel allosteric PARP14 MD2 (second MD of PARP14) inhibitor. We herein report medicinal chem. around this novel chemotype to afford a sub-micromolar PARP14 MD2 inhibitor. This chem. series provides a novel starting point for further development of PARP14 chem. probes. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Computed Properties of 59695-29-3

The Article related to carbazole scaffold preparation allosteric inhibitor parp14 macrodomain md2, inhibitor design, macrodomain, parp, poly-adp ribsose, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Computed Properties of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mrachkovskaya, L. B.; Anisimova, O. S.; Turchin, K. F.; Yakhontov, L. N. published an article in 1976, the title of the article was Formation of the bis(N-methylpiperazide) of monothiooxalic acid from 3-(N-methylpiperazinyl)propionic acid under conditions of the Zelinsky reaction.Formula: C8H18Cl2N2O2 And the article contains the following content:

The title compound I was obtained from piperazinepropionic acid (II) by boiling 2 hr with SOCl2, 2 hr with Br-CHCl3, and 5 hr with EtOH. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2

The Article related to piperazine thiooxalylbismethyl, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Formula: C8H18Cl2N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mrachkovskaya, L. B.; Turchin, K. F.; Yakhontov, L. N. published an article in 1975, the title of the article was Reduction fragmentation of 4-methyl-1-piperazinylmethylidenemalonate.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride And the article contains the following content:

Di-Et 4-methyl-1-piperazinylmethylidenemalonate (I), prepared in 83.5% yield from 1-methylpiperazine (II) and EtOCH:C(CO2Et)2, was reductively cleaved by NaBH4 in absolute EtOH at 20-5掳 to give 65% of a mixture of II and methylmalonic acid (III). Analogous reduction in dioxane gave 11% II-III and in cyclohexane 5% II-III were obtained. Similar results were obtained by catalytic reduction with Pt. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

The Article related to reduction cleavage piperazinylmethylenemalonic acid, pyruvoyl hydrazone reaction hydrazide, triazole acetyl anilino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

On July 15, 2018, Moustakim, Moses; Riedel, Kerstin; Schuller, Marion; Gehring, Andre P.; Monteiro, Octovia P.; Martin, Sarah P.; Fedorov, Oleg; Heer, Jag; Dixon, Darren J.; Elkins, Jonathan M.; Knapp, Stefan; Bracher, Franz; Brennan, Paul E. published an article.Computed Properties of 59695-29-3 The title of the article was Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. And the article contained the following:

The polyadenosine-diphosphate-ribose polymerase 14 (PARP14) has been implicated in DNA damage response pathways for homologous recombination. PARP14 contains three (ADP ribose binding) macrodomains (MD) whose exact contribution to overall PARP14 function in pathol. remains unclear. A medium throughput screen led to the identification of N-(2(-9H-carbazol-1-yl)phenyl)acetamide (GeA-69, 1) as a novel allosteric PARP14 MD2 (second MD of PARP14) inhibitor. We herein report medicinal chem. around this novel chemotype to afford a sub-micromolar PARP14 MD2 inhibitor. This chem. series provides a novel starting point for further development of PARP14 chem. probes. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Computed Properties of 59695-29-3

The Article related to carbazole scaffold preparation allosteric inhibitor parp14 macrodomain md2, inhibitor design, macrodomain, parp, poly-adp ribsose, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Computed Properties of 59695-29-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mrachkovskaya, L. B.; Anisimova, O. S.; Turchin, K. F.; Yakhontov, L. N. published an article in 1976, the title of the article was Formation of the bis(N-methylpiperazide) of monothiooxalic acid from 3-(N-methylpiperazinyl)propionic acid under conditions of the Zelinsky reaction.Formula: C8H18Cl2N2O2 And the article contains the following content:

The title compound I was obtained from piperazinepropionic acid (II) by boiling 2 hr with SOCl2, 2 hr with Br-CHCl3, and 5 hr with EtOH. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Formula: C8H18Cl2N2O2

The Article related to piperazine thiooxalylbismethyl, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Formula: C8H18Cl2N2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mrachkovskaya, L. B.; Turchin, K. F.; Yakhontov, L. N. published an article in 1975, the title of the article was Reduction fragmentation of 4-methyl-1-piperazinylmethylidenemalonate.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride And the article contains the following content:

Di-Et 4-methyl-1-piperazinylmethylidenemalonate (I), prepared in 83.5% yield from 1-methylpiperazine (II) and EtOCH:C(CO2Et)2, was reductively cleaved by NaBH4 in absolute EtOH at 20-5° to give 65% of a mixture of II and methylmalonic acid (III). Analogous reduction in dioxane gave 11% II-III and in cyclohexane 5% II-III were obtained. Similar results were obtained by catalytic reduction with Pt. The experimental process involved the reaction of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride(cas: 59695-29-3).Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

The Article related to reduction cleavage piperazinylmethylenemalonic acid, pyruvoyl hydrazone reaction hydrazide, triazole acetyl anilino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines and other aspects.Quality Control of 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics