Category: 55276-43-2piperazines

55276-43-2, 1-Methanesulfonylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55276-43-2, A mixture of 2-biphenylylcyanamide (3.8 g), 1-methanesulphonylpiperazine (3.8 g) and ethanol (60 ml) was heated at 90-95 C. for 12 hours to give N-(2-biphenylyl)-4-methanesulphonylpiperazine-1-carboxamidine (m.p. 178-180 C.) which was recrystallized from ethanol.

55276-43-2 1-Methanesulfonylpiperazine 709161, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; The Boots Company; US5302720; (1994); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55276-43-2, 1-Methanesulfonylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55276-43-2, (S)-Epichlorohydrin (48.0 mL, 0.612 mol) was added to a stirred solution of piperazine N-methylsulfonamide (87.3 g, 0.532 mol) in ethanol (1.33 L) at room temperature. The reaction mixture was stirred for 18 h and the white solid precipitate which formed was collected by filtration and washed with ethanol to afford (S)-1-chloro-3-(4-methylsulfonyl-1-piperazinyl)-2-propanol (107.76 g) as a white solid which was used without further purification. (m/z): [M+H]+ calcd for C8H17ClN2O3S, 257.07; found, 257.2. 1H-NMR (DMSO): delta (ppm) 2.37 (dd, 1H), 2.45 (dd, 1H), 2.50-2.58 (m, 4H), 2.86 (s, 3H), 3.09 (m, 4H), 3.55 (dd, 1H), 3.65 (dd, 1H), 3.84 (m, 1H), 5.09 (d, 1H).

As the paragraph descriping shows that 55276-43-2 is playing an increasingly important role.

Reference£º
Patent; THERAVANCE, INC.; US2006/100426; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.

Example 1; This Example illustrates the preparation of N- (3-phenyl-3- [4- METHANESULPHONYLPIPERAZIN-1-YL] PROPYL)-4- [2- (4-METHANESULPHONYLPHENYLSULPHONYL) ethyl] – piperidine (Compound No. 8, Table I). N- (3-Phenyl-3-chloropropyl)-4- [2- (4-methanesulphonylphenylsulphonyl) ethyl] – piperidine (prepared according to Method D; 180mg) was added to a solution of N- methanesulphonylpiperazine (61mg) and triethylamine (0. 102ML) in dichloromethane (10ML) and the mixture was allowed to stand at room temperature for 16 hours. The reaction mixture was poured onto a 20g silica Bond Elut eluted with a solvent gradient (ethyl acetate-25% methanol/ethyl acetate). The title compound was obtained, yield 67mg, MHF 612. NMR (CDC13) : 1.6-1. 8 (m, 7H), 2.2-2. 6 (m, 9H), 2.7 (m, 1H), 2.75 (s, 3H), 3.2 (m, 11H), 3.45 (m, 1H), 7.2 (d, 2H), 7.3 (m, 3H), 8.2 (m, 4H)., 55276-43-2

55276-43-2 1-Methanesulfonylpiperazine 709161, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2004/56773; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.

55276-43-2, A suspension of 1-methylsulfonylpiperazine (1.58 g, 9.6 mmol), 3-bromo-1-propanol (1.13 ml, 12 mmol) and potassium carbonate (1.73 g, 12 mmol) in acetonitrile (10 ml) was stirred at 40 C. for 4 hours followed by 2 hours at 70 C. The mixture was cooled, filtered and the filtrate was evaporated under vacuum. The residue was purified by column chromatography eluding with methylene chloride/methanol (97/3 followed by 95/5) to give 3-(4-methylsulfonylpiperazin-1-yl)propan-1-ol (1.95 g, 91%). 1H NMR Spectrum: (CDCl3) 1.8 (m, 2H), 2.7 (m, 6H), 2.8 (s, 3H), 3.3 (m, 4H), 3.82 (t, 2H), 4.5 (br s, 1H) MS: 223.4 (M+H)+

55276-43-2 1-Methanesulfonylpiperazine 709161, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Hennequin, Laurent Francois Andre; US2003/212055; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics