Category: 55121-99-8piperazines

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55121-99-8,(4-Aminophenyl)(4-methylpiperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.

55121-99-8, To a stirred solution of triphosgene (0.373 mg, 1.258 lmol) in anhydr. THF (20 ml) was added 7d (S)-4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)aniline (1.200 mg, 2.097 lmol) at 25 C. The reaction mixture wasstirred for 5 min and NEt3 (45 mL, 0.33 mmol) were added and the reaction mixture was stirred for additional 1 h. Then 9a 4-amino-N-(2-(dimethylamino)ethyl)-N-methylbenzamide (1.392 mg, 6.29 lmol) was added and stirred for another 0.5 h and NEt3 (406 mL, 2.91 mmol) was added and the mixture was stirred over night. The solvents were removed in a N2 stream and the crude mixture was purified by semi-prep-HPLC to obtain 3 as an off white solid (665 mg, 53%).

The synthetic route of 55121-99-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Dehnhardt, Christoph M.; Venkatesan, Aranapakam M.; Chen, Zecheng; Delos-Santos, Efren; Ayral-Kaloustian, Semiramis; Brooijmans, Natasja; Yu, Ker; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Mallon, Robert; Bioorganic and Medicinal Chemistry Letters; vol. 21; 16; (2011); p. 4773 – 4778;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8,55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 257Preparation of 1-{4-[3-(1-methylethyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl}-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea. To a stirred solution of triphosgene (35 mg, 0.12 mmol) in CH2Cl2 (4 mL) was added 4-(3-isopropyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)aniline (50 mg, 0.14 mmol) at 25 C. The reaction mixture was stirred for 15 min and NEt3 (20 muL, 0.14 mmol) was added. Stirring was continued for 1 h and (4-aminophenyl)(4-methylpiperazin-1-yl)methanone (103 mg, 0.43 mmol) and NEt3 (200 muL, 1.4 mmol) were added and the reaction mixture was stirred for additional 1 hr. The solvents were removed in a N2 stream and the crude mixture was purified by semi-prep-HPLC (NH3-method) to give 1-{4-[3-(1-methylethyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl}-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea (43 mg, 39% yield), MS (ESI) m/z 585.4.

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Wyeth; US2009/181963; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics